{"id":"https://openalex.org/W4288753489","doi":"https://doi.org/10.1016/j.ctarc.2022.100616","title":"Vitamin D and colorectal cancer \u2013 A practical review of the literature","display_name":"Vitamin D and colorectal cancer \u2013 A practical review of the literature","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4288753489","doi":"https://doi.org/10.1016/j.ctarc.2022.100616","pmid":"https://pubmed.ncbi.nlm.nih.gov/35940119"},"language":"en","primary_location":{"id":"doi:10.1016/j.ctarc.2022.100616","doi":"https://doi.org/10.1016/j.ctarc.2022.100616","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2022.100616","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468294222001071/pdf","source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2468294222001071/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075109756","display_name":"Renata D\u2019Alpino Peixoto","orcid":"https://orcid.org/0000-0003-0053-7951","observed_orcids":["https://orcid.org/0000-0003-0053-7951"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Renata D'Alpino Peixoto","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Centro Paulista de Oncologia, Oncoclinicas, Av. Brigadeiro Faria Lima 4300, S\u00e3o Paulo, SP 04538-132, Brazil. Electronic address: renata.dalpino@medicos.oncoclinicas.com","Department of Gastrointestinal Medical Oncology, Oncoclinicas, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-0053-7951","affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Centro Paulista de Oncologia, Oncoclinicas, Av. Brigadeiro Faria Lima 4300, S\u00e3o Paulo, SP 04538-132, Brazil. Electronic address: renata.dalpino@medicos.oncoclinicas.com","institution_ids":[]},{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079074760","display_name":"Leandro Jonata de Carvalho Oliveira","orcid":"https://orcid.org/0000-0001-6344-3544","observed_orcids":["https://orcid.org/0000-0001-6344-3544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leandro Jonata de Carvalho Oliveira","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Centro Paulista de Oncologia, Oncoclinicas, Av. Brigadeiro Faria Lima 4300, S\u00e3o Paulo, SP 04538-132, Brazil","Department of Gastrointestinal Medical Oncology, Oncoclinicas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Centro Paulista de Oncologia, Oncoclinicas, Av. Brigadeiro Faria Lima 4300, S\u00e3o Paulo, SP 04538-132, Brazil","institution_ids":[]},{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021835793","display_name":"Thais de Melo Passarini","orcid":"https://orcid.org/0000-0002-0561-7267","observed_orcids":["https://orcid.org/0000-0002-0561-7267"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tha\u00eds de Melo Passarini","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Oncoclinicas, Belo, Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, Belo, Horizonte, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102257320","display_name":"Aline Chaves Andrade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aline Chaves Andrade","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Oncoclinicas, Belo, Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, Belo, Horizonte, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083441342","display_name":"Paulo Henrique Costa Diniz","orcid":"https://orcid.org/0000-0003-2016-5593","observed_orcids":["https://orcid.org/0000-0003-2016-5593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulo Henrique Diniz","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Oncoclinicas, Belo, Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, Belo, Horizonte, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041067804","display_name":"Gabriel Prolla","orcid":"https://orcid.org/0000-0002-4429-1925","observed_orcids":["https://orcid.org/0000-0002-4429-1925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Prolla","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Oncoclinicas, Porto Alegre, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, Porto Alegre, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049928586","display_name":"Larissa Costa Amorim","orcid":"https://orcid.org/0000-0002-0960-2193","observed_orcids":["https://orcid.org/0000-0002-0960-2193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larissa Costa Amorim","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Centro Paulista de Oncologia, Oncoclinicas, Av. Brigadeiro Faria Lima 4300, S\u00e3o Paulo, SP 04538-132, Brazil","Department of Gastrointestinal Medical Oncology, Oncoclinicas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Centro Paulista de Oncologia, Oncoclinicas, Av. Brigadeiro Faria Lima 4300, S\u00e3o Paulo, SP 04538-132, Brazil","institution_ids":[]},{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104034118","display_name":"Mariana Gil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana Gil","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Oncoclinicas, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, Rio de Janeiro, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048559371","display_name":"Flora Lino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flora Lino","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Oncoclinicas, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, Rio de Janeiro, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019899858","display_name":"Bernardo Garicochea","orcid":"https://orcid.org/0009-0007-2694-2089","observed_orcids":["https://orcid.org/0009-0007-2694-2089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernardo Garicochea","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Centro Paulista de Oncologia, Oncoclinicas, Av. Brigadeiro Faria Lima 4300, S\u00e3o Paulo, SP 04538-132, Brazil","Department of Gastrointestinal Medical Oncology, Oncoclinicas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Centro Paulista de Oncologia, Oncoclinicas, Av. Brigadeiro Faria Lima 4300, S\u00e3o Paulo, SP 04538-132, Brazil","institution_ids":[]},{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044974761","display_name":"Alexandre Andrade dos Anjos Jacome","orcid":"https://orcid.org/0000-0001-9070-4383","observed_orcids":["https://orcid.org/0000-0001-9070-4383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandre J\u00e1come","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, Oncoclinicas, Belo, Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, Oncoclinicas, Belo, Horizonte, Brazil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077382664","display_name":"Kimmie Ng","orcid":"https://orcid.org/0000-0003-0631-1494","observed_orcids":["https://orcid.org/0000-0003-0631-1494"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimmie Ng","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA","Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075109756"],"corresponding_institution_ids":[],"apc_list":{"value":1700,"currency":"USD","value_usd":1700},"apc_paid":{"value":1700,"currency":"USD","value_usd":1700},"fwci":0.9894,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.71229698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"32","issue":null,"first_page":"100616","last_page":"100616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.8460000157356262},{"id":"https://openalex.org/keywords/colorectal-cancer-risk-factors","display_name":"colorectal cancer risk factors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/diet-and-lifestyle","display_name":"diet and lifestyle","score":0.6869999766349792},{"id":"https://openalex.org/keywords/calcium-intake","display_name":"calcium intake","score":0.8579999804496765},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.949999988079071},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6029999852180481},{"id":"https://openalex.org/keywords/randomized-controlled-trials","display_name":"randomized controlled trials","score":0.7229999899864197},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.7916857004165649},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7560908794403076},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7303253412246704},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5973624587059021},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.587635338306427},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5682740211486816},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5007116794586182},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.47429874539375305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4714703857898712},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.41948214173316956},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.41500306129455566},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34397614002227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1324482560157776},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.12975013256072998}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ctarc.2022.100616","doi":"https://doi.org/10.1016/j.ctarc.2022.100616","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2022.100616","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468294222001071/pdf","source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},{"id":"pmid:35940119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35940119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment and research communications","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.ufmg.br:1843/61657","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2022.100616","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFMG","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:27bde71ec25047dd86efa402021b1803","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/27bde71ec25047dd86efa402021b1803","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Treatment and Research Communications, Vol 32, Iss , Pp 100616- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ctarc.2022.100616","doi":"https://doi.org/10.1016/j.ctarc.2022.100616","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2022.100616","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468294222001071/pdf","source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288753489.pdf","grobid_xml":"https://content.openalex.org/works/W4288753489.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W158904318","https://openalex.org/W1488591768","https://openalex.org/W1616778816","https://openalex.org/W1806382195","https://openalex.org/W1867012754","https://openalex.org/W1951041268","https://openalex.org/W1959271091","https://openalex.org/W1968135922","https://openalex.org/W1978748811","https://openalex.org/W1981498233","https://openalex.org/W1990859291","https://openalex.org/W1992852809","https://openalex.org/W1994006843","https://openalex.org/W2012382826","https://openalex.org/W2014072133","https://openalex.org/W2018730905","https://openalex.org/W2019962813","https://openalex.org/W2020994990","https://openalex.org/W2025641935","https://openalex.org/W2026644677","https://openalex.org/W2030751364","https://openalex.org/W2033538744","https://openalex.org/W2043677979","https://openalex.org/W2048308258","https://openalex.org/W2048885679","https://openalex.org/W2056866215","https://openalex.org/W2060597065","https://openalex.org/W2063667483","https://openalex.org/W2065133740","https://openalex.org/W2070891612","https://openalex.org/W2076811408","https://openalex.org/W2077575239","https://openalex.org/W2079716869","https://openalex.org/W2080975831","https://openalex.org/W2085124463","https://openalex.org/W2096150705","https://openalex.org/W2102937816","https://openalex.org/W2103076955","https://openalex.org/W2106647095","https://openalex.org/W2107100887","https://openalex.org/W2112996649","https://openalex.org/W2113869887","https://openalex.org/W2115704169","https://openalex.org/W2124070987","https://openalex.org/W2127058741","https://openalex.org/W2135678886","https://openalex.org/W2138153315","https://openalex.org/W2140244530","https://openalex.org/W2144662506","https://openalex.org/W2150118613","https://openalex.org/W2155430176","https://openalex.org/W2156394393","https://openalex.org/W2160033534","https://openalex.org/W2162258804","https://openalex.org/W2163577786","https://openalex.org/W2168472523","https://openalex.org/W2171345315","https://openalex.org/W2172080383","https://openalex.org/W2254563264","https://openalex.org/W2268006712","https://openalex.org/W2562762007","https://openalex.org/W2615017225","https://openalex.org/W2752451197","https://openalex.org/W2772839225","https://openalex.org/W2788092511","https://openalex.org/W2790015007","https://openalex.org/W2792948634","https://openalex.org/W2802568019","https://openalex.org/W2883845824","https://openalex.org/W2885321600","https://openalex.org/W2899572198","https://openalex.org/W2903410405","https://openalex.org/W2937486128","https://openalex.org/W2938533846","https://openalex.org/W2954085487","https://openalex.org/W2965898410","https://openalex.org/W2976026013","https://openalex.org/W2981197584","https://openalex.org/W2999417355","https://openalex.org/W2999987589","https://openalex.org/W3005178228","https://openalex.org/W3005997453","https://openalex.org/W3009963727","https://openalex.org/W3011173168","https://openalex.org/W3015136353","https://openalex.org/W3031769515","https://openalex.org/W3044052332","https://openalex.org/W3106715539","https://openalex.org/W3116935691","https://openalex.org/W3119260885","https://openalex.org/W3128646645","https://openalex.org/W3131317793","https://openalex.org/W3164522618","https://openalex.org/W3172786696","https://openalex.org/W3180340471","https://openalex.org/W4205277254","https://openalex.org/W4293231259","https://openalex.org/W6636518258","https://openalex.org/W6661652350","https://openalex.org/W6681599147"],"related_works":["https://openalex.org/W3090806259","https://openalex.org/W4300716941","https://openalex.org/W4416015918","https://openalex.org/W2076182571","https://openalex.org/W4405369163","https://openalex.org/W4409459326","https://openalex.org/W4386647393","https://openalex.org/W4388328365","https://openalex.org/W2052840896","https://openalex.org/W3172786696"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"(CRC)":[2],"is":[3,146],"the":[4,12,16,27,31,34,43,58,61,70,90,112,115,119,151,184,199,202,206,213,218,225,228,235,242],"third":[5],"leading":[6],"cause":[7,18],"of":[8,60,69,92,101,108,114,122,154,186,201,209,217,227,237,245],"cancer-related":[9],"mortality":[10],"in":[11,26,30,33,42,57,77,84,212],"United":[13],"States":[14],"and":[15,72,80,82,87,105,117,136,168,215],"second":[17],"worldwide.":[19],"Its":[20],"incidence":[21],"rates":[22,41],"have":[23],"been":[24,127,132],"decreasing":[25],"overall":[28],"population":[29,44],"US":[32],"past":[35],"few":[36],"decades,":[37],"but":[38,158],"with":[39,63,138,150,159,189,247],"increasing":[40],"younger":[45],"than":[46],"50":[47],"years":[48],"old.":[49],"Environmental":[50],"factors":[51],"are":[52],"supposed":[53],"to":[54,182,197],"be":[55],"involved":[56],"development":[59,214],"disease,":[62],"strong":[64],"evidence":[65],"favoring":[66],"an":[67],"influence":[68,100],"diet":[71,75],"lifestyle.":[73],"A":[74],"high":[76],"red":[78],"meat":[79],"calories,":[81],"low":[83,102,106],"fiber,":[85],"fruits":[86],"vegetables":[88],"increases":[89],"risk":[91,113],"CRC,":[93,193],"as":[94,96,165,173,194,196],"well":[95,195],"physical":[97],"inactivity.":[98],"The":[99],"calcium":[103],"intake":[104],"levels":[107],"vitamin":[109,187,210,238],"D":[110,130,145,188,211,239],"on":[111,118,241],"disease":[116],"clinical":[120,231,243],"outcomes":[121,244],"CRC":[123],"patients":[124,246],"has":[125,131],"also":[126],"investigated.":[128],"Hypovitaminosis":[129],"highly":[133],"prevalent":[134],"worldwide":[135],"associated":[137],"several":[139],"chronic":[140],"diseases,":[141,191],"including":[142],"malignancies.":[143],"Vitamin":[144],"a":[147,174],"steroid":[148],"hormone":[149],"main":[152],"function":[153],"regulating":[155],"bone":[156],"metabolism,":[157],"many":[160],"other":[161],"physiological":[162],"functions,":[163],"such":[164],"anti-inflammatory,":[166],"immunomodulatory,":[167],"antiangiogenic":[169],"effects,":[170],"potentially":[171],"acting":[172],"carcinogenesis":[175],"inhibitor.":[176],"In":[177,220],"this":[178],"review,":[179],"we":[180,222],"aim":[181],"describe":[183],"relation":[185],"malignant":[190],"mainly":[192],"highlight":[198],"results":[200,226],"studies":[203],"which":[204],"addressed":[205],"potential":[207],"role":[208],"progression":[216],"disease.":[219],"addition,":[221],"will":[223],"present":[224],"pivotal":[229],"randomized":[230],"trials":[232],"that":[233],"evaluated":[234],"impact":[236],"supplementation":[240],"CRC.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-30T00:00:00"}