{"id":"https://openalex.org/W4287877076","doi":"https://doi.org/10.4140/tcp.n.2022.329","title":"Aducanumab for Alzheimer's Disease: Summarized Data From EMERGE, ENGAGE, and PRIME Studies","display_name":"Aducanumab for Alzheimer's Disease: Summarized Data From EMERGE, ENGAGE, and PRIME Studies","publication_year":2022,"publication_date":"2022-07-26","ids":{"openalex":"https://openalex.org/W4287877076","doi":"https://doi.org/10.4140/tcp.n.2022.329","pmid":"https://pubmed.ncbi.nlm.nih.gov/35879846"},"language":"en","primary_location":{"id":"doi:10.4140/tcp.n.2022.329","doi":"https://doi.org/10.4140/tcp.n.2022.329","is_oa":false,"landing_page_url":"https://doi.org/10.4140/tcp.n.2022.329","pdf_url":null,"source":{"id":"https://openalex.org/S4210183711","display_name":"The Senior Care Pharmacist","issn_l":"2639-9636","issn":["2639-9636","2639-9644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Senior Care Pharmacist","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054387459","display_name":"Jaylan M. Yuksel","orcid":"https://orcid.org/0000-0002-9645-5047","observed_orcids":["https://orcid.org/0000-0002-9645-5047"]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaylan M. Yuksel","raw_affiliation_strings":["Upstate University Hospital, Syracuse, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upstate University Hospital, Syracuse, New York","institution_ids":["https://openalex.org/I4210106223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017918198","display_name":"John A. Noviasky","orcid":"https://orcid.org/0000-0002-8344-6723","observed_orcids":["https://orcid.org/0000-0002-8344-6723"]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Noviasky","raw_affiliation_strings":["Upstate University Hospital, Syracuse, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upstate University Hospital, Syracuse, New York","institution_ids":["https://openalex.org/I4210106223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058539708","display_name":"Sarah Britton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Britton","raw_affiliation_strings":["Upstate University Hospital, Syracuse, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upstate University Hospital, Syracuse, New York","institution_ids":["https://openalex.org/I4210106223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106223"],"apc_list":null,"apc_paid":null,"fwci":1.0357,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.72898665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"37","issue":"8","first_page":"329","last_page":"334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aducanumab","display_name":"aducanumab","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amyloid-beta-immunotherapy","display_name":"amyloid-beta immunotherapy","score":0.6980000138282776},{"id":"https://openalex.org/keywords/amyloid-related-imaging-abnormalities","display_name":"amyloid-related imaging abnormalities","score":0.9079999923706055},{"id":"https://openalex.org/keywords/clinical-deterioration","display_name":"clinical deterioration","score":0.49900001287460327},{"id":"https://openalex.org/keywords/prime-study","display_name":"PRIME study","score":0.6869999766349792},{"id":"https://openalex.org/keywords/fda-drug-approval","display_name":"FDA drug approval","score":0.7459999918937683},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.859000027179718},{"id":"https://openalex.org/keywords/futility-analysis","display_name":"futility analysis","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5982429385185242},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5827820897102356},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5757734179496765},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5605214238166809},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4653867781162262},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.43301260471343994},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.43183571100234985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3498702049255371},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33539360761642456},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2289430797100067},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.19018366932868958}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017321","descriptor_name":"Clinical Trials, Phase I as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D062072","descriptor_name":"Patient Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4140/tcp.n.2022.329","doi":"https://doi.org/10.4140/tcp.n.2022.329","is_oa":false,"landing_page_url":"https://doi.org/10.4140/tcp.n.2022.329","pdf_url":null,"source":{"id":"https://openalex.org/S4210183711","display_name":"The Senior Care Pharmacist","issn_l":"2639-9636","issn":["2639-9636","2639-9644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Senior Care Pharmacist","raw_type":"journal-article"},{"id":"pmid:35879846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35879846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Senior care pharmacist","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1855997172","https://openalex.org/W1995360192","https://openalex.org/W2109030727","https://openalex.org/W2582073057","https://openalex.org/W2965878453","https://openalex.org/W3097527510","https://openalex.org/W3134488059","https://openalex.org/W3135424924","https://openalex.org/W3211883810"],"related_works":["https://openalex.org/W3111988300","https://openalex.org/W4313640830","https://openalex.org/W3134488059","https://openalex.org/W3217122335","https://openalex.org/W4225741213","https://openalex.org/W4319299508","https://openalex.org/W7045343263","https://openalex.org/W4399350631","https://openalex.org/W4389448895","https://openalex.org/W4226287535"],"abstract_inverted_index":{"Objective":[0],"To":[1],"review":[2],"the":[3,6,29,48,53,108,177,187,197],"data":[4,42,188],"informing":[5],"US":[7],"Food":[8],"and":[9,21,135,174],"Drug":[10],"Administration":[11],"(FDA)":[12],"approval":[13],"for":[14,16,55],"aducanumab":[15,145,200,213],"mild":[17,22,206],"cognitive":[18],"impairment":[19],"(MCI)":[20],"Alzheimer\u2019s":[23],"disease":[24],"(AD).":[25],"Data":[26,98],"Sources":[27],"At":[28],"time":[30],"of":[31,68,82,92,180,199,227],"writing":[32],"there":[33],"were":[34,114],"no":[35,169],"peer-reviewed":[36],"published":[37],"studies":[38,59,233],"on":[39,160,186],"aducanumab.":[40],"All":[41],"presented":[43],"are":[44,234],"derived":[45],"directly":[46],"from":[47],"material":[49],"Biogen":[50],"submitted":[51],"to":[52,124,165,189,194,236],"FDA":[54],"approval.":[56],"The":[57],"three":[58],"that":[60,143],"will":[61],"be":[62],"reviewed":[63],"are:":[64],"Multiple":[65],"Dose":[66],"Study":[67,81,91],"Aducanumab":[69,83,93],"in":[70,84,94,201],"Participants":[71],"With":[72,224],"Prodromal":[73],"or":[74,205],"Mild":[75],"AD":[76,86,96],"(PRIME),":[77],"221AD302":[78],"Phase":[79,89],"3":[80,90],"Early":[85,95],"(EMERGE),":[87],"221AD301":[88],"(ENGAGE).":[97],"Synthesis":[99],"PRIME,":[100],"which":[101,119],"was":[102,146,156],"a":[103,161],"phase":[104,231],"1":[105],"study,":[106],"demonstrated":[107,142,168],"most":[109],"common":[110],"adverse":[111],"drug":[112],"reactions":[113],"amyloid-related":[115],"imaging":[116],"abnormalities":[117],"(ARIA),":[118],"occurred":[120],"at":[121,149],"rates":[122],"up":[123],"47%":[125],"(10":[126],"mg/kg":[127],"group),":[128],"headache":[129],"(25%),":[130],"urinary":[131],"tract":[132,138],"infection":[133,139],"(16%),":[134],"upper":[136],"respiratory":[137],"(19%).":[140],"EMERGE":[141,208],"high-dose":[144,212],"clinically":[147],"significant":[148],"slowing":[150,181,214],"down":[151],"clinical":[152,170,182,215],"decline.":[153,183,216],"However,":[154,217],"ENGAGE":[155,167,218],"terminated":[157],"early":[158],"based":[159],"futility":[162],"analysis.":[163],"Prior":[164],"termination":[166],"difference":[171],"between":[172],"treatment":[173],"placebo":[175],"regarding":[176],"primary":[178],"endpoint":[179],"Conclusion":[184],"Based":[185],"date,":[190],"it":[191],"is":[192],"difficult":[193],"accurately":[195],"assess":[196],"role":[198],"patients":[202],"with":[203,211],"MCI":[204],"AD.":[207],"showed":[209],"benefit":[210],"did":[219],"not":[220],"duplicate":[221],"this":[222],"benefit.":[223],"conflicting":[225],"evidence":[226],"positive":[228],"outcomes,":[229],"future":[230],"III":[232],"needed":[235],"confirm":[237],"efficacy.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-26T00:00:00"}
