{"id":"https://openalex.org/W4289638318","doi":"https://doi.org/10.1021/acssuschemeng.2c02209","title":"Assessing the Potential of New Lignin-Based pH-Responsive Nanoparticles as Drug Carriers for Cancer Treatment","display_name":"Assessing the Potential of New Lignin-Based pH-Responsive Nanoparticles as Drug Carriers for Cancer Treatment","publication_year":2022,"publication_date":"2022-08-03","ids":{"openalex":"https://openalex.org/W4289638318","doi":"https://doi.org/10.1021/acssuschemeng.2c02209"},"language":"en","primary_location":{"id":"doi:10.1021/acssuschemeng.2c02209","doi":"https://doi.org/10.1021/acssuschemeng.2c02209","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssuschemeng.2c02209","pdf_url":null,"source":{"id":"https://openalex.org/S2502047864","display_name":"ACS Sustainable Chemistry & Engineering","issn_l":"2168-0485","issn":["2168-0485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Sustainable Chemistry &amp; Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100934180","display_name":"Zeming Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeming Yang","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101501758","display_name":"Ziwei Zhou","orcid":"https://orcid.org/0000-0001-5836-2811","observed_orcids":["https://orcid.org/0000-0001-5836-2811"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziwei Zhou","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697806","display_name":"Yuqiang Li","orcid":"https://orcid.org/0000-0003-1517-3687","observed_orcids":["https://orcid.org/0000-0003-1517-3687"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqiang Li","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003559708","display_name":"Lichong Zhu","orcid":"https://orcid.org/0000-0002-5817-0251","observed_orcids":["https://orcid.org/0000-0002-5817-0251"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lichong Zhu","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362810","display_name":"Jiawei Chen","orcid":"https://orcid.org/0000-0002-0895-9027","observed_orcids":["https://orcid.org/0000-0002-0895-9027"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Chen","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070917604","display_name":"Junwei Cheng","orcid":"https://orcid.org/0000-0003-3159-5222","observed_orcids":["https://orcid.org/0000-0003-3159-5222"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junwei Cheng","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089680408","display_name":"Jiamin Su","orcid":"https://orcid.org/0009-0006-9162-2834","observed_orcids":["https://orcid.org/0009-0006-9162-2834"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiamin Su","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113983524","display_name":"Zhuoxin Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuoxin Zhuang","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062758481","display_name":"Zhenbo Ning","orcid":"https://orcid.org/0000-0003-1588-5713","observed_orcids":["https://orcid.org/0000-0003-1588-5713"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenbo Ning","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":"https://orcid.org/0000-0003-1588-5713","affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051997810","display_name":"Qingsong Yu","orcid":"https://orcid.org/0000-0003-2165-3054","observed_orcids":["https://orcid.org/0000-0003-2165-3054"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingsong Yu","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":"https://orcid.org/0000-0003-2165-3054","affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112209435","display_name":"Ni Jiang","orcid":"https://orcid.org/0000-0003-4706-9884","observed_orcids":["https://orcid.org/0000-0003-4706-9884"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ni Jiang","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101464738","display_name":"Zhihua Gan","orcid":"https://orcid.org/0000-0001-9906-9638","observed_orcids":["https://orcid.org/0000-0001-9906-9638"]},"institutions":[{"id":"https://openalex.org/I4391768155","display_name":"State Key Laboratory of Organic-Inorganic Composite Materials","ror":"https://ror.org/04t3b2655","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihua Gan","raw_affiliation_strings":["Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China","institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062758481"],"corresponding_institution_ids":["https://openalex.org/I4391768155","https://openalex.org/I75390827"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.6268,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.81809963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"10","issue":"32","first_page":"10590","last_page":"10603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11208","display_name":"Lignin and Wood Chemistry","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-responsive-drug-delivery","display_name":"pH-responsive drug delivery","score":0.8629999756813049},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/polyethylene-glycol-conjugation","display_name":"polyethylene glycol conjugation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/thiol-ene-click-chemistry","display_name":"thiol-ene click chemistry","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alkali-lignin","display_name":"alkali lignin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.7829999923706055},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7080000042915344},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/4t1-cells","display_name":"4T1 cells","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7511736154556274},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.7399104833602905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7312565445899963},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.6102096438407898},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5327911972999573},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5290296077728271},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5037433505058289},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5027821063995361},{"id":"https://openalex.org/C2781052789","wikidata":"https://www.wikidata.org/wiki/Q184817","display_name":"Lignin","level":2,"score":0.491508811712265},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48191097378730774},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.4624635577201843},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.44099748134613037},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.4115505516529083},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3988257348537445},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3909299075603485},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32005417346954346},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29143184423446655},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2832188606262207},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24082797765731812},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.21882975101470947},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1683872938156128},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15450066328048706},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.14201432466506958},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acssuschemeng.2c02209","doi":"https://doi.org/10.1021/acssuschemeng.2c02209","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssuschemeng.2c02209","pdf_url":null,"source":{"id":"https://openalex.org/S2502047864","display_name":"ACS Sustainable Chemistry & Engineering","issn_l":"2168-0485","issn":["2168-0485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Sustainable Chemistry &amp; Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2523066184","display_name":null,"funder_award_id":"1603005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4999147855","display_name":null,"funder_award_id":"52033001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6491190001","display_name":null,"funder_award_id":"2182052","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G6572524859","display_name":"\u7528\u4e8e\u5c3c\u9f996\u6539\u6027\u7684\u5171\u6df7\u7269\u53ca\u5176\u7ed3\u6784\u7814\u7a76","funder_award_id":"51973010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W177021034","https://openalex.org/W1967627244","https://openalex.org/W1971915082","https://openalex.org/W1978098522","https://openalex.org/W1982052532","https://openalex.org/W2003605139","https://openalex.org/W2009749128","https://openalex.org/W2029327248","https://openalex.org/W2041105700","https://openalex.org/W2054677497","https://openalex.org/W2068695041","https://openalex.org/W2199172748","https://openalex.org/W2346799309","https://openalex.org/W2528801719","https://openalex.org/W2570871164","https://openalex.org/W2580862813","https://openalex.org/W2587178396","https://openalex.org/W2607480968","https://openalex.org/W2742860084","https://openalex.org/W2773965548","https://openalex.org/W2794603392","https://openalex.org/W2892334125","https://openalex.org/W2901748905","https://openalex.org/W2921117033","https://openalex.org/W2928062382","https://openalex.org/W2929181488","https://openalex.org/W2963701844","https://openalex.org/W2988318375","https://openalex.org/W2989083977","https://openalex.org/W2989655268","https://openalex.org/W3008594659","https://openalex.org/W3013916106","https://openalex.org/W3015771470","https://openalex.org/W3025356097","https://openalex.org/W3093527533","https://openalex.org/W3129350115","https://openalex.org/W3165616265","https://openalex.org/W3180265186","https://openalex.org/W4206274381","https://openalex.org/W4206461558","https://openalex.org/W4212973822","https://openalex.org/W4256503849"],"related_works":["https://openalex.org/W3003540401","https://openalex.org/W3141513353","https://openalex.org/W4400547995","https://openalex.org/W2759791716","https://openalex.org/W7140215348","https://openalex.org/W2570871164","https://openalex.org/W2179281062","https://openalex.org/W2025702623","https://openalex.org/W4394621527","https://openalex.org/W1965100972"],"abstract_inverted_index":{"In":[0,26],"this":[1],"study,":[2],"we":[3],"prepared":[4],"new":[5],"lignin-based":[6],"pH-responsive":[7],"nanoparticles":[8],"(LG-M(N)-PEG":[9,96],"NPs)":[10,15,97],"and":[11,23,45,58,87,108,125,132],"their":[12],"conjugates":[13],"(LG-M(N-DOX)-PEG":[14],"by":[16,36],"using":[17],"polyethylene":[18],"glycol":[19],"(PEG),":[20],"doxorubicin":[21],"(DOX),":[22],"alkaline":[24],"lignin.":[25],"these":[27],"NPs,":[28],"the":[29,49,65,92,118,152,161],"PEG":[30],"chains":[31],"were":[32],"conjugated":[33],"to":[34,114,138],"lignin":[35,59,124],"an":[37,61],"UV":[38],"irradiated":[39],"thiol\u2013ene":[40],"click":[41],"reaction.":[42],"The":[43],"hydrazine":[44],"\u03b2-thiopropionate":[46],"bonds":[47],"in":[48,64,110,149,160],"NPs":[50,72,93,120,143,153],"could":[51,98,121],"conduct":[52],"pH-triggered":[53],"release":[54],"of":[55],"both":[56,123],"DOX":[57,95],"at":[60],"acidic":[62],"pH":[63],"tumor":[66],"cells.":[67,116],"Results":[68],"showed":[69],"that":[70],"LG-M(N-DOX)-PEG":[71,119,142],"had":[73,128],"a":[74,111,145],"moderate":[75],"particle":[76],"size":[77],"(48.3":[78],"\u00b1":[79],"3.2":[80],"nm),":[81],"significant":[82],"cytotoxicity":[83,113,131],"against":[84],"4T1":[85],"cells,":[86],"enhanced":[88],"cellular":[89,135],"uptake.":[90],"Interestingly,":[91],"without":[94],"increase":[99],"intracellular":[100],"reactive":[101],"oxygen":[102],"species":[103],"generation,":[104],"induce":[105],"cell":[106],"pyroptosis,":[107],"result":[109],"selective":[112],"cancer":[115,134],"While":[117],"deliver":[122],"DOX,":[126],"they":[127],"favorable":[129],"carrier-enhanced":[130],"higher":[133],"uptake":[136],"compared":[137],"free":[139],"DOX.":[140],"Moreover,":[141],"exhibited":[144],"clear":[146],"tumor-inhibiting":[147],"effect":[148],"vivo.":[150],"Therefore,":[151],"described":[154],"here":[155],"have":[156],"great":[157],"potential":[158],"application":[159],"drug":[162],"delivery":[163],"system.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2022-08-03T00:00:00"}
