{"id":"https://openalex.org/W4288748535","doi":"https://doi.org/10.1186/s12967-022-03552-y","title":"The RNA-binding protein PCBP1 represses lung adenocarcinoma progression by stabilizing DKK1 mRNA and subsequently downregulating \u03b2-catenin","display_name":"The RNA-binding protein PCBP1 represses lung adenocarcinoma progression by stabilizing DKK1 mRNA and subsequently downregulating \u03b2-catenin","publication_year":2022,"publication_date":"2022-07-30","ids":{"openalex":"https://openalex.org/W4288748535","doi":"https://doi.org/10.1186/s12967-022-03552-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/35907982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9338556"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-022-03552-y","doi":"https://doi.org/10.1186/s12967-022-03552-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-022-03552-y","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-022-03552-y","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-022-03552-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110295656","display_name":"Yujia Zheng","orcid":"https://orcid.org/0000-0003-0780-9462","observed_orcids":["https://orcid.org/0000-0003-0780-9462"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujia Zheng","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086011032","display_name":"Zheng Y. Zhou","orcid":"https://orcid.org/0000-0003-3397-3290","observed_orcids":["https://orcid.org/0000-0003-3397-3290"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Zhou","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ran Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Wei","raw_affiliation_strings":["Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100716267","display_name":"Xiao Chu","orcid":"https://orcid.org/0000-0002-7780-7975","observed_orcids":["https://orcid.org/0000-0002-7780-7975"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chu Xiao","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396993","display_name":"Hao Zhang","orcid":"https://orcid.org/0000-0002-9957-6741","observed_orcids":["https://orcid.org/0000-0002-9957-6741"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Zhang","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076426188","display_name":"Tao T. Fan","orcid":"https://orcid.org/0000-0002-6097-2413","observed_orcids":["https://orcid.org/0000-0002-6097-2413"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Fan","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034845046","display_name":"Bo Jian Zheng","orcid":"https://orcid.org/0000-0002-1496-0753","observed_orcids":["https://orcid.org/0000-0002-1496-0753"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Zheng","raw_affiliation_strings":["Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695886","display_name":"Chunxiang Li","orcid":"https://orcid.org/0000-0003-3477-1535","observed_orcids":["https://orcid.org/0000-0003-3477-1535"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunxiang Li","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. lichunxiang@cicams.ac.cn","Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. lichunxiang@cicams.ac.cn","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]},{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062028300","display_name":"Ji\u00e9 He","orcid":"https://orcid.org/0000-0003-0327-8852","observed_orcids":["https://orcid.org/0000-0003-0327-8852"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie He","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. prof_jiehe@yeah.net","Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-0327-8852","affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. prof_jiehe@yeah.net","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]},{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062028300","https://openalex.org/A5100695886"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":1.3872,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.80028789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"343","last_page":"343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5648999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.3402999937534332,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcbp1","display_name":"PCBP1","score":1.0},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.8679999709129333},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumour-suppressor","display_name":"tumour suppressor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.9160000085830688},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C2777491412","wikidata":"https://www.wikidata.org/wiki/Q18036610","display_name":"DKK1","level":4,"score":0.7511543035507202},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6759555339813232},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5876020193099976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5835646986961365},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.5372670888900757},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5272734761238098},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5191552042961121},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5013864040374756},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.47376492619514465},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.45665988326072693},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28590553998947144},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2816145420074463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22053733468055725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12967-022-03552-y","doi":"https://doi.org/10.1186/s12967-022-03552-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-022-03552-y","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-022-03552-y","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmid:35907982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35907982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9338556","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9338556/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f2405207c05848109ae77248b71bc6b7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f2405207c05848109ae77248b71bc6b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-18 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12967-022-03552-y","doi":"https://doi.org/10.1186/s12967-022-03552-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-022-03552-y","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-022-03552-y","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1931871868","display_name":null,"funder_award_id":"2021YFF1201303","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2645708537","display_name":null,"funder_award_id":"20211","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3370247315","display_name":null,"funder_award_id":"81972196","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5594215471","display_name":null,"funder_award_id":"2020AAA0109505","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6172196828","display_name":null,"funder_award_id":"2021-1-I2M-012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8221502320","display_name":null,"funder_award_id":"KJZD20191002302","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288748535.pdf","grobid_xml":"https://content.openalex.org/works/W4288748535.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1829409335","https://openalex.org/W1862820015","https://openalex.org/W1954491302","https://openalex.org/W1977629626","https://openalex.org/W1988947063","https://openalex.org/W1993635085","https://openalex.org/W2044098649","https://openalex.org/W2072777138","https://openalex.org/W2080232352","https://openalex.org/W2101926514","https://openalex.org/W2105090865","https://openalex.org/W2105568806","https://openalex.org/W2121882364","https://openalex.org/W2122313645","https://openalex.org/W2128360321","https://openalex.org/W2130410032","https://openalex.org/W2137319242","https://openalex.org/W2145990138","https://openalex.org/W2265243536","https://openalex.org/W2307400859","https://openalex.org/W2328022485","https://openalex.org/W2403731802","https://openalex.org/W2408427435","https://openalex.org/W2520632143","https://openalex.org/W2620416491","https://openalex.org/W2621361823","https://openalex.org/W2746147763","https://openalex.org/W2750717426","https://openalex.org/W2763497408","https://openalex.org/W2767545076","https://openalex.org/W2787553551","https://openalex.org/W2795622837","https://openalex.org/W2810518168","https://openalex.org/W2885101107","https://openalex.org/W2886263444","https://openalex.org/W2888053910","https://openalex.org/W2906067435","https://openalex.org/W2910877029","https://openalex.org/W2914349469","https://openalex.org/W2937441321","https://openalex.org/W2947802838","https://openalex.org/W2967213355","https://openalex.org/W2968159044","https://openalex.org/W3021245041","https://openalex.org/W3025256532","https://openalex.org/W3027244144","https://openalex.org/W3031602396","https://openalex.org/W3049547010","https://openalex.org/W3093216862","https://openalex.org/W3098080011","https://openalex.org/W3107449517","https://openalex.org/W3112915959","https://openalex.org/W3128646645","https://openalex.org/W3139511935","https://openalex.org/W3160588558","https://openalex.org/W3161341716","https://openalex.org/W3170408830","https://openalex.org/W3185354749","https://openalex.org/W3186531850","https://openalex.org/W3187617273","https://openalex.org/W4206658543","https://openalex.org/W4211214747"],"related_works":["https://openalex.org/W6977227889","https://openalex.org/W6920814700","https://openalex.org/W3212363607","https://openalex.org/W2887628006","https://openalex.org/W2886263444","https://openalex.org/W2649305315","https://openalex.org/W3160070346","https://openalex.org/W3004763987","https://openalex.org/W4385827660","https://openalex.org/W3093216862"],"abstract_inverted_index":{"BACKGROUND:":[0],"PolyC-RNA-binding":[1],"protein":[2,147,161],"1":[3],"(PCBP1)":[4],"functions":[5],"as":[6,38,179,212],"a":[7,180,213],"tumour":[8,125,181],"suppressor":[9,182],"and":[10,53,57,68,81,112,135,141],"RNA":[11,93,110],"regulator":[12],"that":[13,42,73,119,176,192],"is":[14,121],"downregulated":[15,122],"in":[16,29,123,129,139,142],"human":[17],"cancers.":[18],"Here,":[19],"we":[20,71],"aimed":[21],"to":[22,78,200],"reveal":[23],"the":[24,79,132,145,159,163,167,185,202,208],"biological":[25],"function":[26],"of":[27,83,95,137,158,187,210],"PCBP1":[28,35,74,96,120,130,148,177,193,211],"lung":[30],"adenocarcinoma":[31],"(LUAD).":[32],"METHODS:":[33],"First,":[34],"was":[36,75,90],"identified":[37],"an":[39],"important":[40],"biomarker":[41],"maintains":[43],"LUAD":[44,84,124,138,150,195],"through":[45],"The":[46,86,99,127],"Cancer":[47],"Genome":[48],"Atlas":[49],"(TCGA)":[50],"project":[51],"screening":[52],"confirmed":[54,72],"by":[55,92,151,197],"immunohistochemistry":[56],"qPCR.":[58],"Via":[59],"colony":[60],"formation,":[61],"CCK8,":[62],"IncuCyte":[63],"cell":[64],"proliferation,":[65,133],"wound":[66],"healing":[67],"Transwell":[69],"assays,":[70],"closely":[76],"related":[77],"proliferation":[80],"migration":[82,134],"cells.":[85,98],"downstream":[87],"gene":[88],"DKK1":[89,153,160,199],"discovered":[91],"sequencing":[94],"knockdown":[97],"underlying":[100],"mechanisms":[101],"were":[102],"further":[103],"investigated":[104],"using":[105],"western":[106],"blot,":[107],"qPCR,":[108],"RIP,":[109],"pulldown":[111],"mRNA":[113],"stability":[114],"assays.":[115],"RESULTS:":[116],"We":[117,190],"demonstrate":[118],"tissues.":[126],"reduction":[128],"promotes":[131],"invasion":[136],"vitro":[140],"vivo.":[143],"Mechanistically,":[144],"RNA-binding":[146],"represses":[149],"stabilizing":[152],"mRNA.":[154],"Subsequently,":[155],"decreased":[156],"expression":[157],"relieves":[162],"inhibitory":[164],"effect":[165],"on":[166],"Wnt/\u03b2-catenin":[168,203],"signalling":[169],"pathway.":[170,204],"Taken":[171],"together,":[172],"these":[173],"results":[174],"show":[175],"acts":[178],"gene,":[183],"inhibiting":[184],"tumorigenesis":[186],"LUAD.":[188],"CONCLUSIONS:":[189],"found":[191],"inhibits":[194],"development":[196],"upregulating":[198],"inactivate":[201],"Our":[205],"findings":[206],"highlight":[207],"potential":[209],"promising":[214],"therapeutic":[215],"target.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-30T00:00:00"}