{"id":"https://openalex.org/W4289260244","doi":"https://doi.org/10.1016/j.ijpharm.2022.122055","title":"Targeted colonic release formulations of mesalazine \u2013 A clinical pharmaco-scintigraphic proof-of-concept study in healthy subjects and patients with mildly active ulcerative colitis","display_name":"Targeted colonic release formulations of mesalazine \u2013 A clinical pharmaco-scintigraphic proof-of-concept study in healthy subjects and patients with mildly active ulcerative colitis","publication_year":2022,"publication_date":"2022-08-01","ids":{"openalex":"https://openalex.org/W4289260244","doi":"https://doi.org/10.1016/j.ijpharm.2022.122055","pmid":"https://pubmed.ncbi.nlm.nih.gov/35926752"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2022.122055","doi":"https://doi.org/10.1016/j.ijpharm.2022.122055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2022.122055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0378517322006093/pdf","source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0378517322006093/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023267784","display_name":"Felipe Varum","orcid":"https://orcid.org/0000-0002-0143-6143","observed_orcids":["https://orcid.org/0000-0002-0143-6143","https://orcid.org/0000-0003-4948-9997"]},"institutions":[{"id":"https://openalex.org/I4210118826","display_name":"Tillotts Pharma (Switzerland)","ror":"https://ror.org/02kejw255","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210118826"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"F. Varum","raw_affiliation_strings":["Tillotts Pharma AG, Rheinfelden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tillotts Pharma AG, Rheinfelden, Switzerland","institution_ids":["https://openalex.org/I4210118826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016547253","display_name":"Helen C. Thorne","orcid":"https://orcid.org/0000-0002-6422-4623","observed_orcids":["https://orcid.org/0000-0002-6422-4623"]},"institutions":[{"id":"https://openalex.org/I4210118826","display_name":"Tillotts Pharma (Switzerland)","ror":"https://ror.org/02kejw255","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210118826"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"H. Thorne","raw_affiliation_strings":["Tillotts Pharma AG, Rheinfelden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tillotts Pharma AG, Rheinfelden, Switzerland","institution_ids":["https://openalex.org/I4210118826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051130750","display_name":"Roberto Bravo","orcid":"https://orcid.org/0000-0001-8873-8699","observed_orcids":["https://orcid.org/0000-0001-8873-8699"]},"institutions":[{"id":"https://openalex.org/I4210118826","display_name":"Tillotts Pharma (Switzerland)","ror":"https://ror.org/02kejw255","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210118826"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R. Bravo","raw_affiliation_strings":["Tillotts Pharma AG, Rheinfelden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tillotts Pharma AG, Rheinfelden, Switzerland","institution_ids":["https://openalex.org/I4210118826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026375446","display_name":"Denise Gilgen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118826","display_name":"Tillotts Pharma (Switzerland)","ror":"https://ror.org/02kejw255","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210118826"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D. Gilgen","raw_affiliation_strings":["Tillotts Pharma AG, Rheinfelden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tillotts Pharma AG, Rheinfelden, Switzerland","institution_ids":["https://openalex.org/I4210118826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066942906","display_name":"Colton J. Hartig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118826","display_name":"Tillotts Pharma (Switzerland)","ror":"https://ror.org/02kejw255","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210118826"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C. Hartig","raw_affiliation_strings":["Tillotts Pharma AG, Rheinfelden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tillotts Pharma AG, Rheinfelden, Switzerland","institution_ids":["https://openalex.org/I4210118826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079386870","display_name":"G.P. Nicolas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G.P. Nicolas","raw_affiliation_strings":["Division of Nuclear Medicine, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023353633","display_name":"Damian Wild","orcid":"https://orcid.org/0000-0002-8135-5350","observed_orcids":["https://orcid.org/0000-0002-8135-5350"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D. Wild","raw_affiliation_strings":["Division of Nuclear Medicine, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083956843","display_name":"Evangelia Liakoni","orcid":"https://orcid.org/0000-0002-2239-1378","observed_orcids":["https://orcid.org/0000-0002-2239-1378"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"E. Liakoni","raw_affiliation_strings":["Clinical Pharmacology & Toxicology, Department of General Internal Medicine, University Hospital Bern, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology & Toxicology, Department of General Internal Medicine, University Hospital Bern, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071531513","display_name":"Manuel Haschke","orcid":"https://orcid.org/0000-0003-1846-8640","observed_orcids":["https://orcid.org/0000-0003-1846-8640"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"M. Haschke","raw_affiliation_strings":["Clinical Pharmacology & Toxicology, Department of General Internal Medicine, University Hospital Bern, University of Bern, Switzerland. Electronic address: manuel.haschke@insel.ch","Clinical Pharmacology & Toxicology, Department of General Internal Medicine, University Hospital Bern, University of Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology & Toxicology, Department of General Internal Medicine, University Hospital Bern, University of Bern, Switzerland. Electronic address: manuel.haschke@insel.ch","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Clinical Pharmacology & Toxicology, Department of General Internal Medicine, University Hospital Bern, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071531513"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"],"apc_list":{"value":4050,"currency":"USD","value_usd":4050},"apc_paid":{"value":4050,"currency":"USD","value_usd":4050},"fwci":1.7401,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.81104616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"625","issue":null,"first_page":"122055","last_page":"122055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.12110000103712082,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":0.9679999947547913},{"id":"https://openalex.org/keywords/enteric-coated-tablets","display_name":"enteric-coated tablets","score":0.6420000195503235},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neutron-activation","display_name":"neutron activation","score":0.44200000166893005},{"id":"https://openalex.org/keywords/resistant-starch","display_name":"resistant starch","score":0.6110000014305115},{"id":"https://openalex.org/keywords/enteric-polymers","display_name":"enteric polymers","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gastrointestinal-transit","display_name":"gastrointestinal transit","score":0.859000027179718},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8759999871253967},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2779174533","wikidata":"https://www.wikidata.org/wiki/Q412479","display_name":"Mesalazine","level":4,"score":0.9304184913635254},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.5859348177909851},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5579323172569275},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4887993037700653},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47523120045661926},{"id":"https://openalex.org/C2777570183","wikidata":"https://www.wikidata.org/wiki/Q1811185","display_name":"Enteric coating","level":3,"score":0.4351407289505005},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4180278778076172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37802308797836304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3505510091781616},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.34565210342407227},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ijpharm.2022.122055","doi":"https://doi.org/10.1016/j.ijpharm.2022.122055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2022.122055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0378517322006093/pdf","source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:35926752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35926752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:doi:10.48350/171755","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/86524","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:171755","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/171755/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Varum, F; Thorne, H; Bravo, R; Gilgen, D; Hartig, C; Nicolas, G P; Wild, D; Liakoni, Ev; Haschke, M (2022). Targeted colonic release formulations of mesalazine - A clinical pharmaco-scintigraphic proof-of-concept study in healthy subjects and patients with mildly active ulcerative colitis. International journal of pharmaceutics, 625, p. 122055. Elsevier 10.1016/j.ijpharm.2022.122055 &lt;http://dx.doi.org/10.1016/j.ijpharm.2022.122055&gt;","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.48350/171755","doi":"https://doi.org/10.48350/171755","is_oa":true,"landing_page_url":"https://doi.org/10.48350/171755","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1016/j.ijpharm.2022.122055","doi":"https://doi.org/10.1016/j.ijpharm.2022.122055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2022.122055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0378517322006093/pdf","source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327535","display_name":"Tillotts Pharma","ror":"https://ror.org/02kejw255"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4289260244.pdf","grobid_xml":"https://content.openalex.org/works/W4289260244.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1561310551","https://openalex.org/W1930299866","https://openalex.org/W1941449984","https://openalex.org/W1964096104","https://openalex.org/W1970072226","https://openalex.org/W1979210724","https://openalex.org/W1981461721","https://openalex.org/W1986857394","https://openalex.org/W1987678585","https://openalex.org/W1989738331","https://openalex.org/W2001488324","https://openalex.org/W2007674178","https://openalex.org/W2009746460","https://openalex.org/W2017678349","https://openalex.org/W2023743179","https://openalex.org/W2037316486","https://openalex.org/W2037945988","https://openalex.org/W2042901922","https://openalex.org/W2055291371","https://openalex.org/W2058005106","https://openalex.org/W2059964008","https://openalex.org/W2060044832","https://openalex.org/W2061019452","https://openalex.org/W2075698556","https://openalex.org/W2079163881","https://openalex.org/W2081219778","https://openalex.org/W2085444179","https://openalex.org/W2089407496","https://openalex.org/W2091606397","https://openalex.org/W2095179999","https://openalex.org/W2099988652","https://openalex.org/W2133264429","https://openalex.org/W2143363925","https://openalex.org/W2163473068","https://openalex.org/W2222899743","https://openalex.org/W2325533081","https://openalex.org/W2617461034","https://openalex.org/W2742166437","https://openalex.org/W2811058527","https://openalex.org/W2902610036","https://openalex.org/W2904180906","https://openalex.org/W2977657271","https://openalex.org/W2980767749","https://openalex.org/W3017398924","https://openalex.org/W3023963425","https://openalex.org/W3161848305","https://openalex.org/W4210258765","https://openalex.org/W4210972027"],"related_works":["https://openalex.org/W7143375911","https://openalex.org/W2387610096","https://openalex.org/W1665232424","https://openalex.org/W4399250454","https://openalex.org/W7097779256","https://openalex.org/W2240711038","https://openalex.org/W4389790663","https://openalex.org/W4405679175","https://openalex.org/W3078092785","https://openalex.org/W2985223579"],"abstract_inverted_index":{"Colonic":[0],"targeting":[1,33],"of":[2,79,103,120,139,164],"orally":[3],"applied":[4],"therapeutic":[5],"drugs":[6],"remains":[7],"a":[8,50],"challenge.":[9],"Tablet":[10],"coatings":[11,88],"relying":[12],"on":[13],"gastrointestinal":[14,124],"pH":[15,178],"and":[16,61,71,82,97,109,123,154,169,179],"colonic":[17],"bacterial":[18],"enzymes":[19],"as":[20],"triggers":[21],"in":[22,49,57,93,136,184],"association":[23],"with":[24,43,64,76,150,186,198],"an":[25,187],"inner":[26,188],"alkaline":[27,189],"layer":[28,190],"are":[29],"expected":[30],"to":[31,114,143,173],"improve":[32],"efficiency.":[34],"Mesalazine":[35,107],"release":[36,91,182,193],"from":[37],"three":[38],"differently":[39],"coated":[40],"tablets":[41],"labelled":[42],"1":[44],"MBq":[45],"153Sm":[46],"was":[47,147],"characterised":[48],"single":[51],"centre,":[52],"open-label,":[53],"parallel":[54],"group":[55],"study":[56],"nineteen":[58],"healthy":[59],"subjects":[60],"seven":[62],"patients":[63],"mildly":[65],"active":[66],"ulcerative":[67],"colitis.":[68],"Two":[69],"semi-organic":[70],"one":[72],"aqueous-based":[73],"outer":[74],"coating":[75],"different":[77,170],"ratios":[78],"enteric":[80,171],"polymer":[81,172],"resistant":[83],"starch":[84],"were":[85,98,112],"tested.":[86],"All":[87],"showed":[89],"comparable":[90],"lagtimes":[92],"biorelevant":[94],"dissolution":[95],"media":[96],"not":[99],"affected":[100],"by":[101],"neutron-activation":[102],"the":[104,131,140,176,195],"samarium":[105],"tracer.":[106],"pharmacokinetics":[108],"gamma":[110],"scintigraphy":[111],"used":[113],"characterise":[115],"drug":[116],"release,":[117],"anatomical":[118],"site":[119,197],"tablet":[121,127,145],"disintegration":[122,128,146],"transit.":[125],"Initial":[126],"occurred":[129],"at":[130,194],"ileo-caecal":[132],"junction":[133],"or":[134],"beyond":[135],"92":[137],"%":[138],"subjects.":[141],"Time":[142],"initial":[144],"inversely":[148],"correlated":[149],"maximal":[151],"plasma":[152],"concentrations":[153],"systemic":[155],"mesalazine":[156,192],"exposure.":[157],"Although":[158],"high":[159,199],"inter-subject":[160],"variability":[161],"precluded":[162],"detection":[163],"differences":[165],"between":[166],"solvent":[167],"types":[168],"polysaccharide":[174],"ratios,":[175],"dual":[177],"enzymatic":[180],"triggered":[181],"system":[183],"combination":[185],"promoted":[191],"target":[196],"accuracy.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-08-01T00:00:00"}
