{"id":"https://openalex.org/W4288087983","doi":null,"title":"211-astatine containing radiotherapeutics for the treatment of cancer","display_name":"211-astatine containing radiotherapeutics for the treatment of cancer","publication_year":2023,"publication_date":"2023-12-18","ids":{"openalex":"https://openalex.org/W4288087983"},"language":"en","primary_location":{"id":"pmh:oai:osti.gov:1600218","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1600218","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.osti.gov/biblio/1600218","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074054064","display_name":"Daniel A. Pryma","orcid":"https://orcid.org/0000-0001-8978-4419","observed_orcids":["https://orcid.org/0000-0001-8978-4419"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pryma, Daniel A.; Lieberman, Brian P.; Makvandi, Mehran; Mach, Robert H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074054064"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00118212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astatine-211","display_name":"astatine-211","score":0.9750000238418579},{"id":"https://openalex.org/keywords/alpha-emitters","display_name":"alpha-emitting radionuclides","score":0.9620000123977661},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.7799999713897705},{"id":"https://openalex.org/keywords/targeted-alpha-therapy","display_name":"targeted alpha therapy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/dihydroisoquinolines","display_name":"dihydroisoquinolines","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C531082785","wikidata":"https://www.wikidata.org/wiki/Q999","display_name":"Astatine","level":3,"score":0.6999590992927551},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.40811434388160706},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.3653268814086914},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.32690340280532837},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3267815113067627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29884612560272217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2625691890716553},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:osti.gov:1600218","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1600218","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:osti.gov:1600218","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1600218","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2190356450","https://openalex.org/W1782711087","https://openalex.org/W4385076595","https://openalex.org/W1963646933","https://openalex.org/W1520166374","https://openalex.org/W7132817665","https://openalex.org/W3115657453","https://openalex.org/W4408258978","https://openalex.org/W1976379955","https://openalex.org/W2007714313"],"abstract_inverted_index":{"Described":[0],"herein":[1],"is":[2,67],"an":[3],"alpha-emitting":[4,54],"radionuclide,":[5],"211At,":[6],"which":[7],"has":[8],"been":[9],"incorporated":[10],"into":[11],"a":[12,22,28,58],"selective":[13],"sigma-2":[14,55],"ligand":[15,56],"moiety":[16],"to":[17,21],"provide":[18],"cytotoxic":[19],"capabilities":[20],"chemical":[23],"compound.":[24],"As":[25],"described":[26],"herein,":[27,40],"compound":[29,66],"of":[30,53],"formula":[31],"(I),":[32],"wherein":[33],"R1-R4,":[34],"m,":[35],"and":[36,43,48],"n":[37],"are":[38],"defined":[39],"was":[41],"prepared":[42],"utilized":[44],"in":[45,46,49,57],"vitro":[47],"vivo":[50],"tumor":[51],"targeting":[52],"breast":[59],"cancer":[60],"model.":[61],"In":[62],"one":[63],"embodiment,":[64],"the":[65],"5-(211At)\u2014N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide.":[68]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-07-28T00:00:00"}