{"id":"https://openalex.org/W428964357","doi":null,"title":"Specification and regulation of mammalian extraembryonic and pluripotent embryonic lineages in vivo and in vitro","display_name":"Specification and regulation of mammalian extraembryonic and pluripotent embryonic lineages in vivo and in vitro","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W428964357","mag":"428964357"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt9db2r8kw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9db2r8kw","pdf_url":"https://escholarship.org/uc/item/9db2r8kw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/9db2r8kw","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053830418","display_name":"Stephanie Blij","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephanie Blij","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053830418"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pluripotency-regulation","display_name":"pluripotency regulation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/extraembryonic-lineages","display_name":"extraembryonic lineages","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pluripotent-stem-cells","display_name":"pluripotent stem cells","score":0.7080000042915344},{"id":"https://openalex.org/keywords/maternal-transcription-factors","display_name":"maternal transcription factors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.9200000166893005},{"id":"https://openalex.org/keywords/placental-stem-cells","display_name":"placental stem cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/naive-pluripotency","display_name":"naive pluripotency","score":0.7689999938011169},{"id":"https://openalex.org/keywords/genetic-background","display_name":"genetic background","score":0.5849999785423279},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/signaling-networks","display_name":"signaling networks","score":0.7620000243186951},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8732015490531921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7899959087371826},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7485263347625732},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5947057604789734},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5139800906181335},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.44722381234169006},{"id":"https://openalex.org/C27390768","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Cell potency","level":5,"score":0.43176504969596863},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40657204389572144},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20143252611160278}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt9db2r8kw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9db2r8kw","pdf_url":"https://escholarship.org/uc/item/9db2r8kw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:428964357","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt9db2r8kw/qt9db2r8kw.pdf?t=nflqbv","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt9db2r8kw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9db2r8kw","pdf_url":"https://escholarship.org/uc/item/9db2r8kw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W428964357.pdf","grobid_xml":"https://content.openalex.org/works/W428964357.grobid-xml"},"referenced_works_count":165,"referenced_works":["https://openalex.org/W38424337","https://openalex.org/W162714915","https://openalex.org/W183377943","https://openalex.org/W1608762409","https://openalex.org/W1845796408","https://openalex.org/W1894129931","https://openalex.org/W1900275326","https://openalex.org/W1968062255","https://openalex.org/W1968807484","https://openalex.org/W1969770877","https://openalex.org/W1970195398","https://openalex.org/W1970508192","https://openalex.org/W1971582979","https://openalex.org/W1971645561","https://openalex.org/W1972095962","https://openalex.org/W1972471503","https://openalex.org/W1973028805","https://openalex.org/W1974365957","https://openalex.org/W1974690566","https://openalex.org/W1975751233","https://openalex.org/W1976392356","https://openalex.org/W1978798972","https://openalex.org/W1979165357","https://openalex.org/W1981088384","https://openalex.org/W1982533604","https://openalex.org/W1986944049","https://openalex.org/W1988685629","https://openalex.org/W1989360008","https://openalex.org/W1992663780","https://openalex.org/W1993333696","https://openalex.org/W1994144105","https://openalex.org/W1994257511","https://openalex.org/W1995307938","https://openalex.org/W1996419268","https://openalex.org/W1999980501","https://openalex.org/W2000225283","https://openalex.org/W2000447286","https://openalex.org/W2000520401","https://openalex.org/W2002329350","https://openalex.org/W2002511118","https://openalex.org/W2004102023","https://openalex.org/W2005572825","https://openalex.org/W2006441710","https://openalex.org/W2006499356","https://openalex.org/W2007909080","https://openalex.org/W2008314043","https://openalex.org/W2010608530","https://openalex.org/W2011044632","https://openalex.org/W2012305943","https://openalex.org/W2012763636","https://openalex.org/W2014643937","https://openalex.org/W2015814034","https://openalex.org/W2017050785","https://openalex.org/W2019172827","https://openalex.org/W2022229270","https://openalex.org/W2022751506","https://openalex.org/W2022959322","https://openalex.org/W2023508819","https://openalex.org/W2025017240","https://openalex.org/W2027200579","https://openalex.org/W2035181962","https://openalex.org/W2044039536","https://openalex.org/W2045628618","https://openalex.org/W2045857127","https://openalex.org/W2045899482","https://openalex.org/W2045999565","https://openalex.org/W2050264932","https://openalex.org/W2051529474","https://openalex.org/W2052857937","https://openalex.org/W2053482584","https://openalex.org/W2053700159","https://openalex.org/W2056401732","https://openalex.org/W2057093077","https://openalex.org/W2057159461","https://openalex.org/W2058406877","https://openalex.org/W2058521801","https://openalex.org/W2060245619","https://openalex.org/W2064586774","https://openalex.org/W2064604181","https://openalex.org/W2069375339","https://openalex.org/W2070166996","https://openalex.org/W2070700342","https://openalex.org/W2071241326","https://openalex.org/W2073610802","https://openalex.org/W2074048845","https://openalex.org/W2075564676","https://openalex.org/W2079174004","https://openalex.org/W2079370150","https://openalex.org/W2079625772","https://openalex.org/W2080342872","https://openalex.org/W2082906360","https://openalex.org/W2084865454","https://openalex.org/W2085979052","https://openalex.org/W2086943348","https://openalex.org/W2086979403","https://openalex.org/W2088514277","https://openalex.org/W2090260381","https://openalex.org/W2090465993","https://openalex.org/W2091924715","https://openalex.org/W2092099264","https://openalex.org/W2092126277","https://openalex.org/W2092250528","https://openalex.org/W2097192405","https://openalex.org/W2098709153","https://openalex.org/W2102298903","https://openalex.org/W2104893769","https://openalex.org/W2107167447","https://openalex.org/W2107205820","https://openalex.org/W2107575419","https://openalex.org/W2107793443","https://openalex.org/W2107825410","https://openalex.org/W2110015307","https://openalex.org/W2110737932","https://openalex.org/W2113579248","https://openalex.org/W2113732577","https://openalex.org/W2117025925","https://openalex.org/W2117637538","https://openalex.org/W2118001375","https://openalex.org/W2118290853","https://openalex.org/W2121817763","https://openalex.org/W2123829995","https://openalex.org/W2124059822","https://openalex.org/W2125987139","https://openalex.org/W2126580353","https://openalex.org/W2126851387","https://openalex.org/W2127799088","https://openalex.org/W2128353741","https://openalex.org/W2128665076","https://openalex.org/W2128718933","https://openalex.org/W2129066547","https://openalex.org/W2129638724","https://openalex.org/W2130100751","https://openalex.org/W2130104786","https://openalex.org/W2130273514","https://openalex.org/W2130765177","https://openalex.org/W2132069716","https://openalex.org/W2132401094","https://openalex.org/W2134148250","https://openalex.org/W2135801344","https://openalex.org/W2141221032","https://openalex.org/W2142046859","https://openalex.org/W2142303444","https://openalex.org/W2142482111","https://openalex.org/W2143297890","https://openalex.org/W2144517755","https://openalex.org/W2145295859","https://openalex.org/W2145492799","https://openalex.org/W2146890924","https://openalex.org/W2150013759","https://openalex.org/W2151510743","https://openalex.org/W2153839236","https://openalex.org/W2155018872","https://openalex.org/W2155862946","https://openalex.org/W2156653121","https://openalex.org/W2157073241","https://openalex.org/W2158979552","https://openalex.org/W2163679188","https://openalex.org/W2166666516","https://openalex.org/W2169529166","https://openalex.org/W2171609896","https://openalex.org/W2182697244","https://openalex.org/W2240229801","https://openalex.org/W2258959524","https://openalex.org/W2529740935","https://openalex.org/W4299948084"],"related_works":["https://openalex.org/W2334056159","https://openalex.org/W4411253246","https://openalex.org/W94590184","https://openalex.org/W2126731419","https://openalex.org/W2943663283","https://openalex.org/W2147294027","https://openalex.org/W2261502434","https://openalex.org/W2093923075","https://openalex.org/W7096443841","https://openalex.org/W2149277119"],"abstract_inverted_index":{"Pluripotency":[0],"establishment":[1],"and":[2,13,46,53,61,86,94],"maintenance":[3],"are":[4],"critical":[5],"for":[6],"both":[7,57],"the":[8,14,22,73,95],"development":[9],"of":[10,16,70,75,83,97,104],"mammalian":[11],"embryos":[12],"production":[15],"pluripotent":[17,35,49,58],"stem":[18,59,92,99],"cells.":[19],"Investigations":[20],"into":[21],"molecular":[23],"mechanisms":[24],"underlying":[25],"pluripotency":[26,71,105],"have":[27],"revealed":[28],"multiple":[29],"signaling":[30],"networks":[31],"that":[32],"generate":[33],"diverse":[34],"states.":[36],"The":[37],"relationship":[38],"between":[39],"these":[40],"networks,":[41],"their":[42,47],"upstream":[43],"transcription":[44,77],"factors,":[45],"associated":[48],"states":[50],"is":[51],"complex":[52],"poorly":[54],"understood":[55],"in":[56,79,106],"cells":[60],"embryos.":[62],"In":[63],"this":[64],"thesis":[65],"I":[66],"examine":[67],"three":[68],"aspects":[69],"regulation:":[72],"role":[74],"maternal":[76],"factors":[78,101],"embryogenesis,":[80],"novel":[81],"effects":[82],"genetic":[84],"background":[85],"naivety":[87],"on":[88],"differentiation":[89],"to":[90,102],"placental":[91],"cells,":[93],"contribution":[96],"known":[98],"cell":[100],"regulation":[103],"vivo.":[107]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
