{"id":"https://openalex.org/W4289517166","doi":"https://doi.org/10.3389/fvets.2022.950063","title":"Effects of zearalenone on ovarian development of prepubertal gilts through growth hormone axis","display_name":"Effects of zearalenone on ovarian development of prepubertal gilts through growth hormone axis","publication_year":2022,"publication_date":"2022-08-03","ids":{"openalex":"https://openalex.org/W4289517166","doi":"https://doi.org/10.3389/fvets.2022.950063","pmid":"https://pubmed.ncbi.nlm.nih.gov/35990263","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9382108"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2022.950063","doi":"https://doi.org/10.3389/fvets.2022.950063","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.950063","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.950063/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.950063/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053946485","display_name":"Fengyang Wu","orcid":"https://orcid.org/0000-0002-1706-943X","observed_orcids":["https://orcid.org/0000-0002-1706-943X"]},"institutions":[{"id":"https://openalex.org/I108160477","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44","country_code":"CN","type":"education","lineage":["https://openalex.org/I108160477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyang Wu","raw_affiliation_strings":["College of Animal Science and Technology, Hebei Agricultural University, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Hebei Agricultural University, Baoding, China","institution_ids":["https://openalex.org/I108160477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102053952","display_name":"Lijie Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108160477","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44","country_code":"CN","type":"education","lineage":["https://openalex.org/I108160477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijie Gao","raw_affiliation_strings":["College of Animal Science and Technology, Hebei Agricultural University, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Hebei Agricultural University, Baoding, China","institution_ids":["https://openalex.org/I108160477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325813","display_name":"Fei Li","orcid":"https://orcid.org/0000-0002-3555-739X","observed_orcids":["https://orcid.org/0000-0002-3555-739X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fei Li","raw_affiliation_strings":["Hebei Provincial Animal Husbandry Station, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Provincial Animal Husbandry Station, Shijiazhuang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028396253","display_name":"Jia Cui","orcid":"https://orcid.org/0000-0001-6277-6435","observed_orcids":["https://orcid.org/0000-0001-6277-6435","https://orcid.org/0009-0007-1246-0142"]},"institutions":[{"id":"https://openalex.org/I108160477","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44","country_code":"CN","type":"education","lineage":["https://openalex.org/I108160477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Cui","raw_affiliation_strings":["College of Animal Science and Technology, Hebei Agricultural University, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Hebei Agricultural University, Baoding, China","institution_ids":["https://openalex.org/I108160477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033266172","display_name":"Xinyu Yang","orcid":"https://orcid.org/0000-0001-5498-1877","observed_orcids":["https://orcid.org/0000-0001-5498-1877"]},"institutions":[{"id":"https://openalex.org/I108160477","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44","country_code":"CN","type":"education","lineage":["https://openalex.org/I108160477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Yang","raw_affiliation_strings":["College of Animal Science and Technology, Hebei Agricultural University, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Hebei Agricultural University, Baoding, China","institution_ids":["https://openalex.org/I108160477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317726","display_name":"Yanhua Liu","orcid":"https://orcid.org/0000-0003-4667-2083","observed_orcids":["https://orcid.org/0000-0003-4667-2083"]},"institutions":[{"id":"https://openalex.org/I108160477","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44","country_code":"CN","type":"education","lineage":["https://openalex.org/I108160477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhua Liu","raw_affiliation_strings":["College of Animal Science and Technology, Hebei Agricultural University, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Hebei Agricultural University, Baoding, China","institution_ids":["https://openalex.org/I108160477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109835257","display_name":"Sai\u2010Juan Chen","orcid":"https://orcid.org/0000-0003-3789-1284","observed_orcids":["https://orcid.org/0000-0003-3789-1284"]},"institutions":[{"id":"https://openalex.org/I108160477","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44","country_code":"CN","type":"education","lineage":["https://openalex.org/I108160477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Saijuan Chen","raw_affiliation_strings":["Agricultural Technology Innovation Center in Mountainous Areas of Hebei Province, Baoding, China","Mountainous Area Research Institute of Hebei Province, Hebei Agricultural University, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural Technology Innovation Center in Mountainous Areas of Hebei Province, Baoding, China","institution_ids":[]},{"raw_affiliation_string":"Mountainous Area Research Institute of Hebei Province, Hebei Agricultural University, Baoding, China","institution_ids":["https://openalex.org/I108160477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103018054","display_name":"Baojiang Chen","orcid":"https://orcid.org/0000-0002-7193-6055","observed_orcids":["https://orcid.org/0000-0002-7193-6055"]},"institutions":[{"id":"https://openalex.org/I108160477","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44","country_code":"CN","type":"education","lineage":["https://openalex.org/I108160477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Baojiang Chen","raw_affiliation_strings":["College of Animal Science and Technology, Hebei Agricultural University, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Hebei Agricultural University, Baoding, China","institution_ids":["https://openalex.org/I108160477"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103018054","https://openalex.org/A5109835257"],"corresponding_institution_ids":["https://openalex.org/I108160477"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.5211,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58111934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"950063","last_page":"950063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.08219999819993973,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zearalenone","display_name":"zearalenone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mycotoxins","display_name":"mycotoxins","score":0.746999979019165},{"id":"https://openalex.org/keywords/ovarian-development","display_name":"ovarian development","score":0.9490000009536743},{"id":"https://openalex.org/keywords/prepubertal-gilts","display_name":"prepubertal gilts","score":0.9850000143051147},{"id":"https://openalex.org/keywords/growth-hormone-axis","display_name":"growth hormone axis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/growth-hormone-receptor","display_name":"growth hormone receptor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/growth-hormone-releasing-hormone","display_name":"growth hormone-releasing hormone","score":0.8619999885559082},{"id":"https://openalex.org/keywords/jak2","display_name":"JAK2","score":0.9340000152587891},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9449999928474426},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C113675107","wikidata":"https://www.wikidata.org/wiki/Q2299608","display_name":"Growth hormone receptor","level":4,"score":0.9788028001785278},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6791499853134155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6745495796203613},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.6369761228561401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5710656642913818},{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.47756630182266235},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.4348662495613098},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4147948920726776},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.39352819323539734},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.3118949830532074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14057400822639465}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fvets.2022.950063","doi":"https://doi.org/10.3389/fvets.2022.950063","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.950063","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.950063/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmid:35990263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35990263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9382108","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9382108/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Vet Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a8ac8dbfd8494aa09c6dfd08d8acceda","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a8ac8dbfd8494aa09c6dfd08d8acceda","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2022.950063","doi":"https://doi.org/10.3389/fvets.2022.950063","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.950063","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.950063/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.6875,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2216550972","display_name":null,"funder_award_id":"3003003","funder_id":"https://openalex.org/F4320327483","funder_display_name":"Hebei Agricultural University"}],"funders":[{"id":"https://openalex.org/F4320327483","display_name":"Hebei Agricultural University","ror":"https://ror.org/009fw8j44"},{"id":"https://openalex.org/F4320328876","display_name":"Hebei Provincial Key Research Projects","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4289517166.pdf","grobid_xml":"https://content.openalex.org/works/W4289517166.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W314223618","https://openalex.org/W1976501377","https://openalex.org/W1981784666","https://openalex.org/W1987699299","https://openalex.org/W2022602188","https://openalex.org/W2043593464","https://openalex.org/W2050190834","https://openalex.org/W2298695892","https://openalex.org/W2299261647","https://openalex.org/W2756081492","https://openalex.org/W2790718366","https://openalex.org/W2861306612","https://openalex.org/W2886420348","https://openalex.org/W2889203844","https://openalex.org/W2903894137","https://openalex.org/W2922390929","https://openalex.org/W2949771722","https://openalex.org/W2956078079","https://openalex.org/W2964541741","https://openalex.org/W2965939465","https://openalex.org/W2971157369","https://openalex.org/W2998411387","https://openalex.org/W3006992267","https://openalex.org/W3027010525","https://openalex.org/W3042591531","https://openalex.org/W3093198155","https://openalex.org/W3128620350","https://openalex.org/W3139196573","https://openalex.org/W3160658419","https://openalex.org/W3161323988","https://openalex.org/W3169239182"],"related_works":["https://openalex.org/W3128620350","https://openalex.org/W3196434715","https://openalex.org/W3103001823","https://openalex.org/W880373476","https://openalex.org/W2299261647","https://openalex.org/W2756081492","https://openalex.org/W2132940733","https://openalex.org/W2269818503","https://openalex.org/W4309704308","https://openalex.org/W4214503495"],"abstract_inverted_index":{"This":[0],"experiment":[1],"aimed":[2],"to":[3,48,84,139],"establish":[4],"the":[5,17,85,95,122,128,140,169,175,178,187],"effects":[6],"of":[7,72,97,107,119,124,160,172,177,190,200],"zearalenone":[8],"(ZEN)":[9],"on":[10],"ovarian":[11],"development":[12,96,176],"in":[13,121,127],"prepubertal":[14,43,125],"gilts":[15,44,126],"through":[16],"growth":[18,26,30],"hormone":[19,23,27,31],"axis":[20],"[growth":[21],"hormone-releasing":[22],"(GHRH)":[24],"/":[25,29],"(GH)":[28],"receptor":[32],"(GHR)].":[33],"In":[34,165],"a":[35,53],"40-day":[36],"experiment,":[37],"48":[38],"Landrace":[39],"\u00d7":[40],"Yorkshire":[41],"crossbred":[42],"were":[45],"randomly":[46],"allocated":[47],"four":[49],"dietary":[50],"treatments,":[51],"including":[52],"basal":[54],"diet":[55],"supplemented":[56],"with":[57],"0":[58],"(control),":[59],"400":[60],"(T1),":[61],"800":[62],"(T2),":[63],"and":[64,77,99,115,155,158,181,193,197],"1,600":[65],"(T3)":[66],"\u03bcg/kg":[67],"ZEN.":[68],"The":[69,101,143],"ovary":[70,179,196],"index":[71],"T2":[73,129],"(P":[74,79],"=":[75,80],"0.058)":[76],"T3":[78,144],"0.065)":[81],"increased":[82,132],"compared":[83,138],"control":[86,141],"group.":[87,142],"Besides,":[88],"histopathological":[89],"examination":[90],"revealed":[91],"that":[92],"ZEN":[93,167],"promoted":[94],"ovaries":[98,123],"follicles.":[100],"GHR":[102,120,149,201],"content,":[103,150],"relative":[104,151],"expression":[105,153,188],"levels":[106],"GHR,":[108,191],"janus":[109],"activated":[110],"kinase":[111],"2":[112],"(JAK2)":[113],"mRNA,":[114],"mean":[116],"optical":[117],"density":[118],"experimental":[130],"group":[131,145],"significantly":[133,147],"at":[134],"P":[135],"<":[136],"0.05":[137],"had":[146],"higher":[148],"JAK2":[152],"levels,":[154],"signal":[156],"transducer":[157],"activator":[159],"transcriptions":[161],"3":[162],"(STAT3)":[163],"mRNA.":[164],"conclusion,":[166],"enhances":[168],"biological":[170],"effect":[171],"GH,":[173],"promotes":[174],"(follicle),":[180],"exerts":[182],"reproductive":[183],"toxicity":[184],"by":[185],"increasing":[186],"level":[189],"JAK2,":[192],"STAT3":[194],"mRNA":[195],"immune":[198],"intensity":[199],"protein.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-08-03T00:00:00"}