{"id":"https://openalex.org/W4287560865","doi":null,"title":"Autophagy is required for in vitro myogenesis in piglets","display_name":"Autophagy is required for in vitro myogenesis in piglets","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W4287560865"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-03142047v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-03142047","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"71. Annual Meeting of the European Federation of Animal Science (EAAP), Dec 2020, Virtual meeting, Portugal. Wageningen Academic Publishers, Book of abstracts, 26, pp.354, 2020, Book of abstracts of the 71st annual meeting of the european federation of animal science","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091205861","display_name":"Annie Vincent","orcid":"https://orcid.org/0000-0002-8140-0799","observed_orcids":["https://orcid.org/0000-0002-8140-0799"]},"institutions":[{"id":"https://openalex.org/I4210094622","display_name":"Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage","ror":"https://ror.org/00mg8nf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210094622","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent, Annie","raw_affiliation_strings":["Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage [Rennes]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage [Rennes]","institution_ids":["https://openalex.org/I4210094622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075713204","display_name":"Marie\u2010H\u00e9l\u00e8ne Perruchot","orcid":"https://orcid.org/0000-0002-6608-9445","observed_orcids":["https://orcid.org/0000-0002-6608-9445"]},"institutions":[{"id":"https://openalex.org/I4210094622","display_name":"Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage","ror":"https://ror.org/00mg8nf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210094622","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Perruchot, Marie-H\u00e9l\u00e8ne","raw_affiliation_strings":["Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage [Rennes]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage [Rennes]","institution_ids":["https://openalex.org/I4210094622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059463050","display_name":"Isabelle Louveau","orcid":"https://orcid.org/0000-0001-9684-6294","observed_orcids":["https://orcid.org/0000-0001-9684-6294"]},"institutions":[{"id":"https://openalex.org/I4210094622","display_name":"Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage","ror":"https://ror.org/00mg8nf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210094622","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Louveau, Isabelle","raw_affiliation_strings":["Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage [Rennes]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage [Rennes]","institution_ids":["https://openalex.org/I4210094622"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029769785","display_name":"Fr\u00e9d\u00e9ric Dessauge","orcid":"https://orcid.org/0000-0002-5785-2365","observed_orcids":["https://orcid.org/0000-0002-5785-2365"]},"institutions":[{"id":"https://openalex.org/I4210094622","display_name":"Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage","ror":"https://ror.org/00mg8nf58","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210094622","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dessauge, Frederic","raw_affiliation_strings":["Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage [Rennes]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiologie, Environnement et G\u00e9n\u00e9tique pour l'Animal et les Syst\u00e8mes d'Elevage [Rennes]","institution_ids":["https://openalex.org/I4210094622"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210094622"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"26","first_page":"354","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.49219998717308044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.49219998717308044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.486299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/piglets","display_name":"piglets","score":0.7599999904632568},{"id":"https://openalex.org/keywords/skeletal-muscle-homeostasis","display_name":"skeletal muscle homeostasis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/myotube-differentiation","display_name":"myotube differentiation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.7689999938011169},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.703000009059906},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bafilomycin-a1","display_name":"bafilomycin A1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cell-fusion","display_name":"cell fusion","score":0.5950000286102295},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.6269999742507935},{"id":"https://openalex.org/keywords/longissimus-muscle","display_name":"longissimus dorsi","score":0.7229999899864197},{"id":"https://openalex.org/keywords/autophagy-related-proteins","display_name":"autophagy-related proteins","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8588953018188477},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.7735365629196167},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.679002046585083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6585826277732849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34755939245224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32921668887138367},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.240658700466156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13690492510795593},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.06456831097602844}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-03142047v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-03142047","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"71. Annual Meeting of the European Federation of Animal Science (EAAP), Dec 2020, Virtual meeting, Portugal. Wageningen Academic Publishers, Book of abstracts, 26, pp.354, 2020, Book of abstracts of the 71st annual meeting of the european federation of animal science","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362702162","https://openalex.org/W2314998955","https://openalex.org/W4206890880","https://openalex.org/W4385774161","https://openalex.org/W2441930534","https://openalex.org/W3121492098","https://openalex.org/W4308592517","https://openalex.org/W2735474285","https://openalex.org/W2594038545","https://openalex.org/W4405947510"],"abstract_inverted_index":{"Autophagy":[0],"is":[1,81,268],"a":[2,7,207,221],"lysosomal":[3],"degradation":[4],"pathway":[5],"with":[6,234],"role":[8,50],"in":[9,43,53,109,138,151,184,255,275],"the":[10,17,49,61,76,91,98,116,249,296],"turnover":[11],"of":[12,51,63,73,97,118,124,194,200,204,210,237,251,293,299],"cell":[13,111,121,214,225,258,273,289],"components":[14],"via":[15],"self-digestion.Over":[16],"past":[18],"decade,":[19],"it":[20],"has":[21,37],"been":[22,38],"recognised":[23],"as":[24],"an":[25,82,152,235],"essential":[26],"process":[27,42],"to":[28,40,68,85,102,105,114,142,145,159,242,282],"maintain":[29],"cellular":[30],"and":[31,57,113,148,164,177,187,192,213,216,295],"energy":[32],"homeostasis.":[33],"Nevertheless,":[34],"little":[35],"attention":[36],"paid":[39],"this":[41,110],"agronomical":[44],"animal":[45],"species.":[46],"In":[47,261],"pigs,":[48],"autophagy":[52,88,93,107,119,238,245,267],"skeletal":[54],"muscle":[55,65,78,126],"homeostasis":[56],"more":[58],"specifically":[59],"on":[60,120],"formation":[62],"multi-nucleated":[64],"fibres":[66],"needs":[67],"be":[69,281],"determined.":[70],"Primary":[71],"culture":[72,154,259],"satellite":[74,134,257,272],"cells,":[75,80],"resident":[77],"stem":[79],"appropriate":[83,153],"model":[84,112],"investigate":[86],"macro":[87],"(hereafter":[89],"autophagy),":[90],"main":[92],"process.":[94],"The":[95,196,277],"objective":[96],"current":[99],"study":[100],"was":[101,246],"evaluate":[103],"tools":[104],"monitor":[106],"flux":[108],"determine":[115],"impact":[117],"differentiation.":[122,195],"Samples":[123],"longissimus":[125],"were":[127,136,167,179,227,232],"collected":[128],"from":[129],"4-day-old":[130],"piglets.":[131],"After":[132],"isolation,":[133],"cells":[135,166,186,231],"plated":[137],"growth":[139],"medium,":[140],"allowed":[141],"proliferate":[143],"up":[144],"80%":[146],"confluence":[147],"then":[149],"placed":[150],"medium":[155],"for":[156,224,270],"6":[157,193],"days":[158],"differentiate":[160],"into":[161,253],"myotubes.":[162],"Proliferating":[163],"differentiating":[165],"explored.":[168],"Autophagy-related":[169],"proteins":[170],"(LC3-I,":[171],"LC3-II,":[172],"ULK-1,":[173],"Beclin,":[174],"p53,":[175],"PI3K":[176],"p62)":[178],"detected":[180],"by":[181],"Western":[182],"blotting":[183],"proliferating":[185],"at":[188],"day":[189],"1,":[190],"3":[191],"two":[197],"major":[198,222],"regulators":[199],"metabolism:":[201],"mammalian":[202],"target":[203],"rapamycin":[205],"(mTOR),":[206],"central":[208],"hub":[209],"nutrient":[211],"signalling":[212],"growth,":[215],"AMP-activated":[217],"protein":[218],"kinase":[219],"(AMPK),":[220],"sensor":[223],"energy,":[226],"also":[228],"detected.":[229],"Then,":[230],"treated":[233],"inhibitor":[236],"flux,":[239],"bafilomycin":[240],"A1":[241],"confirm":[243],"that":[244,265,284],"activated":[247],"during":[248,291],"conversion":[250],"myoblasts":[252],"myotubes":[254],"our":[256],"model.":[260],"conclusion,":[262],"we":[263],"demonstrated":[264],"basal":[266],"required":[269],"porcine":[271],"differentiation":[274,294],"vitro.":[276],"next":[278],"step":[279,298],"will":[280],"demonstrate":[283],"autophagosome":[285],"biogenesis":[286],"impairment":[287],"halts":[288],"fusion":[290,297],"stages":[292],"myocytes.":[300]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-07-25T00:00:00"}
