{"id":"https://openalex.org/W4288064247","doi":null,"title":"Role of prostate stem cells and treatment strategies in benign prostate hyperplasia.","display_name":"Role of prostate stem cells and treatment strategies in benign prostate hyperplasia.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4288064247","pmid":"https://pubmed.ncbi.nlm.nih.gov/35874288","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9301063"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9301063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9301063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9301063","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026058598","display_name":"Kalyan J. Gangavarapu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalyan J Gangavarapu","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055485710","display_name":"Peter Jowdy","orcid":"https://orcid.org/0000-0003-4489-0976","observed_orcids":["https://orcid.org/0000-0003-4489-0976"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter F Jowdy","raw_affiliation_strings":["Department of Dermatology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA","Jacobs School of Medicine and Biomedical Sciences, University at Buffalo Buffalo, NY 14203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Jacobs School of Medicine and Biomedical Sciences, University at Buffalo Buffalo, NY 14203, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001441690","display_name":"Barbara A. Foster","orcid":"https://orcid.org/0000-0003-0459-7011","observed_orcids":["https://orcid.org/0000-0003-0459-7011"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara A Foster","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067861660","display_name":"Wendy J. Huss","orcid":"https://orcid.org/0000-0002-0812-8696","observed_orcids":["https://orcid.org/0000-0002-0812-8696"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy J Huss","raw_affiliation_strings":["Department of Dermatology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA","Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9989,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.85112504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"3","first_page":"154","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prostate-stem-cells","display_name":"prostate stem cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lower-urinary-tract-symptoms","display_name":"lower urinary tract symptoms","score":0.8510000109672546},{"id":"https://openalex.org/keywords/prostate-development","display_name":"prostate development","score":0.7049999833106995},{"id":"https://openalex.org/keywords/stem-cell-targeted-therapy","display_name":"stem cell-targeted therapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/treatment-side-effects","display_name":"treatment side effects","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.8037810921669006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7044346332550049},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.6966280937194824},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6935323476791382},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.6486161351203918},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6198639273643494},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.420745313167572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28221166133880615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11624667048454285},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:9301063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9301063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},{"id":"pmid:35874288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35874288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical and experimental urology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9301063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9301063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W38078248","https://openalex.org/W52512388","https://openalex.org/W93756624","https://openalex.org/W158180555","https://openalex.org/W161126637","https://openalex.org/W198934061","https://openalex.org/W205075771","https://openalex.org/W1491869245","https://openalex.org/W1687391854","https://openalex.org/W1722430236","https://openalex.org/W1933041105","https://openalex.org/W1963980491","https://openalex.org/W1968840300","https://openalex.org/W1969755299","https://openalex.org/W1970318111","https://openalex.org/W1977180230","https://openalex.org/W1977456450","https://openalex.org/W1979398376","https://openalex.org/W1980112752","https://openalex.org/W1980796821","https://openalex.org/W1984935646","https://openalex.org/W1987146157","https://openalex.org/W1989245520","https://openalex.org/W1991390275","https://openalex.org/W1992103956","https://openalex.org/W1994048261","https://openalex.org/W1994262469","https://openalex.org/W1995142571","https://openalex.org/W1995647489","https://openalex.org/W1998001353","https://openalex.org/W2002518605","https://openalex.org/W2003733247","https://openalex.org/W2005010706","https://openalex.org/W2005232533","https://openalex.org/W2005274657","https://openalex.org/W2006038635","https://openalex.org/W2006991648","https://openalex.org/W2009990191","https://openalex.org/W2010013468","https://openalex.org/W2010559663","https://openalex.org/W2014308187","https://openalex.org/W2015201969","https://openalex.org/W2016264010","https://openalex.org/W2019544029","https://openalex.org/W2021423217","https://openalex.org/W2023507149","https://openalex.org/W2024858033","https://openalex.org/W2027820660","https://openalex.org/W2029280248","https://openalex.org/W2029808948","https://openalex.org/W2031300004","https://openalex.org/W2034492715","https://openalex.org/W2034831129","https://openalex.org/W2035104343","https://openalex.org/W2038261670","https://openalex.org/W2038693293","https://openalex.org/W2044900847","https://openalex.org/W2045278381","https://openalex.org/W2047918294","https://openalex.org/W2051131004","https://openalex.org/W2053135991","https://openalex.org/W2058203708","https://openalex.org/W2058712340","https://openalex.org/W2059089773","https://openalex.org/W2059480246","https://openalex.org/W2060284451","https://openalex.org/W2061362924","https://openalex.org/W2062755781","https://openalex.org/W2063110843","https://openalex.org/W2064589748","https://openalex.org/W2064844805","https://openalex.org/W2064988924","https://openalex.org/W2066051121","https://openalex.org/W2069432968","https://openalex.org/W2069590452","https://openalex.org/W2080492299","https://openalex.org/W2081725277","https://openalex.org/W2084816867","https://openalex.org/W2087186578","https://openalex.org/W2087943951","https://openalex.org/W2092585267","https://openalex.org/W2094475675","https://openalex.org/W2094955435","https://openalex.org/W2095037241","https://openalex.org/W2099876620","https://openalex.org/W2104447909","https://openalex.org/W2105669626","https://openalex.org/W2106930684","https://openalex.org/W2106998820","https://openalex.org/W2109193598","https://openalex.org/W2111642061","https://openalex.org/W2114891019","https://openalex.org/W2115444343","https://openalex.org/W2119823198","https://openalex.org/W2121302487","https://openalex.org/W2121759271","https://openalex.org/W2121991468","https://openalex.org/W2126039417","https://openalex.org/W2129509993","https://openalex.org/W2131915710","https://openalex.org/W2133271484","https://openalex.org/W2135389629","https://openalex.org/W2143253449","https://openalex.org/W2144490947","https://openalex.org/W2144881953","https://openalex.org/W2149464366","https://openalex.org/W2152801513","https://openalex.org/W2153000202","https://openalex.org/W2160053067","https://openalex.org/W2161497959","https://openalex.org/W2323868208","https://openalex.org/W2331302678","https://openalex.org/W2333783097","https://openalex.org/W2333983707","https://openalex.org/W2334096923","https://openalex.org/W2396961956","https://openalex.org/W2404866767","https://openalex.org/W2416107013","https://openalex.org/W2464606777","https://openalex.org/W2468111280","https://openalex.org/W2554565213","https://openalex.org/W2891334368","https://openalex.org/W2917260283","https://openalex.org/W2943309477","https://openalex.org/W2946686871","https://openalex.org/W2964673115","https://openalex.org/W2966060845","https://openalex.org/W2998735788","https://openalex.org/W3004876731","https://openalex.org/W3030460230","https://openalex.org/W3084261092","https://openalex.org/W3084449635","https://openalex.org/W3088177554","https://openalex.org/W3119708221","https://openalex.org/W3179442655","https://openalex.org/W3188825894","https://openalex.org/W3190109435","https://openalex.org/W3195632253"],"related_works":["https://openalex.org/W2034492715","https://openalex.org/W7096041008","https://openalex.org/W2161497959","https://openalex.org/W2049146620","https://openalex.org/W2327765256","https://openalex.org/W2006991648","https://openalex.org/W2400381927","https://openalex.org/W2382232484","https://openalex.org/W3084261092","https://openalex.org/W2059949517"],"abstract_inverted_index":{"Benign":[0],"prostate":[1,52,62,133,173],"hyperplasia":[2],"(BPH)":[3],"is":[4,65,75,119,164],"a":[5,9],"progressive":[6],"disease":[7],"with":[8],"direct":[10],"correlation":[11],"between":[12],"incidence":[13],"and":[14,19,27,45,73,107,129,154,175,200,211],"age.":[15],"Since":[16],"the":[17,33,35,68,71,101,105,111,113,123,132,145,151,161,170,176,186,189,213,216],"treatment":[18],"management":[20],"of":[21,30,38,70,84,104,110,116,122,131,147,156,160,172,178,203,215],"BPH":[22,64,74,127,137,199],"involve":[23],"harmful":[24],"side":[25,209],"effects":[26,210],"decreased":[28],"quality":[29],"life":[31],"for":[32,126,136,144,188],"patient,":[34],"primary":[36],"focus":[37],"research":[39],"should":[40],"be":[41,58],"to":[42,60,92,165,198],"find":[43],"better":[44],"longer-lasting":[46],"therapeutic":[47,201],"options.":[48],"The":[49,158],"mechanisms":[50],"regulating":[51],"stem":[53,117,148,179,193,204],"cells":[54,118,149,180,205],"in":[55,100,150,181],"development":[56,174],"can":[57,196],"exploited":[59],"decrease":[61],"growth.":[63],"defined":[66],"as":[67],"overgrowth":[69],"prostate,":[72,112],"often":[76],"diagnosed":[77],"when":[78],"lower":[79],"urinary":[80],"tract":[81],"symptoms":[82,89],"(LUTS)":[83],"urine":[85],"storage":[86],"or":[87],"voiding":[88],"cause":[90],"patients":[91],"seek":[93],"treatment.":[94],"While":[95],"multiple":[96],"factors":[97],"are":[98],"involved":[99],"hyperplastic":[102],"growth":[103],"stromal":[106],"epithelial":[108],"compartments":[109],"clonal":[114],"proliferation":[115],"considered":[120],"one":[121],"main":[124],"reasons":[125,143],"initiation":[128],"regrowth":[130,214],"after":[134],"therapies":[135],"fail.":[138],"Several":[139],"theories":[140],"explain":[141],"possible":[142],"involvement":[146],"development,":[152],"progression,":[153],"pathogenesis":[155],"BPH.":[157,182],"aim":[159],"current":[162,167],"review":[163,184],"discuss":[166],"literature":[168],"on":[169],"fundamentals":[171],"role":[177],"This":[183],"examines":[185],"rationale":[187],"hypothesis":[190],"that":[191],"unregulated":[192],"cell":[194],"properties":[195],"lead":[197],"targeting":[202],"may":[206],"reduce":[207],"treatment-related":[208],"prevent":[212],"prostate.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-07-28T00:00:00"}