{"id":"https://openalex.org/W4289711973","doi":"https://doi.org/10.48075/vscs.v8i1.29090","title":"A\u00c7\u00c3O COMBINADA DA L-GLUTAMINA E INSULINOTERAPIA MELHORA A MORFOMETRIA DOS \u00c1CINOS DA PAR\u00d3TIDA DE RATOS DIAB\u00c9TICOS","display_name":"A\u00c7\u00c3O COMBINADA DA L-GLUTAMINA E INSULINOTERAPIA MELHORA A MORFOMETRIA DOS \u00c1CINOS DA PAR\u00d3TIDA DE RATOS DIAB\u00c9TICOS","publication_year":2022,"publication_date":"2022-08-02","ids":{"openalex":"https://openalex.org/W4289711973","doi":"https://doi.org/10.48075/vscs.v8i1.29090"},"language":"pt","primary_location":{"id":"doi:10.48075/vscs.v8i1.29090","doi":"https://doi.org/10.48075/vscs.v8i1.29090","is_oa":true,"landing_page_url":"https://doi.org/10.48075/vscs.v8i1.29090","pdf_url":"https://e-revista.unioeste.br/index.php/variasaude/article/download/29090/20805","source":{"id":"https://openalex.org/S4210178552","display_name":"Varia Scientia - Ci\u00eancias da Sa\u00fade","issn_l":"2446-8118","issn":["2446-8118"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Varia Scientia - Ci\u00eancias da Sa\u00fade","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://e-revista.unioeste.br/index.php/variasaude/article/download/29090/20805","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002816021","display_name":"\u00c2ngela Maria Pereira Alves","orcid":"https://orcid.org/0000-0001-6290-2649","observed_orcids":["https://orcid.org/0000-0001-6290-2649"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Angela Maria Pereira Alves","raw_affiliation_strings":["Doutora em Ci\u00eancias Biol\u00f3gicas (Biologia Celular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente Adjunto da Universidade Estadual de Maring\u00e1, Maring\u00e1 (PR), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doutora em Ci\u00eancias Biol\u00f3gicas (Biologia Celular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente Adjunto da Universidade Estadual de Maring\u00e1, Maring\u00e1 (PR), Brasil","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042674020","display_name":"Marli Aparecida Defani","orcid":"https://orcid.org/0000-0002-5740-743X","observed_orcids":["https://orcid.org/0000-0002-5740-743X"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marli Aparecida Defani","raw_affiliation_strings":["Doutora em Ci\u00eancias Biol\u00f3gicas (Biologia Celular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente Adjunto da Universidade Estadual de Maring\u00e1, Maring\u00e1 (PR), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doutora em Ci\u00eancias Biol\u00f3gicas (Biologia Celular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente Adjunto da Universidade Estadual de Maring\u00e1, Maring\u00e1 (PR), Brasil","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046379890","display_name":"Vilma Aparecida Ferreira de Godoi","orcid":"https://orcid.org/0000-0003-0340-6746","observed_orcids":["https://orcid.org/0000-0003-0340-6746"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vilma Aparecida Ferreira de Godoi","raw_affiliation_strings":["Doutora em Ci\u00eancias Biol\u00f3gicas (Biologia Celular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente Adjunto da Universidade Estadual de Maring\u00e1, Maring\u00e1 (PR), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doutora em Ci\u00eancias Biol\u00f3gicas (Biologia Celular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente Adjunto da Universidade Estadual de Maring\u00e1, Maring\u00e1 (PR), Brasil","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017256444","display_name":"Stephanie Carvalho Borges","orcid":"https://orcid.org/0000-0002-2534-143X","observed_orcids":["https://orcid.org/0000-0002-2534-143X"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]},{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Stephanie Carvalho Borges","raw_affiliation_strings":["Doutora em Ci\u00eancias Biol\u00f3gicas (Biologia Celular e Molecular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente da Universidade Federal de Santa Catarina, Ararangu\u00e1 (SC), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doutora em Ci\u00eancias Biol\u00f3gicas (Biologia Celular e Molecular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente da Universidade Federal de Santa Catarina, Ararangu\u00e1 (SC), Brasil","institution_ids":["https://openalex.org/I123443094","https://openalex.org/I4104125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075822502","display_name":"\u00c9der Paulo Belato Alves","orcid":"https://orcid.org/0000-0002-6500-0867","observed_orcids":["https://orcid.org/0000-0002-6500-0867"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"\u00c9der Paulo Belato Alves","raw_affiliation_strings":["Doutor em Ci\u00eancias Biol\u00f3gicas (Biologia Celular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente Adjunto da Universidade Estadual de Maring\u00e1, Maring\u00e1 (PR), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doutor em Ci\u00eancias Biol\u00f3gicas (Biologia Celular) pela UEM/PR, Universidade Estadual de Maring\u00e1, Docente Adjunto da Universidade Estadual de Maring\u00e1, Maring\u00e1 (PR), Brasil","institution_ids":["https://openalex.org/I123443094"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12563234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"1","first_page":"46","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7630000114440918},{"id":"https://openalex.org/keywords/parotid-gland","display_name":"parotid gland","score":0.9279999732971191},{"id":"https://openalex.org/keywords/acinar-atrophy","display_name":"acinar atrophy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6330000162124634},{"id":"https://openalex.org/keywords/pancreatic-duct-ligation","display_name":"pancreatic duct ligation","score":0.4959999918937683},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5618466734886169},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.428437739610672}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48075/vscs.v8i1.29090","doi":"https://doi.org/10.48075/vscs.v8i1.29090","is_oa":true,"landing_page_url":"https://doi.org/10.48075/vscs.v8i1.29090","pdf_url":"https://e-revista.unioeste.br/index.php/variasaude/article/download/29090/20805","source":{"id":"https://openalex.org/S4210178552","display_name":"Varia Scientia - Ci\u00eancias da Sa\u00fade","issn_l":"2446-8118","issn":["2446-8118"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Varia Scientia - Ci\u00eancias da Sa\u00fade","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.48075/vscs.v8i1.29090","doi":"https://doi.org/10.48075/vscs.v8i1.29090","is_oa":true,"landing_page_url":"https://doi.org/10.48075/vscs.v8i1.29090","pdf_url":"https://e-revista.unioeste.br/index.php/variasaude/article/download/29090/20805","source":{"id":"https://openalex.org/S4210178552","display_name":"Varia Scientia - Ci\u00eancias da Sa\u00fade","issn_l":"2446-8118","issn":["2446-8118"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Varia Scientia - Ci\u00eancias da Sa\u00fade","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321371","display_name":"Inje University","ror":"https://ror.org/04xqwq985"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4289711973.pdf","grobid_xml":"https://content.openalex.org/works/W4289711973.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W117196910","https://openalex.org/W1500415172","https://openalex.org/W1902766224","https://openalex.org/W1993112888","https://openalex.org/W2024019881","https://openalex.org/W2034327086","https://openalex.org/W2059486263","https://openalex.org/W2068972343","https://openalex.org/W2102619124","https://openalex.org/W2136913126","https://openalex.org/W2155682477","https://openalex.org/W2288006138","https://openalex.org/W2464983768","https://openalex.org/W2606010588","https://openalex.org/W2606264420","https://openalex.org/W2897213700","https://openalex.org/W3004863251","https://openalex.org/W3087165503","https://openalex.org/W3089177242","https://openalex.org/W3127517072","https://openalex.org/W3213181461"],"related_works":["https://openalex.org/W3094358271","https://openalex.org/W1975221316","https://openalex.org/W7120906045","https://openalex.org/W2075068779","https://openalex.org/W1998474363","https://openalex.org/W1629148139","https://openalex.org/W2196939122","https://openalex.org/W1571016498","https://openalex.org/W7120304844","https://openalex.org/W3082616247"],"abstract_inverted_index":{"Objetivo:":[0],"Objetivou-se":[1],"neste":[2],"estudo,":[3],"analisar":[4],"se":[5],"a":[6,120,153,181,185],"a\u00e7\u00e3o":[7],"combinada":[8,179],"da":[9,19,177,190],"L-glutamina":[10,75,178],"e":[11,26,44,52,57,80,117,167,187],"insulinoterapia":[12],"melhora":[13],"os":[14,135,150],"par\u00e2metros":[15],"morfoquantitativos":[16],"dos":[17,99],"\u00e1cinos":[18],"par\u00f3tida":[20,192],"de":[21,48,61,83,193],"ratos":[22,28,194],"diab\u00e9ticos.":[23,195],"M\u00e9todos:":[24],"Vinte":[25],"cinco":[27,32],"foram":[29],"distribu\u00eddos":[30],"em":[31,102,143],"grupos:":[33],"Normoglic\u00eamico":[34],"(CSS);":[35],"diab\u00e9tico":[36,38,43,53,132],"(DSS);":[37],"suplementado":[39,54],"com":[40,45,55,58,71,112,114,129,180],"L-GLN":[41,56,121],"(D-GLN-S);":[42],"inje\u00e7\u00e3o":[46,59,81],"subcut\u00e2nea":[47,60,82],"insulina":[49,62,115,118,182],"Tresiba\u00ae":[50,63,88],"(D-S-TRE)":[51,116],"(D-GLN-TRE).":[64],"Durante":[65],"30":[66],"dias,":[67],"houve":[68,93],"suplementa\u00e7\u00e3o":[69],"di\u00e1ria":[70],"solu\u00e7\u00e3o":[72,84],"salina":[73,85],"e/ou":[74,86],"(400":[76],"mg/kg":[77],"por":[78],"gavagem),":[79],"Insulina":[87],"(5":[89],"U/kg).":[90],"Resultados:":[91],"N\u00e3o":[92],"diferen\u00e7a":[94],"significativa":[95],"na":[96],"densidade":[97,125,186],"acinar":[98,126,141,155,189],"grupos":[100,136,151,164],"diab\u00e9ticos":[101,137],"rela\u00e7\u00e3o":[103,144],"ao":[104,145,183],"grupo":[105,110,131,146,158],"controle":[106,147],"CSS.":[107,148],"Por\u00e9m,":[108],"o":[109,130,174],"tratado":[111],"apenas":[113],"mais":[119],"(D-GLN-TRE)":[122],"mostraram":[123],"menor":[124,139],"quando":[127],"comprados":[128],"DSS.":[133],"Todos":[134],"apresentaram":[138],"\u00e1rea":[140,154],"m\u00e9dia":[142,156],"Entre":[149],"diab\u00e9ticos,":[152],"do":[157],"D-GLN-TRE":[159],"foi":[160],"maior":[161],"comparada":[162],"aos":[163],"DSS,":[165],"D-GLN-S":[166],"D-S-TRE.":[168],"Conclus\u00e3o:":[169],"Estes":[170],"dados":[171],"apontam":[172],"para":[173],"efeito":[175],"protetor":[176],"prevenir":[184],"atrofia":[188],"gl\u00e2ndula":[191]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-08-04T00:00:00"}