{"id":"https://openalex.org/W4288713698","doi":"https://doi.org/10.3389/fneur.2022.899396","title":"Case report: First case of neuromelioidosis in Europe: CNS infection caused by Burkholderia pseudomallei","display_name":"Case report: First case of neuromelioidosis in Europe: CNS infection caused by Burkholderia pseudomallei","publication_year":2022,"publication_date":"2022-07-29","ids":{"openalex":"https://openalex.org/W4288713698","doi":"https://doi.org/10.3389/fneur.2022.899396","pmid":"https://pubmed.ncbi.nlm.nih.gov/35968288","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9372356"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2022.899396","doi":"https://doi.org/10.3389/fneur.2022.899396","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2022.899396","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2022.899396/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fneur.2022.899396/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065061887","display_name":"Nikolaos G. Dimitriou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolaos G. Dimitriou","raw_affiliation_strings":["Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001849749","display_name":"Greta Fl\u00fch","orcid":"https://orcid.org/0000-0001-6188-2439","observed_orcids":["https://orcid.org/0000-0001-6188-2439"]},"institutions":[{"id":"https://openalex.org/I4210105468","display_name":"Laboratory Dr. Wisplinghoff","ror":"https://ror.org/00zy16k74","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210105468"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Greta Fl\u00fch","raw_affiliation_strings":["Labor Dr. Wisplinghoff, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Labor Dr. Wisplinghoff, Cologne, Germany","institution_ids":["https://openalex.org/I4210105468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032254909","display_name":"Sabine Zange","orcid":"https://orcid.org/0000-0001-8721-9248","observed_orcids":["https://orcid.org/0000-0001-8721-9248"]},"institutions":[{"id":"https://openalex.org/I4403928284","display_name":"Institut f\u00fcr Mikrobiologie der Bundeswehr","ror":"https://ror.org/01xexwj76","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4387152969","https://openalex.org/I4403928284"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Zange","raw_affiliation_strings":["Bundeswehr Institute of Microbiology, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bundeswehr Institute of Microbiology, Munich, Germany","institution_ids":["https://openalex.org/I4403928284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039124681","display_name":"Aykut Aytulun","orcid":"https://orcid.org/0000-0002-9738-034X","observed_orcids":["https://orcid.org/0000-0002-9738-034X"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Aykut Aytulun","raw_affiliation_strings":["Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006544972","display_name":"Bernd Turowski","orcid":"https://orcid.org/0000-0002-7191-725X","observed_orcids":["https://orcid.org/0000-0002-7191-725X"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Turowski","raw_affiliation_strings":["Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063615479","display_name":"Hans\u2010Peter Hartung","orcid":"https://orcid.org/0000-0002-0614-6989","observed_orcids":["https://orcid.org/0000-0002-0614-6989"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Peter Hartung","raw_affiliation_strings":["Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034872348","display_name":"Sven Guenther Meuth","orcid":"https://orcid.org/0000-0003-2571-3501","observed_orcids":["https://orcid.org/0000-0003-2571-3501"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven G. Meuth","raw_affiliation_strings":["Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024529032","display_name":"Michael Gliem","orcid":"https://orcid.org/0000-0002-0446-9776","observed_orcids":["https://orcid.org/0000-0002-0446-9776"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Gliem","raw_affiliation_strings":["Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024529032"],"corresponding_institution_ids":["https://openalex.org/I44260953"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.2026,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.74250032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"899396","last_page":"899396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12833","display_name":"Bartonella species infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burkholderia-pseudomallei","display_name":"Burkholderia pseudomallei","score":0.9980000257492065},{"id":"https://openalex.org/keywords/melioidosis","display_name":"melioidosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/central-nervous-system-infection","display_name":"central nervous system infection","score":0.9629999995231628},{"id":"https://openalex.org/keywords/brain-biopsy","display_name":"brain biopsy","score":0.5019999742507935},{"id":"https://openalex.org/keywords/otitis-media","display_name":"otitis media","score":0.5870000123977661},{"id":"https://openalex.org/keywords/neurological-complications","display_name":"neurological complications","score":0.3889999985694885},{"id":"https://openalex.org/keywords/diagnostic-challenges","display_name":"diagnostic challenges","score":0.39800000190734863},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8382756114006042},{"id":"https://openalex.org/C2779110727","wikidata":"https://www.wikidata.org/wiki/Q140475","display_name":"Burkholderia pseudomallei","level":3,"score":0.6530625224113464},{"id":"https://openalex.org/C2777639682","wikidata":"https://www.wikidata.org/wiki/Q225957","display_name":"Dysarthria","level":2,"score":0.5387459993362427},{"id":"https://openalex.org/C2779775996","wikidata":"https://www.wikidata.org/wiki/Q963944","display_name":"Melioidosis","level":2,"score":0.48941507935523987},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.46673262119293213},{"id":"https://openalex.org/C2776439223","wikidata":"https://www.wikidata.org/wiki/Q480700","display_name":"Otitis","level":2,"score":0.429464191198349},{"id":"https://openalex.org/C2776429142","wikidata":"https://www.wikidata.org/wiki/Q1620189","display_name":"Brain biopsy","level":3,"score":0.42280113697052},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3869580030441284},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.346974641084671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2372553050518036},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.21683847904205322},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17765367031097412},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15121519565582275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fneur.2022.899396","doi":"https://doi.org/10.3389/fneur.2022.899396","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2022.899396","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2022.899396/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmid:35968288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35968288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:9372356","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9372356/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8d566537ff4f4d86a3f51f9981d9a18b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8d566537ff4f4d86a3f51f9981d9a18b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2022.899396","doi":"https://doi.org/10.3389/fneur.2022.899396","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2022.899396","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2022.899396/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288713698.pdf","grobid_xml":"https://content.openalex.org/works/W4288713698.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1921135678","https://openalex.org/W1949236270","https://openalex.org/W2032947887","https://openalex.org/W2107966948","https://openalex.org/W4211084778","https://openalex.org/W4211166774","https://openalex.org/W4242142362"],"related_works":["https://openalex.org/W4394601710","https://openalex.org/W4410031562","https://openalex.org/W7139992225","https://openalex.org/W7212351757","https://openalex.org/W4399916607","https://openalex.org/W4401185919","https://openalex.org/W4416822198","https://openalex.org/W7215119069","https://openalex.org/W7159667493","https://openalex.org/W3094850602"],"abstract_inverted_index":{"and":[0,6,13,37,41,61,71,93,121],"is":[1],"characterized":[2],"by":[3],"high":[4],"morbidity":[5],"mortality.":[7],"Our":[8],"report":[9],"presents":[10],"the":[11,17,47,87],"diagnostic":[12,109,114],"therapeutic":[14],"approach":[15],"of":[16,20,32,56,80,117],"first":[18],"case":[19],"neuromelioidosis":[21,81],"confirmed":[22],"in":[23,95],"Europe.":[24],"A":[25],"47-year-old":[26],"man":[27],"with":[28,35,52],"a":[29,78,96,108],"medical":[30],"history":[31],"recurrent":[33],"otitis":[34],"otorrhea":[36],"fever":[38],"after":[39],"tympanoplasty":[40],"radical":[42],"cavity":[43],"revision":[44],"operation":[45],"on":[46],"left":[48],"ear":[49],"was":[50,82],"admitted":[51],"headache,":[53],"decreased":[54],"level":[55],"consciousness,":[57],"dysarthria,":[58],"left-sided":[59],"hemiparesis,":[60],"urinary":[62],"incontinence.":[63],"After":[64],"extensive":[65,113],"investigations":[66],"including":[67],"MRI,":[68],"microbiological,":[69],"serological,":[70],"CSF":[72],"analyses,":[73],"and,":[74],"ultimately,":[75],"brain":[76],"biopsy,":[77],"diagnosis":[79],"established.":[83],"Despite":[84],"antibiotic":[85],"treatment,":[86],"patient":[88],"showed":[89],"no":[90],"clinical":[91,120],"improvement":[92],"remained":[94],"severely":[97],"compromised":[98],"neurological":[99],"state":[100],"under":[101],"mandatory":[102],"mechanical":[103],"ventilation.":[104],"Neuromelioidosis":[105],"can":[106],"pose":[107],"challenge":[110],"requiring":[111],"an":[112],"evaluation":[115],"because":[116],"its":[118],"uncommon":[119],"radiological":[122],"presentations.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-30T00:00:00"}