{"id":"https://openalex.org/W4288036360","doi":"https://doi.org/10.1002/hep.32685","title":"Letter to the editor: County\u2010level variation in hepatitis C virus mortality and trends in the United States, 2005\u20132017","display_name":"Letter to the editor: County\u2010level variation in hepatitis C virus mortality and trends in the United States, 2005\u20132017","publication_year":2022,"publication_date":"2022-07-26","ids":{"openalex":"https://openalex.org/W4288036360","doi":"https://doi.org/10.1002/hep.32685","pmid":"https://pubmed.ncbi.nlm.nih.gov/35881668"},"language":"en","primary_location":{"id":"doi:10.1002/hep.32685","doi":"https://doi.org/10.1002/hep.32685","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.32685","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017930949","display_name":"Muhammad Shehryar","orcid":"https://orcid.org/0000-0002-0008-7324","observed_orcids":["https://orcid.org/0000-0002-0008-7324"]},"institutions":[{"id":"https://openalex.org/I142016965","display_name":"King Edward Medical University","ror":"https://ror.org/02rrbpf42","country_code":"PK","type":"education","lineage":["https://openalex.org/I142016965"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Muhammad Shehryar","raw_affiliation_strings":["King Edward Medical University, Lahore, Pakistan","Muhammad Shehryar, King Edward Medical University, Lahore, Pakistan. Email: [email\u00a0protected]"],"raw_orcid":"https://orcid.org/0000-0002-0008-7324","affiliations":[{"raw_affiliation_string":"King Edward Medical University, Lahore, Pakistan","institution_ids":["https://openalex.org/I142016965"]},{"raw_affiliation_string":"Muhammad Shehryar, King Edward Medical University, Lahore, Pakistan. Email: [email\u00a0protected]","institution_ids":["https://openalex.org/I142016965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035209550","display_name":"Muhammad Zawar Asif","orcid":"https://orcid.org/0000-0001-5138-441X","observed_orcids":["https://orcid.org/0000-0001-5138-441X"]},"institutions":[{"id":"https://openalex.org/I142016965","display_name":"King Edward Medical University","ror":"https://ror.org/02rrbpf42","country_code":"PK","type":"education","lineage":["https://openalex.org/I142016965"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Zawar Asif","raw_affiliation_strings":["King Edward Medical University, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-5138-441X","affiliations":[{"raw_affiliation_string":"King Edward Medical University, Lahore, Pakistan","institution_ids":["https://openalex.org/I142016965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100726598","display_name":"Muhammad Umair","orcid":"https://orcid.org/0000-0002-9858-3595","observed_orcids":["https://orcid.org/0000-0002-9858-3595"]},"institutions":[{"id":"https://openalex.org/I142016965","display_name":"King Edward Medical University","ror":"https://ror.org/02rrbpf42","country_code":"PK","type":"education","lineage":["https://openalex.org/I142016965"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Umair","raw_affiliation_strings":["King Edward Medical University, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-9858-3595","affiliations":[{"raw_affiliation_string":"King Edward Medical University, Lahore, Pakistan","institution_ids":["https://openalex.org/I142016965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017930949"],"corresponding_institution_ids":["https://openalex.org/I142016965"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"1","first_page":"E8","last_page":"E8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hcv-mortality","display_name":"HCV mortality","score":0.8970000147819519},{"id":"https://openalex.org/keywords/county-level-variation","display_name":"county-level variation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mortality-trends","display_name":"mortality trends","score":0.628000020980835},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.7129999995231628},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hepatitis-b-virus-coinfection","display_name":"hepatitis B coinfection","score":0.7229999899864197},{"id":"https://openalex.org/keywords/hepatitis-c-treatment","display_name":"hepatitis C treatment","score":0.4830000102519989},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8046914339065552},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6330583095550537},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6170410513877869},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.6150144338607788},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.54468834400177},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.47933873534202576},{"id":"https://openalex.org/C2993512173","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral therapy","level":4,"score":0.4732834994792938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4529199004173279},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.449135422706604},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.4411192536354065},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.4187389314174652},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33816251158714294},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2950299382209778},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.2444373369216919},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.32685","doi":"https://doi.org/10.1002/hep.32685","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.32685","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:35881668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35881668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1968194021","https://openalex.org/W2054938157","https://openalex.org/W2071634494","https://openalex.org/W2139773897","https://openalex.org/W3130683503"],"related_works":["https://openalex.org/W3130683503","https://openalex.org/W4412045394","https://openalex.org/W4402894014","https://openalex.org/W2071634494","https://openalex.org/W2191991616","https://openalex.org/W3095707936","https://openalex.org/W2287727581","https://openalex.org/W2160124272","https://openalex.org/W2805952851","https://openalex.org/W2126454283"],"abstract_inverted_index":{"To":[0,343],"the":[1,16,30,37,50,93,130,146,208,215,238,323,345],"editor,":[2],"Hall":[3],"et":[4,150,184],"al.'s":[5],"\u201cCounty\u2010Level":[6],"Variation":[7],"in":[8,15,53,75,322,348,366],"Hepatitis":[9],"C":[10,55],"Virus":[11,56],"Mortality":[12],"and":[13,29,40,45,66,95,106,121,137,159,162,167,196,227,251,280,288,302,337,358],"Trends":[14],"United":[17],"States,":[18],"2005\u20132017\u201d":[19],"was":[20,23,108,175,282],"well\u2010received.1":[21],"It":[22],"great":[24],"to":[25,48,63,87,91,128,284,292,356],"read":[26],"this":[27],"article,":[28],"author":[31],"deserves":[32],"appreciation.":[33],"We":[34],"agree":[35],"that":[36],"trend's":[38],"direction":[39],"degree":[41],"vary":[42],"by":[43,118,243],"place":[44],"age.":[46],"Efforts":[47],"continue":[49],"nationwide":[51],"decline":[52,347],"hepatitis":[54,156],"(HCV)":[57],"mortality":[58,81,116,369],"will":[59,353],"require":[60],"new":[61,307],"strategies":[62],"improve":[64,92],"testing":[65,357],"care":[67,359],"for":[68,198,218,237,247,256,360],"persons":[69],"living":[70],"with":[71,77,278,306,362],"HCV":[72,80,160,179,199,212,258,276,297,316,349,363],"infection,":[73,364],"especially":[74,365],"counties":[76,367],"persistently":[78],"high":[79],"rates.":[82],"However,":[83],"we":[84],"feel":[85],"obligated":[86],"add":[88],"more":[89,312,332],"points":[90],"content":[94],"expand":[96],"earlier":[97,335],"material.":[98],"Anti\u2010HCV":[99],"prevalence":[100,131],"increased":[101,285],"alanine":[102],"aminotransferase":[103],"(ALT)":[104],"levels,":[105,136],"thrombocytopenia":[107],"not":[109,126,268,295],"supplied":[110],"as":[111],"medians,":[112],"ranges,":[113],"or":[114,193,233,253,272],"standard":[115],"ratios":[117],"nation.":[119],"Simple":[120],"multiple":[122],"linear":[123],"regressions":[124],"were":[125],"done":[127],"describe":[129],"of":[132,211,224,262,325],"thrombocytopenia,":[133],"elevated":[134],"ALT":[135],"hepatocellular":[138],"carcinoma":[139],"(HCC)":[140],"mortality,":[141],"which":[142],"would":[143],"have":[144,310,338],"validated":[145],"study's":[147],"validity.":[148],"Tsai":[149],"al.2":[151],"found":[152],"a":[153,260,339],"connection":[154],"between":[155],"B":[157],"virus":[158],"infections":[161],"male":[163],"(r2":[164,169],"=":[165,170],"0.62)":[166],"female":[168],"0.53)":[171],"HCC":[172],"mortality.":[173],"There":[174],"no":[176],"information":[177],"on":[178,204],"infection":[180],"severity":[181],"management.":[182],"Bruggmann":[183],"al.":[185],"obtained":[186],"annual":[187],"liver":[188,326],"transplant":[189],"data":[190],"from":[191],"national":[192],"international":[194],"sources":[195],"corrected":[197],"proportion.3":[200],"Existing":[201],"differences":[202],"exist":[203],"patient":[205],"treatment.":[206],"Given":[207],"rapid":[209],"rate":[210],"pharmaceutical":[213],"research,":[214],"10\u2010year":[216],"scope":[217],"future":[219],"therapies":[220],"includes":[221],"dual":[222],"therapy":[223,255,320],"peginterferon":[225],"(PEG\u2010IFN)":[226],"ribavirin":[228],"(RBV)":[229],"(non\u2010genotype":[230],"1":[231],"[G1])":[232],"triple":[234,252],"therapeutics":[235],"(G1)":[236],"first":[239],"five":[240],"years,":[241],"followed":[242],"an":[244],"interferon\u2010free":[245],"regimen":[246],"G2/3":[248],"treatment\u2010naive":[249],"patients":[250],"quadruple":[254],"others.":[257],"causes":[259],"number":[261],"extrahepatic":[263,300],"symptoms.":[264,274],"Previous":[265],"paragraphs":[266],"did":[267,294],"mention":[269],"ophthalmological,":[270],"mucocutaneous,":[271],"immunologic":[273],"Successful":[275],"eradication":[277,298],"PEG\u2010IFN":[279],"RBV":[281],"linked":[283],"attention,":[286],"vigilance,":[287],"working":[289],"memory.":[290],"Nonresponders":[291],"virology":[293],"benefit.4":[296],"reduces":[299],"symptoms,":[301],"larger":[303],"cure":[304],"rates":[305,370],"regimens":[308,330],"may":[309],"even":[311,321],"pronounced":[313],"effects.":[314],"Extrahepatic":[315],"symptoms":[317],"justify":[318],"anti\u2010HCV":[319],"absence":[324],"disease.":[327],"Currently":[328],"practiced":[329],"are":[331,371],"acceptable":[333],"than":[334],"drugs":[336],"better":[340],"risk/benefit":[341],"ratio.":[342],"sustain":[344],"statewide":[346],"fatalities,":[350],"additional":[351],"steps":[352],"enhance":[354],"access":[355],"people":[361],"where":[368],"high.5":[372]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-27T00:00:00"}