{"id":"https://openalex.org/W4289520173","doi":"https://doi.org/10.1038/s41467-022-31709-2","title":"CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns","display_name":"CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns","publication_year":2022,"publication_date":"2022-08-02","ids":{"openalex":"https://openalex.org/W4289520173","doi":"https://doi.org/10.1038/s41467-022-31709-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/35918315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9346114"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-31709-2","doi":"https://doi.org/10.1038/s41467-022-31709-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-31709-2","pdf_url":"https://www.nature.com/articles/s41467-022-31709-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-31709-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019180077","display_name":"Simon D. van Haren","orcid":"https://orcid.org/0000-0002-1791-0161","observed_orcids":["https://orcid.org/0000-0002-1791-0161","https://orcid.org/0000-0002-5555-2051"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simon D. van Haren","raw_affiliation_strings":["Department of Pediatrics, Harvard Medical School, Boston, MA, USA. simon.vanharen@childrens.harvard.edu","Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA. simon.vanharen@childrens.harvard.edu","Department of Pediatrics, Harvard Medical School, Boston, MA, USA","Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-1791-0161","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA, USA. simon.vanharen@childrens.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA. simon.vanharen@childrens.harvard.edu","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048150333","display_name":"Gabriel Kristian Pedersen","orcid":"https://orcid.org/0000-0001-6872-3975","observed_orcids":["https://orcid.org/0000-0001-6872-3975"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Gabriel K. Pedersen","raw_affiliation_strings":["Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101182757","display_name":"Azad Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405268911","display_name":"Vaccine Research Center","ror":"https://ror.org/02fve6a73","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268911"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Azad Kumar","raw_affiliation_strings":["Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405268911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038903505","display_name":"Tracy J. Ruckwardt","orcid":"https://orcid.org/0000-0002-0007-7169","observed_orcids":["https://orcid.org/0000-0002-0007-7169"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405268911","display_name":"Vaccine Research Center","ror":"https://ror.org/02fve6a73","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268911"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy J. Ruckwardt","raw_affiliation_strings":["Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-0007-7169","affiliations":[{"raw_affiliation_string":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405268911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006019980","display_name":"Syed Mohammad Moin","orcid":"https://orcid.org/0000-0001-8789-9167","observed_orcids":["https://orcid.org/0000-0001-8789-9167"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405268911","display_name":"Vaccine Research Center","ror":"https://ror.org/02fve6a73","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268911"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed Moin","raw_affiliation_strings":["Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405268911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007400359","display_name":"Ian N. Moore","orcid":"https://orcid.org/0000-0002-0391-6466","observed_orcids":["https://orcid.org/0000-0002-0391-6466"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian N. Moore","raw_affiliation_strings":["Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050609317","display_name":"Mahnaz Minai","orcid":"https://orcid.org/0000-0002-3642-8063","observed_orcids":["https://orcid.org/0000-0002-3642-8063","https://orcid.org/0000-0002-4610-4863"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahnaz Minai","raw_affiliation_strings":["Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086719536","display_name":"Mark Liu","orcid":"https://orcid.org/0000-0002-4048-2214","observed_orcids":["https://orcid.org/0000-0002-4048-2214"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Liu","raw_affiliation_strings":["Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4048-2214","affiliations":[{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004327810","display_name":"Jensen Pak","orcid":"https://orcid.org/0000-0002-4455-7842","observed_orcids":["https://orcid.org/0000-0002-4455-7842"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jensen Pak","raw_affiliation_strings":["Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4455-7842","affiliations":[{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034826569","display_name":"Francesco Borriello","orcid":"https://orcid.org/0000-0001-9074-4828","observed_orcids":["https://orcid.org/0000-0001-9074-4828"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Francesco Borriello","raw_affiliation_strings":["Department of Pediatrics, Harvard Medical School, Boston, MA, USA","Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy","Generate Biomedicines, Cambridge, MA, USA","Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Generate Biomedicines, Cambridge, MA, USA","institution_ids":[]},{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006942152","display_name":"Simon Doss-Gollin","orcid":"https://orcid.org/0000-0001-8797-7452","observed_orcids":["https://orcid.org/0000-0001-8797-7452"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Doss-Gollin","raw_affiliation_strings":["Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-8797-7452","affiliations":[{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063109052","display_name":"Elisabeth M. S. Beijnen","orcid":"https://orcid.org/0000-0001-9359-7819","observed_orcids":["https://orcid.org/0000-0001-9359-7819"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabeth M. S. Beijnen","raw_affiliation_strings":["Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9359-7819","affiliations":[{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032899682","display_name":"Saima Ahmed","orcid":"https://orcid.org/0000-0003-0293-036X","observed_orcids":["https://orcid.org/0000-0003-0293-036X","https://orcid.org/0009-0003-6609-7853"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saima Ahmed","raw_affiliation_strings":["Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035490111","display_name":"Michaela Helmel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michaela Helmel","raw_affiliation_strings":["Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090428914","display_name":"Peter Law\u00e6tz Andersen","orcid":"https://orcid.org/0000-0002-5869-2551","observed_orcids":["https://orcid.org/0000-0002-5869-2551"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]},{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Andersen","raw_affiliation_strings":["Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark","Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]},{"raw_affiliation_string":"Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021608465","display_name":"Barney S. Graham","orcid":"https://orcid.org/0000-0001-8112-0853","observed_orcids":["https://orcid.org/0000-0001-8112-0853"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405268911","display_name":"Vaccine Research Center","ror":"https://ror.org/02fve6a73","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268911"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barney S. Graham","raw_affiliation_strings":["Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405268911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053181499","display_name":"Hanno Steen","orcid":"https://orcid.org/0000-0003-0179-6648","observed_orcids":["https://orcid.org/0000-0003-0179-6648"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanno Steen","raw_affiliation_strings":["Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA","Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0179-6648","affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034593036","display_name":"Dennis Christensen","orcid":"https://orcid.org/0000-0003-2382-8639","observed_orcids":["https://orcid.org/0000-0003-2382-8639"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Dennis Christensen","raw_affiliation_strings":["Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2382-8639","affiliations":[{"raw_affiliation_string":"Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068050214","display_name":"Ofer Levy","orcid":"https://orcid.org/0000-0002-5859-1945","observed_orcids":["https://orcid.org/0000-0002-5859-1945","https://orcid.org/0000-0003-1095-6156","https://orcid.org/0000-0003-2606-7484"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ofer Levy","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Boston, MA, USA","Department of Pediatrics, Harvard Medical School, Boston, MA, USA","Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5859-1945","affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Boston, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5019180077"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":2.6285,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91575077,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"4234","last_page":"4234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neonatal-vaccination","display_name":"neonatal vaccination","score":0.6919999718666077},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tlr7-8","display_name":"TLR7/8","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mincle","display_name":"Mincle","score":0.8880000114440918},{"id":"https://openalex.org/keywords/c-type-lectin-receptors","display_name":"C-type lectin receptors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/protein-kinase-c-delta","display_name":"protein kinase C delta","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cross-presentation","display_name":"cross-presentation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pediatric-vaccines","display_name":"pediatric vaccines","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.7130094766616821},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6739226579666138},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5521409511566162},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5499075651168823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5245243310928345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37490400671958923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3227798342704773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08976742625236511}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014760","descriptor_name":"Viral Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018113","descriptor_name":"Respiratory Syncytial Virus, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022261","descriptor_name":"Respiratory Syncytial Virus Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-022-31709-2","doi":"https://doi.org/10.1038/s41467-022-31709-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-31709-2","pdf_url":"https://www.nature.com/articles/s41467-022-31709-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-178876/v1","doi":"https://doi.org/10.21203/rs.3.rs-178876/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-178876/v1","pdf_url":"https://www.researchsquare.com/article/rs-178876/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:35918315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35918315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9346114","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9346114/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire/c9cc0ea9-c1e1-41a6-b7dc-485af1256db8","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/c9cc0ea9-c1e1-41a6-b7dc-485af1256db8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van Haren, S D, Pedersen, G K, Kumar, A, Ruckwardt, T J, Moin, S, Moore, I N, Minai, M, Liu, M, Pak, J, Borriello, F, Doss-Gollin, S, Beijnen, E M S, Ahmed, S, Helmel, M, Andersen, P, Graham, B S, Steen, H, Christensen, D & Levy, O 2022, 'CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns', Nature Communications, vol. 13, no. 1, 4234. https://doi.org/10.1038/s41467-022-31709-2","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31709-2","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-31709-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:928f6a30307d40df8ee70a438b361824","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/928f6a30307d40df8ee70a438b361824","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-31709-2","doi":"https://doi.org/10.1038/s41467-022-31709-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-31709-2","pdf_url":"https://www.nature.com/articles/s41467-022-31709-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1836308875","display_name":null,"funder_award_id":"HHSN272201400052C","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G1887288462","display_name":null,"funder_award_id":"HHSN272201400052C","funder_id":"https://openalex.org/F4320332294","funder_display_name":"DHHS Office of the Secretary"},{"id":"https://openalex.org/G2277489774","display_name":null,"funder_award_id":"U19AI118608","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2793857255","display_name":"Pediatric Infectious Diseases Research Training","funder_award_id":"T32HD055148","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2814664472","display_name":null,"funder_award_id":"U01AI124284-01","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2893880928","display_name":"Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity","funder_award_id":"U19AI118608","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4794409194","display_name":"Dissecting the mechanism of age-specific adjuvant synergy in vitro and in vivo","funder_award_id":"U01AI124284","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6100960918","display_name":null,"funder_award_id":"HHSN272201400052C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G640848416","display_name":"Children's Hospital Boston - to apply unique human in vitro platforms to characterize immune responses of adjuvants that are being developed for Global Health vaccines","funder_award_id":"INV-004886","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G6879041785","display_name":null,"funder_award_id":"HHSN272201400052C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8312510772","display_name":null,"funder_award_id":"5T32HD055148-10","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320308347","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94"},{"id":"https://openalex.org/F4320309356","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332294","display_name":"DHHS Office of the Secretary","ror":null},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4289520173.pdf","grobid_xml":"https://content.openalex.org/works/W4289520173.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W259039846","https://openalex.org/W1529869158","https://openalex.org/W1560468264","https://openalex.org/W1599185640","https://openalex.org/W1650324696","https://openalex.org/W1971819575","https://openalex.org/W1973256540","https://openalex.org/W1975664491","https://openalex.org/W1979731533","https://openalex.org/W1981775472","https://openalex.org/W1983719979","https://openalex.org/W1984642581","https://openalex.org/W1985122745","https://openalex.org/W1988459634","https://openalex.org/W1989277387","https://openalex.org/W1991656907","https://openalex.org/W1991730258","https://openalex.org/W1994048581","https://openalex.org/W1996380614","https://openalex.org/W2007056945","https://openalex.org/W2011290533","https://openalex.org/W2019576909","https://openalex.org/W2021204204","https://openalex.org/W2023947892","https://openalex.org/W2029884055","https://openalex.org/W2036613016","https://openalex.org/W2043056303","https://openalex.org/W2045693101","https://openalex.org/W2052685738","https://openalex.org/W2054329126","https://openalex.org/W2057745345","https://openalex.org/W2060203912","https://openalex.org/W2062144811","https://openalex.org/W2065233521","https://openalex.org/W2069542935","https://openalex.org/W2070186258","https://openalex.org/W2080932940","https://openalex.org/W2082199453","https://openalex.org/W2083349939","https://openalex.org/W2093714333","https://openalex.org/W2094048920","https://openalex.org/W2097122003","https://openalex.org/W2099540110","https://openalex.org/W2100608881","https://openalex.org/W2115541182","https://openalex.org/W2122500082","https://openalex.org/W2123817481","https://openalex.org/W2125065061","https://openalex.org/W2126114330","https://openalex.org/W2126163156","https://openalex.org/W2126280097","https://openalex.org/W2126355151","https://openalex.org/W2128134586","https://openalex.org/W2139254860","https://openalex.org/W2144021590","https://openalex.org/W2148317624","https://openalex.org/W2150069228","https://openalex.org/W2151038767","https://openalex.org/W2154567574","https://openalex.org/W2163592077","https://openalex.org/W2165103789","https://openalex.org/W2170776626","https://openalex.org/W2171599819","https://openalex.org/W2177385981","https://openalex.org/W2339186749","https://openalex.org/W2462053388","https://openalex.org/W2463195069","https://openalex.org/W2509196986","https://openalex.org/W2537623931","https://openalex.org/W2548306936","https://openalex.org/W2555426966","https://openalex.org/W2559588208","https://openalex.org/W2581822728","https://openalex.org/W2586676015","https://openalex.org/W2727509207","https://openalex.org/W2738123535","https://openalex.org/W2771640821","https://openalex.org/W2777423019","https://openalex.org/W2783102765","https://openalex.org/W2784885284","https://openalex.org/W2788416903","https://openalex.org/W2789824531","https://openalex.org/W2799919967","https://openalex.org/W2884537568","https://openalex.org/W2899760200","https://openalex.org/W2903449449","https://openalex.org/W2908786159","https://openalex.org/W2947296408","https://openalex.org/W2964965456","https://openalex.org/W3159141025","https://openalex.org/W4233698560","https://openalex.org/W6647548779","https://openalex.org/W7098128289"],"related_works":["https://openalex.org/W4319432199","https://openalex.org/W2088838439","https://openalex.org/W3055806597","https://openalex.org/W2134013694","https://openalex.org/W2794096257","https://openalex.org/W3034847824","https://openalex.org/W2766966717","https://openalex.org/W2528229474","https://openalex.org/W1972365992","https://openalex.org/W2783239992"],"abstract_inverted_index":{"Abstract":[0],"Respiratory":[1],"syncytial":[2],"virus":[3],"is":[4],"a":[5,39,75,99,104,133,144],"leading":[6],"cause":[7],"of":[8,26,34,55,122,141,149],"morbidity":[9],"and":[10,59,73,90,127,137,155],"mortality":[11],"in":[12,15,49,86,95,101],"children,":[13],"due":[14],"part":[16],"to":[17,44,69],"their":[18],"distinct":[19],"immune":[20],"system,":[21],"characterized":[22],"by":[23,120],"impaired":[24],"induction":[25,121],"Th":[27,46],"1":[28,47],"immunity.":[29],"Here":[30],"we":[31,131],"show":[32],"application":[33],"cationic":[35],"adjuvant":[36,135],"formulation":[37,42,136],"CAF08,":[38],"liposomal":[40],"vaccine":[41],"tailored":[43],"induce":[45],"immunity":[48],"early":[50,150],"life":[51,151],"via":[52],"synergistic":[53],"engagement":[54],"Toll-like":[56],"Receptor":[57],"7/8":[58],"the":[60],"C-type":[61],"lectin":[62],"receptor":[63],"Mincle.":[64],"We":[65],"apply":[66],"quantitative":[67],"phosphoproteomics":[68],"human":[70],"dendritic":[71,88],"cells":[72,89],"reveal":[74],"role":[76],"for":[77,81,147],"Protein":[78],"Kinase":[79],"C-\u03b4":[80],"enhanced":[82],"Th1":[83,128],"cytokine":[84],"production":[85],"neonatal":[87],"identify":[91],"signaling":[92],"events":[93],"resulting":[94],"antigen":[96,113],"cross-presentation.":[97],"In":[98],"murine":[100],"vivo":[102],"model":[103],"single":[105],"immunization":[106],"at":[107],"birth":[108],"with":[109],"CAF08-adjuvanted":[110],"RSV":[111,118,154],"pre-fusion":[112],"protects":[114],"newborn":[115],"mice":[116],"from":[117],"infection":[119],"antigen-specific":[123],"CD8":[124],"+":[125],"T-cells":[126],"cells.":[129],"Overall,":[130],"describe":[132],"pediatric":[134],"characterize":[138],"its":[139],"mechanism":[140],"action":[142],"providing":[143],"promising":[145],"avenue":[146],"development":[148],"vaccines":[152],"against":[153],"other":[156],"respiratory":[157],"viral":[158],"pathogens.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-08-03T00:00:00"}