{"id":"https://openalex.org/W4288458652","doi":"https://doi.org/10.21037/tp-22-289","title":"Correlation between 5-HTTLPR gene polymorphism and cognitive function of traumatic stress in Chinese Han children","display_name":"Correlation between 5-HTTLPR gene polymorphism and cognitive function of traumatic stress in Chinese Han children","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4288458652","doi":"https://doi.org/10.21037/tp-22-289","pmid":"https://pubmed.ncbi.nlm.nih.gov/35958016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360820"},"language":"en","primary_location":{"id":"doi:10.21037/tp-22-289","doi":"https://doi.org/10.21037/tp-22-289","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tp-22-289","pdf_url":"https://tp.amegroups.com/article/viewFile/98697/pdf","source":{"id":"https://openalex.org/S2764863491","display_name":"Translational Pediatrics","issn_l":"2224-4336","issn":["2224-4336","2224-4344"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://tp.amegroups.com/article/viewFile/98697/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068536366","display_name":"Ming Ting Wu","orcid":"https://orcid.org/0000-0002-0800-5506","observed_orcids":["https://orcid.org/0000-0002-0800-5506","https://orcid.org/0009-0006-7248-8684","https://orcid.org/0000-0001-9427-8211"]},"institutions":[{"id":"https://openalex.org/I4210088110","display_name":"The Fourth People's Hospital","ror":"https://ror.org/001v2ey71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Wu","raw_affiliation_strings":["Department of Pediatrics, The Fourth People's Hospital of Haikou, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Fourth People's Hospital of Haikou, Haikou, China","institution_ids":["https://openalex.org/I4210088110"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lufei Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088110","display_name":"The Fourth People's Hospital","ror":"https://ror.org/001v2ey71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lufei Lin","raw_affiliation_strings":["Department of Pediatrics, The Fourth People's Hospital of Haikou, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Fourth People's Hospital of Haikou, Haikou, China","institution_ids":["https://openalex.org/I4210088110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100806717","display_name":"Yuebiao Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088110","display_name":"The Fourth People's Hospital","ror":"https://ror.org/001v2ey71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuebiao Wu","raw_affiliation_strings":["Department of Pediatrics, The Fourth People's Hospital of Haikou, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Fourth People's Hospital of Haikou, Haikou, China","institution_ids":["https://openalex.org/I4210088110"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088110","display_name":"The Fourth People's Hospital","ror":"https://ror.org/001v2ey71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zheng","raw_affiliation_strings":["Department of Pediatrics, The Fourth People's Hospital of Haikou, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The Fourth People's Hospital of Haikou, Haikou, China","institution_ids":["https://openalex.org/I4210088110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002747558","display_name":"Haidan Chen","orcid":"https://orcid.org/0000-0002-6086-7402","observed_orcids":["https://orcid.org/0000-0002-6086-7402"]},"institutions":[{"id":"https://openalex.org/I4210134288","display_name":"Sanya Central Hospital","ror":"https://ror.org/03t65z939","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134288"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haidan Chen","raw_affiliation_strings":["Department of Pediatrics, Sanya Central Hospital (Hainan Third People's Hospital), Sanya, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Sanya Central Hospital (Hainan Third People's Hospital), Sanya, China","institution_ids":["https://openalex.org/I4210134288"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002747558"],"corresponding_institution_ids":["https://openalex.org/I4210134288"],"apc_list":null,"apc_paid":null,"fwci":1.359,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.78529939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"11","issue":"7","first_page":"1251","last_page":"1260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.12200000137090683,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-httlpr","display_name":"5-HTTLPR","score":0.9290000200271606},{"id":"https://openalex.org/keywords/serotonin-transporter-gene-polymorphism","display_name":"serotonin transporter gene polymorphism","score":0.8970000147819519},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9739999771118164},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5860000252723694},{"id":"https://openalex.org/keywords/gene-gene-association","display_name":"gene-gene association","score":0.531000018119812},{"id":"https://openalex.org/keywords/han-chinese-children","display_name":"Han Chinese children","score":0.5419999957084656},{"id":"https://openalex.org/keywords/genotype-frequency","display_name":"genotype frequency","score":0.4359999895095825},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C5284366","wikidata":"https://www.wikidata.org/wiki/Q3299516","display_name":"5-HTTLPR","level":5,"score":0.7327194213867188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6540710926055908},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5977970361709595},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5438123941421509},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.541410505771637},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5177794694900513},{"id":"https://openalex.org/C2778159538","wikidata":"https://www.wikidata.org/wiki/Q16920843","display_name":"Traumatic stress","level":2,"score":0.5029606223106384},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.48973679542541504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4618171155452728},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.44279909133911133},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.42695915699005127},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.31969234347343445},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27677321434020996},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27130600810050964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0750805139541626},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/tp-22-289","doi":"https://doi.org/10.21037/tp-22-289","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tp-22-289","pdf_url":"https://tp.amegroups.com/article/viewFile/98697/pdf","source":{"id":"https://openalex.org/S2764863491","display_name":"Translational Pediatrics","issn_l":"2224-4336","issn":["2224-4336","2224-4344"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Pediatrics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9360820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Pediatr","raw_type":"Text"},{"id":"pmid:35958016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35958016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational pediatrics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/tp-22-289","doi":"https://doi.org/10.21037/tp-22-289","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tp-22-289","pdf_url":"https://tp.amegroups.com/article/viewFile/98697/pdf","source":{"id":"https://openalex.org/S2764863491","display_name":"Translational Pediatrics","issn_l":"2224-4336","issn":["2224-4336","2224-4344"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288458652.pdf","grobid_xml":"https://content.openalex.org/works/W4288458652.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W162706120","https://openalex.org/W170792860","https://openalex.org/W197086841","https://openalex.org/W1865617808","https://openalex.org/W1967484670","https://openalex.org/W1976174683","https://openalex.org/W1978016195","https://openalex.org/W1981456658","https://openalex.org/W1996620918","https://openalex.org/W2000904449","https://openalex.org/W2007516104","https://openalex.org/W2012618914","https://openalex.org/W2018211429","https://openalex.org/W2022699528","https://openalex.org/W2023136414","https://openalex.org/W2026836897","https://openalex.org/W2036271547","https://openalex.org/W2061428806","https://openalex.org/W2062445968","https://openalex.org/W2066095975","https://openalex.org/W2091096177","https://openalex.org/W2092354644","https://openalex.org/W2106095564","https://openalex.org/W2106557234","https://openalex.org/W2116772823","https://openalex.org/W2120147955","https://openalex.org/W2126285573","https://openalex.org/W2150523152","https://openalex.org/W2151135161","https://openalex.org/W2151357909","https://openalex.org/W2156743186","https://openalex.org/W2160854040","https://openalex.org/W2162079205","https://openalex.org/W2162196924","https://openalex.org/W2168557513","https://openalex.org/W2173765887","https://openalex.org/W2285774466","https://openalex.org/W2729998533","https://openalex.org/W2927069780","https://openalex.org/W2939263357","https://openalex.org/W2939997140","https://openalex.org/W2969256198","https://openalex.org/W2971402876","https://openalex.org/W2989875042","https://openalex.org/W2989908931","https://openalex.org/W2993335014","https://openalex.org/W2998888159","https://openalex.org/W3017093464","https://openalex.org/W3024469465","https://openalex.org/W3025712168","https://openalex.org/W3048663799","https://openalex.org/W3126689115","https://openalex.org/W3136805430","https://openalex.org/W4200460497","https://openalex.org/W6776410501"],"related_works":["https://openalex.org/W2946846092","https://openalex.org/W2979828809","https://openalex.org/W2120222617","https://openalex.org/W2910676237","https://openalex.org/W2780843692","https://openalex.org/W7096273409","https://openalex.org/W7096514580","https://openalex.org/W2969256198","https://openalex.org/W2160854040","https://openalex.org/W2150523152"],"abstract_inverted_index":{"Background:":[0],"Post-traumatic":[1],"stress":[2],"disorder":[3,9],"(PTSD)":[4],"is":[5,233],"a":[6],"trauma-related":[7],"psychological":[8],"with":[10,48,69,235,242],"serious":[11],"social":[12],"and":[13,41,121,140,152,162,165,170,186,190,196,199,208,213],"familial":[14],"impacts.":[15],"The":[16,105,119],"involvement":[17],"of":[18,53,82,101,146,149,179,184,211,221,229],"5-hydroxytryptamine":[19],"transporter":[20],"gene-linked":[21],"polymorphic":[22],"region":[23],"(5-HTTLPR)":[24],"in":[25,44,132,154,174,192,201,224,238],"numerous":[26],"mental":[27],"disorders":[28],"has":[29],"been":[30],"documented.":[31],"This":[32],"study":[33,67],"explored":[34],"the":[35,79,85,91,97,133,206,230],"correlation":[36],"between":[37],"5-HTTLPR":[38,106,231],"gene":[39,107,181,232],"polymorphism":[40,108],"cognitive":[42,80,236],"function":[43,81],"Chinese":[45,239],"Han":[46,240],"children":[47,56,73,156,241],"PTSD.":[49,243],"Methods:":[50],"A":[51],"total":[52],"60":[54,71],"PTSD":[55,92,134,155,193,225],"treated":[57],"from":[58,219],"December":[59,62],"2019":[60],"to":[61],"2021":[63],"were":[64,124,157,188,197,216],"selected":[65,74],"as":[66,75],"participants,":[68],"another":[70],"healthy":[72,175,202],"controls.":[76,176],"We":[77],"assessed":[78],"participants":[83],"using":[84],"Mini-Mental":[86],"State":[87],"Examination":[88],"(MMSE).":[89],"Additionally,":[90],"level":[93],"was":[94,109],"estimated":[95],"by":[96,111],"Children\u2019s":[98],"Revised":[99],"Impact":[100],"Event":[102],"Scale":[103],"(CRIES).":[104],"detected":[110],"reverse":[112],"transcription":[113],"quantitative":[114],"polymerase":[115],"chain":[116],"reaction":[117],"(RT-qPCR).":[118],"genotype":[120,223],"allele":[122,180],"frequency":[123],"evaluated":[125],"via":[126],"case-control":[127],"association":[128],"analysis.":[129],"Results:":[130],"Children":[131],"group":[135],"showed":[136],"low":[137],"MMSE":[138,209],"scores":[139,210],"high":[141],"CRIES":[142,207],"scores.":[143],"In":[144,177],"terms":[145,178],"genotype,":[147],"cases":[148,173],"LL,":[150],"LS,":[151],"SS":[153,214],"4":[158],"(6.67%),":[159],"20":[160],"(33.3%),":[161],"36":[163],"(60.00%),":[164],"18":[166],"(30.00%),":[167],"28":[168],"(46.67%),":[169],"14":[171],"(23.33%)":[172],"frequency,":[182],"incidences":[183],"L":[185],"S":[187],"23.33%":[189],"76.67%":[191],"children,":[194],"respectively,":[195],"53.33%":[198],"46.67%":[200],"controls,":[203],"respectively.":[204],"Moreover,":[205],"LS":[212],"genotypes":[215],"evidently":[217],"different":[218],"those":[220],"LL":[222],"children.":[226],"Conclusions:":[227],"Polymorphism":[228],"correlated":[234],"dysfunction":[237]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-07-29T00:00:00"}