{"id":"https://openalex.org/W4287969578","doi":"https://doi.org/10.17615/06b1-7p72","title":"Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis","display_name":"Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis","publication_year":2021,"publication_date":"2021-06-23","ids":{"openalex":"https://openalex.org/W4287969578","doi":"https://doi.org/10.17615/06b1-7p72"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:6t053q568","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/06b1-7p72","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Microbiology, 5(1)","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/06b1-7p72","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081191794","display_name":"G. Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patel, G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084941155","display_name":"Rita Tamayo","orcid":"https://orcid.org/0000-0002-3745-3316","observed_orcids":["https://orcid.org/0000-0002-3745-3316"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamayo, R.","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075656317","display_name":"H. van Bakel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"van Bakel, H.","raw_affiliation_strings":["School of Medicine, Department of Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Department of Microbiology and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006400763","display_name":"S. Huprikar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huprikar, S.","raw_affiliation_strings":["School of Medicine, Department of Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Department of Microbiology and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038910983","display_name":"M. Touchon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Touchon, M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030015663","display_name":"Ognjen Sekulovi\u0107","orcid":"https://orcid.org/0000-0003-1006-0595","observed_orcids":["https://orcid.org/0000-0003-1006-0595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sekulovic, O.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083863074","display_name":"Alyssa Bashir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bashir, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052656556","display_name":"C. Beckford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beckford, C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006082485","display_name":"G. Deikus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deikus, G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079673052","display_name":"Camille L. A. Hamula","orcid":"https://orcid.org/0000-0002-9246-7980","observed_orcids":["https://orcid.org/0000-0002-9246-7980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamula, C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073383296","display_name":"R. Sebra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebra, R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071426189","display_name":"Martha Lewis-Sandari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lewis-Sandari, M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053570876","display_name":"E.A. Mead","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mead, E.A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053926525","display_name":"F. Wallach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wallach, F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041153525","display_name":"S. Bunyavanich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bunyavanich, S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023995589","display_name":"N.E. Zeitouni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeitouni, N.E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063850392","display_name":"Dominika Trzilova","orcid":"https://orcid.org/0000-0003-3165-6443","observed_orcids":["https://orcid.org/0000-0003-3165-6443"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trzilova, D.","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044658886","display_name":"A. Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051017537","display_name":"S. Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhu, S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021811217","display_name":"P.H. Oliveira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliveira, P.H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000169905","display_name":"John W. Ribis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ribis, J.W.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081248027","display_name":"Guangyuan Fang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang, G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018967581","display_name":"D.R. Altman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Altman, D.R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081948334","display_name":"T. Pak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pak, T.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042284444","display_name":"A.K. Aggarwal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aggarwal, A.K.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083560960","display_name":"E.E. Schadt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schadt, E.E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032714338","display_name":"Andrew Kasarskis","orcid":"https://orcid.org/0000-0001-6454-9076","observed_orcids":["https://orcid.org/0000-0001-6454-9076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kasarskis, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005585510","display_name":"Aimee Shen","orcid":"https://orcid.org/0000-0002-9786-5742","observed_orcids":["https://orcid.org/0000-0002-9786-5742","https://orcid.org/0000-0002-6430-4076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shen, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028025047","display_name":"E. Webster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Webster, E.","raw_affiliation_strings":["School of Medicine, Department of Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Department of Microbiology and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043048142","display_name":"Elizabeth M. Garrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett, E.M.","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064820082","display_name":"I. Oussenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oussenko, I.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2748945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridioides-difficile","display_name":"Clostridium difficile","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.8989999890327454},{"id":"https://openalex.org/keywords/epigenome","display_name":"epigenome","score":0.6800000071525574},{"id":"https://openalex.org/keywords/sporulation","display_name":"sporulation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cell-length","display_name":"cell length","score":0.75},{"id":"https://openalex.org/keywords/host-colonization","display_name":"host colonization","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2910067853","wikidata":"https://www.wikidata.org/wiki/Q27438828","display_name":"Clostridioides","level":2,"score":0.7986737489700317},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.7387403249740601},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.5448229312896729},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5047870874404907},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4803570508956909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.406791090965271},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.403232216835022},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3782007098197937},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.37448906898498535},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.368217796087265},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2630375623703003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24438327550888062},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.14717397093772888},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12441956996917725},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11617690324783325}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:6t053q568","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/06b1-7p72","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Microbiology, 5(1)","raw_type":"Article"},{"id":"doi:10.17615/06b1-7p72","doi":"https://doi.org/10.17615/06b1-7p72","is_oa":true,"landing_page_url":"https://doi.org/10.17615/06b1-7p72","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.17615/06b1-7p72","doi":"https://doi.org/10.17615/06b1-7p72","is_oa":true,"landing_page_url":"https://doi.org/10.17615/06b1-7p72","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2946746360","https://openalex.org/W2606237140","https://openalex.org/W2100856525","https://openalex.org/W2119272378","https://openalex.org/W2028791115","https://openalex.org/W2303263226","https://openalex.org/W1499793237","https://openalex.org/W2143007402","https://openalex.org/W2372572407","https://openalex.org/W2165434334"],"abstract_inverted_index":{"Clostridioides":[0],"(formerly":[1],"Clostridium)":[2],"difficile":[3,27,47,90,106],"is":[4,75,134],"a":[5,40,54,67,101,121,147,165],"leading":[6],"cause":[7],"of":[8,20,25,45,57,73,84,94,167],"healthcare-associated":[9],"infections.":[10],"Although":[11],"considerable":[12],"progress":[13],"has":[14,32],"been":[15,34],"made":[16],"in":[17,82,104,157],"the":[18,23,70,85,95],"understanding":[19],"its":[21,29],"genome,":[22],"epigenome":[24],"C.":[26,46,89,105],"and":[28,52,81,109,120,127,141,172],"functional":[30],"impact":[31],"not":[33],"systematically":[35],"explored.":[36],"Here,":[37],"we":[38,176],"perform":[39],"comprehensive":[41],"DNA":[42,64],"methylome":[43],"analysis":[44],"using":[48],"36":[49],"human":[50],"isolates":[51],"observe":[53],"high":[55],"level":[56],"epigenomic":[58,184],"diversity.":[59],"We":[60],"discovered":[61],"an":[62],"orphan":[63],"methyltransferase":[65,96],"with":[66,136],"well-defined":[68],"specificity,":[69],"corresponding":[71],"gene":[72,97],"which":[74,175],"highly":[76],"conserved":[77],"across":[78],"our":[79],"dataset":[80],"all":[83],"approximately":[86],"300":[87],"global":[88],"genomes":[91],"examined.":[92],"Inactivation":[93],"negatively":[98],"impacts":[99],"sporulation,":[100],"key":[102],"step":[103],"disease":[107],"transmission,":[108],"these":[110],"results":[111],"are":[112],"consistently":[113],"supported":[114],"by":[115],"multiomics":[116],"data,":[117],"genetic":[118],"experiments":[119],"mouse":[122],"colonization":[123],"model.":[124],"Further":[125],"experimental":[126],"transcriptomic":[128],"analyses":[129],"suggest":[130],"that":[131],"epigenetic":[132,149],"regulation":[133],"associated":[135],"cell":[137],"length,":[138],"biofilm":[139],"formation":[140],"host":[142],"colonization.":[143],"These":[144],"findings":[145],"provide":[146],"unique":[148],"dimension":[150],"to":[151,178,182],"characterize":[152],"medically":[153],"relevant":[154],"biological":[155],"processes":[156],"this":[158],"important":[159],"pathogen.":[160],"This":[161],"study":[162],"also":[163],"provides":[164],"set":[166],"methods":[168],"for":[169],"comparative":[170],"epigenomics":[171],"integrative":[173],"analysis,":[174],"expect":[177],"be":[179],"broadly":[180],"applicable":[181],"bacterial":[183],"studies.":[185]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}