{"id":"https://openalex.org/W4288036563","doi":"https://doi.org/10.1002/bmc.5456","title":"Simultaneous determination of nirmatrelvir and ritonavir in human plasma using LC\u2013MS/MS and its pharmacokinetic application in healthy Chinese volunteers","display_name":"Simultaneous determination of nirmatrelvir and ritonavir in human plasma using LC\u2013MS/MS and its pharmacokinetic application in healthy Chinese volunteers","publication_year":2022,"publication_date":"2022-07-26","ids":{"openalex":"https://openalex.org/W4288036563","doi":"https://doi.org/10.1002/bmc.5456","pmid":"https://pubmed.ncbi.nlm.nih.gov/35881032"},"language":"en","primary_location":{"id":"doi:10.1002/bmc.5456","doi":"https://doi.org/10.1002/bmc.5456","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.5456","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043035050","display_name":"Chenxi Liu","orcid":"https://orcid.org/0000-0003-0931-5677","observed_orcids":["https://orcid.org/0000-0003-0931-5677"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenxi Liu","raw_affiliation_strings":["China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China"],"raw_orcid":"https://orcid.org/0000-0003-0931-5677","affiliations":[{"raw_affiliation_string":"China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014912973","display_name":"Miqun Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miqun Zhu","raw_affiliation_strings":["China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110809781","display_name":"Liyun Cao","orcid":"https://orcid.org/0000-0001-8539-3453","observed_orcids":["https://orcid.org/0000-0001-8539-3453"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyun Cao","raw_affiliation_strings":["China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control  China","Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control  China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079484535","display_name":"Hamza Boucetta","orcid":"https://orcid.org/0000-0002-5861-4297","observed_orcids":["https://orcid.org/0000-0002-5861-4297"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hamza Boucetta","raw_affiliation_strings":["China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057507401","display_name":"Min Song","orcid":"https://orcid.org/0000-0002-0002-0568","observed_orcids":["https://orcid.org/0000-0002-0002-0568"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Song","raw_affiliation_strings":["China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103193918","display_name":"Taijun Hang","orcid":"https://orcid.org/0000-0002-3057-4705","observed_orcids":["https://orcid.org/0000-0002-3057-4705"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Taijun Hang","raw_affiliation_strings":["China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102840782","display_name":"Yuting Lu","orcid":"https://orcid.org/0000-0002-2770-7300","observed_orcids":["https://orcid.org/0000-0002-2770-7300"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuting Lu","raw_affiliation_strings":["China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Narcotics Control Commission\u2014China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"Department of Pharmaceutical Analysis China Pharmaceutical University  Nanjing China","institution_ids":["https://openalex.org/I161716053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102840782","https://openalex.org/A5103193918"],"corresponding_institution_ids":["https://openalex.org/I161716053"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":3.8032,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.95984302,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"36","issue":"11","first_page":"e5456","last_page":"e5456"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nirmatrelvir","display_name":"nirmatrelvir","score":1.0},{"id":"https://openalex.org/keywords/ritonavir","display_name":"ritonavir","score":1.0},{"id":"https://openalex.org/keywords/nirmatrelvir-ritonavir","display_name":"nirmatrelvir/ritonavir","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7850000262260437},{"id":"https://openalex.org/keywords/human-plasma","display_name":"human plasma","score":0.6880000233650208},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.796999990940094},{"id":"https://openalex.org/keywords/covid-19-antivirals","display_name":"COVID-19 antiviral drugs","score":0.9020000100135803},{"id":"https://openalex.org/keywords/lc-ms-ms-method-validation","display_name":"LC-MS/MS method validation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8446212410926819},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8065694570541382},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8023190498352051},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.7974320650100708},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6322688460350037},{"id":"https://openalex.org/C2777379063","wikidata":"https://www.wikidata.org/wiki/Q161233","display_name":"Formic acid","level":2,"score":0.6287146806716919},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.5198124647140503},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.5170376896858215},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31984999775886536},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.282482773065567},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.10298630595207214},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.08751070499420166},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.06224742531776428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05399778485298157},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.04453650116920471}],"mesh":[{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bmc.5456","doi":"https://doi.org/10.1002/bmc.5456","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.5456","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},{"id":"pmid:35881032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35881032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical chromatography : BMC","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1983757610","https://openalex.org/W2075023376","https://openalex.org/W2142415798","https://openalex.org/W2158934554","https://openalex.org/W2170886596","https://openalex.org/W3000413850","https://openalex.org/W3015252146","https://openalex.org/W3189646261","https://openalex.org/W3196045004","https://openalex.org/W3214271933","https://openalex.org/W4205109497","https://openalex.org/W4205942182","https://openalex.org/W4210513260","https://openalex.org/W4210736465","https://openalex.org/W4212908017","https://openalex.org/W4212949239","https://openalex.org/W4213072928","https://openalex.org/W4214636699","https://openalex.org/W4221009931","https://openalex.org/W4221056874","https://openalex.org/W4225338642"],"related_works":["https://openalex.org/W4306407248","https://openalex.org/W4380904375","https://openalex.org/W4399160406","https://openalex.org/W4387582474","https://openalex.org/W4392756798","https://openalex.org/W4379276111","https://openalex.org/W4403236088","https://openalex.org/W6977133782","https://openalex.org/W4324265084","https://openalex.org/W4403399947"],"abstract_inverted_index":{"Abstract":[0],"Paxlovid,":[1],"a":[2,67],"copackaged":[3],"medication":[4],"of":[5,20,44,121,142,159,167],"nirmatrelvir":[6,45,101,125],"tablets":[7,12],"(150":[8],"mg)":[9,14],"and":[10,46,53,82,102,114,126,155],"ritonavir":[11,47,103],"(100":[13],"developed":[15],"by":[16,106],"Pfizer,":[17],"is":[18],"one":[19],"the":[21,96,119,132,139,165],"first":[22],"orally":[23],"accessible":[24],"COVID\u201019":[25],"antiviral":[26],"medicines":[27],"to":[28],"be":[29],"approved":[30],"for":[31,41,124,129,137],"emergency":[32],"usage.":[33],"In":[34],"this":[35,168],"research,":[36],"an":[37,58],"efficient":[38],"LC\u2013MS/MS":[39],"method":[40,134],"simultaneous":[42],"determination":[43],"in":[48,144],"human":[49],"plasma":[50],"was":[51,135],"established":[52,133],"validated":[54],"with":[55,89,164],"remdesivir":[56],"as":[57,84],"internal":[59],"standard.":[60],"Chromatographic":[61],"separations":[62],"were":[63,104,116],"carried":[64],"out":[65],"on":[66,95],"Thermo":[68],"BDS":[69],"Hypersil":[70],"C18":[71],"column":[72],"(4.6":[73],"\u00d7":[74],"100":[75],"mm,":[76],"2.4":[77],"\u03bcm)":[78],"using":[79],"deionized":[80],"water":[81],"methanol":[83],"mobile":[85],"phase,":[86],"both":[87],"added":[88],"0.1%":[90],"(v/v)":[91],"formic":[92],"acid.":[93],"Based":[94],"positive":[97],"electrospray":[98],"ionization":[99],"mode,":[100],"analyzed":[105],"selective":[107],"reaction":[108],"monitoring.":[109],"Excellent":[110],"precision,":[111],"accuracy,":[112],"recovery,":[113],"linearity":[115],"demonstrated,":[117],"covering":[118],"range":[120],"50\u20135000":[122],"ng/mL":[123,128],"10\u20131000":[127],"ritonavir.":[130],"Then,":[131],"used":[136],"determining":[138],"pharmacokinetic":[140,149,169],"profile":[141],"Paxlovid":[143],"healthy":[145],"Chinese":[146],"volunteers.":[147],"The":[148],"parameters,":[150],"including":[151],"Cmax,":[152],"Tmax,":[153],"t1/2,":[154],"AUC0":[156],"\u2212":[157],"\u221e":[158],"Western":[160],"volunteers,":[161],"correspond":[162],"well":[163],"results":[166],"investigation.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-27T00:00:00"}