{"id":"https://openalex.org/W4288941202","doi":"https://doi.org/10.1002/jcp.30842","title":"Influence of sphingomyelin metabolism during epithelial\u2013mesenchymal transition associated with aging in the renal papilla","display_name":"Influence of sphingomyelin metabolism during epithelial\u2013mesenchymal transition associated with aging in the renal papilla","publication_year":2022,"publication_date":"2022-07-31","ids":{"openalex":"https://openalex.org/W4288941202","doi":"https://doi.org/10.1002/jcp.30842","pmid":"https://pubmed.ncbi.nlm.nih.gov/35908199"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.30842","doi":"https://doi.org/10.1002/jcp.30842","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.30842","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056732897","display_name":"Yamila Romina Brand\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144271","display_name":"National University of La Rioja","ror":"https://ror.org/03qvyzg66","country_code":"AR","type":"education","lineage":["https://openalex.org/I4210144271"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Yamila Romina Brand\u00e1n","raw_affiliation_strings":["Instituto de Investigaciones en Ciencias de la Salud Humana (IICSHUM), Universidad Nacional de La Rioja, La Rioja, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones en Ciencias de la Salud Humana (IICSHUM), Universidad Nacional de La Rioja, La Rioja, Argentina","institution_ids":["https://openalex.org/I4210144271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065594985","display_name":"Nicol\u00e1s Octavio Favale","orcid":"https://orcid.org/0000-0002-7246-3800","observed_orcids":["https://orcid.org/0000-0002-7246-3800"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210149401","display_name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas","ror":"https://ror.org/0469ejq24","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210149401","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Nicol\u00e1s Octavio Favale","raw_affiliation_strings":["Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Biolog\u00eda Celular y Molecular Universidad de Buenos Aires  Buenos Aires Argentina","Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas CONICET\u2014Universidad de Buenos Aires  Buenos Aires Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Biolog\u00eda Celular y Molecular Universidad de Buenos Aires  Buenos Aires Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas CONICET\u2014Universidad de Buenos Aires  Buenos Aires Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210149401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032186335","display_name":"Lucila Gisele Pescio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210149401","display_name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas","ror":"https://ror.org/0469ejq24","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210149401","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Lucila Gisele Pescio","raw_affiliation_strings":["Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Biolog\u00eda Celular y Molecular Universidad de Buenos Aires  Buenos Aires Argentina","Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas CONICET\u2014Universidad de Buenos Aires  Buenos Aires Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Biolog\u00eda Celular y Molecular Universidad de Buenos Aires  Buenos Aires Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas CONICET\u2014Universidad de Buenos Aires  Buenos Aires Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210149401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047537975","display_name":"Bruno Jaime Santacreu","orcid":"https://orcid.org/0000-0003-2506-5006","observed_orcids":["https://orcid.org/0000-0003-2506-5006"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210149401","display_name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas","ror":"https://ror.org/0469ejq24","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210149401","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Bruno Jaime Santacreu","raw_affiliation_strings":["Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Biolog\u00eda Celular y Molecular Universidad de Buenos Aires  Buenos Aires Argentina","Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas CONICET\u2014Universidad de Buenos Aires  Buenos Aires Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Biolog\u00eda Celular y Molecular Universidad de Buenos Aires  Buenos Aires Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas CONICET\u2014Universidad de Buenos Aires  Buenos Aires Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210149401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057011897","display_name":"Edith del Valle Guaytima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144271","display_name":"National University of La Rioja","ror":"https://ror.org/03qvyzg66","country_code":"AR","type":"education","lineage":["https://openalex.org/I4210144271"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Edith del Valle Guaytima","raw_affiliation_strings":["Instituto de Investigaciones en Ciencias de la Salud Humana (IICSHUM), Universidad Nacional de La Rioja, La Rioja, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones en Ciencias de la Salud Humana (IICSHUM), Universidad Nacional de La Rioja, La Rioja, Argentina","institution_ids":["https://openalex.org/I4210144271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111821383","display_name":"Norma Beatriz Sterin-Speziale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210149401","display_name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas","ror":"https://ror.org/0469ejq24","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210149401","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Norma B. Sterin\u2010Speziale","raw_affiliation_strings":["Laboratorio Nacional de Investigaci\u00f3n y Servicios de P\u00e9ptidos y Prote\u00ednas \u2010 Espectrometr\u00eda de Masa (LANAIS PROEM), Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas CONICET \u2010 Universidad de Buenos Aires  Buenos Aires Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Nacional de Investigaci\u00f3n y Servicios de P\u00e9ptidos y Prote\u00ednas \u2010 Espectrometr\u00eda de Masa (LANAIS PROEM), Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas CONICET \u2010 Universidad de Buenos Aires  Buenos Aires Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210149401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058026485","display_name":"Mar\u0131\u0301a Gabriela M\u00e1rquez","orcid":"https://orcid.org/0000-0003-2575-0505","observed_orcids":["https://orcid.org/0000-0003-2575-0505"]},"institutions":[{"id":"https://openalex.org/I4210144271","display_name":"National University of La Rioja","ror":"https://ror.org/03qvyzg66","country_code":"AR","type":"education","lineage":["https://openalex.org/I4210144271"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Mar\u00eda Gabriela M\u00e1rquez","raw_affiliation_strings":["Instituto de Investigaciones en Ciencias de la Salud Humana (IICSHUM), Universidad Nacional de La Rioja, La Rioja, Argentina"],"raw_orcid":"https://orcid.org/0000-0003-2575-0505","affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones en Ciencias de la Salud Humana (IICSHUM), Universidad Nacional de La Rioja, La Rioja, Argentina","institution_ids":["https://openalex.org/I4210144271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058026485"],"corresponding_institution_ids":["https://openalex.org/I4210144271"],"apc_list":{"value":4800,"currency":"USD","value_usd":4800},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06861558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"237","issue":"10","first_page":"3883","last_page":"3899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingomyelin-metabolism","display_name":"sphingomyelin metabolism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/renal-papilla","display_name":"renal papilla","score":0.8460000157356262},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sphingomyelin-synthase-1","display_name":"sphingomyelin synthase 1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neutral-sphingomyelinase","display_name":"neutral sphingomyelinase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8230000138282776},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/plasma-membrane-microdomains","display_name":"plasma membrane microdomains","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6982463002204895},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5722601413726807},{"id":"https://openalex.org/C2780371755","wikidata":"https://www.wikidata.org/wiki/Q2409399","display_name":"Renal papilla","level":3,"score":0.5516192317008972},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5343733429908752},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.5323441624641418},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4957481324672699},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.4815109670162201},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47213488817214966},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4330006241798401},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.42200326919555664},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3883047103881836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3800942897796631},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37333083152770996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2021085023880005},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.16192719340324402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1432184875011444},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.07740256190299988},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.30842","doi":"https://doi.org/10.1002/jcp.30842","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.30842","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:35908199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35908199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1302878667","display_name":null,"funder_award_id":"PICT\u20102015\u20102941 and PICT\u20102017\u20102601","funder_id":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G313953996","display_name":null,"funder_award_id":"UBACYT20020190100137BA","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G4214147851","display_name":null,"funder_award_id":"PIP 11220150100502CO","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G4595241074","display_name":null,"funder_award_id":"UBACYT20020190200138BA","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320323257","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513"},{"id":"https://openalex.org/F4320337954","display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1563888013","https://openalex.org/W1684625763","https://openalex.org/W1963501822","https://openalex.org/W1966452335","https://openalex.org/W1967623265","https://openalex.org/W1969109536","https://openalex.org/W1974913152","https://openalex.org/W1993093223","https://openalex.org/W2006715755","https://openalex.org/W2008274227","https://openalex.org/W2011143322","https://openalex.org/W2041614750","https://openalex.org/W2041681732","https://openalex.org/W2042848482","https://openalex.org/W2049533449","https://openalex.org/W2052092179","https://openalex.org/W2054282870","https://openalex.org/W2058667985","https://openalex.org/W2069921134","https://openalex.org/W2070378123","https://openalex.org/W2087617952","https://openalex.org/W2093805100","https://openalex.org/W2094494114","https://openalex.org/W2095911112","https://openalex.org/W2101303553","https://openalex.org/W2120350838","https://openalex.org/W2121893424","https://openalex.org/W2123233663","https://openalex.org/W2135570731","https://openalex.org/W2145002455","https://openalex.org/W2148479501","https://openalex.org/W2150806796","https://openalex.org/W2154589460","https://openalex.org/W2294944558","https://openalex.org/W2410064233","https://openalex.org/W2562918265","https://openalex.org/W2615504228","https://openalex.org/W2767939008","https://openalex.org/W2768617092","https://openalex.org/W2902201839","https://openalex.org/W2908757806","https://openalex.org/W2920935501","https://openalex.org/W3009065009","https://openalex.org/W3052634481","https://openalex.org/W3091968197","https://openalex.org/W3096616122","https://openalex.org/W3216677597","https://openalex.org/W4311503923"],"related_works":["https://openalex.org/W2148479501","https://openalex.org/W2088515381","https://openalex.org/W2913817601","https://openalex.org/W2105730373","https://openalex.org/W7161588292","https://openalex.org/W2365097452","https://openalex.org/W2045250251","https://openalex.org/W2087617952","https://openalex.org/W1763348166","https://openalex.org/W2886594625"],"abstract_inverted_index":{"The":[0],"renal":[1,69,123,133,213,248],"collecting":[2],"ducts":[3],"(CD)":[4],"are":[5,76],"formed":[6],"by":[7,34,200],"a":[8,35,205,228],"fully":[9],"differentiated":[10],"epithelium,":[11],"and":[12,16,49,84,140,147,162,167,193,224,236],"their":[13,46],"tissue":[14],"organization":[15],"function":[17],"require":[18],"the":[19,29,43,51,54,85,101,106,112,115,119,122,173,179,186,220,231,240],"presence":[20],"of":[21,53,60,87,108,114,121,132,172,188,222,230,233,242],"mature":[22],"cell":[23,73],"adhesion":[24,74],"structures.":[25],"In":[26,100],"certain":[27],"circumstances,":[28],"cells":[30,44,94,116,136,156,235],"can":[31],"undergo":[32,96,157],"de-differentiation":[33],"process":[36],"called":[37],"epithelial-mesenchymal":[38],"transition":[39],"(EMT),":[40],"in":[41,68,78,160,181,196],"which":[42,57,212],"lose":[45],"epithelial":[47],"phenotype":[48],"acquire":[50],"characteristics":[52],"mesenchymal":[55],"cells,":[56,72],"includes":[58],"loss":[59],"cell-cell":[61],"adhesion.":[62],"We":[63],"have":[64],"previously":[65],"shown":[66],"that":[67,117,154,168],"papillary":[70,134],"CD":[71,93,120,135,155,234],"structures":[75],"located":[77],"sphingomyelin":[79],"(SM)-enriched":[80],"plasma":[81],"membrane":[82],"microdomains":[83],"inhibition":[86],"SM":[88,109,182,190,197,226],"synthase":[89,191],"1":[90],"activity":[91,192],"induced":[92],"to":[95,185,239,244],"an":[97,158,194],"EMT":[98,113,164],"process.":[99],"present":[102],"study,":[103],"we":[104,150],"evaluated":[105],"influence":[107],"metabolism":[110],"during":[111,125,165,250],"form":[118],"papilla":[124],"aging.":[126,251],"To":[127],"this":[128,176],"end,":[129],"primary":[130],"cultures":[131],"from":[137],"young,":[138],"middle-,":[139],"aged-rats":[141],"were":[142],"performed.":[143],"By":[144],"combining":[145],"biochemical":[146],"immunofluorescence":[148],"studies,":[149],"found":[151],"experimental":[152],"evidence":[153],"increase":[159,195],"spontaneous":[161],"reversible":[163],"aging":[166],"at":[169],"least":[170],"one":[171],"reasons":[174],"for":[175,208],"phenomenon":[177],"is":[178,204,215],"decrease":[180],"content":[183],"due":[184],"combination":[187],"decreased":[189],"degradation":[198],"mediated":[199],"neutral":[201],"sphingomyelinase.":[202],"Age":[203],"risk":[206],"factor":[207],"many":[209],"diseases,":[210],"among":[211],"fibrosis":[214,249],"included.":[216],"Our":[217],"findings":[218],"highlight":[219],"importance":[221],"sphingolipids":[223],"particularly":[225],"as":[227],"modulator":[229],"fate":[232],"probably":[237],"contribute":[238],"development":[241],"treatments":[243],"avoid":[245],"or":[246],"reverse":[247]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-31T00:00:00"}