{"id":"https://openalex.org/W4288062893","doi":"https://doi.org/10.1063/5.0093972","title":"Overexpression of mCAT1 on human heterogenic cell lines for EcoHIV infection","display_name":"Overexpression of mCAT1 on human heterogenic cell lines for EcoHIV infection","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4288062893","doi":"https://doi.org/10.1063/5.0093972"},"language":"en","primary_location":{"id":"doi:10.1063/5.0093972","doi":"https://doi.org/10.1063/5.0093972","is_oa":false,"landing_page_url":"https://doi.org/10.1063/5.0093972","pdf_url":null,"source":{"id":"https://openalex.org/S2764696622","display_name":"AIP conference proceedings","issn_l":"0094-243X","issn":["0094-243X","1551-7616","1935-0465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIP Conference Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084244882","display_name":"Hao Hu","orcid":"https://orcid.org/0000-0003-4796-9882","observed_orcids":["https://orcid.org/0000-0003-4796-9882"]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Hu","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434467","display_name":"Jiahao Chen","orcid":"https://orcid.org/0000-0001-7719-3216","observed_orcids":["https://orcid.org/0000-0001-7719-3216","https://orcid.org/0009-0002-1015-3273"]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahao Chen","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083606232","display_name":"Mengdan Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengdan Song","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067981474","display_name":"Qiying Yu","orcid":"https://orcid.org/0009-0008-8245-3914","observed_orcids":["https://orcid.org/0009-0008-8245-3914"]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiying Yu","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108751578","display_name":"Yan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Ma","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049176642","display_name":"Zhihong Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihong Song","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063129736","display_name":"Haifei Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haifei Shang","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xuejiao Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejiao Xia","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110175294","display_name":"Chaojiang Gu","orcid":"https://orcid.org/0009-0002-6835-000X","observed_orcids":["https://orcid.org/0009-0002-6835-000X"]},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chaojiang Gu","raw_affiliation_strings":["College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, 430000, China","institution_ids":["https://openalex.org/I43922553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110175294"],"corresponding_institution_ids":["https://openalex.org/I43922553"],"apc_list":null,"apc_paid":null,"fwci":0.4146,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.82178218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2511","issue":null,"first_page":"020009","last_page":"020009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cat1","display_name":"CAT1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ecotropic-murine-leukemia-virus","display_name":"ecotropic murine leukemia virus","score":0.8970000147819519},{"id":"https://openalex.org/keywords/gp80","display_name":"gp80","score":0.5329999923706055},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.6389999985694885},{"id":"https://openalex.org/keywords/human-cell-lines","display_name":"human cell lines","score":0.6880000233650208},{"id":"https://openalex.org/keywords/hiv-1-infection-model","display_name":"HIV-1 infection model","score":0.7110000252723694},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.8137237429618835},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7342799305915833},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6676335334777832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5903586149215698},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5340086221694946},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4596838653087616},{"id":"https://openalex.org/C2779562191","wikidata":"https://www.wikidata.org/wiki/Q673848","display_name":"Murine leukemia virus","level":3,"score":0.44014424085617065},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4348791539669037},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.41549697518348694},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15804585814476013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0705682635307312}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1063/5.0093972","doi":"https://doi.org/10.1063/5.0093972","is_oa":false,"landing_page_url":"https://doi.org/10.1063/5.0093972","pdf_url":null,"source":{"id":"https://openalex.org/S2764696622","display_name":"AIP conference proceedings","issn_l":"0094-243X","issn":["0094-243X","1551-7616","1935-0465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIP Conference Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1581359237","https://openalex.org/W1931238275","https://openalex.org/W1981636515","https://openalex.org/W1984948609","https://openalex.org/W1985667653","https://openalex.org/W2020972755","https://openalex.org/W2023595420","https://openalex.org/W2028272667","https://openalex.org/W2062274686","https://openalex.org/W2133968571","https://openalex.org/W2334860476","https://openalex.org/W2577654108","https://openalex.org/W2598118151","https://openalex.org/W2806117049","https://openalex.org/W2898368813","https://openalex.org/W2981626399"],"related_works":["https://openalex.org/W2133968571","https://openalex.org/W7163566086","https://openalex.org/W1998314027","https://openalex.org/W2040459906","https://openalex.org/W2127394526","https://openalex.org/W4210900723","https://openalex.org/W4415376987","https://openalex.org/W2091869250","https://openalex.org/W2098746214","https://openalex.org/W4367279144"],"abstract_inverted_index":{"Infection":[0],"of":[1,13,29,54,93,102,113],"conventional":[2],"mice":[3],"with":[4,35],"chimeric":[5],"HIV-1,":[6],"EcoHIV,":[7],"have":[8],"been":[9],"used":[10],"for":[11,69,108],"study":[12,112],"systemic":[14],"HIV-1":[15,34,103],"infection,":[16],"antiviral":[17],"immune":[18],"responses":[19],"and":[20,86,110],"neuroinvasiveness.":[21],"Chimeric":[22],"virus":[23,44],"EcoHIV":[24,52,91],"was":[25,72,84],"constructed":[26],"by":[27,89],"replacement":[28],"the":[30,36,100],"gp120":[31],"region":[32],"in":[33,75,105],"envelope":[37],"gene":[38],"gp80":[39],"from":[40],"ecotropic":[41,70],"murine":[42],"leukemia":[43],"(MLV)":[45],"that":[46],"infects":[47],"only":[48],"rodent":[49],"cells.":[50],"For":[51],"infection":[53,92,104],"human":[55,94,106],"cell":[56,77,82,96],"lines,":[57],"mouse":[58],"high":[59],"affinity":[60],"cationic":[61],"amine":[62],"acid":[63],"transporter":[64],"1,":[65],"mCAT1,":[66],"a":[67],"receptor":[68],"MLV,":[71],"stably":[73],"expressed":[74],"Hela":[76],"line.":[78],"The":[79],"resulting":[80],"Hela-mCAT1":[81],"line":[83],"successfully":[85],"efficiently":[87],"infected":[88],"EcoHIV.":[90],"heterogenic":[95],"lines":[97],"greatly":[98],"recapitulate":[99],"characteristics":[101],"beings":[107],"convenient":[109],"safe":[111],"HIV-1IAIDS.":[114]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-07-28T00:00:00"}
