{"id":"https://openalex.org/W4288077428","doi":"https://doi.org/10.3389/fimmu.2022.926550","title":"Emerging translational strategies and challenges for enhancing regulatory T cell therapy for graft-versus-host disease","display_name":"Emerging translational strategies and challenges for enhancing regulatory T cell therapy for graft-versus-host disease","publication_year":2022,"publication_date":"2022-07-28","ids":{"openalex":"https://openalex.org/W4288077428","doi":"https://doi.org/10.3389/fimmu.2022.926550","pmid":"https://pubmed.ncbi.nlm.nih.gov/35967386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9366169"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.926550","doi":"https://doi.org/10.3389/fimmu.2022.926550","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.926550","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.926550/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.926550/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072729295","display_name":"Keli Lee Hippen","orcid":"https://orcid.org/0000-0002-8050-270X","observed_orcids":["https://orcid.org/0000-0002-8050-270X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keli L. Hippen","raw_affiliation_strings":["University of Minnesota Cancer Center and the Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, Minneapolis, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center and the Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, Minneapolis, MN, United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067492340","display_name":"Mehrdad Hefazi","orcid":"https://orcid.org/0000-0001-8860-3380","observed_orcids":["https://orcid.org/0000-0001-8860-3380"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehrdad Hefazi","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000186474","display_name":"Jemma H. Larson","orcid":"https://orcid.org/0000-0002-2920-8986","observed_orcids":["https://orcid.org/0000-0002-2920-8986"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jemma H. Larson","raw_affiliation_strings":["University of Minnesota Cancer Center and the Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, Minneapolis, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center and the Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, Minneapolis, MN, United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058268746","display_name":"Bruce R. Blazar","orcid":"https://orcid.org/0000-0002-9608-9841","observed_orcids":["https://orcid.org/0000-0002-9608-9841"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce R. Blazar","raw_affiliation_strings":["University of Minnesota Cancer Center and the Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, Minneapolis, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center and the Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, Minneapolis, MN, United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072729295"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.2317,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.77816764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"926550","last_page":"926550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/treg-expansion","display_name":"Treg expansion","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tcr-engineering","display_name":"TCR engineering","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/il-2-stat5-signaling","display_name":"IL-2/STAT5 signaling","score":0.8960000276565552},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.7419999837875366},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.6340000033378601},{"id":"https://openalex.org/keywords/treg-subsets","display_name":"Treg subsets","score":0.6010000109672546},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6686698198318481},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6207985281944275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5741441249847412},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5714952349662781},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.5514715909957886},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5412613153457642},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5257083773612976},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.50928795337677},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5046206712722778},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.48447513580322266},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46509113907814026},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4470158815383911},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4234876036643982},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3622874617576599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2727268934249878},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.17638269066810608},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13622257113456726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10087385773658752},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2022.926550","doi":"https://doi.org/10.3389/fimmu.2022.926550","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.926550","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.926550/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:35967386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35967386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9366169","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9366169/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8a74f734babe469ca7e47881bdd7db40","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8a74f734babe469ca7e47881bdd7db40","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.926550","doi":"https://doi.org/10.3389/fimmu.2022.926550","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.926550","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.926550/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1687387222","display_name":"T-Cell Targeting for GVHD","funder_award_id":"R01HL056067","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2036154642","display_name":null,"funder_award_id":"R01 HL11879","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2896368367","display_name":"Exploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory Disease","funder_award_id":"R01HL155114","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3795906028","display_name":"Mechanisms, Prevention and Treatment of Chronic Graft-vs.-Host Disease","funder_award_id":"P01CA142106","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4076955590","display_name":null,"funder_award_id":"R01HL11879","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4468582213","display_name":"Nongenotoxic conditioning for gene therapy and allogeneic transplantation in Fanconi anemia","funder_award_id":"R01HL147324","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4608600911","display_name":null,"funder_award_id":"HL11879","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5940164027","display_name":null,"funder_award_id":"AI344495","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7701328355","display_name":"Inducible Regulatory T Cells for the Prevention and Treatment of Acute GVHD","funder_award_id":"R01HL114512","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8050863362","display_name":"T Cell Costimulatory Pathways:  Functions and Interactions","funder_award_id":"P01AI056299","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8536349776","display_name":null,"funder_award_id":"CA142106, CA065493","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000877125","display_name":"In Vivo Prevention of Murine GVHD","funder_award_id":"R37AI034495","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000900684","display_name":"Enhancing Treg Therapeutic Efficacy in GVHD","funder_award_id":"R01HL118979","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000908608","display_name":"Off-the-Shelf Immune Effector Cells for Hematological Malignancies","funder_award_id":"P01CA065493","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306156","display_name":"Children's Cancer Research Fund","ror":"https://ror.org/02wv5fj21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288077428.pdf","grobid_xml":"https://content.openalex.org/works/W4288077428.grobid-xml"},"referenced_works_count":216,"referenced_works":["https://openalex.org/W47217405","https://openalex.org/W91015143","https://openalex.org/W1511438228","https://openalex.org/W1523413731","https://openalex.org/W1528148028","https://openalex.org/W1535141082","https://openalex.org/W1548135960","https://openalex.org/W1556467835","https://openalex.org/W1575253744","https://openalex.org/W1593575953","https://openalex.org/W1599864954","https://openalex.org/W1608695296","https://openalex.org/W1619959770","https://openalex.org/W1661658508","https://openalex.org/W1736404394","https://openalex.org/W1795844187","https://openalex.org/W1807395491","https://openalex.org/W1916911965","https://openalex.org/W1964580130","https://openalex.org/W1967363186","https://openalex.org/W1967782952","https://openalex.org/W1970246068","https://openalex.org/W1974596058","https://openalex.org/W1975451639","https://openalex.org/W1978482149","https://openalex.org/W1981298448","https://openalex.org/W1981690705","https://openalex.org/W1984172120","https://openalex.org/W1986741896","https://openalex.org/W1987006648","https://openalex.org/W1988474688","https://openalex.org/W1990295999","https://openalex.org/W1991390262","https://openalex.org/W1993971516","https://openalex.org/W1995900768","https://openalex.org/W1998935634","https://openalex.org/W2002148098","https://openalex.org/W2003788503","https://openalex.org/W2004844427","https://openalex.org/W2006120701","https://openalex.org/W2010438746","https://openalex.org/W2011675173","https://openalex.org/W2018715802","https://openalex.org/W2018779510","https://openalex.org/W2018938924","https://openalex.org/W2025694570","https://openalex.org/W2025743850","https://openalex.org/W2028776342","https://openalex.org/W2030682069","https://openalex.org/W2031551895","https://openalex.org/W2037845887","https://openalex.org/W2039341040","https://openalex.org/W2040282375","https://openalex.org/W2040790884","https://openalex.org/W2042626190","https://openalex.org/W2045343528","https://openalex.org/W2046361773","https://openalex.org/W2050941564","https://openalex.org/W2053351225","https://openalex.org/W2054901613","https://openalex.org/W2055254092","https://openalex.org/W2068173904","https://openalex.org/W2068392572","https://openalex.org/W2068859282","https://openalex.org/W2072853625","https://openalex.org/W2073045132","https://openalex.org/W2073137315","https://openalex.org/W2073310925","https://openalex.org/W2079622572","https://openalex.org/W2080095070","https://openalex.org/W2085180060","https://openalex.org/W2085358094","https://openalex.org/W2085704445","https://openalex.org/W2086226733","https://openalex.org/W2087482409","https://openalex.org/W2087590696","https://openalex.org/W2091483766","https://openalex.org/W2094292853","https://openalex.org/W2094788591","https://openalex.org/W2096470758","https://openalex.org/W2100142435","https://openalex.org/W2102826458","https://openalex.org/W2105239628","https://openalex.org/W2106083290","https://openalex.org/W2106190040","https://openalex.org/W2110641805","https://openalex.org/W2110957620","https://openalex.org/W2115008199","https://openalex.org/W2116169090","https://openalex.org/W2117856994","https://openalex.org/W2119860862","https://openalex.org/W2120549636","https://openalex.org/W2121950548","https://openalex.org/W2123013608","https://openalex.org/W2124387157","https://openalex.org/W2125270092","https://openalex.org/W2126060249","https://openalex.org/W2128444087","https://openalex.org/W2134990960","https://openalex.org/W2135280067","https://openalex.org/W2137768092","https://openalex.org/W2140791963","https://openalex.org/W2141173072","https://openalex.org/W2141565645","https://openalex.org/W2145353379","https://openalex.org/W2146934919","https://openalex.org/W2148360092","https://openalex.org/W2149076983","https://openalex.org/W2151328705","https://openalex.org/W2152591595","https://openalex.org/W2152835711","https://openalex.org/W2153389047","https://openalex.org/W2153643980","https://openalex.org/W2156964052","https://openalex.org/W2158384308","https://openalex.org/W2160700813","https://openalex.org/W2163366601","https://openalex.org/W2164386968","https://openalex.org/W2191493147","https://openalex.org/W2293794047","https://openalex.org/W2303852857","https://openalex.org/W2337931770","https://openalex.org/W2387461462","https://openalex.org/W2417406456","https://openalex.org/W2460642271","https://openalex.org/W2470430235","https://openalex.org/W2516163675","https://openalex.org/W2516298309","https://openalex.org/W2555431842","https://openalex.org/W2559842146","https://openalex.org/W2563216164","https://openalex.org/W2563656670","https://openalex.org/W2572678120","https://openalex.org/W2576439665","https://openalex.org/W2589911436","https://openalex.org/W2597359422","https://openalex.org/W2604240183","https://openalex.org/W2606705797","https://openalex.org/W2611559486","https://openalex.org/W2619691134","https://openalex.org/W2728369882","https://openalex.org/W2734658983","https://openalex.org/W2750710572","https://openalex.org/W2755035105","https://openalex.org/W2756060362","https://openalex.org/W2756066029","https://openalex.org/W2765753782","https://openalex.org/W2767496597","https://openalex.org/W2768338741","https://openalex.org/W2769990542","https://openalex.org/W2775205191","https://openalex.org/W2782025094","https://openalex.org/W2789780246","https://openalex.org/W2791316427","https://openalex.org/W2792959391","https://openalex.org/W2804087898","https://openalex.org/W2809371807","https://openalex.org/W2886029455","https://openalex.org/W2886525139","https://openalex.org/W2895637293","https://openalex.org/W2899447277","https://openalex.org/W2900744589","https://openalex.org/W2905370254","https://openalex.org/W2913219069","https://openalex.org/W2914476301","https://openalex.org/W2921873774","https://openalex.org/W2922108048","https://openalex.org/W2923979336","https://openalex.org/W2929109925","https://openalex.org/W2941582519","https://openalex.org/W2944910640","https://openalex.org/W2946663348","https://openalex.org/W2951623837","https://openalex.org/W2953154651","https://openalex.org/W2960419095","https://openalex.org/W2972613199","https://openalex.org/W2994399541","https://openalex.org/W2995369077","https://openalex.org/W2999475127","https://openalex.org/W3006443846","https://openalex.org/W3014985924","https://openalex.org/W3016619242","https://openalex.org/W3028740982","https://openalex.org/W3034330381","https://openalex.org/W3035152389","https://openalex.org/W3072963690","https://openalex.org/W3087143787","https://openalex.org/W3088828887","https://openalex.org/W3089339285","https://openalex.org/W3091149548","https://openalex.org/W3118994613","https://openalex.org/W3134348614","https://openalex.org/W3135626951","https://openalex.org/W3152966026","https://openalex.org/W3155568211","https://openalex.org/W3158074194","https://openalex.org/W3172794367","https://openalex.org/W3173900521","https://openalex.org/W3192924181","https://openalex.org/W3197726683","https://openalex.org/W3198942109","https://openalex.org/W3199150393","https://openalex.org/W3200040940","https://openalex.org/W3200255374","https://openalex.org/W3200937149","https://openalex.org/W3204247169","https://openalex.org/W3209156130","https://openalex.org/W3214321036","https://openalex.org/W4200110378","https://openalex.org/W4200466896","https://openalex.org/W4200593773","https://openalex.org/W4210401235","https://openalex.org/W4214480816","https://openalex.org/W4236572065","https://openalex.org/W4256399029","https://openalex.org/W6633155215"],"related_works":["https://openalex.org/W3197726683","https://openalex.org/W4415706083","https://openalex.org/W2998455155","https://openalex.org/W2977778437","https://openalex.org/W7117454828","https://openalex.org/W4409487724","https://openalex.org/W4395006530","https://openalex.org/W2967127993","https://openalex.org/W2602149594","https://openalex.org/W2614498142"],"abstract_inverted_index":{"Allogeneic":[0],"hematopoietic":[1],"stem":[2],"cell":[3,53,80],"transplantation":[4],"(allo-HSCT)":[5],"is":[6,238],"a":[7,36,51,208,252,321],"curative":[8],"therapy":[9,81],"for":[10,56,122,126,161,204,212,314],"many":[11],"types":[12],"of":[13,26,39,65,136,150,177,185,210,224,318,334],"cancer.":[14],"Genetic":[15],"disparities":[16],"between":[17],"donor":[18],"and":[19,41,63,91,119,141,155,183,194,197,283,307,312],"host":[20,27,33],"can":[21,99,247],"result":[22],"in":[23,88,93,133,137,142,144,148,156,180,233,241,256,292],"immune-mediated":[24],"attack":[25],"tissues,":[28],"known":[29],"as":[30,328],"graft":[31],"versus":[32],"disease":[34],"(GVHD),":[35],"major":[37],"cause":[38],"morbidity":[40],"mortality":[42],"following":[43,188,271],"HSCT.":[44],"Regulatory":[45],"CD4+":[46],"T":[47,67],"cells":[48,68],"(Tregs)":[49],"are":[50,71,131],"rare":[52],"type":[54],"crucial":[55],"immune":[57,152],"system":[58],"homeostasis,":[59],"limiting":[60],"the":[61,134,175],"activation":[62],"differentiation":[64],"effector":[66],"(Teff)":[69],"that":[70,95,246,265,273],"self-reactive":[72],"or":[73,269],"stimulated":[74],"by":[75],"foreign":[76],"antigen":[77,219],"exposure.":[78],"Adoptive":[79],"(ACT)":[82],"with":[83],"Treg":[84,97,108,117,124,146,198,205,249,293,299,305,319],"has":[85],"demonstrated,":[86],"first":[87],"murine":[89],"models":[90],"now":[92],"patients,":[94],"prophylactic":[96],"infusion":[98,331],"also":[100,262],"suppress":[101],"GVHD.":[102,162],"While":[103],"clinical":[104],"trials":[105],"have":[106,261],"demonstrated":[107],"reduce":[109],"severe":[110],"GVHD":[111,181,234],"occurrence,":[112],"several":[113],"impediments":[114],"remain,":[115],"including":[116],"variability":[118],"practical":[120],"need":[121],"individualized":[123],"production":[125,199,294,323],"each":[127],"patient.":[128],"Additionally,":[129],"there":[130],"challenges":[132],"use":[135],"vitro":[138,202],"expansion":[139,203,237],"techniques":[140],"achieving":[143],"vivo":[145],"persistence":[147],"context":[149],"both":[151],"suppressive":[153],"drugs":[154,231],"lymphoreplete":[157],"patients":[158,242],"being":[159],"treated":[160],"This":[163],"review":[164,288],"will":[165,289],"focus":[166],"on":[167],"3":[168],"main":[169],"translational":[170],"approaches":[171,211,302],"taken":[172],"to":[173,215,229,296,303,325],"improve":[174,216],"efficacy":[176],"tTreg":[178,267,310],"ACT":[179,206,272],"prophylaxis":[182],"development":[184],"treatment":[186],"options,":[187],"HSCT:":[189],"genetic":[190],"modification,":[191],"manipulating":[192],"TCR":[193],"cytokine":[195],"signaling,":[196,282],"protocols.":[200],"In":[201],"presents":[207],"multitude":[209],"gene":[213],"modification":[214],"efficacy,":[217],"including:":[218,277],"specificity,":[220],"tissue":[221,297],"targeting,":[222],"deletion":[223],"negative":[225],"regulators/exhaustion":[226],"markers,":[227],"resistance":[228],"immunosuppressive":[230],"common":[232],"treatment.":[235],"Such":[236],"particularly":[239],"important":[240],"without":[243],"significant":[244],"lymphopenia":[245],"drive":[248],"expansion,":[250,311],"enabling":[251],"favorable":[253],"Treg:Teff":[254],"ratio":[255],"vivo.":[257],"Several":[258],"potential":[259,313],"therapeutics":[260],"been":[263],"identified":[264],"enhance":[266],"stability":[268,308],"persistence/expansion":[270],"target":[274],"specific":[275],"pathways,":[276],"DNA/histone":[278],"methylation":[279],"status,":[280],"TCR/co-stimulation":[281],"IL-2/STAT5":[284],"signaling.":[285],"Finally,":[286],"this":[287],"discuss":[290],"improvements":[291],"related":[295],"source,":[298],"subsets,":[300],"therapeutic":[301],"increase":[304],"suppression":[306],"during":[309],"storing":[315],"large":[316],"numbers":[317],"from":[320],"single":[322],"run":[324],"be":[326],"used":[327],"an":[329],"off-the-shelf":[330],"product":[332],"capable":[333],"treating":[335],"multiple":[336],"recipients.":[337]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-28T00:00:00"}
