{"id":"https://openalex.org/W4289536086","doi":"https://doi.org/10.14791/btrt.2022.0017","title":"Local Drug Delivery Strategies for Glioblastoma Treatment","display_name":"Local Drug Delivery Strategies for Glioblastoma Treatment","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4289536086","doi":"https://doi.org/10.14791/btrt.2022.0017","pmid":"https://pubmed.ncbi.nlm.nih.gov/35929112","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9353160"},"language":"en","primary_location":{"id":"doi:10.14791/btrt.2022.0017","doi":"https://doi.org/10.14791/btrt.2022.0017","is_oa":true,"landing_page_url":"https://doi.org/10.14791/btrt.2022.0017","pdf_url":null,"source":{"id":"https://openalex.org/S2764476047","display_name":"Brain Tumor Research and Treatment","issn_l":"2288-2405","issn":["2288-2405","2288-2413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","kci-candidate"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Tumor Research and Treatment","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.14791/btrt.2022.0017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103040822","display_name":"Gi Doo Cha","orcid":"https://orcid.org/0000-0002-4771-3396","observed_orcids":["https://orcid.org/0000-0002-4771-3396"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gi Doo Cha","raw_affiliation_strings":["Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea","Department of Radiology, Seoul National University College of Medicine, Seoul, Korea","School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-4771-3396","affiliations":[{"raw_affiliation_string":"Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Radiology, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024493481","display_name":"Sonwoo Jung","orcid":"https://orcid.org/0000-0002-3797-8024","observed_orcids":["https://orcid.org/0000-0002-3797-8024"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sonwoo Jung","raw_affiliation_strings":["Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea","School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-3797-8024","affiliations":[{"raw_affiliation_string":"Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067997284","display_name":"Seung Hong Choi","orcid":"https://orcid.org/0000-0002-0412-2270","observed_orcids":["https://orcid.org/0000-0002-0412-2270"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seung Hong Choi","raw_affiliation_strings":["Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea","Department of Radiology, Seoul National University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-0412-2270","affiliations":[{"raw_affiliation_string":"Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Radiology, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079017148","display_name":"Dae\u2010Hyeong Kim","orcid":"https://orcid.org/0000-0002-4722-1893","observed_orcids":["https://orcid.org/0000-0002-4722-1893"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dae-Hyeong Kim","raw_affiliation_strings":["Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea","Department of Materials Science and Engineering, College of Engineering, Seoul National University, Seoul, Korea","School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-4722-1893","affiliations":[{"raw_affiliation_string":"Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, College of Engineering, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067997284","https://openalex.org/A5079017148"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4210104335"],"apc_list":null,"apc_paid":null,"fwci":0.8519,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.70570678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"10","issue":"3","first_page":"151","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.9900000095367432},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8100000023841858},{"id":"https://openalex.org/keywords/local-chemotherapy","display_name":"local chemotherapy","score":0.7110000252723694},{"id":"https://openalex.org/keywords/brain-tumor-recurrence","display_name":"brain tumor recurrence","score":0.5839999914169312},{"id":"https://openalex.org/keywords/drug-delivery-devices","display_name":"drug delivery devices","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9077014923095703},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7430083155632019},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6567769646644592},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.648755669593811},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.48559850454330444},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4646916091442108},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4604732394218445},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43244466185569763},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3383936882019043},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2387787401676178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22397884726524353},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13788828253746033},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1160254180431366},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.06974133849143982},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.14791/btrt.2022.0017","doi":"https://doi.org/10.14791/btrt.2022.0017","is_oa":true,"landing_page_url":"https://doi.org/10.14791/btrt.2022.0017","pdf_url":null,"source":{"id":"https://openalex.org/S2764476047","display_name":"Brain Tumor Research and Treatment","issn_l":"2288-2405","issn":["2288-2405","2288-2413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","kci-candidate"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Tumor Research and Treatment","raw_type":"journal-article"},{"id":"pmid:35929112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35929112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain tumor research and treatment","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9353160","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9353160/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Tumor Res Treat","raw_type":"Text"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/189435","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/189435","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.14791/btrt.2022.0017","doi":"https://doi.org/10.14791/btrt.2022.0017","is_oa":true,"landing_page_url":"https://doi.org/10.14791/btrt.2022.0017","pdf_url":null,"source":{"id":"https://openalex.org/S2764476047","display_name":"Brain Tumor Research and Treatment","issn_l":"2288-2405","issn":["2288-2405","2288-2413"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","kci-candidate"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Tumor Research and Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1540291181","display_name":null,"funder_award_id":"IBS\u2010R006\u2010A1","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"}],"funders":[{"id":"https://openalex.org/F4320326441","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W92501227","https://openalex.org/W1979031104","https://openalex.org/W1979850852","https://openalex.org/W1993034243","https://openalex.org/W1997934415","https://openalex.org/W2015541518","https://openalex.org/W2044013857","https://openalex.org/W2052110007","https://openalex.org/W2089028118","https://openalex.org/W2099431752","https://openalex.org/W2100567246","https://openalex.org/W2111726732","https://openalex.org/W2120427205","https://openalex.org/W2239185014","https://openalex.org/W2326103518","https://openalex.org/W2337239674","https://openalex.org/W2344644350","https://openalex.org/W2550127991","https://openalex.org/W2557035343","https://openalex.org/W2563647161","https://openalex.org/W2592857905","https://openalex.org/W2594625701","https://openalex.org/W2626252985","https://openalex.org/W2748074339","https://openalex.org/W2802818037","https://openalex.org/W2803361339","https://openalex.org/W2804345513","https://openalex.org/W2896006729","https://openalex.org/W2899366602","https://openalex.org/W2914644214","https://openalex.org/W2920887476","https://openalex.org/W2936375023","https://openalex.org/W2936409314","https://openalex.org/W2986437218","https://openalex.org/W2991305886","https://openalex.org/W3001648271","https://openalex.org/W3003662453","https://openalex.org/W3016598477","https://openalex.org/W3016898086","https://openalex.org/W3083589002","https://openalex.org/W3108030727","https://openalex.org/W3112558105","https://openalex.org/W3118553428","https://openalex.org/W3127021983","https://openalex.org/W3147989648","https://openalex.org/W3158489045","https://openalex.org/W3164354926","https://openalex.org/W3165400544","https://openalex.org/W3166278644","https://openalex.org/W3196248214","https://openalex.org/W3204524847","https://openalex.org/W4200019527","https://openalex.org/W4200371713","https://openalex.org/W4206311579","https://openalex.org/W4207034676","https://openalex.org/W4220881837"],"related_works":["https://openalex.org/W3083589002","https://openalex.org/W2145046260","https://openalex.org/W3183632913","https://openalex.org/W4413790720","https://openalex.org/W4378696115","https://openalex.org/W3197521059","https://openalex.org/W4200512631","https://openalex.org/W2054077061","https://openalex.org/W7222832648","https://openalex.org/W7127974625"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"(GBM)":[2],"is":[3,21],"a":[4,70,132],"brain":[5,67],"tumor":[6,68],"notorious":[7],"for":[8,14,81,96,147],"its":[9],"malignancy.":[10],"The":[11],"key":[12],"reason":[13],"the":[15,22,39,55,66,90,97,112,124,136],"limited":[16],"efficacy":[17,84],"of":[18,26,42,93,100,115,135,143],"standard":[19],"treatment":[20],"high":[23],"recurrence":[24],"rate":[25],"GBM,":[27],"even":[28],"after":[29,51],"surgical":[30],"resection.":[31],"Hence,":[32],"intensive":[33],"postsurgical":[34],"chemical":[35],"therapies,":[36],"such":[37],"as":[38],"systemic":[40,59],"delivery":[41,77,99,118],"various":[43,74],"drugs":[44,64,102],"and/or":[45],"drug":[46,76,117],"combinations,":[47],"are":[48],"typically":[49],"followed":[50],"surgery.":[52],"However,":[53],"overcoming":[54],"blood-brain":[56],"barrier":[57],"by":[58],"administration":[60],"to":[61,65,103],"efficiently":[62],"deliver":[63],"remains":[69],"daunting":[71],"goal.":[72],"Therefore,":[73],"local":[75,116],"methods":[78,146],"showing":[79],"potential":[80],"improved":[82],"therapeutic":[83],"have":[85],"been":[86],"proposed.":[87],"In":[88],"particular,":[89],"recent":[91,113],"application":[92],"electronic":[94],"devices":[95],"controlled":[98],"chemotherapy":[101,145],"GBM":[104],"tissue":[105],"has":[106],"attracted":[107],"attention.":[108],"We":[109,129],"herein":[110],"review":[111],"progress":[114],"strategies,":[119,122],"including":[120],"electronics-assisted":[121],"at":[123],"research":[125,141],"and":[126,139],"commercial":[127],"level.":[128],"also":[130],"present":[131],"brief":[133],"discussion":[134],"unsolved":[137],"challenges":[138],"future":[140],"direction":[142],"localized":[144],"GBM.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-03T00:00:00"}
