{"id":"https://openalex.org/W4288692001","doi":"https://doi.org/10.1186/s13071-022-05408-2","title":"Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii","display_name":"Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii","publication_year":2022,"publication_date":"2022-07-29","ids":{"openalex":"https://openalex.org/W4288692001","doi":"https://doi.org/10.1186/s13071-022-05408-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/35906695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9338554"},"language":"en","primary_location":{"id":"doi:10.1186/s13071-022-05408-2","doi":"https://doi.org/10.1186/s13071-022-05408-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13071-022-05408-2","pdf_url":"https://parasitesandvectors.biomedcentral.com/counter/pdf/10.1186/s13071-022-05408-2","source":{"id":"https://openalex.org/S80413395","display_name":"Parasites & Vectors","issn_l":"1756-3305","issn":["1756-3305"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasites & Vectors","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://parasitesandvectors.biomedcentral.com/counter/pdf/10.1186/s13071-022-05408-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104276300","display_name":"Chun\u2010Xue Zhou","orcid":"https://orcid.org/0009-0007-5878-138X","observed_orcids":["https://orcid.org/0009-0007-5878-138X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chun-Xue Zhou","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China. zhouchunxue23@163.com","Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China. zhouchunxue23@163.com","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100623762","display_name":"Lingyu Li","orcid":"https://orcid.org/0000-0002-4559-2711","observed_orcids":["https://orcid.org/0000-0002-4559-2711"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Yu Li","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102964505","display_name":"Cuiqin Huang","orcid":"https://orcid.org/0000-0002-6543-5780","observed_orcids":["https://orcid.org/0000-0002-6543-5780"]},"institutions":[{"id":"https://openalex.org/I181361081","display_name":"Longyan University","ror":"https://ror.org/0483s5p06","country_code":"CN","type":"education","lineage":["https://openalex.org/I181361081"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cui-Qin Huang","raw_affiliation_strings":["Engineering Research Center for the Prevention and Control of Animal Original Zoonosis, Fujian Province University & College of Life Science, Longyan University, Longyan, 364012, Fujian, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center for the Prevention and Control of Animal Original Zoonosis, Fujian Province University & College of Life Science, Longyan University, Longyan, 364012, Fujian, People's Republic of China","institution_ids":["https://openalex.org/I181361081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054726963","display_name":"Xudong Guo","orcid":"https://orcid.org/0000-0002-7720-1885","observed_orcids":["https://orcid.org/0000-0002-7720-1885","https://orcid.org/0009-0009-9491-4359"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu-Dong Guo","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052952842","display_name":"Xu-Dian An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu-Dian An","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102644302","display_name":"Fang-Fang Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang-Fang Luo","raw_affiliation_strings":["Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100724066","display_name":"Wei Cong","orcid":"https://orcid.org/0000-0003-0471-1689","observed_orcids":["https://orcid.org/0000-0003-0471-1689"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Cong","raw_affiliation_strings":["Marine College, Shandong University, Weihai, 264209, Shandong, People's Republic of China. messicw@163.com","Marine College, Shandong University, Weihai, 264209, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine College, Shandong University, Weihai, 264209, Shandong, People's Republic of China. messicw@163.com","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Marine College, Shandong University, Weihai, 264209, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100724066","https://openalex.org/A5104276300"],"corresponding_institution_ids":["https://openalex.org/I154099455"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.2825,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71497696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"271","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":0.9990000128746033},{"id":"https://openalex.org/keywords/toxoplasmosis","display_name":"toxoplasmosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/urinary-metabolome","display_name":"urinary metabolome","score":0.9589999914169312},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.7149999737739563},{"id":"https://openalex.org/keywords/avirulent-strains","display_name":"avirulent strains","score":0.7350000143051147},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.8650000095367432},{"id":"https://openalex.org/keywords/acute-infection","display_name":"acute infection","score":0.925000011920929},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.7799999713897705},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.9470000267028809},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":1.0},{"id":"https://openalex.org/keywords/nicotinate-and-nicotinamide-metabolism","display_name":"nicotinate and nicotinamide metabolism","score":0.9580000042915344},{"id":"https://openalex.org/keywords/body-fluids","display_name":"biological fluids","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.8476675152778625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8315109014511108},{"id":"https://openalex.org/C190612196","wikidata":"https://www.wikidata.org/wiki/Q180502","display_name":"Parasitology","level":2,"score":0.8266497850418091},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7341554164886475},{"id":"https://openalex.org/C2776529007","wikidata":"https://www.wikidata.org/wiki/Q9820","display_name":"BALB/c","level":3,"score":0.6371943950653076},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.6278805732727051},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5756357908248901},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.57228022813797},{"id":"https://openalex.org/C2778062946","wikidata":"https://www.wikidata.org/wiki/Q154878","display_name":"Toxoplasmosis","level":2,"score":0.527725338935852},{"id":"https://openalex.org/C3020527817","wikidata":"https://www.wikidata.org/wiki/Q20811883","display_name":"Mouse strain","level":3,"score":0.5129916071891785},{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.5129215717315674},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3864445984363556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29179513454437256},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1611441969871521},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15928620100021362},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.1419755220413208},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.1414952278137207},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.12703189253807068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11501407623291016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05912092328071594},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014123","descriptor_name":"Toxoplasmosis","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13071-022-05408-2","doi":"https://doi.org/10.1186/s13071-022-05408-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13071-022-05408-2","pdf_url":"https://parasitesandvectors.biomedcentral.com/counter/pdf/10.1186/s13071-022-05408-2","source":{"id":"https://openalex.org/S80413395","display_name":"Parasites & Vectors","issn_l":"1756-3305","issn":["1756-3305"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasites & Vectors","raw_type":"journal-article"},{"id":"pmid:35906695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35906695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasites & vectors","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9338554","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9338554/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasit Vectors","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9f241274e2234001b6650185ddef4979","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9f241274e2234001b6650185ddef4979","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Parasites & Vectors, Vol 15, Iss 1, Pp 1-10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13071-022-05408-2","doi":"https://doi.org/10.1186/s13071-022-05408-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13071-022-05408-2","pdf_url":"https://parasitesandvectors.biomedcentral.com/counter/pdf/10.1186/s13071-022-05408-2","source":{"id":"https://openalex.org/S80413395","display_name":"Parasites & Vectors","issn_l":"1756-3305","issn":["1756-3305"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasites & Vectors","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1326917200","display_name":null,"funder_award_id":"202001005","funder_id":"https://openalex.org/F4320329863","funder_display_name":"Postdoctoral Innovation Project of Shandong Province"},{"id":"https://openalex.org/G1966588800","display_name":null,"funder_award_id":"20820211009","funder_id":"https://openalex.org/F4320311026","funder_display_name":"Shandong University"},{"id":"https://openalex.org/G4475875772","display_name":null,"funder_award_id":"2018M642663","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G6539016462","display_name":null,"funder_award_id":"82002161","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320311026","display_name":"Shandong University","ror":"https://ror.org/0207yh398"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320329863","display_name":"Postdoctoral Innovation Project of Shandong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288692001.pdf","grobid_xml":"https://content.openalex.org/works/W4288692001.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1528685627","https://openalex.org/W1580003617","https://openalex.org/W1582489273","https://openalex.org/W1925356096","https://openalex.org/W1956013940","https://openalex.org/W1991916578","https://openalex.org/W1999432988","https://openalex.org/W2036154532","https://openalex.org/W2038982445","https://openalex.org/W2062311239","https://openalex.org/W2064790749","https://openalex.org/W2084572740","https://openalex.org/W2097659338","https://openalex.org/W2114546524","https://openalex.org/W2118261210","https://openalex.org/W2149360212","https://openalex.org/W2318393934","https://openalex.org/W2324561278","https://openalex.org/W2396766738","https://openalex.org/W2417098255","https://openalex.org/W2580771590","https://openalex.org/W2739646638","https://openalex.org/W2781688423","https://openalex.org/W2834019972","https://openalex.org/W2886472734","https://openalex.org/W2964464377","https://openalex.org/W2974587351","https://openalex.org/W2975219453","https://openalex.org/W2985897872","https://openalex.org/W3014241614","https://openalex.org/W3032496765","https://openalex.org/W3035934928","https://openalex.org/W3092331462","https://openalex.org/W3097599714","https://openalex.org/W3108168291","https://openalex.org/W3117286581","https://openalex.org/W3118288921","https://openalex.org/W3152765551","https://openalex.org/W3152937051","https://openalex.org/W3159995035","https://openalex.org/W4200192515"],"related_works":["https://openalex.org/W2396766738","https://openalex.org/W2737359719","https://openalex.org/W2781688423","https://openalex.org/W1854805732","https://openalex.org/W2804495347","https://openalex.org/W6887881853","https://openalex.org/W6962584012","https://openalex.org/W3041588300","https://openalex.org/W6939181643","https://openalex.org/W6962710863"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,160],"protozoan":[2],"parasite":[3],"Toxoplasma":[4],"gondii":[5,158],"is":[6,142,166],"a":[7],"major":[8],"concern":[9],"for":[10],"human":[11],"and":[12,48,63,72,83,96,135,137,168,177],"animal":[13],"health.":[14],"Although":[15],"the":[16,26,76,143,172],"metabolic":[17,29,151],"understanding":[18,173],"of":[19,28,153,163,174,179],"toxoplasmosis":[20],"has":[21,169],"increased":[22],"in":[23,34,75,117,125,171],"recent":[24],"years,":[25],"analysis":[27,51,94,101],"alterations":[30],"through":[31],"noninvasive":[32],"methodologies":[33],"biofluids":[35],"remains":[36],"limited.":[37],"METHODS:":[38],"Here,":[39],"we":[40,69],"applied":[41],"liquid":[42],"chromatography-tandem":[43],"mass":[44],"spectrometry":[45],"(LC-MS/MS)-based":[46],"metabolomics":[47],"multivariate":[49],"statistical":[50],"to":[52,128,146],"analyze":[53],"BALB/c":[54,154],"mouse":[55,155,165],"urine":[56,111,118,150,161],"collected":[57],"from":[58,91,109,119],"acutely":[59],"infected,":[60],"chronically":[61],"infected":[62,164],"control":[64],"subjects.":[65],"RESULTS:":[66],"In":[67],"total,":[68],"identified":[70],"2065":[71],"1409":[73],"metabolites":[74],"positive":[77],"electrospray":[78],"ionization":[79],"(ESI":[80],"+)":[81],"mode":[82],"ESI":[84],"-":[85],"mode,":[86],"respectively.":[87],"Metabolomic":[88],"patterns":[89],"generated":[90],"principal":[92],"component":[93],"(PCA)":[95],"partial":[97],"least":[98],"squares":[99],"discriminant":[100],"(PLS-DA)":[102],"score":[103],"plots":[104],"clearly":[105],"separated":[106],"T.":[107,120,157],"gondii-infected":[108,121],"uninfected":[110],"samples.":[112],"Metabolites":[113],"with":[114,156],"altered":[115],"levels":[116],"mice":[122],"revealed":[123],"changes":[124],"pathways":[126],"related":[127],"amino":[129],"acid":[130,133],"metabolism,":[131,134],"fatty":[132],"nicotinate":[136],"nicotinamide":[138],"metabolism.":[139],"CONCLUSIONS:":[140],"This":[141],"first":[144],"study":[145],"our":[147],"knowledge":[148],"on":[149],"profiling":[152],"infection.":[159],"metabolome":[162],"distinctive":[167],"value":[170],"Toxoplasmosis":[175],"pathogenesis":[176],"improvement":[178],"treatment.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-30T00:00:00"}