{"id":"https://openalex.org/W4289599078","doi":"https://doi.org/10.1201/9781003001560-39","title":"Recommendations for Planning In Vivo Studies for RNAi Therapeutics","display_name":"Recommendations for Planning In Vivo Studies for RNAi Therapeutics","publication_year":2022,"publication_date":"2022-07-18","ids":{"openalex":"https://openalex.org/W4289599078","doi":"https://doi.org/10.1201/9781003001560-39"},"language":"en","primary_location":{"id":"doi:10.1201/9781003001560-39","doi":"https://doi.org/10.1201/9781003001560-39","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781003001560-39","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA Nanotechnology and Therapeutics","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4289599043","display_name":"RNA Nanotechnology and Therapeutics"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005958845","display_name":"Lorena Parlea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorena Parlea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010562576","display_name":"Bruce A. Shapiro","orcid":"https://orcid.org/0000-0002-4443-0788","observed_orcids":["https://orcid.org/0000-0002-4443-0788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce A. Shapiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3953,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42902601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"341","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnai-therapeutics","display_name":"RNAi therapeutics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/off-target-effects","display_name":"off-target effects","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/delivery-agents","display_name":"delivery agents","score":0.8050000071525574},{"id":"https://openalex.org/keywords/in-vivo-toxicity","display_name":"in vivo toxicity","score":0.746999979019165},{"id":"https://openalex.org/keywords/dose-selection","display_name":"dose selection","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6176972985267639},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45164865255355835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4289562702178955},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39651811122894287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.289937824010849},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.11978623270988464},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0801803469657898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04371023178100586},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9781003001560-39","doi":"https://doi.org/10.1201/9781003001560-39","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781003001560-39","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA Nanotechnology and Therapeutics","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2141547126","https://openalex.org/W2122060511","https://openalex.org/W2350251429","https://openalex.org/W2046725620","https://openalex.org/W1966105046","https://openalex.org/W2370858329","https://openalex.org/W2044628104","https://openalex.org/W90792108","https://openalex.org/W2054587076","https://openalex.org/W2728534755"],"abstract_inverted_index":{"This":[0],"chapter":[1],"discusses":[2],"some":[3],"considerations":[4],"for":[5,11,41],"planning":[6],"in":[7,54,118,126],"vivo":[8,55,79,127],"studies,":[9],"especially":[10],"a":[12,96],"particular":[13],"class":[14],"of":[15,26,50,88,94,115],"therapeutics":[16,28,52],"acting":[17],"through":[18],"the":[19,36,83,89,92,111,116,139],"RNA":[20],"interference":[21],"(RNAi)":[22],"pathway.":[23],"The":[24],"design":[25],"RNAi":[27,51],"can":[29,81,108],"be":[30,101],"computationally":[31],"modeled":[32],"and":[33,39,63,69,74,86,113],"validated":[34],"against":[35],"desired":[37],"targets":[38],"verified":[40],"no":[42],"off-target":[43],"effects":[44],"with":[45],"various":[46,122],"software":[47],"platforms.":[48],"Formulations":[49],"studied":[53],"include":[56],"doses":[57],"as":[58,60,64,66,104,106,134],"low":[59],"0.05":[61],"mg/kg,":[62,68],"high":[65],"24":[67],"commonly":[70],"range":[71],"between":[72],"1":[73],"5":[75],"mg/kg":[76],"dose.":[77],"In":[78],"studies":[80],"determine":[82],"biodistribution,":[84],"cytotoxicity,":[85],"efficacy":[87],"drug.":[90],"Additionally,":[91],"possibility":[93],"using":[95],"delivery":[97],"agent":[98],"needs":[99],"to":[100,124],"carefully":[102],"considered":[103],"well,":[105],"it":[107],"greatly":[109],"affect":[110],"properties":[112],"characteristics":[114],"therapeutic":[117],"vivo.":[119],"There":[120],"are":[121],"ways":[123],"define":[125],"toxicity,":[128],"but":[129],"generally":[130],"toxicity":[131],"is":[132],"regarded":[133],"an":[135],"undesired":[136],"effect":[137],"at":[138],"cellular,":[140],"tissue,":[141],"or":[142],"organism":[143],"level.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-08-03T00:00:00"}