{"id":"https://openalex.org/W4289867121","doi":null,"title":"Predicting the steady-state rate of mRNA translation in protein biosynthesis","display_name":"Predicting the steady-state rate of mRNA translation in protein biosynthesis","publication_year":2017,"publication_date":"2017-07-16","ids":{"openalex":"https://openalex.org/W4289867121"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-01938988v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01938988","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"19th IUPAB congress and 11th EBSA congress, Jul 2017, Edinburgh, United Kingdom","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028343194","display_name":"Juraj Szavits-Nossan","orcid":"https://orcid.org/0000-0002-1540-5209","observed_orcids":["https://orcid.org/0000-0002-1540-5209"]},"institutions":[{"id":"https://openalex.org/I4210125355","display_name":"Scottish Universities Physics Alliance","ror":"https://ror.org/026efkc57","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210125355"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Szavits-Nossan, Juraj","raw_affiliation_strings":["SUPA School of Physics and Astronomy [Edinburgh]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUPA School of Physics and Astronomy [Edinburgh]","institution_ids":["https://openalex.org/I4210125355","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004472589","display_name":"Luca Ciandrini","orcid":"https://orcid.org/0000-0001-5859-2764","observed_orcids":["https://orcid.org/0000-0001-5859-2764"]},"institutions":[{"id":"https://openalex.org/I4210128986","display_name":"Laboratoire Charles Coulomb","ror":"https://ror.org/02ftce284","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210098836","https://openalex.org/I4210128986"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ciandrini, Luca","raw_affiliation_strings":["Laboratoire Charles Coulomb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Charles Coulomb","institution_ids":["https://openalex.org/I4210128986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054318366","display_name":"Carmen Maria Romano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Romano, Carmen Maria","raw_affiliation_strings":["Institute of Complex Systems and Mathematical Biology, University of Aberdeen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Complex Systems and Mathematical Biology, University of Aberdeen","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41758014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/codon-usage-bias","display_name":"codon usage bias","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ribosome-density","display_name":"ribosome density","score":0.6359999775886536},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/steady-state-solutions","display_name":"stationary solutions","score":0.7210000157356262},{"id":"https://openalex.org/keywords/analytical-solution","display_name":"analytical solution","score":0.6669999957084656},{"id":"https://openalex.org/keywords/kinetic-model","display_name":"kinetic model","score":0.5339999794960022},{"id":"https://openalex.org/keywords/translation-efficiency","display_name":"translation efficiency","score":0.7580000162124634},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ribosome-profiling","display_name":"ribosome profiling","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.7297641038894653},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.7254296541213989},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5667900443077087},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5599006414413452},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5389453172683716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4772481918334961},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3389800190925598},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3212476372718811},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30108726024627686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18931201100349426},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16266325116157532},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12959125638008118},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.07740482687950134}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-01938988v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01938988","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"19th IUPAB congress and 11th EBSA congress, Jul 2017, Edinburgh, United Kingdom","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2999194912","https://openalex.org/W4301525843","https://openalex.org/W2991352720","https://openalex.org/W4299319605","https://openalex.org/W2025569664","https://openalex.org/W3022806322","https://openalex.org/W2792459789","https://openalex.org/W2908789548","https://openalex.org/W2075487771","https://openalex.org/W2493555073"],"abstract_inverted_index":{"Existing":[0],"evidence":[1],"such":[2,66],"as":[3,67],"codon":[4,42],"usage":[5],"bias":[6],"suggests":[7],"that":[8,30,100,121],"protein":[9,59],"translation":[10,99,141,161,181],"of":[11,48,76,106,116,173,180],"fast-growing":[12],"organisms":[13],"has":[14],"been":[15],"optimised":[16],"for":[17,24,40,98,150,159],"accuracy":[18],"and":[19,80,118,163],"better":[20],"yield.":[21],"One":[22],"possibility":[23],"optimisation":[25],"stems":[26],"from":[27],"the":[28,46,87,110,135,140,151,160,174,178],"fact":[29],"different":[31,36],"codons":[32],"are":[33],"translated":[34],"at":[35],"rates.":[37],"Common":[38],"measures":[39],"optimal":[41],"choice,":[43],"which":[44],"ignore":[45],"dynamics":[47],"this":[49,77,91,117],"process,":[50],"have":[51],"so":[52],"far":[53],"had":[54],"mixed":[55],"success":[56],"in":[57,63],"predicting":[58],"levels.":[60],"Recent":[61],"advances":[62],"experimental":[64],"techniques":[65],"ribosome":[68,164],"profiling":[69],"allow":[70],"us":[71],"to":[72,85,124,133,154,170],"study":[73,94],"dynamical":[74],"details":[75],"intricate":[78],"process":[79],"theoretical":[81],"modelling":[82],"is":[83,143],"required":[84],"interpret":[86],"new":[88],"data.":[89],"In":[90],"work":[92],"we":[93,127],"a":[95,129,144],"kinetic":[96],"model":[97],"takes":[101],"into":[102],"account":[103],"stochastic":[104],"movement":[105],"individual":[107],"ribosomes":[108],"along":[109],"mRNA":[111],"molecule.":[112],"Unlike":[113],"previous":[114],"studies":[115],"similar":[119],"models":[120],"were":[122],"limited":[123],"numerical":[125],"simulations,":[126],"develop":[128],"novel":[130],"mathematical":[131],"method":[132],"find":[134,155],"steady":[136],"state":[137],"solution":[138],"when":[139],"initiation":[142],"rate-limiting":[145],"step.":[146],"This":[147],"allows":[148],"us,":[149],"first":[152],"time,":[153],"an":[156],"analytic":[157],"prediction":[158],"rate":[162],"density.":[165],"We":[166],"use":[167],"these":[168],"predictions":[169],"address":[171],"some":[172],"long-standing":[175],"controversies":[176],"surrounding":[177],"determinants":[179],"efficiency.":[182]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-08-05T00:00:00"}