{"id":"https://openalex.org/W4289868948","doi":"https://doi.org/10.3389/fnins.2022.931161","title":"Identification of key genes and pathways revealing the central regulatory mechanism of brain-derived glucagon-like peptide-1 on obesity using bioinformatics analysis","display_name":"Identification of key genes and pathways revealing the central regulatory mechanism of brain-derived glucagon-like peptide-1 on obesity using bioinformatics analysis","publication_year":2022,"publication_date":"2022-08-05","ids":{"openalex":"https://openalex.org/W4289868948","doi":"https://doi.org/10.3389/fnins.2022.931161","pmid":"https://pubmed.ncbi.nlm.nih.gov/35992905","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9389235"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2022.931161","doi":"https://doi.org/10.3389/fnins.2022.931161","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.931161","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.931161/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.931161/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109599029","display_name":"Yu-Wei Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuwei Shao","raw_affiliation_strings":["Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429256","display_name":"Jun Tian","orcid":"https://orcid.org/0000-0001-6134-100X","observed_orcids":["https://orcid.org/0000-0001-6134-100X"]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Tian","raw_affiliation_strings":["Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636314","display_name":"Yanan Yang","orcid":"https://orcid.org/0009-0000-2717-7453","observed_orcids":["https://orcid.org/0009-0000-2717-7453","https://orcid.org/0009-0008-6190-8094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanan Yang","raw_affiliation_strings":["Department of Traditional Chinese Medicine, China Resources Wugang General Hospital, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine, China Resources Wugang General Hospital, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102783031","display_name":"Yan Hu","orcid":"https://orcid.org/0000-0003-1255-6797","observed_orcids":["https://orcid.org/0000-0003-1255-6797","https://orcid.org/0000-0001-7208-1952"]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Hu","raw_affiliation_strings":["Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101842452","display_name":"Ye Zhu","orcid":"https://orcid.org/0000-0002-9687-3089","observed_orcids":["https://orcid.org/0000-0002-9687-3089"]},"institutions":[{"id":"https://openalex.org/I870392255","display_name":"Wuhan Sports University","ror":"https://ror.org/004je0088","country_code":"CN","type":"education","lineage":["https://openalex.org/I870392255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Zhu","raw_affiliation_strings":["College of Health Sciences, Wuhan Sports University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health Sciences, Wuhan Sports University, Wuhan, China","institution_ids":["https://openalex.org/I870392255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041772903","display_name":"Qing Shu","orcid":"https://orcid.org/0000-0001-7610-7419","observed_orcids":["https://orcid.org/0000-0001-7610-7419"]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Shu","raw_affiliation_strings":["Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041772903"],"corresponding_institution_ids":["https://openalex.org/I4210120234"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.2639,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.46376812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":null,"first_page":"931161","last_page":"931161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9380000233650208},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/biglycan","display_name":"biglycan","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mapkapk3","display_name":"MAPKAPK3","score":0.953000009059906},{"id":"https://openalex.org/keywords/chemogenetic-activation","display_name":"chemogenetic activation","score":0.5260000228881836},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.699999988079071},{"id":"https://openalex.org/keywords/body-mass","display_name":"body mass","score":0.7490000128746033},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8009999990463257},{"id":"https://openalex.org/keywords/appetite-suppression","display_name":"appetite suppression","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.8869283199310303},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7252168655395508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6338629722595215},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4753260910511017},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4523738622665405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39229387044906616},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3655654788017273},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.24003776907920837}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnins.2022.931161","doi":"https://doi.org/10.3389/fnins.2022.931161","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.931161","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.931161/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9389235","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9389235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:35992905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35992905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:302acebddbcc42c1bc0e9b4c7ff29d43","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/302acebddbcc42c1bc0e9b4c7ff29d43","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 16 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2022.931161","doi":"https://doi.org/10.3389/fnins.2022.931161","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2022.931161","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2022.931161/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1617768031","display_name":null,"funder_award_id":"81804180","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4315072783","display_name":null,"funder_award_id":"WJ2019H163","funder_id":"https://openalex.org/F4320317798","funder_display_name":"Health Commission of Hubei Province"}],"funders":[{"id":"https://openalex.org/F4320317798","display_name":"Health Commission of Hubei Province","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324116","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17"},{"id":"https://openalex.org/F4320329542","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4289868948.pdf","grobid_xml":"https://content.openalex.org/works/W4289868948.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1509983325","https://openalex.org/W1853525790","https://openalex.org/W1965498876","https://openalex.org/W1968939832","https://openalex.org/W1973766879","https://openalex.org/W1974515660","https://openalex.org/W1979288606","https://openalex.org/W1997218140","https://openalex.org/W2015331972","https://openalex.org/W2074501705","https://openalex.org/W2090147204","https://openalex.org/W2102321702","https://openalex.org/W2106036385","https://openalex.org/W2110256992","https://openalex.org/W2129874885","https://openalex.org/W2146534889","https://openalex.org/W2150833441","https://openalex.org/W2152001256","https://openalex.org/W2161271012","https://openalex.org/W2180065345","https://openalex.org/W2306799387","https://openalex.org/W2346504440","https://openalex.org/W2399947804","https://openalex.org/W2481166072","https://openalex.org/W2499342204","https://openalex.org/W2534293284","https://openalex.org/W2559588208","https://openalex.org/W2606501233","https://openalex.org/W2745223669","https://openalex.org/W2753168407","https://openalex.org/W2755719114","https://openalex.org/W2810188382","https://openalex.org/W2900569176","https://openalex.org/W2901264897","https://openalex.org/W2904541118","https://openalex.org/W2912684103","https://openalex.org/W2913202413","https://openalex.org/W2914227154","https://openalex.org/W2924479779","https://openalex.org/W2968500473","https://openalex.org/W2968992941","https://openalex.org/W2972217240","https://openalex.org/W2983027288","https://openalex.org/W3011908879","https://openalex.org/W3017351980","https://openalex.org/W3033972450","https://openalex.org/W3041314279","https://openalex.org/W3118786201","https://openalex.org/W3119033633","https://openalex.org/W3173884465"],"related_works":["https://openalex.org/W2566010803","https://openalex.org/W4200273037","https://openalex.org/W7203640528","https://openalex.org/W7172098269","https://openalex.org/W4404800980","https://openalex.org/W2161565659","https://openalex.org/W3184607597","https://openalex.org/W3137550402","https://openalex.org/W4416850224","https://openalex.org/W4416142614"],"abstract_inverted_index":{"Objective":[0],"Central":[1],"glucagon-like":[2],"peptide-1":[3],"(GLP-1)":[4],"is":[5],"a":[6,269,344],"target":[7,349],"in":[8,31,132,150,216,224,245,266,271,293,313,337],"treating":[9],"obesity":[10,340],"due":[11],"to":[12,36,105,125,254,339],"its":[13],"effect":[14],"on":[15],"suppressing":[16],"appetite,":[17],"but":[18],"the":[19,39,74,107,113,127,133,140,151,180,220,231,255,281,301,314,324,334],"possible":[20],"downstream":[21,40],"key":[22],"genes":[23,43,116,145,171,178,212,240,251],"that":[24,202,238,308,320],"GLP-1":[25,46,130,158,265,290,321,338],"regulated":[26],"have":[27],"not":[28],"been":[29],"studied":[30],"depth.":[32],"This":[33],"study":[34],"intends":[35],"screen":[37],"out":[38],"feeding":[41],"regulation":[42],"of":[44,87,112,129,142,157,163,198,208,230,264,289,303,309,327],"central":[45],"neurons":[47,131],"through":[48],"bioinformatics":[49,119],"analysis":[50,200,236],"and":[51,65,84,89,100,138,146,172,187,222,260,274,286,307,329,341,347],"verify":[52],"them":[53],"by":[54,297],"chemical":[55],"genetics,":[56],"which":[57],"may":[58],"provide":[59,343],"insights":[60],"for":[61,350],"future":[62],"research.":[63],"Materials":[64],"methods":[66,124],"GSE135862":[67],"genetic":[68],"expression":[69,182,288,302,326],"profiles":[70],"were":[71,95,103,166,184,204,213,291],"extracted":[72],"from":[73],"Gene":[75],"Expression":[76],"Omnibus":[77],"(GEO)":[78],"database.":[79],"The":[80,176,196,228,248,284],"gene":[81,285],"ontology":[82],"(GO)":[83],"Kyoto":[85],"Encyclopedia":[86],"Genes":[88],"Genomes":[90],"pathway":[91,234],"(KEGG)":[92],"enrichment":[93,235],"analyses":[94],"carried":[96],"out.":[97],"STRING":[98],"database":[99],"Cytoscape":[101,256],"software":[102,257],"used":[104],"map":[106],"protein-protein":[108],"interaction":[109],"(PPI)":[110],"network":[111,336],"differentially":[114],"expressed":[115],"(DEGs).":[117],"After":[118],"analysis,":[120],"we":[121],"applied":[122],"chemogenetic":[123,278],"modulate":[126,323],"activities":[128],"nucleus":[134],"tractus":[135],"solitarius":[136],"(NTS)":[137],"observed":[139],"alterations":[141],"screened":[143],"differential":[144,209,239],"their":[147],"protein":[148,189,192,287,325],"expressions":[149],"hypothalamus":[152],"under":[153],"different":[154],"excitatory":[155],"conditions":[156],"neurons.":[159],"Results":[160],"A":[161],"total":[162],"49":[164],"DEGs":[165],"discovered,":[167],"including":[168],"38":[169],"downregulated":[170,312],"11":[173],"upregulated":[174,292,306],"genes.":[175,210],"two":[177],"with":[179],"highest":[181],"scores":[183],"biglycan":[185],"(Bgn)":[186],"mitogen-activated":[188],"kinase":[190,193],"activated":[191,296],"3":[194],"(Mapkapk3).":[195],"results":[197,229],"GO":[199],"showed":[201,237,319],"there":[203],"10":[205,225],"molecular":[206],"functions":[207],"Differential":[211],"mainly":[214],"localized":[215],"seven":[217,246],"regions":[218],"around":[219],"cells,":[221],"enriched":[223],"biology":[226],"processes.":[227],"KEGG":[232],"signaling":[233],"played":[241],"an":[242],"important":[243],"role":[244],"pathways.":[247],"top":[249],"15":[250],"selected":[252],"according":[253],"included":[258],"Bgn":[259,304,328],"Mapkapk3.":[261,330],"Chemogenetic":[262],"activation":[263],"NTS":[267,294],"induced":[268,280],"decrease":[270],"food":[272],"intake":[273],"body":[275],"mass,":[276],"while":[277],"inhibition":[279],"opposite":[282],"effect.":[283],"when":[295],"chemogenetics.":[298],"In":[299],"addition,":[300],"was":[305,311],"Mapkapk3":[310],"hypothalamus.":[315],"Conclusion":[316],"Our":[317,331],"data":[318],"could":[322],"findings":[332],"elucidated":[333],"regulatory":[335],"might":[342],"novel":[345],"diagnostic":[346],"therapeutic":[348],"obesity.":[351]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-08-05T00:00:00"}
