{"id":"https://openalex.org/W428857","doi":null,"title":"Anti-TNF-alpha therapy modulates resistin in patients with rheumatoid arthritis.","display_name":"Anti-TNF-alpha therapy modulates resistin in patients with rheumatoid arthritis.","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W428857","mag":"428857","pmid":"https://pubmed.ncbi.nlm.nih.gov/18565254"},"language":"en","primary_location":{"id":"pmid:18565254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18565254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016922988","display_name":"Miguel \u00c1ngel Gonz\u00e1lez-Gay","orcid":"https://orcid.org/0000-0002-7924-7406","observed_orcids":["https://orcid.org/0000-0002-7924-7406"]},"institutions":[{"id":"https://openalex.org/I4210158468","display_name":"Hospital Xeral Calde","ror":"https://ror.org/00zbht122","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158468"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M A Gonzalez-Gay","raw_affiliation_strings":["Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain. miguelaggay@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain. miguelaggay@hotmail.com","institution_ids":["https://openalex.org/I4210158468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051418515","display_name":"Mar\u00eda Teresa Garc\u00eda\u2010Unzueta","orcid":"https://orcid.org/0000-0003-2531-3284","observed_orcids":["https://orcid.org/0000-0003-2531-3284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M T Garcia-Unzueta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107888161","display_name":"Carlos Gonz\u00e1lez\u2010Juanatey","orcid":"https://orcid.org/0000-0002-4483-9778","observed_orcids":["https://orcid.org/0000-0002-4483-9778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Gonzalez-Juanatey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110330690","display_name":"Jos\u00e9 Alberto Miranda-Filloy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Miranda-Filloy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076108618","display_name":"Tom\u00e1s R. V\u00e1zquez-Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-6718-5044","observed_orcids":["https://orcid.org/0000-0001-6718-5044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T R Vazquez-Rodriguez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113893330","display_name":"J M De Matias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M De Matias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069412319","display_name":"Javier J. Martin","orcid":"https://orcid.org/0000-0002-2202-0622","observed_orcids":["https://orcid.org/0000-0002-2202-0622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015159950","display_name":"Patrick Hector Dessein","orcid":"https://orcid.org/0000-0002-9357-4630","observed_orcids":["https://orcid.org/0000-0002-9357-4630","https://orcid.org/0009-0008-3092-9474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P H Dessein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049778476","display_name":"Javier Llorca","orcid":"https://orcid.org/0000-0001-8569-861X","observed_orcids":["https://orcid.org/0000-0001-8569-861X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Llorca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0563,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.96416008,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"26","issue":"2","first_page":"311","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.9150000214576721},{"id":"https://openalex.org/keywords/anti-tnf-therapy","display_name":"anti-TNF therapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chronic-systemic-inflammation","display_name":"chronic systemic inflammation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.972000002861023},{"id":"https://openalex.org/keywords/erythrocyte-sedimentation-rate","display_name":"erythrocyte sedimentation rate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.9879999756813049},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9449999928474426},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.989413857460022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9379528760910034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.787765383720398},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.774115800857544},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7717989683151245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5138154625892639},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.47921615839004517},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.47503355145454407},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.46517038345336914},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36655277013778687},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3393769860267639},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16248315572738647},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.14781302213668823},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.08153903484344482}],"mesh":[{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001799","descriptor_name":"Blood Sedimentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D052243","descriptor_name":"Resistin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D052243","descriptor_name":"Resistin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:18565254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18565254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Clinical Trial"},{"id":"mag:428857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18565254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W54474866","https://openalex.org/W65358577","https://openalex.org/W1515255326","https://openalex.org/W1675830194","https://openalex.org/W1708748675","https://openalex.org/W1750895917","https://openalex.org/W1785226454","https://openalex.org/W1964044812","https://openalex.org/W1996472975","https://openalex.org/W2004997688","https://openalex.org/W2014266615","https://openalex.org/W2015025775","https://openalex.org/W2026730648","https://openalex.org/W2032257407","https://openalex.org/W2072117604","https://openalex.org/W2097796010","https://openalex.org/W2099559598","https://openalex.org/W2102935782","https://openalex.org/W2110678596","https://openalex.org/W2118336146","https://openalex.org/W2137499656","https://openalex.org/W2139889887","https://openalex.org/W2149849190","https://openalex.org/W2152348310","https://openalex.org/W2152746369","https://openalex.org/W2160427887","https://openalex.org/W2166376415","https://openalex.org/W2170874916","https://openalex.org/W2292025369"],"related_works":["https://openalex.org/W54474866","https://openalex.org/W6976575362","https://openalex.org/W2319622081","https://openalex.org/W1755074524","https://openalex.org/W96159479","https://openalex.org/W2339967094","https://openalex.org/W7098347738","https://openalex.org/W1708748675","https://openalex.org/W2149849190","https://openalex.org/W65358577"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Chronic":[1],"systemic":[2],"inflammation":[3],"plays":[4],"a":[5,33,108,158,172,188],"pivotal":[6],"role":[7,190],"in":[8,13,57,157,165,193,197],"the":[9,18,112,137,140,194],"development":[10],"of":[11,31,40,139,161,178,191],"atherosclerosis":[12],"rheumatoid":[14],"arthritis":[15],"(RA).":[16],"In":[17],"present":[19,150],"study,":[20],"we":[21],"investigated":[22,67],"whether":[23],"anti-TNF-alpha":[24,154],"antagonist-monoclonal":[25],"antibody-infliximab":[26],"administration":[27],"alters":[28],"circulating":[29,41],"levels":[30,79,145,164],"resistin,":[32],"proinflammatory":[34],"adipokine.":[35],"We":[36,66],"further":[37],"assessed":[38],"associations":[39],"resistin":[42,78,96,144,163,183,192],"concentrations":[43,97],"with":[44,63,70,75,167],"CRP":[45,118,128,181],"and":[46,51,54,85,117,124,131,142,182],"ESR":[47,114,125],"levels,":[48],"platelet":[49,132],"counts":[50],"metabolic":[52],"syndrome":[53],"demographic":[55],"characteristics":[56],"RA":[58,71],"patients":[59,69,166],"on":[60,72],"periodical":[61,73],"treatment":[62,74],"infliximab.":[64,76],"METHODS:":[65],"33":[68],"Serum":[77],"were":[80],"determined":[81],"immediately":[82],"prior":[83],"to":[84,103],"after":[86],"infliximab":[87,91],"infusion.":[88],"RESULTS:":[89],"Upon":[90],"administration,":[92],"mean":[93,113],"(SD)":[94],"serum":[95,162],"(ng/ml)":[98],"decreased":[99],"from":[100,121],"21.9":[101],"(9.9)":[102],"17.4":[104],"(8.9)":[105],"(p=0.005).":[106],"Also,":[107],"significant":[109],"association":[110,174],"between":[111,175],"(r=0.405;":[115],"p=0.03)":[116],"(r=0.571;":[119],"p=0.0005)":[120,130],"disease":[122],"diagnosis":[123],"(r=0.486;":[126],"p=0.004),":[127],"(r=0.599;":[129],"count":[133],"(r=0.559;":[134],"p=0.0007)":[135],"at":[136],"time":[138],"study":[141,151],"baseline":[143],"was":[146],"found.":[147],"CONCLUSION:":[148],"The":[149],"shows":[152],"that":[153],"therapy":[155],"results":[156],"rapid":[159],"reduction":[160],"RA.":[168,198],"It":[169],"also":[170],"confirms":[171],"close":[173],"laboratory":[176],"markers":[177],"inflammation,":[179],"particularly":[180],"levels.":[184],"These":[185],"observations":[186],"support":[187],"potential":[189],"inflammatory":[195],"cascade":[196]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
