{"id":"https://openalex.org/W4287871782","doi":null,"title":"Cloning and Expression of an Oxantel Sensitive Homomeric Nicotinic Acetylcholine Receptor of Trichuris, the Tsu-ACR-16-like receptor","display_name":"Cloning and Expression of an Oxantel Sensitive Homomeric Nicotinic Acetylcholine Receptor of Trichuris, the Tsu-ACR-16-like receptor","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W4287871782"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-03154829v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-03154829","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anthelminitics IV : from discovery to ressitance, Feb 2020, Santa Monica, United States","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065924859","display_name":"Tina Vicky Alstrup Hansen","orcid":"https://orcid.org/0000-0002-2744-3093","observed_orcids":["https://orcid.org/0000-0002-2744-3093"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hansen, Tina Vicky Alstrup","raw_affiliation_strings":["Department of Veterinary and Animal Sciences [Copenhagen] (Gr\u00f8nneg\u00e5rdsvej 15\r\nDK-1870 Frederiksberg C - Denmark)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences [Copenhagen] (Gr\u00f8nneg\u00e5rdsvej 15\r\nDK-1870 Frederiksberg C - Denmark)","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074300840","display_name":"Dan Arne Klaerke","orcid":"https://orcid.org/0000-0003-4415-0361","observed_orcids":["https://orcid.org/0000-0003-4415-0361"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Klaerke, Dan","raw_affiliation_strings":["Department of Veterinary and Animal Sciences [Copenhagen] (Gr\u00f8nneg\u00e5rdsvej 15\r\nDK-1870 Frederiksberg C - Denmark)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences [Copenhagen] (Gr\u00f8nneg\u00e5rdsvej 15\r\nDK-1870 Frederiksberg C - Denmark)","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007616294","display_name":"Susanna Cirera","orcid":"https://orcid.org/0000-0001-8105-1579","observed_orcids":["https://orcid.org/0000-0001-8105-1579"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Cirera, Susanna","raw_affiliation_strings":["Department of Veterinary and Animal Sciences [Copenhagen] (Gr\u00f8nneg\u00e5rdsvej 15\r\nDK-1870 Frederiksberg C - Denmark)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences [Copenhagen] (Gr\u00f8nneg\u00e5rdsvej 15\r\nDK-1870 Frederiksberg C - Denmark)","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016852756","display_name":"C\u00e9dric Neveu","orcid":"https://orcid.org/0000-0003-4314-1850","observed_orcids":["https://orcid.org/0000-0003-4314-1850"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210147048","display_name":"Infectiologie et sant\u00e9 publique","ror":"https://ror.org/0454zjr22","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I4210088668","https://openalex.org/I4210147048"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Neveu, C\u00e9dric","raw_affiliation_strings":["ISP - Infectiologie et Sant\u00e9 Publique (INRAE  Val de Loire UMR ISP 1282 37380 Nouzilly / Facult\u00e9 de M\u00e9decine UMR ISP 1282 10 boulevard Tonnell\u00e9 37032 Tours Cedex 1 / Facult\u00e9 de Pharmacie UMR ISP 1282 31 avenue Monge 37200 Tours - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISP - Infectiologie et Sant\u00e9 Publique (INRAE  Val de Loire UMR ISP 1282 37380 Nouzilly / Facult\u00e9 de M\u00e9decine UMR ISP 1282 10 boulevard Tonnell\u00e9 37032 Tours Cedex 1 / Facult\u00e9 de Pharmacie UMR ISP 1282 31 avenue Monge 37200 Tours - France)","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210147048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055188626","display_name":"Kirstine Call\u00f8e","orcid":"https://orcid.org/0000-0002-1777-7938","observed_orcids":["https://orcid.org/0000-0002-1777-7938","https://orcid.org/0000-0002-8228-4195"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Calloe, Kirstine","raw_affiliation_strings":["Department of Veterinary and Animal Sciences [Copenhagen] (Gr\u00f8nneg\u00e5rdsvej 15\r\nDK-1870 Frederiksberg C - Denmark)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Animal Sciences [Copenhagen] (Gr\u00f8nneg\u00e5rdsvej 15\r\nDK-1870 Frederiksberg C - Denmark)","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033749081","display_name":"Richard J. Martin","orcid":"https://orcid.org/0000-0003-2422-1847","observed_orcids":["https://orcid.org/0000-0003-2422-1847"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin, Richard J.","raw_affiliation_strings":["ISU - Iowa State University (Ames, Iowa 50011 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISU - Iowa State University (Ames, Iowa 50011 - United States)","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45779765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.23029999434947968,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.1111999973654747,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/trichuris","display_name":"Trichuris","score":0.8370000123977661},{"id":"https://openalex.org/keywords/homomeric-receptors","display_name":"homomeric receptors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/gene-cloning","display_name":"gene cloning","score":0.6579999923706055},{"id":"https://openalex.org/keywords/receptor-expression","display_name":"receptor expression","score":0.781000018119812},{"id":"https://openalex.org/keywords/anthelmintic-drug-targets","display_name":"anthelmintic drug targets","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2776104367","wikidata":"https://www.wikidata.org/wiki/Q5891451","display_name":"Homomeric","level":4,"score":0.9535345435142517},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.6938654780387878},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.5801258087158203},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49144160747528076},{"id":"https://openalex.org/C2779861936","wikidata":"https://www.wikidata.org/wiki/Q738375","display_name":"Trichuris","level":3,"score":0.4433603584766388},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.4300377368927002},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4247162938117981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3786323070526123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3630051612854004},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1777801811695099},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.16531279683113098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13315531611442566},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09338134527206421},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:HAL:hal-03154829v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-03154829","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anthelminitics IV : from discovery to ressitance, Feb 2020, Santa Monica, United States","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ad305976-845e-402d-8725-0a84d39288c7","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/ad305976-845e-402d-8725-0a84d39288c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hansen , T V A , Kl\u00e6rke , D A , Cirera , S , Neveu , C , Call\u00f8 , K & Martin , R 2020 , ' Cloning and Expression of an Oxantel Sensitive Homomeric Nicotinic Acetylcholine Receptor of Trichuris, the Tsu-ACR-16-like receptor ' , 4th International conference of \u201cAnthelmintics: From Discovery to Resistance , Santa Monica , United States , 03/01/2020 - 07/02/2020 .","raw_type":"conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3126792139","https://openalex.org/W4412223128","https://openalex.org/W3184123089","https://openalex.org/W2489928659","https://openalex.org/W2963364612","https://openalex.org/W2783414578","https://openalex.org/W1975972945","https://openalex.org/W4297791322","https://openalex.org/W1978294750","https://openalex.org/W3109236711"],"abstract_inverted_index":{"Background":[0],"and":[1,20,63,150,174,188,207,215,223,229],"purpose:":[2],"Anthelmintic":[3],"resistance":[4],"and/or":[5],"decreased":[6,33],"susceptibility":[7,34,66],"to":[8,35,58,67,143,237,265],"anthelmintics":[9],"is":[10,21,52,76,99,122,130,145,234],"a":[11,73,83,107,123,153,186,261],"major":[12],"global":[13],"problem":[14],"in":[15,26,132,170,226],"parasitic":[16,126],"nematodes":[17],"of":[18,22,95,141,192,249,255,269],"livestock":[19],"great":[23],"concern,":[24],"mainly":[25],"the":[27,46,77,92,113,139,148,193,199,212,246,252,267],"Soil":[28],"Transmitted":[29],"Helminths":[30],"(STHs),":[31],"where":[32],"albendazole":[36],"has":[37,82,106],"already":[38],"been":[39],"reported":[40],"for":[41,155],"some":[42,110],"parasites,":[43],"amongst":[44],"these,":[45],"human":[47],"whipworm,":[48],"Trichuris":[49,51,87,98,129],"triciura.":[50],"an":[53],"interesting":[54],"nematode":[55],"genus":[56],"due":[57],"its":[59,64],"broad":[60],"host":[61],"spectrum":[62],"low":[65],"several":[68],"anthelmintic":[69,204],"drug":[70],"classes.":[71],"However,":[72],"noteworthy":[74],"exception":[75],"cholinergic":[78,203],"agonist":[79],"oxantel,":[80,250],"which":[81],"high":[84,187],"efficacy":[85],"against":[86,275],"spp.":[88],"Despite":[89],"this":[90,256,276],"knowledge,":[91],"molecular":[93],"target(s)":[94],"oxantel":[96,105,144,156,184,238],"within":[97,157],"still":[100],"unknown.":[101],"In":[102,181],"Ascaris":[103,120],"suum,":[104],"low,":[108],"but":[109,251],"effect":[111,268],"on":[112],"homomeric":[114],"nicotinic":[115],"Ach":[116],"receptor":[117,161,195,200,213,233,242,258],"ACR-16":[118],"(Asu-ACR-16).":[119],"suum":[121],"Clade":[124,133],"III":[125],"nematode,":[127],"whereas":[128,196],"included":[131],"I.":[134],"We":[135],"therefore":[136],"hypothesized":[137],"that":[138],"sensitivity":[140],"Tsu-ACR-16":[142],"different":[146],"from":[147],"Asu-ACR-16":[149],"could":[151],"be":[152,245],"target":[154,248],"Trichuris.Methodology:":[158],"A":[159],"Tsu-acr-16-like":[160],"was":[162],"identified,":[163],"amplified":[164],"by":[165],"PCR,":[166],"cloned,":[167],"functionally":[168],"expressed":[169],"Xenopus":[171],"laevis":[172],"oocytes":[173],"pharmacologically":[175],"characterized":[176],"under":[177],"two-electrode":[178],"voltage-clamp.":[179],"Results:":[180],"electrophysiological":[182],"experiments,":[183],"produced":[185],"robust":[189],"current":[190],"response":[191],"Tsu-ACR-16-like":[194,232,257],"pyrantel":[197],"activated":[198],"moderately.":[201],"The":[202,231],"compounds":[205,274],"morantel":[206],"levamisole":[208],"did":[209],"not":[210,244],"activate":[211],"significantly":[214],"nAChR":[216],"agonists,":[217],"including":[218],"epibathidine,":[219],"nicotine,":[220],"cytisine,":[221],"dimethylpiperazine":[222],"3-bromocytisine":[224],"resulted":[225],"minor":[227],"responses.Conclusion":[228],"perspective:":[230],"more":[235],"sensitive":[236],"than":[239],"Asu-ACR-16.":[240],"This":[241],"may":[243],"only":[247],"functional":[253],"expression":[254],"can":[259],"prove":[260],"valuable":[262],"screening":[263],"tool":[264],"evaluate":[266],"new":[270],"synthetic":[271],"or":[272],"natural":[273],"genus.":[277]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-07-26T00:00:00"}