{"id":"https://openalex.org/W4289334452","doi":"https://doi.org/10.1016/j.actbio.2022.07.054","title":"A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation","display_name":"A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation","publication_year":2022,"publication_date":"2022-08-01","ids":{"openalex":"https://openalex.org/W4289334452","doi":"https://doi.org/10.1016/j.actbio.2022.07.054","pmid":"https://pubmed.ncbi.nlm.nih.gov/35926780","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9810539"},"language":"en","primary_location":{"id":"doi:10.1016/j.actbio.2022.07.054","doi":"https://doi.org/10.1016/j.actbio.2022.07.054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2022.07.054","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1742706122004573/pdf","source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1742706122004573/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046898090","display_name":"Blaise Louis","orcid":"https://orcid.org/0000-0002-5289-2245","observed_orcids":["https://orcid.org/0000-0002-5289-2245"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Blaise Louis","raw_affiliation_strings":["Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK"],"raw_orcid":"https://orcid.org/0000-0002-5289-2245","affiliations":[{"raw_affiliation_string":"Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052129929","display_name":"Mukul Tewary","orcid":"https://orcid.org/0000-0003-2356-942X","observed_orcids":["https://orcid.org/0000-0003-2356-942X"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mukul Tewary","raw_affiliation_strings":["Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038471113","display_name":"Andrew W. Bremer","orcid":"https://orcid.org/0000-0001-5451-0530","observed_orcids":["https://orcid.org/0000-0001-5451-0530"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew W. Bremer","raw_affiliation_strings":["University of California, Berkeley, 278 Stanley Hall, Berkeley, CA 94720-3220, USA; Department of Pharmaceutical Chemistry, University of California at San Francisco, 600 16th St, Rm N512E, UCSF Box 2280, San Francisco, CA 94158, USA","Department of Pharmaceutical Chemistry, University of California at San Francisco, 600 16th St, Rm N512E, UCSF Box 2280, San Francisco, CA 94158, USA","University of California, Berkeley, 278 Stanley Hall, Berkeley, CA 94720-3220, USA"],"raw_orcid":"https://orcid.org/0000-0001-5451-0530","affiliations":[{"raw_affiliation_string":"University of California, Berkeley, 278 Stanley Hall, Berkeley, CA 94720-3220, USA; Department of Pharmaceutical Chemistry, University of California at San Francisco, 600 16th St, Rm N512E, UCSF Box 2280, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California at San Francisco, 600 16th St, Rm N512E, UCSF Box 2280, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California, Berkeley, 278 Stanley Hall, Berkeley, CA 94720-3220, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013636802","display_name":"Christina Philippeos","orcid":"https://orcid.org/0000-0001-8654-0291","observed_orcids":["https://orcid.org/0000-0001-8654-0291"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christina Philippeos","raw_affiliation_strings":["Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057952089","display_name":"Victor Augusti Negri","orcid":"https://orcid.org/0000-0002-9188-1370","observed_orcids":["https://orcid.org/0000-0002-9188-1370"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victor A. Negri","raw_affiliation_strings":["Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058266217","display_name":"Sebastiaan Zijl","orcid":"https://orcid.org/0000-0002-2856-1331","observed_orcids":["https://orcid.org/0000-0002-2856-1331"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sebastiaan Zijl","raw_affiliation_strings":["Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052760522","display_name":"Zev J. Gartner","orcid":"https://orcid.org/0000-0001-7803-1219","observed_orcids":["https://orcid.org/0000-0001-7803-1219"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zev J. Gartner","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California at San Francisco, 600 16th St, Rm N512E, UCSF Box 2280, San Francisco, CA 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California at San Francisco, 600 16th St, Rm N512E, UCSF Box 2280, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013729741","display_name":"David V. Schaffer","orcid":"https://orcid.org/0000-0002-9625-0121","observed_orcids":["https://orcid.org/0000-0002-9625-0121"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David V. Schaffer","raw_affiliation_strings":["University of California, Berkeley, 278 Stanley Hall, Berkeley, CA 94720-3220, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Berkeley, 278 Stanley Hall, Berkeley, CA 94720-3220, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068471552","display_name":"Fiona M. Watt","orcid":"https://orcid.org/0000-0001-9151-5154","observed_orcids":["https://orcid.org/0000-0001-9151-5154"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Fiona M. Watt","raw_affiliation_strings":["Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK. Electronic address: fiona.watt@kcl.ac.uk","Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK. Electronic address: fiona.watt@kcl.ac.uk","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]},{"raw_affiliation_string":"Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068471552"],"corresponding_institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.335,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.76468577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"150","issue":null,"first_page":"265","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.2485000044107437,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.8059999942779541},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/human-epidermal-stem-cells","display_name":"human epidermal stem cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cellular-microenvironment","display_name":"cell microenvironment","score":0.5879999995231628},{"id":"https://openalex.org/keywords/cell-substrate-adhesion","display_name":"cell-substrate adhesion","score":0.7379999756813049},{"id":"https://openalex.org/keywords/geometric-confinement","display_name":"confined geometries","score":0.5950000286102295},{"id":"https://openalex.org/keywords/involucrin","display_name":"involucrin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.652999997138977},{"id":"https://openalex.org/keywords/suspension-culture","display_name":"suspension culture","score":0.40799999237060547},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2777577635","wikidata":"https://www.wikidata.org/wiki/Q18028085","display_name":"Involucrin","level":4,"score":0.9324542880058289},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6834093332290649},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.6601535677909851},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5704004764556885},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5428379774093628},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5231966972351074},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5014398097991943},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4731118381023407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45071470737457275},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.436028391122818},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17841887474060059},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11365664005279541},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07115224003791809},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.actbio.2022.07.054","doi":"https://doi.org/10.1016/j.actbio.2022.07.054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2022.07.054","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1742706122004573/pdf","source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9810539","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9810539","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomater","raw_type":"Text"},{"id":"pmid:35926780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35926780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta biomaterialia","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/2f040e55-3f0f-49ad-8be0-ebb759651c17","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/2f040e55-3f0f-49ad-8be0-ebb759651c17","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Louis, B, Tewary, M, Bremer, A W, Philippeos, C, Negri, V A, Zijl, S, Gartner, Z J, Schaffer, D V & Watt, F M 2022, 'A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation', Acta Biomaterialia, vol. 150, pp. 265-276. https://doi.org/10.1016/j.actbio.2022.07.054","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.actbio.2022.07.054","doi":"https://doi.org/10.1016/j.actbio.2022.07.054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2022.07.054","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1742706122004573/pdf","source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3333361732","display_name":"UK human iPS cell consortium: genotype to phenotype.","funder_award_id":"098503/Z/12/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G339059223","display_name":null,"funder_award_id":"Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G397306497","display_name":null,"funder_award_id":"MR/PO18823/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4530043294","display_name":"UK human iPS cell consortium: genotype to phenotype.","funder_award_id":"098503","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6201161090","display_name":null,"funder_award_id":"DNRF135","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G6465506519","display_name":"Center for Cellular Signal Patterns (CellPAT)","funder_award_id":"DNRF135","funder_id":"https://openalex.org/F4320320943","funder_display_name":"Danmarks Grundforskningsfond"},{"id":"https://openalex.org/G7570265281","display_name":"Dynamic cell transition states in mammalian epidermis","funder_award_id":"206439","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G9000337125","display_name":null,"funder_award_id":"206439/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312400","display_name":"King's College Hospital NHS Foundation Trust","ror":"https://ror.org/01n0k5m85"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319994","display_name":"Department of Health and Social Care","ror":"https://ror.org/03sbpja79"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320868","display_name":"Boehringer Ingelheim Fonds","ror":"https://ror.org/00dkye506"},{"id":"https://openalex.org/F4320320943","display_name":"Danmarks Grundforskningsfond","ror":"https://ror.org/00znyv691"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4289334452.pdf","grobid_xml":"https://content.openalex.org/works/W4289334452.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W86524283","https://openalex.org/W1584211240","https://openalex.org/W1968956851","https://openalex.org/W1973697421","https://openalex.org/W1977109906","https://openalex.org/W1977608305","https://openalex.org/W1979580749","https://openalex.org/W1981241659","https://openalex.org/W1985091308","https://openalex.org/W2005630031","https://openalex.org/W2012046594","https://openalex.org/W2020372308","https://openalex.org/W2029675195","https://openalex.org/W2031811488","https://openalex.org/W2036496674","https://openalex.org/W2039396493","https://openalex.org/W2040115147","https://openalex.org/W2042464350","https://openalex.org/W2043854809","https://openalex.org/W2049043712","https://openalex.org/W2053416720","https://openalex.org/W2058393114","https://openalex.org/W2065550445","https://openalex.org/W2067667069","https://openalex.org/W2085021251","https://openalex.org/W2086100872","https://openalex.org/W2088253659","https://openalex.org/W2108038175","https://openalex.org/W2110711494","https://openalex.org/W2120795306","https://openalex.org/W2135073071","https://openalex.org/W2141605081","https://openalex.org/W2142087770","https://openalex.org/W2146186083","https://openalex.org/W2161104768","https://openalex.org/W2167192225","https://openalex.org/W2189426703","https://openalex.org/W2264324436","https://openalex.org/W2336032538","https://openalex.org/W2346241491","https://openalex.org/W2504691746","https://openalex.org/W2524912519","https://openalex.org/W2591611173","https://openalex.org/W2595741404","https://openalex.org/W2738146199","https://openalex.org/W2751928832","https://openalex.org/W2769238697","https://openalex.org/W2808592836","https://openalex.org/W2887357191","https://openalex.org/W2952888409","https://openalex.org/W2963723259","https://openalex.org/W2977022946","https://openalex.org/W2980821730","https://openalex.org/W3011516270","https://openalex.org/W3012259550","https://openalex.org/W3032142305","https://openalex.org/W3092890663","https://openalex.org/W6721832327"],"related_works":["https://openalex.org/W2058393114","https://openalex.org/W2042464350","https://openalex.org/W4412725685","https://openalex.org/W2414454811","https://openalex.org/W2010701993","https://openalex.org/W2327893181","https://openalex.org/W1993212221","https://openalex.org/W2110711494","https://openalex.org/W974872885","https://openalex.org/W4316466281"],"abstract_inverted_index":{"The":[0],"balance":[1],"between":[2,13,127],"stem":[3,284,306],"cell":[4,38,188,231,285],"renewal":[5],"and":[6,17,36,71,248,270,280,287,312,330],"differentiation":[7,44,104,137,168,288],"is":[8,199,233],"determined":[9],"by":[10,21,235],"the":[11,22,65,132,141,147,177,191,203,219,222,242,245,260,313,321],"interplay":[12],"intrinsic":[14,200],"cellular":[15],"controls":[16],"extrinsic":[18],"factors":[19],"presented":[20],"microenvironment,":[23],"or":[24],"'niche'.":[25],"Previous":[26],"studies":[27],"on":[28,102,140,152,160,224,327],"cultured":[29],"human":[30,304],"epidermis":[31],"have":[32,295],"utilised":[33],"suspension":[34,88],"culture":[35],"restricted":[37],"spreading":[39],"to":[40,53,63,78,89,119,171,266,299],"investigate":[41,64],"regulation":[42],"of":[43,68,81,105,117,134,149,176,205,221,238,244,253,262,274,303,323],"in":[45,56,87,131,169,202,208,282,336],"single":[46,128,143,161],"keratinocytes.":[47,106],"However,":[48,146],"keratinocytes":[49,82,118],"are":[50,257,289],"typically":[51],"adherent":[52],"neighbouring":[54],"cells":[55,151,335],"vivo.":[57],"We":[58,74,107,318],"therefore":[59],"developed":[60,109],"experimental":[61,95],"models":[62],"combined":[66],"effects":[67],"cell-ECM":[69],"adhesion":[70,302,325,329],"cell-cell":[72,97,125,165,206,249,324],"contact.":[73],"utilized":[75],"lipid-modified":[76,310],"oligonucleotides":[77],"form":[79],"clusters":[80],"which":[83,283],"were":[84],"subsequently":[85],"placed":[86],"induce":[90],"terminal":[91],"differentiation.":[92,210,226],"In":[93,291],"this":[94,292],"model":[96],"contact":[98,126,166,207],"had":[99],"no":[100],"effect":[101,204,220,322],"suspension-induced":[103],"next":[108],"a":[110,236],"high-throughput":[111],"platform":[112],"for":[113],"robust":[114],"geometrical":[115],"confinement":[116],"hexagonal":[120,144,316],"ECM-coated":[121],"islands":[122,155,180],"permitting":[123],"direct":[124],"cells.":[129,184],"As":[130],"case":[133],"circular":[135],"islands,":[136,162],"was":[138,156,189,193],"stimulated":[139],"smallest":[142],"islands.":[145],"percentage":[148],"involucrin-positive":[150,183,190],"small":[153,178],"bowtie":[154,179],"significantly":[157],"lower":[158],"than":[159],"demonstrating":[163],"that":[164,197,320,333],"reduced":[167],"response":[170],"decreased":[172],"substrate":[173,247],"adhesion.":[174],"None":[175],"contained":[181],"two":[182,297,334],"Rather,":[185],"if":[186],"one":[187,308],"other":[192,314],"involucrin-negative.":[194],"This":[195],"suggests":[196],"there":[198],"asymmetry":[201],"decreasing":[209],"Thus,":[211],"our":[212,272],"reductionist":[213],"approaches":[214],"provide":[215],"new":[216,264],"insights":[217],"into":[218],"niche":[223],"keratinocyte":[225],"STATEMENT":[227],"OF":[228],"SIGNIFICANCE:":[229],"Stem":[230],"behaviour":[232],"regulated":[234],"combination":[237],"external":[239],"signals,":[240],"including":[241],"nature":[243],"adhesive":[246],"interactions.":[250],"An":[251],"understanding":[252,273],"how":[254],"different":[255],"signals":[256],"integrated":[258],"creates":[259],"possibility":[261],"developing":[263],"biomaterials":[265],"promote":[267],"tissue":[268],"regeneration":[269],"broaden":[271],"skin":[275],"diseases":[276],"such":[277],"as":[278],"eczema":[279],"psoriasis,":[281],"proliferation":[286],"perturbed.":[290],"study":[293],"we":[294],"applied":[296],"methods":[298],"engineer":[300],"intercellular":[301],"epidermal":[305],"cells,":[307],"involving":[309,315],"DNA":[311],"micropatterns.":[317],"show":[319],"depends":[326],"cell-substrate":[328],"uncover":[331],"evidence":[332],"equivalent":[337],"environments":[338],"can":[339],"nevertheless":[340],"behave":[341],"differently.":[342]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-02T00:00:00"}
