{"id":"https://openalex.org/W4289778752","doi":"https://doi.org/10.1002/adbi.202200187","title":"Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells","display_name":"Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells","publication_year":2022,"publication_date":"2022-08-04","ids":{"openalex":"https://openalex.org/W4289778752","doi":"https://doi.org/10.1002/adbi.202200187","pmid":"https://pubmed.ncbi.nlm.nih.gov/35925609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9474679"},"language":"en","primary_location":{"id":"doi:10.1002/adbi.202200187","doi":"https://doi.org/10.1002/adbi.202200187","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adbi.202200187","pdf_url":null,"source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9474679","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072334865","display_name":"Mar\u00eda Daniela Santi","orcid":"https://orcid.org/0000-0002-3866-1424","observed_orcids":["https://orcid.org/0000-0002-3866-1424"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Daniela Santi","raw_affiliation_strings":["Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001434696","display_name":"Morgan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Zhang","raw_affiliation_strings":["Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087974285","display_name":"Elizabeth Salvo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Salvo","raw_affiliation_strings":["Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030395315","display_name":"Kesava R. Asam","orcid":"https://orcid.org/0000-0002-6247-9905","observed_orcids":["https://orcid.org/0000-0002-6247-9905"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kesava Asam","raw_affiliation_strings":["Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072286188","display_name":"Chi Tonglien Viet","orcid":"https://orcid.org/0000-0001-5078-7807","observed_orcids":["https://orcid.org/0000-0001-5078-7807"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi T. Viet","raw_affiliation_strings":["Loma Linda University School of Dentistry, Loma Linda, CA, 92350 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University School of Dentistry, Loma Linda, CA, 92350 USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073502048","display_name":"Tongxin Xie","orcid":"https://orcid.org/0009-0005-1620-8927","observed_orcids":["https://orcid.org/0009-0005-1620-8927"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tongxin Xie","raw_affiliation_strings":["Head &amp; Neck Surgery The University of Texas MD Anderson Cancer Center  Houston TX 77030 USA","Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head &amp; Neck Surgery The University of Texas MD Anderson Cancer Center  Houston TX 77030 USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030 USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020811172","display_name":"Moran Amit","orcid":"https://orcid.org/0000-0002-9720-7766","observed_orcids":["https://orcid.org/0000-0002-9720-7766"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moran Amit","raw_affiliation_strings":["Head &amp; Neck Surgery The University of Texas MD Anderson Cancer Center  Houston TX 77030 USA","Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head &amp; Neck Surgery The University of Texas MD Anderson Cancer Center  Houston TX 77030 USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030 USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008145165","display_name":"Bradley E. Aouizerat","orcid":"https://orcid.org/0000-0002-6047-9397","observed_orcids":["https://orcid.org/0000-0002-6047-9397"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley Aouizerat","raw_affiliation_strings":["Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101652031","display_name":"Yi Ye","orcid":"https://orcid.org/0000-0002-1075-5584","observed_orcids":["https://orcid.org/0000-0002-1075-5584"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yi Ye","raw_affiliation_strings":["Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA"],"raw_orcid":"https://orcid.org/0000-0002-1075-5584","affiliations":[{"raw_affiliation_string":"Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Oral Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, 10012 USA","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101652031"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.2739,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77834829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"6","issue":"9","first_page":"e2200187","last_page":"e2200187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.44600000977516174},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.718999981880188},{"id":"https://openalex.org/keywords/hallmarks-of-cancer","display_name":"cancer hallmarks","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8539999723434448},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9319999814033508},{"id":"https://openalex.org/keywords/proteoglycans-in-cancer","display_name":"proteoglycans in cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.689601480960846},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.666205644607544},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6040620803833008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5792102813720703},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5634582042694092},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.536030650138855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37002086639404297},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32803019881248474},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11484694480895996}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/adbi.202200187","doi":"https://doi.org/10.1002/adbi.202200187","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adbi.202200187","pdf_url":null,"source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},{"id":"pmid:35925609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35925609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9474679","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9474679","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Biol (Weinh)","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-3448","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/2505","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9474679","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9474679","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Biol (Weinh)","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1253232778","display_name":"Schwann cell activation in oral cancer perineurial invasion and neuropathic pain","funder_award_id":"R01DE029493","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2154278428","display_name":"Schwann Cell Activation and Oral Cancer Pain","funder_award_id":"R03DE027777","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000910189","display_name":"Clinical study to evaluate the methylation signature of head and neck squamous cell carcinoma pain","funder_award_id":"K23DE030250","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000920793","display_name":"The REASON Score: An Epigenetic And Clinicopathologic Score to Predict Risk of Poor Survival in Early Stage Oral Squamous Cell Carcinoma Patients","funder_award_id":"R01DE031395","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1578104218","https://openalex.org/W1586171642","https://openalex.org/W1793958682","https://openalex.org/W1837051231","https://openalex.org/W1969131602","https://openalex.org/W1982242924","https://openalex.org/W1986657538","https://openalex.org/W1997774562","https://openalex.org/W2014058353","https://openalex.org/W2025894409","https://openalex.org/W2056950988","https://openalex.org/W2082641730","https://openalex.org/W2086641174","https://openalex.org/W2096121913","https://openalex.org/W2096252197","https://openalex.org/W2117098158","https://openalex.org/W2120421863","https://openalex.org/W2122539169","https://openalex.org/W2143468862","https://openalex.org/W2149314308","https://openalex.org/W2209781374","https://openalex.org/W2306715392","https://openalex.org/W2310326452","https://openalex.org/W2346820190","https://openalex.org/W2395470723","https://openalex.org/W2396814975","https://openalex.org/W2397525825","https://openalex.org/W2412418897","https://openalex.org/W2520632143","https://openalex.org/W2565655079","https://openalex.org/W2581841075","https://openalex.org/W2608458533","https://openalex.org/W2792389397","https://openalex.org/W2794233257","https://openalex.org/W2794391482","https://openalex.org/W2809059040","https://openalex.org/W2884043412","https://openalex.org/W2888292467","https://openalex.org/W2896220657","https://openalex.org/W2906406865","https://openalex.org/W2914115582","https://openalex.org/W2922685970","https://openalex.org/W2923057410","https://openalex.org/W2927114316","https://openalex.org/W2968074903","https://openalex.org/W2969721714","https://openalex.org/W2985258296","https://openalex.org/W2997271239","https://openalex.org/W3001425747","https://openalex.org/W3003716634","https://openalex.org/W3004733773","https://openalex.org/W3005587360","https://openalex.org/W3008720198","https://openalex.org/W3013793544","https://openalex.org/W3015450697","https://openalex.org/W3028612365","https://openalex.org/W3048789311","https://openalex.org/W3078821236","https://openalex.org/W3080449104","https://openalex.org/W3083326408","https://openalex.org/W3107527779","https://openalex.org/W3107791012","https://openalex.org/W3112735128","https://openalex.org/W3123628395","https://openalex.org/W3136278209","https://openalex.org/W3160140570","https://openalex.org/W3163215845","https://openalex.org/W3175053183","https://openalex.org/W3184132417","https://openalex.org/W3209628825","https://openalex.org/W3212053300","https://openalex.org/W4211177931","https://openalex.org/W4223571129","https://openalex.org/W4229449740"],"related_works":["https://openalex.org/W7164830982","https://openalex.org/W7084161088","https://openalex.org/W2324753312","https://openalex.org/W2915348578","https://openalex.org/W2914115582","https://openalex.org/W2306715392","https://openalex.org/W3123628395","https://openalex.org/W4311511481","https://openalex.org/W7024378806","https://openalex.org/W4212877747"],"abstract_inverted_index":{"Head":[0],"and":[1,24,65,96,111,140,169],"neck":[2],"cancer":[3,10,22,46,60,85,102,122,139,168,186,197],"(HNC)":[4],"is":[5,75],"the":[6,12,26,68,78,136,143],"seventh":[7],"most":[8],"common":[9],"worldwide,":[11],"majority":[13],"being":[14],"oral":[15,84,101,121,185,196],"squamous":[16],"cell":[17,61,98,141,151],"carcinoma.":[18],"Despite":[19],"advances":[20],"in":[21,58,70,120,132,135,167,183],"diagnosis":[23],"treatment,":[25],"survival":[27],"rate":[28],"of":[29,45,52,80,138,159],"patients":[30],"with":[31,108,115],"HNC":[32],"remains":[33],"stagnant.":[34],"The":[35],"cancer-nerve":[36],"interaction":[37],"has":[38],"been":[39,56],"recognized":[40],"as":[41,191],"an":[42],"important":[43],"driver":[44],"progression.":[47,198],"Schwann":[48,81,116,127,181],"cells,":[49,161],"a":[50,177,192],"type":[51],"peripheral":[53],"glia,":[54],"have":[55],"implicated":[57],"promoting":[59,90],"growth,":[62],"migration,":[63],"dispersion,":[64],"invasion":[66],"into":[67],"nerve":[69],"many":[71],"cancers.":[72],"Here,":[73],"it":[74],"demonstrated":[76],"that":[77],"presence":[79],"cells":[82,86,103,123,128,182],"makes":[83],"more":[87,106,109],"aggressive":[88],"by":[89],"their":[91,189],"proliferation,":[92],"extracellular":[93],"matrix":[94],"breakdown,":[95],"altering":[97],"metabolism.":[99],"Furthermore,":[100],"became":[104],"larger,":[105],"circular,":[107],"projections":[110],"nuclei":[112],"following":[113,124],"co-culturing":[114],"cells.":[117],"RNA-sequencing":[118],"analysis":[119],"exposure":[125],"to":[126,194],"shows":[129],"corresponding":[130],"changes":[131],"genes":[133],"involved":[134],"hallmarks":[137],"metabolism;":[142],"enriched":[144],"KEGG":[145],"pathways":[146,156],"are":[147],"spliceosome,":[148],"RNA":[149],"transport,":[150],"cycle,":[152],"axon":[153],"guidance,":[154],"signaling":[155],"regulating":[157],"pluripotency":[158],"stem":[160],"cAMP":[162],"signaling,":[163,165],"WNT":[164],"proteoglycans":[166],"PI3K-Akt":[170],"signaling.":[171],"Taken":[172],"together,":[173],"these":[174],"results":[175],"suggest":[176],"significant":[178],"role":[179],"for":[180],"facilitating":[184],"progression,":[187],"highlighting":[188],"potential":[190],"target":[193],"treat":[195]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-04T00:00:00"}
