{"id":"https://openalex.org/W4288044923","doi":"https://doi.org/10.1097/hjh.0000000000003154","title":"Silent brain infarcts, peripheral vascular disease and the risk of cardiovascular events in patients with hypertension","display_name":"Silent brain infarcts, peripheral vascular disease and the risk of cardiovascular events in patients with hypertension","publication_year":2022,"publication_date":"2022-07-05","ids":{"openalex":"https://openalex.org/W4288044923","doi":"https://doi.org/10.1097/hjh.0000000000003154","pmid":"https://pubmed.ncbi.nlm.nih.gov/35881448"},"language":"en","primary_location":{"id":"doi:10.1097/hjh.0000000000003154","doi":"https://doi.org/10.1097/hjh.0000000000003154","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0000000000003154","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044478173","display_name":"Joan Jim\u00e9nez-Balad\u00f3","orcid":"https://orcid.org/0000-0003-4125-9134","observed_orcids":["https://orcid.org/0000-0003-4125-9134"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Joan Jim\u00e9nez-Balado","raw_affiliation_strings":["Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","institution_ids":["https://openalex.org/I4210102407"]},{"raw_affiliation_string":"Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020124188","display_name":"Iolanda Riba Llena","orcid":"https://orcid.org/0000-0002-7276-0979","observed_orcids":["https://orcid.org/0000-0002-7276-0979"]},"institutions":[{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Iolanda Riba-Llena","raw_affiliation_strings":["Neurovascular Research Lab, Vall d\u2019Hebron Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","institution_ids":["https://openalex.org/I4210102407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090239409","display_name":"Cristina Nafr\u00eda","orcid":"https://orcid.org/0000-0001-9298-9271","observed_orcids":["https://orcid.org/0000-0001-9298-9271"]},"institutions":[{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Nafr\u00eda","raw_affiliation_strings":["Neurovascular Research Lab, Vall d\u2019Hebron Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","institution_ids":["https://openalex.org/I4210102407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017090185","display_name":"Jes\u00fas Pizarro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Pizarro","raw_affiliation_strings":["Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","institution_ids":["https://openalex.org/I4210102407"]},{"raw_affiliation_string":"Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078863380","display_name":"David Rodr\u00edguez\u2010Luna","orcid":"https://orcid.org/0000-0001-8053-4536","observed_orcids":["https://orcid.org/0000-0001-8053-4536"]},"institutions":[{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Rodr\u00edguez-Luna","raw_affiliation_strings":["Stroke Unit. Neurology Department. Hospital and Research Institute Vall d\u2019Hebron"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Unit. Neurology Department. Hospital and Research Institute Vall d\u2019Hebron","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046520236","display_name":"Olga Maisterra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Olga Maisterra","raw_affiliation_strings":["Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","institution_ids":["https://openalex.org/I4210102407"]},{"raw_affiliation_string":"Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089425773","display_name":"Alejandro Ballv\u00e9","orcid":"https://orcid.org/0000-0001-7587-2768","observed_orcids":["https://orcid.org/0000-0001-7587-2768"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Ballv\u00e9","raw_affiliation_strings":["Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074574185","display_name":"Xavier Mundet","orcid":"https://orcid.org/0000-0002-0318-8657","observed_orcids":["https://orcid.org/0000-0002-0318-8657"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210129525","display_name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol","ror":"https://ror.org/0370bpp07","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210129525"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xavier Mundet","raw_affiliation_strings":["Primary Healthcare University Research Institute IDIAP Jordi Gol, Universitat Aut\u00f2noma de Barcelona","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Primary Healthcare University Research Institute IDIAP Jordi Gol, Universitat Aut\u00f2noma de Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210129525"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003252008","display_name":"Concepci\u00f3n Viol\u00e1n","orcid":"https://orcid.org/0000-0003-3309-5360","observed_orcids":["https://orcid.org/0000-0003-3309-5360"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210129525","display_name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol","ror":"https://ror.org/0370bpp07","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210129525"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Concepci\u00f3n Violan","raw_affiliation_strings":["Primary Healthcare University Research Institute IDIAP Jordi Gol, Universitat Aut\u00f2noma de Barcelona","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Primary Healthcare University Research Institute IDIAP Jordi Gol, Universitat Aut\u00f2noma de Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210129525"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Oriol Ventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Oriol Ventura","raw_affiliation_strings":["Neurovascular Research Lab, Vall d\u2019Hebron Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","institution_ids":["https://openalex.org/I4210102407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048009605","display_name":"Joan Montaner","orcid":"https://orcid.org/0000-0003-4845-2279","observed_orcids":["https://orcid.org/0000-0003-4845-2279","https://orcid.org/0000-0001-9796-2422"]},"institutions":[{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joan Montaner","raw_affiliation_strings":["Neurovascular Research Lab, Vall d\u2019Hebron Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","institution_ids":["https://openalex.org/I4210102407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053795176","display_name":"Pilar Delgado","orcid":"https://orcid.org/0000-0002-1628-4488","observed_orcids":["https://orcid.org/0000-0002-1628-4488"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Delgado","raw_affiliation_strings":["Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurovascular Research Lab, Vall d\u2019Hebron Research Institute","institution_ids":["https://openalex.org/I4210102407"]},{"raw_affiliation_string":"Vall d\u2019Hebron University Hospital, Universitat Aut\u00f2noma de Barcelona, Dementia Unit, Neurology Service, Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210127641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020124188","https://openalex.org/A5044478173"],"corresponding_institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210102407","https://openalex.org/I4210127641"],"apc_list":null,"apc_paid":null,"fwci":0.69,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64649655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"40","issue":"8","first_page":"1469","last_page":"1477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.33570000529289246,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silent-cerebral-infarction","display_name":"silent cerebral infarction","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":0.953000009059906},{"id":"https://openalex.org/keywords/peripheral-vascular-disease","display_name":"peripheral vascular disease","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.703000009059906},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.9629999995231628},{"id":"https://openalex.org/keywords/target-organ-damage","display_name":"target organ damage","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ankle-brachial-index","display_name":"ankle-brachial index","score":0.9459999799728394},{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.878000020980835},{"id":"https://openalex.org/keywords/cerebral-microbleeds","display_name":"cerebral microbleeds","score":0.9319999814033508},{"id":"https://openalex.org/keywords/enlarged-perivascular-spaces","display_name":"enlarged perivascular spaces","score":0.9679999947547913},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cardiovascular-risk-stratification","display_name":"cardiovascular risk stratification","score":0.875},{"id":"https://openalex.org/keywords/incident-cardiovascular-events","display_name":"incident cardiovascular events","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.948711633682251},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7206171751022339},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6858317255973816},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6216732263565063},{"id":"https://openalex.org/C2781203188","wikidata":"https://www.wikidata.org/wiki/Q1676817","display_name":"Microalbuminuria","level":3,"score":0.5809643864631653},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5532912611961365},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5425430536270142},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.44916918873786926},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.44062158465385437},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.41560444235801697},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.394264280796051},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2142695188522339},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13465899229049683},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016491","descriptor_name":"Peripheral Vascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020520","descriptor_name":"Brain Infarction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D059345","descriptor_name":"Cerebral Small Vessel Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D059345","descriptor_name":"Cerebral Small Vessel Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D063177","descriptor_name":"Pulse Wave Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/hjh.0000000000003154","doi":"https://doi.org/10.1097/hjh.0000000000003154","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0000000000003154","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:35881448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35881448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1821665499","https://openalex.org/W1822779864","https://openalex.org/W1973420021","https://openalex.org/W1980740386","https://openalex.org/W1992383773","https://openalex.org/W2020175051","https://openalex.org/W2026039330","https://openalex.org/W2041235848","https://openalex.org/W2041506386","https://openalex.org/W2077449266","https://openalex.org/W2085400271","https://openalex.org/W2103699485","https://openalex.org/W2104855192","https://openalex.org/W2106849104","https://openalex.org/W2108329377","https://openalex.org/W2110065044","https://openalex.org/W2112316706","https://openalex.org/W2114586150","https://openalex.org/W2122477279","https://openalex.org/W2142232925","https://openalex.org/W2147684460","https://openalex.org/W2155965977","https://openalex.org/W2158742097","https://openalex.org/W2171078840","https://openalex.org/W2171186547","https://openalex.org/W2279364518","https://openalex.org/W2294863901","https://openalex.org/W2298659923","https://openalex.org/W2414345635","https://openalex.org/W2520700064","https://openalex.org/W2531618711","https://openalex.org/W2566738615","https://openalex.org/W2584146692","https://openalex.org/W2775834309","https://openalex.org/W2783460436","https://openalex.org/W2783505031","https://openalex.org/W2786712777","https://openalex.org/W2794933458","https://openalex.org/W2801464741","https://openalex.org/W2883701292","https://openalex.org/W2888589263","https://openalex.org/W2890102324","https://openalex.org/W2894622017","https://openalex.org/W2921012991","https://openalex.org/W2984766121","https://openalex.org/W3021406499","https://openalex.org/W3023529892","https://openalex.org/W3032896825","https://openalex.org/W3089971081","https://openalex.org/W3161638097","https://openalex.org/W3165052108","https://openalex.org/W4210995510","https://openalex.org/W4239096779","https://openalex.org/W4239987022","https://openalex.org/W4288066324","https://openalex.org/W4293084779","https://openalex.org/W6676550427","https://openalex.org/W6685135036","https://openalex.org/W6807939792"],"related_works":["https://openalex.org/W2969943029","https://openalex.org/W1988404310","https://openalex.org/W3080948592","https://openalex.org/W4220906968","https://openalex.org/W2103699485","https://openalex.org/W2885490951","https://openalex.org/W2077449266","https://openalex.org/W4321116092","https://openalex.org/W2907621925","https://openalex.org/W2027157370"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"We":[3,142,157,171],"aimed":[4],"to":[5,127,166,231],"study":[6,49],"the":[7,25,35,61,64,91,129,135,232,247],"relationship":[8,130],"between":[9,131],"cerebral":[10,100],"small":[11],"vessel":[12],"disease":[13],"(cSVD)":[14],"lesions,":[15],"as":[16],"markers":[17,87],"of":[18,88,137,150,169,206,211,223,228,238],"subclinical":[19],"target":[20],"organ":[21],"damage":[22],"(TOD)":[23],"in":[24,40,51,214,219,251],"brain,":[26],"and":[27,47,58,76,80,102,112,134,189,240],"incident":[28,162,207],"cardiovascular":[29,138,248],"events":[30,139],"(CVE).":[31,140],"METHODS:":[32],"Data":[33],"from":[34,90,107],"ISSYS":[36],"(Investigating":[37],"Silent":[38],"Strokes":[39],"hYpertensives":[41],"Study),":[42],"which":[43,164],"is":[44],"a":[45,69,72,147,167,215],"longitudinal":[46],"observational":[48],"conducted":[50],"patients":[52,160,252],"with":[53,203,225,253],"hypertension":[54],"aged":[55],"50-70":[56],"years,":[57],"stroke-free":[59],"at":[60],"inclusion.":[62],"At":[63],"baseline":[65],"visit,":[66],"participants":[67],"underwent":[68],"clinical":[70,216],"interview,":[71],"brain":[73,92,97],"MRI,":[74],"urine":[75],"blood":[77],"sampling":[78],"collection":[79],"vascular":[81],"testing":[82],"studies.":[83],"Therefore,":[84],"we":[85],"obtained":[86],"TOD":[89],"[white":[93],"matter":[94],"hyperintensities,":[95],"silent":[96],"infarcts":[98],"(SBI),":[99],"microbleeds":[101],"enlarged":[103],"perivascular":[104],"spaces":[105],"(EPVS)],":[106],"kidney":[108],"(microalbuminuria,":[109],"glomerular":[110],"filtration)":[111],"regarding":[113],"large":[114],"vessels":[115],"[ankle-to-brachial":[116],"index":[117],"(ABI),":[118],"carotid-femoral":[119],"pulse":[120],"wave":[121],"velocity].":[122],"Survival":[123],"analyses":[124],"were":[125],"used":[126],"assess":[128],"these":[132],"predictors":[133],"incidence":[136],"RESULTS:":[141],"followed-up":[143],"964":[144],"individuals":[145,224],"within":[146],"median":[148],"time":[149],"5":[151],"years":[152],"(4.7-5),":[153],"representing":[154],"4377.1":[155],"persons-year.":[156],"found":[158,172],"73":[159],"presenting":[161],"CVE,":[163],"corresponds":[165],"rate":[168],"8.2%.":[170],"ABI":[173,241],"less":[174,242],"than":[175,243],"0.9":[176,244],"[hazard":[177],"ratio,":[178,192],"2.2;":[179],"95%":[180,194],"confidence":[181],"interval":[182],"(CI)":[183],"1.17-4.13,":[184],"P":[185,197],"value":[186,198],"=":[187,199],"0.014]":[188],"SBI":[190,239],"(hazard":[191],"2.9;":[193],"CI":[195],"1.47-5.58,":[196],"0.002)":[200],"independently":[201],"associated":[202],"higher":[204],"risk":[205,249],"CVE.":[208],"The":[209],"inclusion":[210],"both":[212],"variables":[213],"model":[217],"resulted":[218],"an":[220],"increased":[221],"discrimination":[222,234],"new":[226],"CVE":[227],"4.72%,":[229],"according":[230],"integrated":[233],"index.":[235],"CONCLUSION:":[236],"Assessment":[237],"may":[245],"refine":[246],"stratification":[250],"hypertension.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-07-27T00:00:00"}