{"id":"https://openalex.org/W4288044241","doi":"https://doi.org/10.1097/wnr.0000000000001817","title":"Blast-related traumatic brain injury is mediated by the kynurenine pathway","display_name":"Blast-related traumatic brain injury is mediated by the kynurenine pathway","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4288044241","doi":"https://doi.org/10.1097/wnr.0000000000001817","pmid":"https://pubmed.ncbi.nlm.nih.gov/35894672"},"language":"en","primary_location":{"id":"doi:10.1097/wnr.0000000000001817","doi":"https://doi.org/10.1097/wnr.0000000000001817","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnr.0000000000001817","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100433418","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0001-8066-7275","observed_orcids":["https://orcid.org/0000-0001-8066-7275"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["The Third Affiliated Hospital of Xinxiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Xinxiang Medical University","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436146","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0003-3870-3388","observed_orcids":["https://orcid.org/0000-0003-3870-3388"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang, Henan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang, Henan Province, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051611503","display_name":"Wenjie Ren","orcid":"https://orcid.org/0000-0003-4711-2352","observed_orcids":["https://orcid.org/0000-0003-4711-2352"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenjie Ren","raw_affiliation_strings":["Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang, Henan Province, China","to Wenjie Ren, PhD, Institute of Brain Trauma, Institutes of Health Central Plains, Xinxiang Medical University, No. 601, Jinsui Avenue, Xinxiang, Henan Province, 453003 China, Tel: +00 86 0373-3831761"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang, Henan Province, China","institution_ids":["https://openalex.org/I80626142"]},{"raw_affiliation_string":"to Wenjie Ren, PhD, Institute of Brain Trauma, Institutes of Health Central Plains, Xinxiang Medical University, No. 601, Jinsui Avenue, Xinxiang, Henan Province, 453003 China, Tel: +00 86 0373-3831761","institution_ids":["https://openalex.org/I80626142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051611503"],"corresponding_institution_ids":["https://openalex.org/I80626142"],"apc_list":null,"apc_paid":null,"fwci":0.9524,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62596401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"33","issue":"13","first_page":"569","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.5199999809265137,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.5199999809265137,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.4262999892234802,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blast-related-traumatic-brain-injury","display_name":"blast-related traumatic brain injury","score":0.996999979019165},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/kynurenine-3-monooxygenase","display_name":"kynurenine 3-monooxygenase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/kynureninase","display_name":"kynureninase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6639999747276306},{"id":"https://openalex.org/keywords/ca1-neurons","display_name":"CA1 neurons","score":0.7149999737739563},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2779026782","wikidata":"https://www.wikidata.org/wiki/Q818165","display_name":"Benserazide","level":5,"score":0.5281507968902588},{"id":"https://openalex.org/C2776710720","wikidata":"https://www.wikidata.org/wiki/Q80417","display_name":"Kynurenine pathway","level":5,"score":0.5044828653335571},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4977305233478546},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.48133525252342224},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.46562522649765015},{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.4505480229854584},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38355088233947754},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37398678064346313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36534613370895386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23269525170326233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19847288727760315},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.17580941319465637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14652034640312195},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14624398946762085},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10621005296707153},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.07057279348373413},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.05167067050933838},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001545","descriptor_name":"Benserazide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050601","descriptor_name":"Kynurenine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/wnr.0000000000001817","doi":"https://doi.org/10.1097/wnr.0000000000001817","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnr.0000000000001817","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},{"id":"pmid:35894672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35894672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1573025925","https://openalex.org/W1630487145","https://openalex.org/W1976643760","https://openalex.org/W2010326184","https://openalex.org/W2014231324","https://openalex.org/W2044390612","https://openalex.org/W2045462497","https://openalex.org/W2047894505","https://openalex.org/W2061749458","https://openalex.org/W2097798721","https://openalex.org/W2100068521","https://openalex.org/W2105985886","https://openalex.org/W2109256081","https://openalex.org/W2416151618","https://openalex.org/W2528828376","https://openalex.org/W2595826119","https://openalex.org/W2884877816","https://openalex.org/W2887743090","https://openalex.org/W2901872708","https://openalex.org/W2912181843","https://openalex.org/W2945451092","https://openalex.org/W2979820907","https://openalex.org/W3007873073","https://openalex.org/W3041286309","https://openalex.org/W3209693130"],"related_works":["https://openalex.org/W4415787490","https://openalex.org/W1573025925","https://openalex.org/W4380085146","https://openalex.org/W2041091334","https://openalex.org/W7171362050","https://openalex.org/W7120363427","https://openalex.org/W4226254569","https://openalex.org/W7220600109","https://openalex.org/W2954406404","https://openalex.org/W4405316390"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,230],"overactivation":[2],"of":[3,11,44,97,104,140,146,155,174,187,210,233,242],"the":[4,7,67,74,94,102,122,138,144,152,156,172,178,185,188,199,208,225,240,243,252,256],"kynurenine":[5,31,52],"pathway,":[6,53],"major":[8],"metabolic":[9],"pathway":[10,32],"tryptophan,":[12],"induced":[13],"by":[14],"inflammation":[15],"and":[16,41,46,82,99,116,121,148,164,194,217,235],"oxidative":[17],"stress,":[18],"might":[19,250],"bring":[20],"about":[21],"excessive":[22],"neurotoxic":[23],"metabolites.":[24],"This":[25],"study":[26],"aimed":[27],"to":[28,65,92],"investigate":[29],"whether":[30,42],"is":[33],"overactivated":[34],"in":[35,51,57,73,151,177,198,224,239],"blast-related":[36],"traumatic":[37],"brain":[38],"injury":[39],"(bTBI)":[40],"inhibitors":[43],"kynureninase":[45,98,117,147,165,236],"kynurenine-3-monooxygenase":[47],"(KMO),":[48],"important":[49],"enzymes":[50],"could":[54,170,220],"alleviate":[55],"bTBI":[56,68,105,189,211,244,253],"rats.":[58],"METHODS:":[59],"A":[60],"shock":[61],"tube":[62],"was":[63,90,126,191,213],"used":[64,91],"establish":[66],"animal":[69],"models.":[70],"Pathological":[71],"changes":[72],"hippocampus":[75,200,241],"were":[76,109,237],"observed":[77],"using":[78,128],"Nissl,":[79],"propidium":[80],"iodide":[81],"TdT-mediated":[83],"dUTP":[84],"Nick-End":[85],"Labeling":[86],"(TUNEL)":[87],"staining.":[88],"Immunohistochemistry":[89],"evaluate":[93],"expression":[95,145,231],"levels":[96,232],"KMO.":[100],"After":[101,135],"establishment":[103],"rat":[106,157],"models,":[107],"they":[108],"treated":[110],"with":[111],"KMO":[112,149,161,234,257],"inhibitor":[113,118,162,166,258],"(Ro":[114],"61-8048)":[115],"(benserazide":[119,167],"hydrochloride),":[120],"animals'":[123],"behavioral":[124],"performance":[125],"assessed":[127],"an":[129],"elevated":[130],"plus":[131],"maze":[132],"(EPM).":[133],"RESULTS:":[134],"blast":[136],"exposure,":[137],"number":[139],"neurons":[141,176,196],"decreased,":[142],"whereas":[143],"increased":[150,238],"CA1":[153,201,227],"area":[154],"hippocampus.":[158,179],"In":[159,180],"vitro,":[160],"(Ro)":[163],"hydrochloride)":[168],"intervention":[169],"reduce":[171],"proportion":[173],"TUNEL-positive":[175],"vivo,":[181],"after":[182],"Ro":[183],"treatment,":[184,207],"behavior":[186,209],"rats":[190,212],"significantly":[192,215],"improved,":[193,216],"more":[195],"survived":[197],"region;":[202],"however,":[203],"following":[204],"benserazide":[205],"hydrochloride":[206],"not":[214,221],"neuron":[218],"survival":[219],"be":[222],"improved":[223],"hippocampal":[226],"region.":[228],"CONCLUSION:":[229],"rats,":[245],"suggesting":[246],"that":[247],"these":[248],"factors":[249],"mediate":[251],"damage.":[254],"Furthermore,":[255],"showed":[259],"a":[260],"significant":[261],"protective":[262],"effect":[263],"on":[264],"bTBI.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-27T00:00:00"}