{"id":"https://openalex.org/W4289529336","doi":"https://doi.org/10.4314/epj.v37i1.2","title":"Wound Healing, Anti-inflammatory and Antibacterial Activities of 80% Methanol Leaf Extract of Vernonia leopoldi (Sch. Bip. Ex Walp.) Vatke in Mice","display_name":"Wound Healing, Anti-inflammatory and Antibacterial Activities of 80% Methanol Leaf Extract of Vernonia leopoldi (Sch. Bip. Ex Walp.) Vatke in Mice","publication_year":2022,"publication_date":"2022-07-30","ids":{"openalex":"https://openalex.org/W4289529336","doi":"https://doi.org/10.4314/epj.v37i1.2"},"language":"en","primary_location":{"id":"doi:10.4314/epj.v37i1.2","doi":"https://doi.org/10.4314/epj.v37i1.2","is_oa":false,"landing_page_url":"https://doi.org/10.4314/epj.v37i1.2","pdf_url":null,"source":{"id":"https://openalex.org/S2764971028","display_name":"Ethiopian Pharmaceutical Journal","issn_l":"1029-5933","issn":["1029-5933"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethiopian Pharmaceutical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024202156","display_name":"Aklilu Asmelash","orcid":"https://orcid.org/0009-0002-7783-9982","observed_orcids":["https://orcid.org/0009-0002-7783-9982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aklilu Asmelash","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109030670","display_name":"Workineh Shibeshi","orcid":"https://orcid.org/0000-0003-3478-6235","observed_orcids":["https://orcid.org/0000-0003-3478-6235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Workineh Shibeshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049442442","display_name":"Haile Alemayehu","orcid":"https://orcid.org/0000-0002-8012-821X","observed_orcids":["https://orcid.org/0000-0002-8012-821X","https://orcid.org/0000-0002-9695-8576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haile Alemayehu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037843937","display_name":"Ephrem Engidawork","orcid":"https://orcid.org/0000-0002-9931-6421","observed_orcids":["https://orcid.org/0000-0002-9931-6421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ephrem Engidawork","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2081,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.41227014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"37","issue":"1","first_page":"15","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9850000143051147},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":1.0},{"id":"https://openalex.org/keywords/methanolic-leaf-extract","display_name":"methanolic leaf extract","score":0.9359999895095825},{"id":"https://openalex.org/keywords/topical-ointment","display_name":"topical ointment","score":0.9750000238418579},{"id":"https://openalex.org/keywords/excisional-wounds","display_name":"excision wound","score":0.6309999823570251},{"id":"https://openalex.org/keywords/incised-wounds","display_name":"incision wound","score":0.9959999918937683},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.796999990940094},{"id":"https://openalex.org/keywords/wound-contraction","display_name":"wound contraction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/skin-tensile-strength","display_name":"skin tensile strength","score":0.8349999785423279},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.7829999923706055},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nitrofurazone","display_name":"nitrofurazone","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.906000018119812},{"id":"https://openalex.org/keywords/wound-infection","display_name":"wound infection","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.759535551071167},{"id":"https://openalex.org/C2909802241","wikidata":"https://www.wikidata.org/wiki/Q425502","display_name":"Nitrofurazone","level":2,"score":0.5462212562561035},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5441324710845947},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5180304646492004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5179478526115417},{"id":"https://openalex.org/C2993365394","wikidata":"https://www.wikidata.org/wiki/Q5120022","display_name":"Breaking strength","level":2,"score":0.5140527486801147},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.508026123046875},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.4290415346622467},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.41150158643722534},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38136178255081177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3221327066421509},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2569248676300049},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23311850428581238},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21453920006752014},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2077924609184265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12873870134353638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12709006667137146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4314/epj.v37i1.2","doi":"https://doi.org/10.4314/epj.v37i1.2","is_oa":false,"landing_page_url":"https://doi.org/10.4314/epj.v37i1.2","pdf_url":null,"source":{"id":"https://openalex.org/S2764971028","display_name":"Ethiopian Pharmaceutical Journal","issn_l":"1029-5933","issn":["1029-5933"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-1"],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethiopian Pharmaceutical Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3012267151","https://openalex.org/W2070136565","https://openalex.org/W2954512661","https://openalex.org/W4319294541","https://openalex.org/W3184062763","https://openalex.org/W2730802001","https://openalex.org/W4400488796","https://openalex.org/W3008954973","https://openalex.org/W6978170473","https://openalex.org/W2292647990"],"abstract_inverted_index":{"The":[0,31,65,105,226,249,268],"leaf":[1],"of":[2,17,28,33,43,48,101,109,124,150,177,183,247,261,292],"Vernonia":[3],"leopoldi":[4,50,294],"(Sch.":[5],"Bip.":[6],"Ex":[7],"Walp.)":[8],"Vatke":[9],"has":[10],"been":[11],"used":[12,98],"traditionally":[13],"for":[14,69,99],"the":[15,29,39,44,178,237,266,281,288],"treatment":[16],"wounds.":[18],"However,":[19],"literature":[20],"is":[21,295],"scanty":[22],"on":[23,275],"experimental":[24],"wound":[25,40,63,70,102,106,166,184,200,233,298],"healing":[26,41,55,71,103,234],"activity":[27,42,56,72,119,139,235,274],"plant.":[30],"objective":[32],"this":[34],"study":[35],"was":[36,57,67,120,140,243],"to":[37,245,265],"investigate":[38],"80%":[45,289],"methanol":[46,192,290],"extract":[47,66,179,193,229,250,269,291],"V.":[49,293],"leaves":[51],"in":[52],"mice.":[53],"Wound":[54],"investigated":[58],"using":[59,78,130,143],"excision":[60],"and":[61,82,90,111,127,159,172,189,206,219,240,301],"incision":[62],"models.":[64],"studied":[68],"by":[73,223],"formulating":[74],"a":[75],"topical":[76],"ointment":[77,86,94,186,230,239],"two":[79],"concentrations":[80,149],"(5%":[81],"10%":[83,190,227],"w/w).":[84],"Simple":[85],"base":[87],"(negative":[88],"control)":[89,96],"0.2%":[91],"nitrofurazone":[92],"(w/v)":[93],"(positive":[95],"were":[97,114,180],"comparison":[100],"activity.":[104],"contraction,":[107],"period":[108],"epithelialization":[110,204],"tensile":[112],"strength":[113,210],"evaluated.":[115],"In":[116,136],"addition,":[117],"anti-inflammatory":[118,300],"tested":[121],"at":[122,148],"doses":[123],"100,":[125],"200":[126],"400":[128],"mg/kg":[129],"carrageenan":[131],"hind":[132],"paw":[133],"oedema":[134],"model.":[135],"vitro":[137],"antibacterial":[138,273,302],"also":[141,251,270],"assessed":[142],"agar":[144],"well":[145,212],"diffusion":[146],"technique":[147],"50":[151],"-":[152,259],"500":[153],"\u00b5g/\u00b5l":[154],"against":[155],"both":[156],"Gram-":[157],"positive":[158],"Gram-negative":[160,278],"bacteria":[161],"that":[162,246,287],"are":[163],"associated":[164],"with":[165,185,297],"infections.":[167],"Minimum":[168],"inhibitory":[169],"concentration":[170,175],"(MIC)":[171],"minimum":[173],"bactericidal":[174],"(MBC)":[176],"determined.":[181],"Treatment":[182],"containing":[187],"5%":[188,238],"(w/w)":[191,228],"exhibited":[194],"significantly":[195],"increased":[196,214],"(p":[197,256],"<":[198,257],"0.05)":[199],"contraction":[201],"rate,":[202],"shorter":[203],"time,":[205],"higher":[207],"skin":[208],"breaking":[209],"as":[211,213,221,263],"collagen":[215],"deposition,":[216],"fibroblast":[217],"proliferation":[218],"vascularization":[220],"evidenced":[222],"histopathological":[224],"analysis.":[225],"showed":[231],"better":[232,272],"than":[236,277],"its":[241],"effect":[242],"comparable":[244],"nitrofurazone.":[248],"produced":[252],"dose-dependent":[253],"significant":[254],"reductions":[255],"0.01":[258],"0.001)":[260],"inflammation":[262],"compared":[264],"control.":[267],"displayed":[271],"Gram-positive":[276],"organisms.":[279],"From":[280],"results,":[282],"it":[283],"can":[284],"be":[285],"concluded":[286],"endowed":[296],"healing,":[299],"activities.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-08-03T00:00:00"}
