{"id":"https://openalex.org/W4288034299","doi":"https://doi.org/10.1080/10717544.2022.2103210","title":"Enhanced biological activity of liposomal methylated resveratrol analog 3\u2032-hydroxy-3,4,5,4\u2032-tetramethoxystilbene (DMU-214) in 3D patient-derived ovarian cancer model","display_name":"Enhanced biological activity of liposomal methylated resveratrol analog 3\u2032-hydroxy-3,4,5,4\u2032-tetramethoxystilbene (DMU-214) in 3D patient-derived ovarian cancer model","publication_year":2022,"publication_date":"2022-07-27","ids":{"openalex":"https://openalex.org/W4288034299","doi":"https://doi.org/10.1080/10717544.2022.2103210","pmid":"https://pubmed.ncbi.nlm.nih.gov/35892260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9336483"},"language":"en","primary_location":{"id":"doi:10.1080/10717544.2022.2103210","doi":"https://doi.org/10.1080/10717544.2022.2103210","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10717544.2022.2103210","pdf_url":null,"source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/10717544.2022.2103210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026116934","display_name":"Andrzej Nowicki","orcid":"https://orcid.org/0000-0002-9260-8237","observed_orcids":["https://orcid.org/0000-0002-9260-8237"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Nowicki","raw_affiliation_strings":["Department of Toxicology, Poznan University of Medical Sciences","Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Poznan University of Medical Sciences","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054711408","display_name":"Dariusz Wawrzyniak","orcid":"https://orcid.org/0000-0002-6128-5383","observed_orcids":["https://orcid.org/0000-0002-6128-5383"]},"institutions":[{"id":"https://openalex.org/I4210152414","display_name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences","ror":"https://ror.org/04ejdtr48","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210152414","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Dariusz Wawrzyniak","raw_affiliation_strings":["Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Sciences","Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Sciences","institution_ids":["https://openalex.org/I4210152414","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I4210152414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005458542","display_name":"Miko\u0142aj Czajkowski","orcid":"https://orcid.org/0000-0002-8630-3373","observed_orcids":["https://orcid.org/0000-0002-8630-3373"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Miko\u0142aj Czajkowski","raw_affiliation_strings":["Department of Inorganic & Analytical Chemistry, Collegium Pharmaceuticum, Poznan University of Medical Sciences","Department of Inorganic & Analytical Chemistry, Collegium Pharmaceuticum, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inorganic & Analytical Chemistry, Collegium Pharmaceuticum, Poznan University of Medical Sciences","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Department of Inorganic & Analytical Chemistry, Collegium Pharmaceuticum, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075022235","display_name":"Ma\u0142gorzata J\u00f3zkowiak","orcid":"https://orcid.org/0000-0003-1129-1563","observed_orcids":["https://orcid.org/0000-0003-1129-1563"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata J\u00f3zkowiak","raw_affiliation_strings":["Department of Toxicology, Poznan University of Medical Sciences","Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Poznan University of Medical Sciences","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029402201","display_name":"Micha\u0142 Pawlak","orcid":"https://orcid.org/0000-0001-7679-5493","observed_orcids":["https://orcid.org/0000-0001-7679-5493"]},"institutions":[{"id":"https://openalex.org/I4210112614","display_name":"Greater Poland Cancer Center","ror":"https://ror.org/0243nmr44","country_code":"PL","type":"other","lineage":["https://openalex.org/I4210112614"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Micha\u0142 Pawlak","raw_affiliation_strings":["Greater Poland Cancer Centre","Greater Poland Cancer Centre, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greater Poland Cancer Centre","institution_ids":["https://openalex.org/I4210112614"]},{"raw_affiliation_string":"Greater Poland Cancer Centre, Poznan, Poland","institution_ids":["https://openalex.org/I4210112614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049340784","display_name":"Marcin Wierzchowski","orcid":"https://orcid.org/0000-0003-2619-0466","observed_orcids":["https://orcid.org/0000-0003-2619-0466"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marcin Wierzchowski","raw_affiliation_strings":["Department of Chemical Technology of Drugs, Poznan University of Medical Sciences","Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Poznan, PL, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Technology of Drugs, Poznan University of Medical Sciences","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Poznan, PL, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056177435","display_name":"Katarzyna Rolle","orcid":"https://orcid.org/0000-0002-4175-2490","observed_orcids":["https://orcid.org/0000-0002-4175-2490"]},"institutions":[{"id":"https://openalex.org/I4210152414","display_name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences","ror":"https://ror.org/04ejdtr48","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210152414","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna Rolle","raw_affiliation_strings":["Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Sciences","Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Sciences","institution_ids":["https://openalex.org/I4210152414","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I4210152414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025436124","display_name":"Paulina Skupin-Mrugalska","orcid":"https://orcid.org/0000-0002-2495-6504","observed_orcids":["https://orcid.org/0000-0002-2495-6504"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Paulina Skupin-Mrugalska","raw_affiliation_strings":["Department of Inorganic & Analytical Chemistry, Collegium Pharmaceuticum, Poznan University of Medical Sciences","Department of Inorganic & Analytical Chemistry, Collegium Pharmaceuticum, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inorganic & Analytical Chemistry, Collegium Pharmaceuticum, Poznan University of Medical Sciences","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Department of Inorganic & Analytical Chemistry, Collegium Pharmaceuticum, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052515822","display_name":"Hanna Piotrowska\u2010Kempisty","orcid":"https://orcid.org/0000-0002-8904-2885","observed_orcids":["https://orcid.org/0000-0002-8904-2885"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]},{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Hanna Piotrowska-Kempisty","raw_affiliation_strings":["Department of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun","Department of Toxicology, Poznan University of Medical Sciences","Department of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun, Poland","Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun","institution_ids":["https://openalex.org/I3019271933"]},{"raw_affiliation_string":"Department of Toxicology, Poznan University of Medical Sciences","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Department of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]},{"raw_affiliation_string":"Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025436124"],"corresponding_institution_ids":["https://openalex.org/I120230055"],"apc_list":{"value":2335,"currency":"GBP","value_usd":2864},"apc_paid":{"value":2335,"currency":"GBP","value_usd":2864},"fwci":0.3453,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.34364261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"29","issue":"1","first_page":"2459","last_page":"2468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.777999997138977},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/patient-derived-tumor-cells","display_name":"patient-derived tumor cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/spheroid-model","display_name":"spheroid model","score":0.6539999842643738},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.625},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.6179999709129333},{"id":"https://openalex.org/keywords/fickian-diffusion","display_name":"Fickian diffusion","score":0.7419999837875366},{"id":"https://openalex.org/keywords/skov-3-cells","display_name":"SKOV3 cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/resveratrol-analogs","display_name":"resveratrol analogues","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.8653931617736816},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5924789309501648},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.5024442672729492},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.4627886116504669},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.43419113755226135},{"id":"https://openalex.org/C3018040386","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Lipid vesicle","level":4,"score":0.4181838035583496},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4108465313911438},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39200061559677124},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3906998932361603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36656010150909424},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3480857312679291},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.3044825792312622},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2946900725364685},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28469526767730713},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2355765700340271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1939479410648346},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.17313891649246216},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14630424976348877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1441008448600769},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/10717544.2022.2103210","doi":"https://doi.org/10.1080/10717544.2022.2103210","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10717544.2022.2103210","pdf_url":null,"source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9336483","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9336483/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9336483/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Deliv","raw_type":"Text"},{"id":"pmid:35892260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35892260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug delivery","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:70698842a48e4104a99a611b262971a8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/70698842a48e4104a99a611b262971a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Delivery, Vol 29, Iss 1, Pp 2459-2468 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/10717544.2022.2103210","doi":"https://doi.org/10.1080/10717544.2022.2103210","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10717544.2022.2103210","pdf_url":null,"source":{"id":"https://openalex.org/S70174254","display_name":"Drug Delivery","issn_l":"1071-7544","issn":["1071-7544","1521-0464"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322511","display_name":"Narodowe Centrum Nauki","ror":"https://ror.org/03ha2q922"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4288034299.pdf","grobid_xml":"https://content.openalex.org/works/W4288034299.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W297037589","https://openalex.org/W1968199192","https://openalex.org/W1969688942","https://openalex.org/W1972566068","https://openalex.org/W1990821149","https://openalex.org/W1994190235","https://openalex.org/W1995634417","https://openalex.org/W1996145189","https://openalex.org/W2002906517","https://openalex.org/W2010251891","https://openalex.org/W2015930349","https://openalex.org/W2016551153","https://openalex.org/W2026678555","https://openalex.org/W2031570851","https://openalex.org/W2036604638","https://openalex.org/W2041384877","https://openalex.org/W2050903822","https://openalex.org/W2057957331","https://openalex.org/W2058618472","https://openalex.org/W2070513847","https://openalex.org/W2076226743","https://openalex.org/W2086967717","https://openalex.org/W2111400269","https://openalex.org/W2114513030","https://openalex.org/W2121542859","https://openalex.org/W2136445803","https://openalex.org/W2136830554","https://openalex.org/W2151089147","https://openalex.org/W2162303649","https://openalex.org/W2337341934","https://openalex.org/W2511269956","https://openalex.org/W2598370895","https://openalex.org/W2605749465","https://openalex.org/W2619406261","https://openalex.org/W2779293135","https://openalex.org/W2806009093","https://openalex.org/W2807649309","https://openalex.org/W2889646458","https://openalex.org/W2900960361","https://openalex.org/W2995145725","https://openalex.org/W3004788788","https://openalex.org/W3011445723","https://openalex.org/W3045560651","https://openalex.org/W3087053806","https://openalex.org/W3107095900","https://openalex.org/W3164904027","https://openalex.org/W3170796440","https://openalex.org/W3202865669","https://openalex.org/W3206841143","https://openalex.org/W3215941346","https://openalex.org/W4206041366","https://openalex.org/W4229022507","https://openalex.org/W4238410074"],"related_works":["https://openalex.org/W2511269956","https://openalex.org/W2398133362","https://openalex.org/W3004788788","https://openalex.org/W3023283275","https://openalex.org/W1996145189","https://openalex.org/W7204078012","https://openalex.org/W2973410709","https://openalex.org/W1990821149","https://openalex.org/W4406048626","https://openalex.org/W2041934853"],"abstract_inverted_index":{"3\u2032-hydroxy-3,4,5,4\u2032-tetramethoxystilbene":[0],"(DMU-214)":[1],"belongs":[2],"to":[3,40,54,178],"methoxystilbenes":[4,46],"family":[5],"and":[6,43,69,97,113,137,161,168],"is":[7],"an":[8],"active":[9],"metabolite":[10],"of":[11,16,23,30,83,102,110,121,132,143,148,217,220],"3,4,5,4\u2032-tetramethoxystilbene":[12],"(DMU-212).":[13],"In":[14,58],"several":[15,80],"our":[17],"previous":[18],"studies,":[19],"the":[20,31,55,66,76,88,103,108,124,130,146,187,192,209,215],"anti-apoptotic":[21],"activity":[22,72,142],"DMU-214":[24,52,84,122,144,173,189,222],"was":[25,73,106,127,154],"significantly":[26],"higher":[27],"than":[28,186],"that":[29],"parent":[32],"compound,":[33],"especially":[34],"in":[35,75,107,140,145,166,191,197],"ovarian":[36,77,163,211,229],"cancer":[37,78,164,212,230],"cells.":[38],"Due":[39],"increased":[41],"lipophilicity":[42],"limited":[44],"solubility,":[45],"require":[47],"a":[48,149,224],"solubilization":[49],"strategy":[50],"enabling":[51],"administration":[53],"aqueous":[56],"environment.":[57],"this":[59],"study,":[60],"DMU-214-loaded":[61],"liposomes":[62,126],"were":[63,85,176],"developed":[64],"for":[65,228],"first":[67],"time,":[68],"its":[70],"antitumor":[71],"tested":[74],"model.First,":[79],"liposomal":[81,174,221],"formulations":[82,175],"obtained":[86],"by":[87,95,129],"thin":[89],"lipid":[90],"film":[91],"hydration":[92],"method":[93],"followed":[94],"extrusion":[96],"then":[98],"characterized.":[99],"The":[100,119,202],"diameter":[101],"resulting":[104],"vesicles":[105],"range":[109],"118.0-155.5":[111],"nm,":[112],"samples":[114],"presented":[115],"monodisperse":[116],"size":[117],"distribution.":[118],"release":[120],"from":[123],"studied":[125],"governed":[128],"contribution":[131],"two":[133],"mechanisms,":[134],"Fickian":[135],"diffusion":[136],"liposome":[138],"relaxation.Subsequently,":[139],"vitro":[141],"form":[147],"free":[150,188],"compound":[151],"or":[152],"liposome-bound":[153],"studied,":[155],"including":[156],"commercial":[157],"cell":[158,170],"line":[159],"SK-OV-3":[160],"patient-derived":[162,210],"cells":[165],"monolayer":[167,193],"spheroid":[169,200],"culture":[171],"models.":[172,201],"found":[177],"be":[179],"more":[180,195],"potent":[181],"(had":[182],"lower":[183],"IC50":[184],"values)":[185],"both":[190,198],"and,":[194],"significantly,":[196],"examined":[199],"above":[203],"results,":[204],"with":[205],"particular":[206],"emphasis":[207],"on":[208],"model,":[213],"indicate":[214],"importance":[216],"further":[218],"development":[219],"as":[223],"potential":[225],"anticancer":[226],"formulation":[227],"treatment.":[231]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-07-27T00:00:00"}