{"id":"https://openalex.org/W4288084879","doi":"https://doi.org/10.1093/abt/tbac018","title":"Use of Debye\u2013H\u00fcckel\u2013Henry charge measurements in early antibody development elucidates effects of non-specific association","display_name":"Use of Debye\u2013H\u00fcckel\u2013Henry charge measurements in early antibody development elucidates effects of non-specific association","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4288084879","doi":"https://doi.org/10.1093/abt/tbac018","pmid":"https://pubmed.ncbi.nlm.nih.gov/35983303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9380711"},"language":"en","primary_location":{"id":"doi:10.1093/abt/tbac018","doi":"https://doi.org/10.1093/abt/tbac018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/abt/tbac018","pdf_url":"https://academic.oup.com/abt/article-pdf/5/3/211/45434112/tbac018.pdf","source":{"id":"https://openalex.org/S4210177059","display_name":"Antibody Therapeutics","issn_l":"2516-4236","issn":["2516-4236"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibody Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/abt/article-pdf/5/3/211/45434112/tbac018.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032130950","display_name":"Joshua R. Laber","orcid":"https://orcid.org/0000-0002-7572-4260","observed_orcids":["https://orcid.org/0000-0002-7572-4260"]},"institutions":[{"id":"https://openalex.org/I2800689049","display_name":"Nektar Therapeutics (United States)","ror":"https://ror.org/03p1cbx82","country_code":"US","type":"company","lineage":["https://openalex.org/I2800689049"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua R Laber","raw_affiliation_strings":["Formulation and Biologics Product Development, Nektar Therapeutics , 455 Mission Bay Boulevard South, San Francisco, CA 94158 , USA"],"raw_orcid":"https://orcid.org/0000-0002-7572-4260","affiliations":[{"raw_affiliation_string":"Formulation and Biologics Product Development, Nektar Therapeutics , 455 Mission Bay Boulevard South, San Francisco, CA 94158 , USA","institution_ids":["https://openalex.org/I2800689049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048915972","display_name":"Thomas Maxon Laue","orcid":"https://orcid.org/0000-0003-3571-9368","observed_orcids":["https://orcid.org/0000-0003-3571-9368"]},"institutions":[{"id":"https://openalex.org/I161057412","display_name":"University of New Hampshire","ror":"https://ror.org/01rmh9n78","country_code":"US","type":"education","lineage":["https://openalex.org/I161057412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M Laue","raw_affiliation_strings":["Carpenter Professor Emeritus, University of New Hampshire , Durham, NH 03824 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carpenter Professor Emeritus, University of New Hampshire , Durham, NH 03824 , USA","institution_ids":["https://openalex.org/I161057412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019200226","display_name":"Dana I. Filoti","orcid":"https://orcid.org/0000-0003-0912-6657","observed_orcids":["https://orcid.org/0000-0003-0912-6657"]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dana I Filoti","raw_affiliation_strings":["Analytical Research and Development, AbbVie , 100 Research Drive, Worcester, MA 01605 , USA"],"raw_orcid":"https://orcid.org/0000-0003-0912-6657","affiliations":[{"raw_affiliation_string":"Analytical Research and Development, AbbVie , 100 Research Drive, Worcester, MA 01605 , USA","institution_ids":["https://openalex.org/I2948539688"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019200226"],"corresponding_institution_ids":["https://openalex.org/I2948539688"],"apc_list":{"value":2625,"currency":"USD","value_usd":2625},"apc_paid":{"value":2625,"currency":"USD","value_usd":2625},"fwci":0.1854,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.34655431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"5","issue":"3","first_page":"211","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12274","display_name":"Electrostatics and Colloid Interactions","score":0.16410000622272491,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interdiffusion-coefficient","display_name":"interdiffusion coefficient","score":0.7940000295639038},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8320000171661377},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.5740000009536743},{"id":"https://openalex.org/keywords/electrostatic-repulsion","display_name":"electrostatic repulsion","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antibody-development","display_name":"antibody development","score":0.6050000190734863},{"id":"https://openalex.org/keywords/histidine-buffer","display_name":"histidine buffer","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.619328498840332},{"id":"https://openalex.org/C188082385","wikidata":"https://www.wikidata.org/wiki/Q73792","display_name":"Charge (physics)","level":2,"score":0.6051989793777466},{"id":"https://openalex.org/C64543145","wikidata":"https://www.wikidata.org/wiki/Q162942","display_name":"Intersection (aeronautics)","level":2,"score":0.5831599831581116},{"id":"https://openalex.org/C2780358262","wikidata":"https://www.wikidata.org/wiki/Q1540423","display_name":"Surface charge","level":2,"score":0.527864396572113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5275373458862305},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.43502023816108704},{"id":"https://openalex.org/C184654806","wikidata":"https://www.wikidata.org/wiki/Q898268","display_name":"Debye length","level":3,"score":0.4110693335533142},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.337815523147583},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.31543833017349243},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.2854161262512207},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.18194794654846191},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.15209853649139404},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.09978783130645752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07537427544593811},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/abt/tbac018","doi":"https://doi.org/10.1093/abt/tbac018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/abt/tbac018","pdf_url":"https://academic.oup.com/abt/article-pdf/5/3/211/45434112/tbac018.pdf","source":{"id":"https://openalex.org/S4210177059","display_name":"Antibody Therapeutics","issn_l":"2516-4236","issn":["2516-4236"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibody Therapeutics","raw_type":"journal-article"},{"id":"pmid:35983303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35983303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibody therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9380711","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9380711/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antib Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/abt/tbac018","doi":"https://doi.org/10.1093/abt/tbac018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/abt/tbac018","pdf_url":"https://academic.oup.com/abt/article-pdf/5/3/211/45434112/tbac018.pdf","source":{"id":"https://openalex.org/S4210177059","display_name":"Antibody Therapeutics","issn_l":"2516-4236","issn":["2516-4236"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibody Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309117","display_name":"AbbVie","ror":"https://ror.org/02g5p4n58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288084879.pdf","grobid_xml":"https://content.openalex.org/works/W4288084879.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1601332140","https://openalex.org/W1986854103","https://openalex.org/W2036198404","https://openalex.org/W2036879738","https://openalex.org/W2044505113","https://openalex.org/W2046558283","https://openalex.org/W2053498066","https://openalex.org/W2077656737","https://openalex.org/W2077936377","https://openalex.org/W2082448184","https://openalex.org/W2082493255","https://openalex.org/W2091381410","https://openalex.org/W2096785891","https://openalex.org/W2106401765","https://openalex.org/W2142760719","https://openalex.org/W2168193821","https://openalex.org/W2319569078","https://openalex.org/W2605870583","https://openalex.org/W2742887176","https://openalex.org/W2752932044","https://openalex.org/W2796671993","https://openalex.org/W2872264814","https://openalex.org/W2888529396","https://openalex.org/W2909198805","https://openalex.org/W2922028313","https://openalex.org/W2985803748","https://openalex.org/W2997095426"],"related_works":["https://openalex.org/W2888529396","https://openalex.org/W2096785891","https://openalex.org/W1999213485","https://openalex.org/W3133381904","https://openalex.org/W2319569078","https://openalex.org/W4210767120","https://openalex.org/W4362521811","https://openalex.org/W2044503154","https://openalex.org/W2958990435","https://openalex.org/W4395465617"],"abstract_inverted_index":{"Abstract":[0],"The":[1,81],"diffusion":[2,37],"interaction":[3],"parameter":[4],"(kD)":[5],"has":[6],"been":[7],"demonstrated":[8],"to":[9,95,123],"be":[10],"a":[11,41,90,114],"high-throughput":[12],"technique":[13],"for":[14,51],"characterizing":[15],"interactions":[16,98],"between":[17],"proteins":[18],"in":[19,57,99],"solution.":[20],"kD":[21,86],"reflects":[22],"both":[23],"attractive":[24,94,125],"and":[25],"repulsive":[26,97],"interactions,":[27],"including":[28],"long-ranged":[29],"electrostatic":[30],"repulsions.":[31],"Here,":[32],"we":[33],"plot":[34],"the":[35,44,100,104],"mutual":[36],"coefficient":[38],"(Dm)":[39],"as":[40,85],"function":[42],"of":[43,68,78,103],"experimentally":[45],"determined":[46],"Debye\u2013H\u00fcckel\u2013Henry":[47],"surface":[48,116],"charge":[49,117],"(ZDHH)":[50],"seven":[52],"human":[53],"monoclonal":[54],"antibodies":[55],"(mAbs)":[56],"15":[58],"mM":[59],"histidine":[60],"at":[61,73],"pH":[62],"6.":[63],"We":[64],"find":[65],"that":[66,111],"graphs":[67],"Dm":[69],"versus":[70,87],"ZDHH":[71,88,105],"intersect":[72],"ZDHH,":[74],"~":[75],"2.6,":[76],"independent":[77],"protein":[79],"concentration.":[80],"same":[82,101],"data":[83,109],"plotted":[84],"show":[89],"transition":[91],"from":[92],"net":[93,96],"region":[102],"intersection":[106],"point.":[107],"These":[108],"suggest":[110],"there":[112],"is":[113],"minimum":[115],"necessary":[118],"on":[119],"these":[120],"mAbs":[121],"needed":[122],"overcome":[124],"interactions.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2022-07-28T00:00:00"}
