{"id":"https://openalex.org/W4288949655","doi":"https://doi.org/10.1186/s12929-022-00840-z","title":"TRIM18 is a critical regulator of viral myocarditis and organ inflammation","display_name":"TRIM18 is a critical regulator of viral myocarditis and organ inflammation","publication_year":2022,"publication_date":"2022-07-31","ids":{"openalex":"https://openalex.org/W4288949655","doi":"https://doi.org/10.1186/s12929-022-00840-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/35909127","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9339186"},"language":"en","primary_location":{"id":"doi:10.1186/s12929-022-00840-z","doi":"https://doi.org/10.1186/s12929-022-00840-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12929-022-00840-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12929-022-00840-z.pdf","source":{"id":"https://openalex.org/S52607827","display_name":"Journal of Biomedical Science","issn_l":"1021-7770","issn":["1021-7770","1423-0127"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1186/s12929-022-00840-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084008167","display_name":"Mingli Fang","orcid":"https://orcid.org/0000-0002-2679-4182","observed_orcids":["https://orcid.org/0000-0002-2679-4182"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Mingli Fang","raw_affiliation_strings":["Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China","Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437584","display_name":"Ao Zhang","orcid":"https://orcid.org/0000-0001-7205-9202","observed_orcids":["https://orcid.org/0000-0001-7205-9202"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ao Zhang","raw_affiliation_strings":["Department of Laboratory Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China","Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101502468","display_name":"Yong Du","orcid":"https://orcid.org/0000-0003-2986-6249","observed_orcids":["https://orcid.org/0000-0003-2986-6249"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Du","raw_affiliation_strings":["Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101198447","display_name":"Wenting Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenting Lu","raw_affiliation_strings":["Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115694969","display_name":"Junying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junying Wang","raw_affiliation_strings":["Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022206230","display_name":"Laurie J. Minze","orcid":"https://orcid.org/0000-0002-1430-1846","observed_orcids":["https://orcid.org/0000-0002-1430-1846"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie J. Minze","raw_affiliation_strings":["Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068803926","display_name":"Timothy C. Cox","orcid":"https://orcid.org/0000-0001-8015-5528","observed_orcids":["https://orcid.org/0000-0001-8015-5528"]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy C. Cox","raw_affiliation_strings":["Department of Oral & Craniofacial Sciences, School of Dentistry & Department of Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral & Craniofacial Sciences, School of Dentistry & Department of Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041607266","display_name":"X.C. Li","orcid":"https://orcid.org/0000-0002-5981-2762","observed_orcids":["https://orcid.org/0000-0002-5981-2762","https://orcid.org/0000-0002-3319-4521","https://orcid.org/0000-0001-6823-3335","https://orcid.org/0000-0002-5712-8772","https://orcid.org/0000-0002-8550-8385"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xian Chang Li","raw_affiliation_strings":["Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059112788","display_name":"Junji Xing","orcid":"https://orcid.org/0000-0002-3392-5427","observed_orcids":["https://orcid.org/0000-0002-3392-5427"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junji Xing","raw_affiliation_strings":["Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA. jxing@houstonmethodist.org","Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA. jxing@houstonmethodist.org","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100346727","display_name":"Zhiqiang Zhang","orcid":"https://orcid.org/0000-0003-1796-081X","observed_orcids":["https://orcid.org/0000-0003-1796-081X"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiqiang Zhang","raw_affiliation_strings":["Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA. zzhang@houstonmethodist.org","Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA. zzhang@houstonmethodist.org","Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA"],"raw_orcid":"https://orcid.org/0000-0003-1796-081X","affiliations":[{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA. zzhang@houstonmethodist.org","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA. zzhang@houstonmethodist.org","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5059112788","https://openalex.org/A5100346727"],"corresponding_institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405286254"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":5.1631,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.97252303,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"29","issue":"1","first_page":"55","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-myocarditis","display_name":"viral myocarditis","score":0.906000018119812},{"id":"https://openalex.org/keywords/organ-inflammation","display_name":"organ inflammation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.7889999747276306},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.7289999723434448},{"id":"https://openalex.org/keywords/ppm1a","display_name":"PPM1A","score":0.984000027179718},{"id":"https://openalex.org/keywords/k63-linked-ubiquitination","display_name":"K63-linked ubiquitination","score":0.9120000004768372},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/coxsackievirus-b3","display_name":"coxsackievirus B3","score":0.9290000200271606},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/herpes-simplex-encephalitis","display_name":"herpes simplex encephalitis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/mavs","display_name":"MAVS","score":0.6819999814033508},{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.9990000128746033},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7250000238418579},{"id":"https://openalex.org/keywords/antiviral-signaling","display_name":"antiviral signaling","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6688812971115112},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6534310579299927},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6335652470588684},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5500773191452026},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5212631821632385},{"id":"https://openalex.org/C2909190889","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Viral Myocarditis","level":3,"score":0.5181892514228821},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.508335530757904},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.4484088122844696},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.44316619634628296},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4086788594722748},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3788095712661743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17200279235839844},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071636","descriptor_name":"Protein Phosphatase 2C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020803","descriptor_name":"Encephalitis, Herpes Simplex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12929-022-00840-z","doi":"https://doi.org/10.1186/s12929-022-00840-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12929-022-00840-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12929-022-00840-z.pdf","source":{"id":"https://openalex.org/S52607827","display_name":"Journal of Biomedical Science","issn_l":"1021-7770","issn":["1021-7770","1423-0127"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Science","raw_type":"journal-article"},{"id":"pmid:35909127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35909127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9339186","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9339186/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomed Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:82994d7153f24275860532824be4a797","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/82994d7153f24275860532824be4a797","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-20 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12929-022-00840-z","doi":"https://doi.org/10.1186/s12929-022-00840-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12929-022-00840-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12929-022-00840-z.pdf","source":{"id":"https://openalex.org/S52607827","display_name":"Journal of Biomedical Science","issn_l":"1021-7770","issn":["1021-7770","1423-0127"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1789046545","display_name":"Molecular and cellular mechanisms causing cleft lip/palate","funder_award_id":"R01DE027879","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5358009117","display_name":"Targeting novel checkpoint regulator to control viral myocarditis","funder_award_id":"20CDA35260116","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G9000861303","display_name":"Modulation of innate immune cells to create transplant tolerance","funder_award_id":"R01AI080779","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000912110","display_name":"Studies of a new checkpoint regulator in the control of intestinal inflammation","funder_award_id":"R01AI155488","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320315638","display_name":"Houston Methodist Hospital","ror":"https://ror.org/027zt9171"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333841","display_name":"Houston Methodist Research Institute","ror":null},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288949655.pdf","grobid_xml":"https://content.openalex.org/works/W4288949655.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W1527682346","https://openalex.org/W1966122707","https://openalex.org/W1968178474","https://openalex.org/W1973646620","https://openalex.org/W1994944044","https://openalex.org/W1999029823","https://openalex.org/W2009127910","https://openalex.org/W2022477315","https://openalex.org/W2024562564","https://openalex.org/W2025321617","https://openalex.org/W2028575270","https://openalex.org/W2030194551","https://openalex.org/W2030923942","https://openalex.org/W2033702347","https://openalex.org/W2042433863","https://openalex.org/W2044005732","https://openalex.org/W2047365750","https://openalex.org/W2058448931","https://openalex.org/W2063379758","https://openalex.org/W2067706259","https://openalex.org/W2076361525","https://openalex.org/W2082429447","https://openalex.org/W2082613707","https://openalex.org/W2085192138","https://openalex.org/W2093336713","https://openalex.org/W2099610218","https://openalex.org/W2100665873","https://openalex.org/W2121129477","https://openalex.org/W2123837920","https://openalex.org/W2124950819","https://openalex.org/W2125845521","https://openalex.org/W2128847991","https://openalex.org/W2131617804","https://openalex.org/W2132490889","https://openalex.org/W2136824768","https://openalex.org/W2142888775","https://openalex.org/W2144652247","https://openalex.org/W2144686577","https://openalex.org/W2144787399","https://openalex.org/W2152354323","https://openalex.org/W2152740195","https://openalex.org/W2155584359","https://openalex.org/W2155813655","https://openalex.org/W2157352436","https://openalex.org/W2169917467","https://openalex.org/W2184196649","https://openalex.org/W2237091872","https://openalex.org/W2237990100","https://openalex.org/W2289655038","https://openalex.org/W2417508398","https://openalex.org/W2462526312","https://openalex.org/W2474747771","https://openalex.org/W2514732099","https://openalex.org/W2525002693","https://openalex.org/W2528701520","https://openalex.org/W2537570544","https://openalex.org/W2562210432","https://openalex.org/W2573216293","https://openalex.org/W2595963502","https://openalex.org/W2616830156","https://openalex.org/W2761362534","https://openalex.org/W2765213553","https://openalex.org/W2789352630","https://openalex.org/W2803553304","https://openalex.org/W2898207658","https://openalex.org/W2913776187","https://openalex.org/W2955513834","https://openalex.org/W2994566149","https://openalex.org/W3005079553","https://openalex.org/W3021126245","https://openalex.org/W3021230020","https://openalex.org/W3021390507","https://openalex.org/W3022455098","https://openalex.org/W3023867982","https://openalex.org/W3080487846","https://openalex.org/W3092415006","https://openalex.org/W3143513212","https://openalex.org/W3162280460","https://openalex.org/W3163226127","https://openalex.org/W3176842133","https://openalex.org/W3185608026","https://openalex.org/W4205623122","https://openalex.org/W4281290708"],"related_works":["https://openalex.org/W6902064160","https://openalex.org/W4380769097","https://openalex.org/W6958225450","https://openalex.org/W2898207658","https://openalex.org/W4389956629","https://openalex.org/W4394873205","https://openalex.org/W4404323381","https://openalex.org/W2774253484","https://openalex.org/W2803553304","https://openalex.org/W4395456086"],"abstract_inverted_index":{"BACKGROUND:":[0],"Infections":[1],"by":[2,265,290,296],"viruses":[3],"including":[4],"severe":[5],"acute":[6],"respiratory":[7],"syndrome":[8],"coronavirus":[9],"2":[10],"could":[11],"cause":[12],"organ":[13,34,45,64],"inflammations":[14,46],"such":[15],"as":[16,30,32,278],"myocarditis,":[17,79,199,284],"pneumonia":[18],"and":[19,63,67,85,92,107,110,116,131,183,187,202,248,287,299],"encephalitis.":[20,102],"Innate":[21],"immunity":[22,29,313],"to":[23,136,178,207,225,235],"viral":[24,43,61,78,90,198,200,259,283,315],"nucleic":[25],"acids":[26],"mediates":[27],"antiviral":[28,245,256],"well":[31],"inflammatory":[33],"injury.":[35],"However,":[36],"the":[37,52,55,138],"innate":[38,292,312],"immune":[39,293],"mechanisms":[40,140],"that":[41,159,218,275,305],"control":[42],"induced":[44,295,316],"are":[47],"unclear.":[48],"METHODS:":[49],"To":[50],"understand":[51,137],"role":[53],"of":[54,141,163,172,193,250,269,282,311],"E3":[56],"ligase":[57],"TRIM18":[58,142,164,194,219,262,276,306],"in":[59,143,153,165,176,213,314],"controlling":[60],"myocarditis":[62],"inflammation,":[65],"wild-type":[66],"Trim18":[68],"knockout":[69],"mice":[70,196],"were":[71,105,112,134],"infected":[72],"with":[73,240],"coxsackievirus":[74],"B3":[75],"for":[76,88,98,114,324],"inducing":[77,89,99,266],"influenza":[80],"A":[81],"virus":[82,95,151,189],"PR8":[83],"strain":[84],"human":[86,166],"adenovirus":[87],"pneumonia,":[91,201],"herpes":[93,100,203],"simplex":[94,101,204],"type":[96,145,173,209],"I":[97,146,174,210],"Mice":[103],"survivals":[104],"monitored,":[106],"heart,":[108],"lung":[109,285],"brain":[111,288],"harvested":[113],"histology":[115],"immunohistochemistry":[117],"analysis.":[118],"Real-time":[119],"PCR,":[120],"co-immunoprecipitation,":[121],"immunoblot,":[122],"enzyme-linked":[123],"immunosorbent":[124],"assay,":[125,127],"luciferase":[126],"flow":[128],"cytometry,":[129],"over-expression":[130],"knockdown":[132,160],"techniques":[133],"used":[135],"molecular":[139],"regulating":[144],"interferon":[147,251],"(IFN)":[148],"production":[149,171,212],"after":[150],"infection":[152],"this":[154],"study.":[155],"RESULTS:":[156],"We":[157],"find":[158],"or":[161,167,185],"deletion":[162,192],"mouse":[168],"macrophages":[169],"enhances":[170],"IFN":[175,211],"response":[177],"double":[179],"strand":[180],"(ds)":[181],"RNA":[182,186,298],"dsDNA":[184],"DNA":[188,300],"infection.":[190],"Importantly,":[191],"protects":[195],"from":[197,238],"encephalitis":[205],"due":[206],"enhanced":[208],"vivo.":[214],"Mechanistically,":[215],"we":[216],"show":[217],"recruits":[220],"protein":[221],"phosphatase":[222],"1A":[223],"(PPM1A)":[224],"dephosphorylate":[226],"TANK":[227],"binding":[228],"kinase":[229],"1":[230],"(TBK1),":[231],"which":[232],"inactivates":[233],"TBK1":[234,237],"block":[236],"interacting":[239],"its":[241],"upstream":[242],"adaptors,":[243],"mitochondrial":[244],"signaling":[246,257],"(MAVS)":[247],"stimulator":[249],"genes":[252],"(STING),":[253],"thereby":[254,318],"dampening":[255],"during":[258],"infections.":[260],"Moreover,":[261],"stabilizes":[263],"PPM1A":[264],"K63-linked":[267],"ubiquitination":[268],"PPM1A.":[270],"CONCLUSIONS:":[271],"Our":[272,302],"results":[273],"indicate":[274],"serves":[277],"a":[279,308,320],"negative":[280],"regulator":[281,310],"inflammation":[286],"damage":[289],"downregulating":[291],"activation":[294],"both":[297],"viruses.":[301],"data":[303],"reveal":[304],"is":[307],"critical":[309],"diseases,":[317],"identifying":[319],"potential":[321],"therapeutic":[322],"target":[323],"treatment.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-31T00:00:00"}