{"id":"https://openalex.org/W4289522980","doi":"https://doi.org/10.21203/rs.3.rs-1906166/v1","title":"The effects of adipose-derived stem cell transplantation on tendon-bone healing in a model of chronic rotator cuff tear with suprascapular nerve injury","display_name":"The effects of adipose-derived stem cell transplantation on tendon-bone healing in a model of chronic rotator cuff tear with suprascapular nerve injury","publication_year":2022,"publication_date":"2022-08-02","ids":{"openalex":"https://openalex.org/W4289522980","doi":"https://doi.org/10.21203/rs.3.rs-1906166/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1906166/v1","doi":"https://doi.org/10.21203/rs.3.rs-1906166/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1906166/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-1906166/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010225830","display_name":"Kenichiro Eshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096146","display_name":"Kurume University Hospital","ror":"https://ror.org/00vjxjf30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096146"]},{"id":"https://openalex.org/I4210097362","display_name":"Kurume University Medical Center","ror":"https://ror.org/00srtbf93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097362"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichiro Eshima","raw_affiliation_strings":["Kurume University Hospital","Kurume University Hospital Hiroki Ohzono","Kurume University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Hospital","institution_ids":["https://openalex.org/I4210096146"]},{"raw_affiliation_string":"Kurume University Hospital Hiroki Ohzono","institution_ids":["https://openalex.org/I4210096146"]},{"raw_affiliation_string":"Kurume University Medical Center","institution_ids":["https://openalex.org/I4210097362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021708998","display_name":"Hiroki Ohzono","orcid":"https://orcid.org/0000-0001-7170-5401","observed_orcids":["https://orcid.org/0000-0001-7170-5401"]},"institutions":[{"id":"https://openalex.org/I4210097362","display_name":"Kurume University Medical Center","ror":"https://ror.org/00srtbf93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097362"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroki Ohzono","raw_affiliation_strings":["Kurume University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Medical Center","institution_ids":["https://openalex.org/I4210097362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043753158","display_name":"Masafumi Gotoh","orcid":"https://orcid.org/0000-0002-1079-3425","observed_orcids":["https://orcid.org/0000-0002-1079-3425"]},"institutions":[{"id":"https://openalex.org/I4210096146","display_name":"Kurume University Hospital","ror":"https://ror.org/00vjxjf30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096146"]},{"id":"https://openalex.org/I4210097362","display_name":"Kurume University Medical Center","ror":"https://ror.org/00srtbf93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097362"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masafumi Gotoh","raw_affiliation_strings":["Kurume University Medical Center","Kurume University Hospital Hiroki Ohzono","Kurume University Medical Center Naoto Shiba Kurume University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Medical Center","institution_ids":["https://openalex.org/I4210097362"]},{"raw_affiliation_string":"Kurume University Hospital Hiroki Ohzono","institution_ids":["https://openalex.org/I4210096146"]},{"raw_affiliation_string":"Kurume University Medical Center Naoto Shiba Kurume University Hospital","institution_ids":["https://openalex.org/I4210096146","https://openalex.org/I4210097362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084669341","display_name":"Hidehiro Nakamura","orcid":"https://orcid.org/0000-0002-6269-9588","observed_orcids":["https://orcid.org/0000-0002-6269-9588"]},"institutions":[{"id":"https://openalex.org/I4210096146","display_name":"Kurume University Hospital","ror":"https://ror.org/00vjxjf30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096146"]},{"id":"https://openalex.org/I4210097362","display_name":"Kurume University Medical Center","ror":"https://ror.org/00srtbf93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097362"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidehiro Nakamura","raw_affiliation_strings":["Kurume University Medical Center","Kurume University Hospital Hiroki Ohzono","Kurume University Medical Center Naoto Shiba Kurume University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Medical Center","institution_ids":["https://openalex.org/I4210097362"]},{"raw_affiliation_string":"Kurume University Hospital Hiroki Ohzono","institution_ids":["https://openalex.org/I4210096146"]},{"raw_affiliation_string":"Kurume University Medical Center Naoto Shiba Kurume University Hospital","institution_ids":["https://openalex.org/I4210096146","https://openalex.org/I4210097362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025984398","display_name":"Hisao Shimokobe","orcid":"https://orcid.org/0000-0002-4842-510X","observed_orcids":["https://orcid.org/0000-0002-4842-510X"]},"institutions":[{"id":"https://openalex.org/I4210096146","display_name":"Kurume University Hospital","ror":"https://ror.org/00vjxjf30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096146"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisao Shimokobe","raw_affiliation_strings":["Kurume University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Hospital","institution_ids":["https://openalex.org/I4210096146"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Suguru Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096146","display_name":"Kurume University Hospital","ror":"https://ror.org/00vjxjf30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096146"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Suguru Tanaka","raw_affiliation_strings":["Kurume University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Hospital","institution_ids":["https://openalex.org/I4210096146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110929547","display_name":"Tomonosin Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096146","display_name":"Kurume University Hospital","ror":"https://ror.org/00vjxjf30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096146"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonosin Kanazawa","raw_affiliation_strings":["Kurume University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Hospital","institution_ids":["https://openalex.org/I4210096146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109246459","display_name":"Takahiro Okawa","orcid":"https://orcid.org/0009-0002-6381-2586","observed_orcids":["https://orcid.org/0009-0002-6381-2586","https://orcid.org/0000-0003-2601-6177"]},"institutions":[{"id":"https://openalex.org/I4210096146","display_name":"Kurume University Hospital","ror":"https://ror.org/00vjxjf30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096146"]},{"id":"https://openalex.org/I4210097362","display_name":"Kurume University Medical Center","ror":"https://ror.org/00srtbf93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097362"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Okawa","raw_affiliation_strings":["Kurume University Medical Center","Kurume University Medical Center Naoto Shiba Kurume University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Medical Center","institution_ids":["https://openalex.org/I4210097362"]},{"raw_affiliation_string":"Kurume University Medical Center Naoto Shiba Kurume University Hospital","institution_ids":["https://openalex.org/I4210096146","https://openalex.org/I4210097362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067625862","display_name":"Naoto N. Shiba","orcid":"https://orcid.org/0000-0002-9307-0280","observed_orcids":["https://orcid.org/0000-0002-9307-0280"]},"institutions":[{"id":"https://openalex.org/I4210096146","display_name":"Kurume University Hospital","ror":"https://ror.org/00vjxjf30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096146"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Shiba","raw_affiliation_strings":["Kurume University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurume University Hospital","institution_ids":["https://openalex.org/I4210096146"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021708998"],"corresponding_institution_ids":["https://openalex.org/I4210097362"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10280","display_name":"Shoulder Injury and Treatment","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10280","display_name":"Shoulder Injury and Treatment","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.19290000200271606,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/rotator-cuff-tear","display_name":"rotator cuff tear","score":0.8500000238418579},{"id":"https://openalex.org/keywords/suprascapular-nerve-injury","display_name":"suprascapular nerve injury","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tendon-bone-healing","display_name":"tendon-bone healing","score":0.8980000019073486},{"id":"https://openalex.org/keywords/enthesis","display_name":"enthesis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/supraspinatus-tendon-repair","display_name":"supraspinatus tendon repair","score":0.843999981880188},{"id":"https://openalex.org/keywords/fibrocartilage","display_name":"fibrocartilage","score":0.7400000095367432},{"id":"https://openalex.org/keywords/fatty-infiltration","display_name":"fatty infiltration","score":0.921999990940094},{"id":"https://openalex.org/keywords/tendon-biomechanics","display_name":"tendon biomechanics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/stem-cell-injection","display_name":"stem cell injection","score":0.6579999923706055},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8677264451980591},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6678547859191895},{"id":"https://openalex.org/C2776511800","wikidata":"https://www.wikidata.org/wiki/Q1764136","display_name":"Rotator cuff","level":2,"score":0.6533258557319641},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5712777972221375},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5409174561500549},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.5374171733856201},{"id":"https://openalex.org/C2781218938","wikidata":"https://www.wikidata.org/wiki/Q2192944","display_name":"Fibrocartilage","level":5,"score":0.46847930550575256},{"id":"https://openalex.org/C174286582","wikidata":"https://www.wikidata.org/wiki/Q3055083","display_name":"Enthesis","level":3,"score":0.4455111622810364},{"id":"https://openalex.org/C2776030733","wikidata":"https://www.wikidata.org/wiki/Q3518022","display_name":"Rotator cuff injury","level":3,"score":0.4412897229194641},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.41343992948532104},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.3312445878982544},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2371816337108612},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14603489637374878},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.14555567502975464},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-1906166/v1","doi":"https://doi.org/10.21203/rs.3.rs-1906166/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1906166/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1906166/v1","doi":"https://doi.org/10.21203/rs.3.rs-1906166/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1906166/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1863138831","https://openalex.org/W1972788455","https://openalex.org/W1977444705","https://openalex.org/W1983642219","https://openalex.org/W1997944826","https://openalex.org/W2101182137","https://openalex.org/W2109861804","https://openalex.org/W2118334345","https://openalex.org/W2152963501","https://openalex.org/W2168157515","https://openalex.org/W2523090084","https://openalex.org/W2741608920","https://openalex.org/W2782742282","https://openalex.org/W2804737098","https://openalex.org/W2902049297","https://openalex.org/W2914934476","https://openalex.org/W2986065713","https://openalex.org/W3000345515","https://openalex.org/W3012071677","https://openalex.org/W3012153868","https://openalex.org/W3092537073","https://openalex.org/W3109409752","https://openalex.org/W3118681830"],"related_works":["https://openalex.org/W4392598818","https://openalex.org/W1997944826","https://openalex.org/W2902049297","https://openalex.org/W2154024832","https://openalex.org/W2741608920","https://openalex.org/W4414065751","https://openalex.org/W2328240320","https://openalex.org/W2138038251","https://openalex.org/W4415665925","https://openalex.org/W3093369577"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Recurrence":[2],"of":[3,49,67],"massive":[4],"rotator":[5,75],"cuff":[6,76],"tears":[7],"(RCTs)":[8],"are":[9,35,58],"relatively":[10],"common":[11],"due":[12],"to":[13,63,147,238],"resultant":[14],"muscle":[15],"atrophy":[16],"and":[17,103,119,182,185,189,203,217,249,289],"fatty":[18],"infiltration,":[19],"possibly":[20,313],"caused":[21],"by":[22],"scapular":[23,81],"nerve":[24,82],"(SN)":[25,83],"injury.":[26,84],"Growing":[27],"evidence":[28],"suggests":[29],"that":[30,239],"adipose-derived":[31],"stem":[32],"cells":[33],"(ADSCs)":[34],"useful":[36],"tools":[37],"for":[38],"regeneration":[39],"in":[40,52,72,113,128,208,222,232,240,254,260,302,316],"chronic":[41,53,74,304],"RCT":[42,54,305,318],"models.":[43],"However,":[44],"data":[45],"on":[46,51,69,299],"the":[47,65,100,115,129,139,154,166,209,223,233,241,255,261,269,274,281],"effects":[48],"ADSCs":[50,68],"models":[55],"with":[56,80,162,173,307],"SNI":[57],"limited.":[59],"This":[60],"study":[61],"aimed":[62],"investigate":[64],"effect":[66,298],"tendon-bone":[70,300],"healing":[71,301],"a":[73,136,196,296,303],"tear":[77],"(RCT)":[78],"model":[79,306],"Methods":[85],"Overall,":[86],"36":[87],"adult":[88],"rats":[89],"(weight":[90],"=":[91],"344":[92],"\u00b1":[93],"33":[94],"g)":[95],"were":[96,177,220,277],"equally":[97],"divided":[98],"into":[99],"ADSC":[101,104,130,140,155,163,167,210,224,234,242,256,262,284,293,311],"(+)":[102,141,156,211,235,257],"(-)":[105,131,168,225,243,263],"group.":[106,212,226,244],"Both":[107],"groups":[108],"underwent":[109,158,170,186],"right":[110],"shoulder":[111,127],"surgery":[112],"which":[114],"supraspinatus":[116],"was":[117,122,133,145,206,229,252],"detached,":[118],"SN":[120,308],"injury":[121],"induced;":[123],"he":[124],"untreated":[125],"left":[126],"group":[132,157,169,236,258,264],"used":[134],"as":[135],"control.":[137],"In":[138,193],"group,":[142],"abdominal":[143],"fat":[144],"collected":[146],"culture":[148],"ADSCs.":[149],"At":[150],"6":[151],"weeks":[152,184],"postoperatively,":[153],"surgical":[159],"tendon":[160,171],"repair":[161,172],"injection,":[164],"whereas":[165],"saline":[174],"injection.":[175],"Shoulders":[176],"harvested":[178],"at":[179,265],"10,":[180],"14,":[181],"18":[183,266],"histological,":[187],"fluorescent,":[188],"biomechanical":[190,290],"analyses.":[191],"Results":[192],"bone-tendon":[194],"junction,":[195],"firm":[197],"enthesis,":[198],"including":[199],"dense":[200],"mature":[201],"fibrocartilage":[202,219],"well-aligned":[204],"cells,":[205],"observed":[207,221],"Conversely,":[213],"decreased":[214],"cell":[215],"density":[216],"immature":[218],"Fatty":[227],"infiltration":[228],"more":[230],"uncommon":[231],"compared":[237],"The":[245],"mean":[246,270],"maximum":[247],"stress":[248],"linear":[250],"stiffness":[251],"higher":[253],"than":[259],"weeks.":[267],"Neither":[268],"Young\u2019s":[271],"modulus":[272],"nor":[273],"cross-sectional":[275],"area":[276],"significantly":[278],"different":[279],"throughout":[280],"study.":[282],"Conclusion":[283],"injection":[285,312],"produced":[286],"better":[287],"histological":[288],"outcomes.":[291],"Thus,":[292],"supplementation":[294],"showed":[295],"positive":[297],"injury;":[309],"therefore,":[310],"accelerates":[314],"recovery":[315],"large":[317],"repair.":[319]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-08-03T00:00:00"}