{"id":"https://openalex.org/W4288051832","doi":"https://doi.org/10.1093/clinchem/hvac100","title":"Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection","display_name":"Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection","publication_year":2022,"publication_date":"2022-07-27","ids":{"openalex":"https://openalex.org/W4288051832","doi":"https://doi.org/10.1093/clinchem/hvac100","pmid":"https://pubmed.ncbi.nlm.nih.gov/35896175","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9384580"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/hvac100","doi":"https://doi.org/10.1093/clinchem/hvac100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/clinchem/hvac100","pdf_url":"https://academic.oup.com/clinchem/article-pdf/68/8/1015/45108285/hvac100.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/clinchem/article-pdf/68/8/1015/45108285/hvac100.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037819778","display_name":"Anda Bularga","orcid":"https://orcid.org/0000-0002-5530-527X","observed_orcids":["https://orcid.org/0000-0002-5530-527X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anda Bularga","raw_affiliation_strings":["BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK"],"raw_orcid":"https://orcid.org/0000-0002-5530-527X","affiliations":[{"raw_affiliation_string":"BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021189874","display_name":"Ellen Oskoui","orcid":"https://orcid.org/0000-0002-2835-5431","observed_orcids":["https://orcid.org/0000-0002-2835-5431"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ellen Oskoui","raw_affiliation_strings":["BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK","School of Biological Sciences, University of Edinburgh , Edinburgh , UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071319436","display_name":"Takeshi Fujisawa","orcid":"https://orcid.org/0000-0002-6627-3218","observed_orcids":["https://orcid.org/0000-0002-6627-3218"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Takeshi Fujisawa","raw_affiliation_strings":["BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004283840","display_name":"Sara J. Jenks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sara Jenks","raw_affiliation_strings":["Department Clinical Biochemistry, Royal Infirmary of Edinburgh , Edinburgh , UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Clinical Biochemistry, Royal Infirmary of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I2802789809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109582327","display_name":"Rachel Sutherland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rachel Sutherland","raw_affiliation_strings":["Department of Acute Medicine, Royal Infirmary of Edinburgh , Edinburgh , UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Acute Medicine, Royal Infirmary of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I2802789809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068500647","display_name":"Fred S. Apple","orcid":"https://orcid.org/0000-0002-5920-6498","observed_orcids":["https://orcid.org/0000-0002-5920-6498"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred S Apple","raw_affiliation_strings":["Departments of Laboratory Medicine and Pathology, Hennepin Healthcare/Hennepin County Medical Center and University of Minnesota , Minneapolis, MN , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Laboratory Medicine and Pathology, Hennepin Healthcare/Hennepin County Medical Center and University of Minnesota , Minneapolis, MN , USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2802288015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002643791","display_name":"Ola Hammarsten","orcid":"https://orcid.org/0000-0002-0772-6934","observed_orcids":["https://orcid.org/0000-0002-0772-6934"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ola Hammarsten","raw_affiliation_strings":["Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031579667","display_name":"Nicholas L. Mills","orcid":"https://orcid.org/0000-0003-0533-7991","observed_orcids":["https://orcid.org/0000-0003-0533-7991"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nicholas L Mills","raw_affiliation_strings":["BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK","Usher Institute, University of Edinburgh , Edinburgh , UK"],"raw_orcid":"https://orcid.org/0000-0003-0533-7991","affiliations":[{"raw_affiliation_string":"BHF Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Usher Institute, University of Edinburgh , Edinburgh , UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031579667"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":4088,"currency":"USD","value_usd":4088},"apc_paid":{"value":4088,"currency":"USD","value_usd":4088},"fwci":2.5812,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.91507996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"68","issue":"8","first_page":"1015","last_page":"1019"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.4749000072479248,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.4749000072479248,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.19179999828338623,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.15369999408721924,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-troponin-elevation","display_name":"cardiac troponin elevation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mrna-1273-vaccine","display_name":"mRNA-1273 vaccine","score":0.8820000290870667},{"id":"https://openalex.org/keywords/covid-19-infection","display_name":"COVID-19 infection","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chest-pain","display_name":"chest pain","score":0.8880000114440918},{"id":"https://openalex.org/keywords/high-sensitivity-cardiac-troponin","display_name":"high-sensitivity troponin","score":0.7699999809265137},{"id":"https://openalex.org/keywords/troponin-i","display_name":"troponin I","score":0.675000011920929},{"id":"https://openalex.org/keywords/troponin-t","display_name":"troponin T","score":0.984000027179718},{"id":"https://openalex.org/keywords/vaccine-adverse-events","display_name":"vaccine adverse events","score":0.4480000138282776},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.4819999933242798},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.4259999990463257},{"id":"https://openalex.org/keywords/differential-diagnosis-of-chest-pain","display_name":"differential diagnosis of chest pain","score":0.6269999742507935},{"id":"https://openalex.org/keywords/pericarditis","display_name":"pericarditis","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.740929126739502},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5773196816444397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5692863464355469},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5666923522949219},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5010597705841064},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4845549166202545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4431527853012085},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4431031048297882},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.4398709535598755},{"id":"https://openalex.org/C2909376813","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus Infections","level":5,"score":0.4203885793685913},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.1479804515838623},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.05914032459259033},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0538826584815979},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/clinchem/hvac100","doi":"https://doi.org/10.1093/clinchem/hvac100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/clinchem/hvac100","pdf_url":"https://academic.oup.com/clinchem/article-pdf/68/8/1015/45108285/hvac100.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9384580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9384580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Chem","raw_type":"Text"},{"id":"pmid:35896175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35896175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/04131101-eebc-4631-ab13-5dfcc20285bc","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/04131101-eebc-4631-ab13-5dfcc20285bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bularga, A, Oskoui, E, Fujisawa, T, Jenks, S, Sutherland, R, Apple, F S, Hammarsten, O & Mills, N L 2022, 'Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection', Clinical Chemistry. https://doi.org/10.1093/clinchem/hvac100","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/clinchem/hvac100","doi":"https://doi.org/10.1093/clinchem/hvac100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/clinchem/hvac100","pdf_url":"https://academic.oup.com/clinchem/article-pdf/68/8/1015/45108285/hvac100.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G1514617731","display_name":"High-sensitivity cardiac troponin beyond the acute coronary syndrome","funder_award_id":"RG/20/10/34966","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G5460676972","display_name":null,"funder_award_id":"CH /F/21/90010","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G8650315615","display_name":"Machine learning and the diagnosis of myocardial infarction","funder_award_id":"MR/V007254/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8893448215","display_name":"Research Excellence (round 3)","funder_award_id":"RE/18/5/34216","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288051832.pdf","grobid_xml":"https://content.openalex.org/works/W4288051832.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W22359002","https://openalex.org/W2078712489","https://openalex.org/W2097934944","https://openalex.org/W2140921081","https://openalex.org/W2339724352","https://openalex.org/W3004717788","https://openalex.org/W3083908457","https://openalex.org/W3126729284","https://openalex.org/W4200420340","https://openalex.org/W4225736913"],"related_works":["https://openalex.org/W4288051682","https://openalex.org/W4309533804","https://openalex.org/W7122748357","https://openalex.org/W4316081177","https://openalex.org/W3201015887","https://openalex.org/W3118645514","https://openalex.org/W4413597473","https://openalex.org/W3201276296","https://openalex.org/W4229029628","https://openalex.org/W7139991773"],"abstract_inverted_index":{"Patient":[0,76,143,418,505,789,844,865],"1":[1,402,501,776,790,1197,1583],"was":[2,74,78,133,141,145,166,199,206,220,232,308,443,483,614,711,755,867,1051,1149],"a":[3,10,34,79,99,114,120,128,146,155,192,427,459,473,486,551,579,595,648,690,734,744,758,770,1124,1346,1368,1484,1880,1896,1904],"28-year-old":[4],"Caucasian":[5,81,148],"woman":[6],"who":[7,83,150],"presented":[8,84],"with":[9,52,85,310,331,348,412,472,516,550,689,713,733,757,814,819,906,966,999,1058,1131,1245,1359,1372,1399,1498,1591,1594],"4-day":[11],"history":[12,69,129,193],"of":[13,37,102,117,130,194,244,268,329,339,346,356,363,426,493,512,520,598,612,625,631,639,642,651,659,668,692,696,736,772,879,896,927,936,982,995,1003,1006,1013,1016,1030,1043,1073,1135,1152,1179,1230,1247,1255,1263,1266,1287,1300,1327,1336,1349,1409,1486,1514,1543,1551,1568,1603,1634,1645,1681,1700,1706,1720,1733,1746,1749,1800,1827,1833,1861,1929],"chest":[14,61,86,118,177,809,880,1031],"pain":[15,87,817,881,1032],"to":[16,88,110,182,251,535,618,634,686,720,730,766,784,1081,1109,1165,1224,1312,1319,1443,1468,1522,1608,1677,1694,1727,1741,1803,1835],"the":[17,24,38,89,103,183,235,306,337,354,517,590,636,640,656,670,673,752,836,871,913,932,980,993,1011,1024,1028,1049,1054,1068,1071,1132,1177,1253,1264,1278,1288,1298,1316,1334,1388,1400,1405,1410,1515,1541,1549,1566,1635,1642,1678,1687,1695,1712,1721,1734,1742,1750,1763,1788,1801,1811,1819,1887,1910,1923],"same":[18],"day":[19],"emergency":[20],"care":[21],"unit":[22],"at":[23,208,294,453,828,839,857,889,1445],"Western":[25],"General":[26],"Hospital,":[27,92,186],"Edinburgh,":[28],"Scotland.":[29],"The":[30,63,95,125,189,196,242,266,608,816,1325,1363,1420,1451,1927],"patient":[31,64,96,126,190,373,381,392,446,456,462,678,699,742,1537,1669],"had":[32,65,97,127,151,191,420,463,507,800,863],"received":[33,98,1932,1945],"second":[35,100],"dose":[36,101],"mRNA-1273":[39,104,1034,1320],"(Moderna)":[40,105],"vaccine":[41,106,975,1035,1293,1651],"for":[42,246,270,324,372,380,391,499,527,792,847,919,969,976,1192,1204,1354,1425,1432,1517,1553,1621,1637,1665,1714,1730,1790,1810,1846],"COVID-19":[43,152,173,340,357,902,937,1038,1180,1292,1323,1360,1364,1506,1609,1614,1650],"five":[44],"days":[45,122],"previously.":[46],"After":[47],"vaccination,":[48,1509],"she":[49,59,806],"felt":[50],"unwell":[51],"fever":[53],"and":[54,70,163,165,216,230,254,262,282,299,369,377,383,387,403,410,423,435,476,496,502,672,708,723,747,769,777,802,850,874,904,915,943,1009,1033,1053,1060,1097,1158,1218,1277,1297,1343,1377,1380,1387,1483,1501,1587,1619,1668,1684,1697,1704,1724,1755,1759,1784,1853,1864,1903,1922,1937],"dry":[55],"cough.":[56],"Shortly":[57],"after,":[58],"developed":[60,176],"pain.":[62],"no":[66,311,413,876,925,1831],"background":[67],"medical":[68],"her":[71],"clinical":[72,139,197,1041,1279,1574,1628,1643],"examination":[73,140,198],"unremarkable.":[75],"2":[77,419,434,506,845,1357],"29-year-old":[80],"man":[82,149],"Sahlgrenska":[90,184],"University":[91,185,1928],"Gothenburg,":[93,187],"Sweden.":[94,188],"3":[107,144,211,273,288,393,436,866,1341],"weeks":[108,170,795],"prior":[109],"admission.":[111,797],"He":[112,159],"described":[113,807,1170],"similar":[115,1347],"episode":[116],"discomfort":[119],"few":[121],"after":[123,796,971],"vaccination.":[124,343,360,1184],"asthma":[131],"but":[132,305,448,831,884,1174,1429],"not":[134,946,1066,1175,1472],"receiving":[135],"regular":[136],"medication.":[137],"His":[138],"normal.":[142,200],"19-year-old":[147],"confirmed":[153,172,1673],"using":[154,485,544,583,616,1351],"reverse":[156],"transcription-PCR":[157],"test.":[158],"experienced":[160],"mild":[161],"breathlessness":[162],"headache":[164],"generally":[167],"unwell.":[168],"Six":[169],"following":[171,694,901,1183,1505,1688],"infection,":[174],"he":[175],"pain,":[178],"which":[179,442,467,489],"prompted":[180],"admission":[181],"asthma.":[195],"High-sensitivity":[201],"cardiac":[202,332,349,408,438,1061,1102,1256,1493,1503,1622,1657,1950],"troponin":[203,333,350],"(hs-cTn)":[204],"testing":[205,856,1552,1667],"performed":[207,1626,1767],"presentation,":[209,304],"repeated":[210],"or":[212,226,313,342,359,415,532,540,569,882,1000,1036,1085,1094,1182,1233,1281,1295,1322,1508,1557,1598,1611,1648,1652,1656,1702,1710,1744],"6":[213,731,794],"h":[214],"later,":[215],"on":[217,222,234,303,589,803,854,992,1056,1090,1101,1117,1530,1858,1949],"follow-up.":[218],"hs-cTnI":[219,247,290,364,518,680,707,714,753,761,824,851,885,1146,1157,1452],"measured":[221,233],"Abbott":[223,227,1847,1873,1935,1958,1960],"ARCHITECTSTAT":[224],"(i2000)":[225],"Alinity":[228],"(ci),":[229],"hs-cTnT":[231,271,487,510,709,724,779,832,1153,1159,1240],"Roche":[236,1849,1967],"Diagnostics":[237,1936],"Elecsys":[238],"(Cobas":[239],"e801)":[240],"platforms.":[241],"limit":[243,267],"detection":[245,269,994,1299],"ranges":[248],"from":[249,683,717,727,762,1488,1886,1909,1934,1957],"1.2":[250],"1.9":[252],"ng/L,":[253,296,298,514,688,722,732,830,859],"sex-specific":[255,275],"99th":[256,276],"percentiles":[257,277],"are":[258,278,922,1540,1588,1752,1808,1830],"16":[259,283],"ng/L":[260,264,280,284,302,368,371,376,379,386,390,495,498,522,685,719,729,765,768,841],"(females)":[261,281],"34":[263],"(males).":[265,285],"is":[272,587,605,662,941,945,990,1075,1186,1272,1330,1413,1422,1439,1548,1562,1624,1877,1893,1916],"ng/L,and":[274],"9":[279],"In":[286,600,698,774,987,1020,1236,1285],"all":[287,325,1047,1340,1731,1816],"patients,":[289,1048],"concentrations":[291,365,681,780,825,833,886,1114,1129,1241,1276,1308],"were":[292,366,542,781,812,826,834,929,1107,1115],"increased":[293,509,827,853,888,997,1306,1373,1417],"31":[295],"750":[297],"280":[300,384],"000":[301,385,389,764,891],"electrocardiogram":[307,1050],"normal,":[309],"ST-segment":[312],"T-wave":[314],"abnormalities":[315],"(Table":[316,394,523,842],"1).":[317,395,524,843],"Admission":[318],"laboratory":[319],"investigations":[320],"identified":[321,468,756],"normal":[322,407,444,491],"hematology":[323],"patients.":[326],"Clinical":[327,344,1839,1881],"characteristics":[328,345],"patients":[330,347,397,401,500,775,1200,1342,1358,1497,1586],"assay":[334,351,754,1205,1523,1545,1560,1569],"interference":[335,352,533,1148,1167,1206,1313,1350,1561,1570,1640],"in":[336,353,445,455,578,594,738,760,870,909,931,1046,1128,1141,1171,1176,1195,1198,1222,1228,1239,1249,1252,1339,1356,1397,1404,1416,1447,1461,1480,1573,1581,1584,1627,1641],"context":[338,355,1178],"infection":[341,358,903,1039,1181,1296,1361,1507,1615,1653],"Serial":[361],"measures":[362],"36":[367],"37":[370],"1,":[374,679],"860":[375,521,718],"770":[378],"2,":[382,700],"180":[388,763],"All":[396,1671,1794,1806],"underwent":[398,437],"echocardiography.":[399],"For":[400,677,741],"3,":[404,447,503,743,778],"this":[405,461,939,989,1136,1682],"demonstrated":[406,449,1154],"size":[409],"function":[411],"pericardial":[414],"valve":[416],"disease.":[417],"enlarged":[421,469],"atria":[422],"findings":[424,1055,1140],"suggestive":[425],"restrictive":[428,474],"left":[429],"ventricular":[430,1007],"filling":[431],"pattern.":[432],"Patients":[433],"magnetic":[439,1062,1091],"resonance":[440,1063,1092],"imaging,":[441],"reduced":[450],"ejection":[451],"fraction":[452,675],"54%":[454],"2.":[457],"As":[458,822],"result,":[460],"an":[464,508,701,963,996,1352],"endomyocardial":[465],"biopsy,":[466],"myocytes":[470],"consistent":[471,1130],"cardiomyopathy":[475],"ruled":[477],"out":[478],"myocarditis.":[479,1044,1111],"Stored":[480],"surplus":[481],"sample":[482],"tested":[484],"assay,":[488],"returned":[490,791,846],"values":[492],"4":[494,1689],"8":[497],"respectively.":[504],"concentration":[511],"33":[513,728],"discordant":[515],"value":[519],"To":[525],"test":[526],"immunoglobulin-bound":[528,1554,1595],"cTn":[529,1105,1113,1162,1193,1248,1275,1465,1519,1544,1555,1578,1596,1638],"complexes":[530,1402,1459,1556,1597],"(macrotroponins)":[531],"due":[534,1108,1164,1311,1467,1521],"heterophilic":[536,1212,1592],"antibodies,":[537,1213,1593],"IgG,":[538],"IgA,":[539,1375],"IgM":[541,572,748],"removed":[543],"affinity":[545,565,573,591],"chromatography":[546],"by":[547,787,1010,1315,1333,1345,1879,1895,1918],"treating":[548],"plasma":[549,1374,1418],"protein":[552,641,1386,1412],"G":[553,557],"column":[554,581],"(HiTrap,":[555],"Protein":[556],"HP,":[558],"GE":[559],"Healthcare)":[560],"(1),":[561],"anti-IgA":[562],"(CaptureSelect\u00ae":[563],"IgA":[564],"matrix,":[566,574],"Thermo":[567,575],"Scientific),":[568],"anti-IgM":[570],"(Poros\u00aeCaptureSelect\u00ae":[571],"Scientific)":[576],"resins":[577],"spin":[580],"format":[582],"Bio-Rad":[584],"minicolumn.":[585],"Macrotroponin":[586],"retained":[588],"resin":[592],"resulting":[593,1401,1415,1460],"lower":[596],"recovery":[597,604,691,735,771],"cTn.":[599],"acute":[601,1110,1133,1500,1604,1647],"myocardial":[602,1017,1083],"infarction,":[603],"100%":[606],"(2).":[607,676],"native":[609],"molecular":[610,637,649,657],"weight":[611,638,650,658],"cTnI":[613,646],"analyzed":[615,786],"18%":[617],"42%":[619],"sucrose":[620],"gradient":[621],"ultracentrifugation.":[622,788],"Simultaneous":[623],"centrifugation":[624],"standard":[626],"marker":[627],"proteins":[628,1396],"allows":[629],"estimation":[630],"sedimentation":[632],"coefficients":[633],"determine":[635],"interest":[643,1834],"(3).":[644,1464],"Free":[645],"has":[647,959,1844,1931,1944],"around":[652,663],"20":[653],"kDa":[654,665],"whereas":[655,1120],"macrotroponin":[660,703,749,1216,1337,1469],"complex":[661,704,750,1338,1470],"200":[664],"allowing":[666],"analysis":[667,1703],"both":[669,706,739],"free":[671],"bound":[674,1411],"decreased":[682],"58":[684],"10":[687],"16%":[693],"removal":[695],"IgG.":[697],"IgG":[702,746,1378],"affecting":[705,751],"assays":[710],"detected":[712],"concentrations,":[715,725],"decreasing":[716,726],"5":[721,840],"3%":[737],"cases.":[740],"combined":[745],"decrease":[759],"13":[767],"<1%.":[773],"too":[782],"low":[783],"be":[785,985,1243,1261,1310,1512,1571,1632,1728,1804],"follow-up":[793],"Her":[798],"symptoms":[799,862],"subsided,":[801],"further":[804,877],"questioning,":[805],"recurrent":[808],"pains":[810],"that":[811,948,1188,1305,1738],"associated":[813,905,1244,1590,1654],"movement.":[815],"resolved":[818],"simple":[820],"analgesia.":[821],"previously,":[823],"48":[829],"within":[835],"reference":[837],"interval":[838],"ongoing":[848],"investigations,":[849],"remained":[852,887],"serial":[855,1118],"696":[858],"although":[860],"his":[861],"resolved.":[864,1756],"followed":[868],"up":[869],"ambulatory":[872],"clinic":[873],"reported":[875,900,961,1618],"complaints":[878],"breathlessness,":[883],"93":[890],"ng/L.":[892],"While":[893,1070],"multiple":[894,1395],"cases":[895,926],"myocarditis":[897,928,958,983,1605,1655],"have":[898,1079,1168,1207,1527,1616,1662,1675,1685],"been":[899,960,1169,1208,1617],"mRNA":[907,1365],"vaccination":[908,1234,1321,1610],"young":[910,1144],"adults":[911],"(4),":[912],"cellular":[914],"immune":[916,1317,1370],"mechanisms":[917],"responsible":[918],"these":[920,1139],"observations":[921],"unclear.":[923],"Although":[924],"observed":[930],"randomized,":[933],"placebo-controlled":[934],"trials":[935],"vaccines,":[938,968],"condition":[940],"uncommon,":[942],"it":[944,1438],"surprising":[947],"safety":[949],"concerns":[950],"only":[951],"appeared":[952],"during":[953,1613],"postmarket":[954],"authorization":[955],"surveillance.":[956],"Indeed,":[957],"as":[962,1211,1492,1659],"adverse":[964],"event":[965],"other":[967,1014,1282],"example,":[970],"live":[972],"vaccinia":[973],"virus":[974],"smallpox":[977],"(5).":[978],"Establishing":[979],"diagnosis":[981],"may":[984,1478,1526,1661],"challenging.":[986],"practice,":[988],"based":[991],"cTn,":[998,1433],"without":[1001],"evidence":[1002],"new":[1004],"impairment":[1005],"function,":[1008],"exclusion":[1012],"causes":[1015,1203,1542],"injury":[1018],"(6).":[1019],"our":[1021,1328],"case":[1022],"studies,":[1023],"temporal":[1025,1289],"relationship":[1026],"between":[1027,1156,1274,1291],"onset":[1029],"recent":[1037],"raised":[1040],"suspicion":[1042],"However,":[1045],"unremarkable,":[1052],"imaging":[1057,1064,1093],"echocardiography":[1059,1074],"did":[1065],"support":[1067],"diagnosis.":[1069],"sensitivity":[1072],"limited,":[1076],"one":[1077,1121],"would":[1078,1122],"expected":[1080],"identify":[1082],"edema":[1084],"patchy":[1086],"late":[1087],"gadolinium":[1088],"enhancement":[1089],"lymphocytic":[1095],"infiltration":[1096],"active":[1098],"myocyte":[1099],"necrosis":[1100],"biopsy":[1103],"if":[1104,1270],"increases":[1106,1163,1238,1466,1520],"Furthermore,":[1112],"unchanged":[1116],"measurement":[1119],"expect":[1123],"rise":[1125],"and/or":[1126,1824],"fall":[1127],"nature":[1134],"condition.":[1137],"Given":[1138],"otherwise":[1142],"healthy":[1143],"adults,":[1145],"immunoassay":[1147,1166,1267,1301,1353,1639],"suspected.":[1150],"Measurement":[1151],"discordance":[1155,1273],"concentrations.":[1160,1419],"False-positive":[1161],"many":[1172],"conditions":[1173],"It":[1185],"estimated":[1187],"analytical":[1189],"false":[1190],"positives":[1191],"occur":[1194,1580],"approximately":[1196,1582],"1000":[1199,1585],"(7).":[1201,1235,1450],"Multiple":[1202],"identified,":[1209],"such":[1210,1491],"rheumatoid":[1214],"factor,":[1215],"complex,":[1217],"human":[1219],"antianimal":[1220],"antibodies":[1221,1226,1382,1453],"response":[1223,1318,1371],"monoclonal":[1225,1381],"used":[1227],"production":[1229],"therapeutic":[1231],"agents":[1232],"addition,":[1237],"can":[1242,1393],"reexpression":[1246],"skeletal":[1250],"muscle":[1251],"absence":[1254],"involvement":[1257,1623],"(8).":[1258],"Clinicians":[1259,1630],"should":[1260,1511,1565,1631],"aware":[1262,1513,1633],"possibility":[1265,1567],"interference,":[1268,1302],"particularly":[1269],"there":[1271],"presentation":[1280],"investigation":[1283],"results.":[1284],"view":[1286],"association":[1290],"administration":[1294],"we":[1303],"hypothesize":[1304],"hs-cTn":[1307],"could":[1309],"caused":[1314],"infection.":[1324],"plausibility":[1326],"hypothesis":[1329],"supported":[1331,1878,1894,1917],"directly":[1332],"identification":[1335],"indirectly":[1344],"observation":[1348],"HIV":[1355],"(9).":[1362],"vaccines":[1366],"elicit":[1367],"strong":[1369],"IgM,":[1376],"activity":[1379],"against":[1383],"SARS-CoV-2":[1384],"spike":[1385],"receptor-binding":[1389],"domain":[1390],"(10).":[1391],"Immunoglobulins":[1392],"bind":[1394],"circulation":[1398],"cleared":[1403],"lymphatic":[1406],"system.":[1407],"Clearance":[1408],"delayed":[1414],"phenomenon":[1421],"well":[1423],"known":[1424],"prolactin,":[1426],"called":[1427],"macroprolactin,":[1428],"also":[1430],"occurs":[1431],"especially":[1434],"hs-cTnI,":[1435],"possibly":[1436],"because":[1437],"more":[1440],"immunogenic":[1441],"compared":[1442],"hs-cTnT,":[1444],"least":[1446],"animal":[1448],"models":[1449],"most":[1454],"often":[1455,1589],"form":[1456],"long-lived":[1457],"antibody":[1458],"false-positive":[1462,1518,1577],"results":[1463,1579],"do":[1471],"increase":[1473],"cardiovascular":[1474],"risk;":[1475],"however,":[1476],"they":[1477,1674],"result":[1479],"misdiagnosis,":[1481],"overinvestigation,":[1482],"risk":[1485],"harm":[1487],"invasive":[1489],"procedures,":[1490],"biopsy.":[1494],"When":[1495,1564],"assessing":[1496],"suspected":[1499,1646],"long-term":[1502,1649],"complications":[1504,1658],"clinicians":[1510],"potential":[1516,1636,1825],"interference.":[1524],"This":[1525],"important":[1528,1663,1791],"implications":[1529,1664],"downstream":[1531,1666],"testing,":[1532],"resource":[1533],"utilization,":[1534],"and,":[1535],"importantly,":[1536],"well-being.":[1538,1670],"What":[1539,1547],"interference?":[1546],"process":[1550],"macrotroponins":[1558,1599],"when":[1559],"suspected?":[1563],"considered":[1572],"practice?":[1575],"Analytical":[1576],"increasingly":[1600,1625],"recognized.":[1601],"Episodes":[1602],"temporally":[1606],"related":[1607,1740],"arising":[1612],"screening":[1620],"practice.":[1629],"setting":[1644],"misdiagnosis":[1660],"authors":[1672,1795,1807,1817],"contributed":[1676],"intellectual":[1679,1715,1792],"content":[1680],"paper":[1683],"met":[1686],"requirements:":[1690],"(a)":[1691],"significant":[1692],"contributions":[1693],"conception":[1696],"design,":[1698],"acquisition":[1699],"data,":[1701],"interpretation":[1705],"data;":[1707],"(b)":[1708],"drafting":[1709],"revising":[1711],"article":[1713,1735,1751],"content;":[1716],"(c)":[1717],"final":[1718,1798],"approval":[1719,1799],"published":[1722],"article;":[1723],"(d)":[1725],"agreement":[1726],"accountable":[1729,1809],"aspects":[1732],"thus":[1736],"ensuring":[1737],"questions":[1739],"accuracy":[1743],"integrity":[1745],"any":[1747],"part":[1748],"appropriately":[1753],"investigated":[1754],"A.":[1757,1770,1875],"Bularga":[1758,1876],"N.L.":[1760,1785,1842,1869,1891],"Mills":[1761,1786,1843,1892],"drafted":[1762],"report.":[1764],"O.":[1765,1782,1914],"Hammarsten":[1766,1915],"additional":[1768],"analysis.":[1769],"Bularga,":[1771],"E.":[1772],"Oskoui,":[1773],"T.":[1774],"Fujisawa,":[1775],"S.":[1776],"Jenks,":[1777],"R.":[1778],"Sutherland,":[1779],"F.S.":[1780,1837,1855,1942],"Apple,":[1781,1838],"Hammarsten,":[1783],"revised":[1787],"manuscript":[1789,1814],"content.":[1793],"provided":[1796],"their":[1797],"version":[1802],"published.":[1805],"work.":[1812],"Upon":[1813],"submission,":[1815],"completed":[1818],"author":[1820],"disclosure":[1821],"form.":[1822],"Disclosures":[1823],"conflicts":[1826,1832],"interest:":[1828],"There":[1829],"declare.":[1836],"Chemistry,":[1840],"AACC.":[1841],"consulted":[1845],"Diagnostics,":[1848,1850,1959,1966,1968],"Siemens":[1851,1862,1871,1938,1969],"Healthineers,":[1852,1872],"LumiraDx.":[1854],"Apple":[1856,1943],"served":[1857],"advisory":[1859],"board":[1860],"Healthineers":[1863,1939],"Qorvo":[1865],"Biotechnology.":[1866],"None":[1867,1971,1973],"declared.":[1868,1972,1974],"Mills,":[1870],"Laboratories":[1874],"Research":[1882,1889,1905,1955],"Training":[1883],"Fellowships":[1884],"(MR/V007254/1)":[1885],"Medical":[1888],"Council.":[1890],"Chair":[1897],"Award":[1898,1907],"(CH/F/21/90010),":[1899],"Programme":[1900],"Grant":[1901],"(RG/20/10/34966),":[1902],"Excellent":[1906],"(RE/18/5/34216)":[1908],"British":[1911],"Heart":[1912],"Foundation.":[1913],"Swedish":[1919,1924],"Heart-Lung":[1920],"Foundation":[1921],"Cancer":[1925],"Society.":[1926],"Edinburgh":[1930],"grants":[1933,1947],"(N.L.":[1940],"Mills).":[1941],"research":[1946],"(nonsalaried)":[1948],"biomarkers":[1951],"through":[1952],"Hennepin":[1953],"Healthcare":[1954],"Institute":[1956],"POC,":[1961],"BD,":[1962],"Beckman":[1963],"Coulter,":[1964],"Ortho-Clinical":[1965],"Healthcare.":[1970]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-28T00:00:00"}