{"id":"https://openalex.org/W4289874787","doi":"https://doi.org/10.1002/cmdc.202200350","title":"Isolation of a Natural Killer Group 2D Small\u2010Molecule Ligand from DNA\u2010Encoded Chemical Libraries","display_name":"Isolation of a Natural Killer Group 2D Small\u2010Molecule Ligand from DNA\u2010Encoded Chemical Libraries","publication_year":2022,"publication_date":"2022-08-05","ids":{"openalex":"https://openalex.org/W4289874787","doi":"https://doi.org/10.1002/cmdc.202200350","pmid":"https://pubmed.ncbi.nlm.nih.gov/35929380"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.202200350","doi":"https://doi.org/10.1002/cmdc.202200350","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.202200350","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076594084","display_name":"Sheila Dakhel Plaza","orcid":"https://orcid.org/0000-0003-2546-6053","observed_orcids":["https://orcid.org/0000-0003-2546-6053"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sheila Dakhel","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","These authors contributed equally to this work"],"raw_orcid":"https://orcid.org/0000-0003-2546-6053","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072080476","display_name":"Andrea Galbiati","orcid":"https://orcid.org/0000-0003-0725-0726","observed_orcids":["https://orcid.org/0000-0003-0725-0726"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andrea Galbiati","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","These authors contributed equally to this work"],"raw_orcid":"https://orcid.org/0000-0003-0725-0726","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052169810","display_name":"Francesca Migliorini","orcid":"https://orcid.org/0000-0003-2149-978X","observed_orcids":["https://orcid.org/0000-0003-2149-978X"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Francesca Migliorini","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","These authors contributed equally to this work"],"raw_orcid":"https://orcid.org/0000-0003-2149-978X","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018326898","display_name":"Claudia Comacchio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Claudia Comacchio","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060108598","display_name":"Sebastian Oehler","orcid":"https://orcid.org/0000-0003-2013-7381","observed_orcids":["https://orcid.org/0000-0003-2013-7381"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sebastian Oehler","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-2013-7381","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081852392","display_name":"Luca Prati","orcid":"https://orcid.org/0000-0002-0044-6526","observed_orcids":["https://orcid.org/0000-0002-0044-6526"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luca Prati","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0044-6526","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068786003","display_name":"J\u00f6rg Scheuermann","orcid":"https://orcid.org/0000-0001-7746-4717","observed_orcids":["https://orcid.org/0000-0001-7746-4717"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Scheuermann","raw_affiliation_strings":["Department of Chemistry and Applied Biosciences ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135 8093 Z\u00fcrich Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-7746-4717","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Applied Biosciences ETH Z\u00fcrich  Vladimir-Prelog-Weg 1\u20135 8093 Z\u00fcrich Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023255344","display_name":"Samuele Cazzamalli","orcid":"https://orcid.org/0000-0003-0510-5664","observed_orcids":["https://orcid.org/0000-0003-0510-5664"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Samuele Cazzamalli","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0510-5664","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020168745","display_name":"Dario Neri","orcid":"https://orcid.org/0000-0001-5234-7370","observed_orcids":["https://orcid.org/0000-0001-5234-7370"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dario Neri","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5234-7370","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013570701","display_name":"Gabriele Bassi","orcid":"https://orcid.org/0000-0002-9439-8624","observed_orcids":["https://orcid.org/0000-0002-9439-8624","https://orcid.org/0000-0003-0793-5223","https://orcid.org/0000-0003-3617-9578"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Gabriele Bassi","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-9439-8624","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007857615","display_name":"Nicholas Favalli","orcid":"https://orcid.org/0000-0002-6538-7379","observed_orcids":["https://orcid.org/0000-0002-6538-7379"]},"institutions":[{"id":"https://openalex.org/I4210109060","display_name":"Philochem (Switzerland)","ror":"https://ror.org/01hp71z51","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210109060"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Nicholas Favalli","raw_affiliation_strings":["Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6538-7379","affiliations":[{"raw_affiliation_string":"Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland","institution_ids":["https://openalex.org/I4210109060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007857615","https://openalex.org/A5013570701"],"corresponding_institution_ids":["https://openalex.org/I4210109060"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":0.1872,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.34832142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"17","issue":"21","first_page":"e202200350","last_page":"e202200350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.9940000176429749},{"id":"https://openalex.org/keywords/small-molecule-ligands","display_name":"small-molecule ligands","score":0.7689999938011169},{"id":"https://openalex.org/keywords/dna-encoded-libraries","display_name":"DNA-encoded libraries","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nk-cell-redirection","display_name":"NK cell redirection","score":0.5659999847412109},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6200000047683716},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.6700000166893005},{"id":"https://openalex.org/keywords/bispecific-molecules","display_name":"bispecific molecules","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2778867473","wikidata":"https://www.wikidata.org/wiki/Q17544382","display_name":"NKG2D","level":4,"score":0.8475496768951416},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.607192873954773},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5626611709594727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43688833713531494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4362497925758362},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.42130327224731445},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4176645874977112},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41378432512283325},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.40775227546691895},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3675861358642578},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2307683825492859},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21522217988967896},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19421285390853882},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12535899877548218}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055655","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily K","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/cmdc.202200350","doi":"https://doi.org/10.1002/cmdc.202200350","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.202200350","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:35929380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35929380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/1003811","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11585/1003811","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1148600792","https://openalex.org/W1658020800","https://openalex.org/W1968753037","https://openalex.org/W1973833245","https://openalex.org/W1987857872","https://openalex.org/W2014367004","https://openalex.org/W2024579897","https://openalex.org/W2037057992","https://openalex.org/W2045904095","https://openalex.org/W2053104174","https://openalex.org/W2057064048","https://openalex.org/W2077217249","https://openalex.org/W2082259677","https://openalex.org/W2085341040","https://openalex.org/W2091797975","https://openalex.org/W2112979860","https://openalex.org/W2142548447","https://openalex.org/W2155475165","https://openalex.org/W2230047757","https://openalex.org/W2258214357","https://openalex.org/W2286829287","https://openalex.org/W2301707637","https://openalex.org/W2395275152","https://openalex.org/W2433252540","https://openalex.org/W2488973720","https://openalex.org/W2510341570","https://openalex.org/W2560677837","https://openalex.org/W2592709654","https://openalex.org/W2608365863","https://openalex.org/W2782995788","https://openalex.org/W2783268592","https://openalex.org/W2792466565","https://openalex.org/W2792485109","https://openalex.org/W2803083648","https://openalex.org/W2804736717","https://openalex.org/W2913598126","https://openalex.org/W2930772351","https://openalex.org/W2949370179","https://openalex.org/W2965362447","https://openalex.org/W3007495084","https://openalex.org/W3007682465","https://openalex.org/W3016667495","https://openalex.org/W3038287915","https://openalex.org/W3094753999","https://openalex.org/W3115530920","https://openalex.org/W3116321166","https://openalex.org/W3125114205","https://openalex.org/W3129800693","https://openalex.org/W3132548504","https://openalex.org/W3133851812","https://openalex.org/W3134763925","https://openalex.org/W3135688349","https://openalex.org/W3151660804","https://openalex.org/W3156123897","https://openalex.org/W3159185078","https://openalex.org/W3159583337","https://openalex.org/W3162427447","https://openalex.org/W3169689223","https://openalex.org/W3176208875","https://openalex.org/W3186424684","https://openalex.org/W3197466206","https://openalex.org/W3201812987","https://openalex.org/W3210679153","https://openalex.org/W3210933549","https://openalex.org/W3216143400","https://openalex.org/W4200255107","https://openalex.org/W6739169507"],"related_works":["https://openalex.org/W4387166430","https://openalex.org/W4388178779","https://openalex.org/W2891223165","https://openalex.org/W2324310234","https://openalex.org/W3201812987","https://openalex.org/W6999392384","https://openalex.org/W3028731234","https://openalex.org/W2613791567","https://openalex.org/W4317498742","https://openalex.org/W7110530769"],"abstract_inverted_index":{"Abstract":[0],"Natural":[1],"Killer":[2],"Group":[3],"2D":[4],"(NKG2D)":[5],"is":[6,12],"a":[7,47,79,89],"homo\u2010dimeric":[8],"transmembrane":[9],"protein":[10,49],"which":[11,110,121],"typically":[13],"expressed":[14,50],"on":[15,51],"the":[16,52,62,76,103],"surface":[17,53],"of":[18,43,54,65,78,96,105],"natural":[19,23],"killer":[20,24],"(NK)":[21],"cells,":[22,27,32,56],"T":[25,30],"(NKT)":[26],"gamma":[28],"delta":[29],"(\u03b3\u03b4T)":[31],"activated":[33,38],"CD8":[34],"positive":[35],"T\u2010cells":[36],"and":[37,120],"macrophages.":[39],"Bispecific":[40],"molecules,":[41],"capable":[42],"bridging":[44],"NKG2D":[45,81,99],"with":[46],"target":[48],"tumor":[55,126],"may":[57,101,111,122],"be":[58],"used":[59],"to":[60,116],"redirect":[61],"cytotoxic":[63],"activity":[64],"NK\u2010cells":[66],"towards":[67],"antigen\u2010positive":[68],"malignant":[69],"T\u2010cells.":[70],"In":[71],"this":[72],"work,":[73],"we":[74],"report":[75],"discovery":[77,95],"novel":[80],"small":[82,97],"molecule":[83],"binder":[84],"[KD=(410\u00b160)":[85],"nM],":[86],"isolated":[87],"from":[88,124],"DNA\u2010Encoded":[90],"Chemical":[91],"Library":[92],"(DEL).":[93],"The":[94],"organic":[98],"ligands":[100],"facilitate":[102],"generation":[104],"fully":[106],"synthetic":[107],"bispecific":[108,117],"adaptors,":[109],"serve":[112],"as":[113],"an":[114],"alternative":[115],"antibody":[118],"products":[119],"benefit":[123],"better":[125],"targeting":[127],"properties.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-05T00:00:00"}
