{"id":"https://openalex.org/W4287536302","doi":null,"title":"Is there a latent left ventricular dysfunction in hypertensive patients with preserved ejection fraction?","display_name":"Is there a latent left ventricular dysfunction in hypertensive patients with preserved ejection fraction?","publication_year":2021,"publication_date":"2021-04-01","ids":{"openalex":"https://openalex.org/W4287536302","pmid":"https://pubmed.ncbi.nlm.nih.gov/35244931","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8734485"},"language":"en","primary_location":{"id":"pmid:35244931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35244931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Tunisie medicale","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8734485/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011569755","display_name":"Karima Taamallah","orcid":"https://orcid.org/0000-0002-9904-2897","observed_orcids":["https://orcid.org/0000-0002-9904-2897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karima Taamallah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078808158","display_name":"Bouthaina Besbes","orcid":"https://orcid.org/0000-0001-6178-4863","observed_orcids":["https://orcid.org/0000-0001-6178-4863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bouthaina Besbes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031295743","display_name":"Haythem Raddaoui","orcid":"https://orcid.org/0000-0003-4803-8449","observed_orcids":["https://orcid.org/0000-0003-4803-8449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haythem Raddaoui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113904945","display_name":"Nadhem Hajlaoui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadhem Hajlaoui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009038831","display_name":"Dhaker Lahidheb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dhaker Lahidheb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027994375","display_name":"Wafa Fehri","orcid":"https://orcid.org/0000-0003-0312-8184","observed_orcids":["https://orcid.org/0000-0003-0312-8184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wafa Fehri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3494,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55998478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"99","issue":"4","first_page":"456","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.7829999923706055},{"id":"https://openalex.org/keywords/preserved-ejection-fraction","display_name":"preserved ejection fraction","score":0.9810000061988831},{"id":"https://openalex.org/keywords/left-ventricular-systolic-dysfunction","display_name":"left ventricular systolic dysfunction","score":0.8550000190734863},{"id":"https://openalex.org/keywords/global-longitudinal-strain","display_name":"global longitudinal strain","score":0.796999990940094},{"id":"https://openalex.org/keywords/speckle-tracking-echocardiography","display_name":"speckle tracking echocardiography","score":0.9390000104904175},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/subclinical-myocardial-dysfunction","display_name":"subclinical cardiac dysfunction","score":0.902999997138977},{"id":"https://openalex.org/keywords/diastolic-function","display_name":"diastolic function","score":0.8339999914169312},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.7829999923706055},{"id":"https://openalex.org/keywords/risk-factors-for-heart-failure","display_name":"heart failure risk","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8717731237411499},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.8448282480239868},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8398591876029968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8019144535064697},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.6484630703926086},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5752962827682495},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.5454455614089966},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.46855077147483826},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4488440752029419},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.4464706778526306},{"id":"https://openalex.org/C2778296771","wikidata":"https://www.wikidata.org/wiki/Q7575047","display_name":"Speckle tracking echocardiography","level":4,"score":0.42124420404434204},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.23733729124069214}],"mesh":[{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:35244931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35244931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Tunisie medicale","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8734485","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8734485/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tunis Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8734485","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8734485/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tunis Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1561010946","https://openalex.org/W1933258616","https://openalex.org/W1968122601","https://openalex.org/W1983279131","https://openalex.org/W2013784844","https://openalex.org/W2017619275","https://openalex.org/W2023515446","https://openalex.org/W2036828471","https://openalex.org/W2058957379","https://openalex.org/W2066124237","https://openalex.org/W2100329964","https://openalex.org/W2105400632","https://openalex.org/W2124624517","https://openalex.org/W2156731876","https://openalex.org/W2167611982","https://openalex.org/W2170598749","https://openalex.org/W2195419433","https://openalex.org/W2238977382","https://openalex.org/W2317862318","https://openalex.org/W2419175340","https://openalex.org/W2421809228","https://openalex.org/W2427094903","https://openalex.org/W2474269498","https://openalex.org/W2475148686","https://openalex.org/W2614093009","https://openalex.org/W2705928104","https://openalex.org/W2761947337","https://openalex.org/W2793399999","https://openalex.org/W2803636077","https://openalex.org/W2888589263","https://openalex.org/W2894820892","https://openalex.org/W2911168310","https://openalex.org/W2914601874","https://openalex.org/W2971111962","https://openalex.org/W2997642612","https://openalex.org/W3008625638"],"related_works":["https://openalex.org/W3216917841","https://openalex.org/W2167611982","https://openalex.org/W7125598937","https://openalex.org/W2474269498","https://openalex.org/W3190652537","https://openalex.org/W3006255799","https://openalex.org/W2781772183","https://openalex.org/W4410587777","https://openalex.org/W4313363401","https://openalex.org/W4406600399"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Early":[1],"detection":[2],"of":[3,48,74,108,160,227,243,253],"left":[4,134,139,154,237],"ventricular":[5,135,155,238],"(LV)":[6],"dysfunction":[7,256],"may":[8,274],"represent":[9],"a":[10,85,220,250],"clinical":[11],"finding":[12],"that":[13,247,262],"would":[14],"justify":[15],"aggressive":[16],"treatment":[17],"aimed":[18],"to":[19,44],"reduce":[20],"cardiovascular":[21],"morbidity":[22],"and":[23,35,70,77,80,120,137,147,188,214,271],"mortality.":[24],"AIM:":[25],"To":[26],"evaluate":[27],"longitudinal":[28],"contractility":[29],"in":[30,41,164,199,211,232,257],"patients":[31,64,109,129,151,200,218,264],"with":[32,67,192,201,236],"essential":[33],"hypertension":[34],"preserved":[36,68],"LV":[37,49,117,161],"ejection":[38],"fraction":[39],"(EF),":[40],"an":[42],"attempt":[43],"detect":[45],"latent":[46],"impairment":[47],"systolic":[50],"function.":[51],"METHODS:":[52],"Prospective":[53],"case-control":[54],"study":[55,245],"carried":[56],"out":[57],"on":[58],"121":[59],"(67":[60],"male/54":[61],"female)":[62],"hypertensive":[63,217,234,258],"(HTN":[65],"group)":[66],"EF":[69],"without":[71],"any":[72],"symptoms":[73],"heart":[75,269],"failure":[76,270],"39":[78],"age-":[79],"gender-matched":[81],"healthy":[82],"subjects":[83],"as":[84,91,93],"control":[86],"group.":[87],"Conventional":[88],"echocardiographic":[89],"study,":[90],"well":[92],"2D":[94],"Longitudinal":[95],"strain":[96],"imaging":[97],"by":[98],"2D-speckle":[99],"tracking":[100],"echocardiography":[101],"(2D-STE),":[102],"were":[103,122],"performed.":[104],"RESULTS:":[105],"Mean":[106],"age":[107],"was":[110,162,177,196,229],"60,48":[111],"\u00b1":[112,204,209],"10.5":[113],"years":[114],"old.":[115],"The":[116,158,225,241],"end-diastolic":[118],"diameter":[119],"LVEF":[121],"comparable":[123],"between":[124,173],"the":[125,174,233],"two":[126,175],"groups.":[127],"Hypertensive":[128],"had":[130,153,219],"greater":[131],"septal":[132],"thickness,":[133],"mass,":[136],"maximum":[138],"atrium":[140],"volume":[141],"(p":[142],"respectively":[143],"at":[144,265],"0.02;":[145],"0.04;":[146],"0.01).":[148],"Only":[149],"20":[150],"(16.5%)":[152],"hypertrophy":[156],"(LVH).":[157],"architecture":[159],"normal":[163,193],"57.8":[165],"%":[166,206],"(n=70)":[167],"patients.":[168],"A":[169],"statistically":[170],"significant":[171],"difference":[172],"groups":[176],"found":[178],"for":[179,268],"all":[180],"diastolic":[181],"function":[182],"parameters":[183],"except":[184],"Em":[185],"/Ea":[186],"ratio":[187],"DTEm.":[189],"In":[190],"comparison":[191],"controls,":[194],"GLS":[195,228,248],"significantly":[197],"attenuated":[198],"HTN":[202],"(-17.69":[203],"4.06":[205],"versus":[207],"-22.70":[208],"5.02%":[210],"controls":[212],"(p=0.000)":[213],"67":[215],"(55.4%)":[216],"GLS<-20%":[221],"(in":[222],"absolute":[223],"value).":[224],"decrease":[226],"more":[230],"marked":[231],"group":[235],"hypertrophy.":[239],"CONCLUSION:":[240],"results":[242],"our":[244],"confirmed":[246],"is":[249],"sensitive":[251],"biomarker":[252],"subclinical":[254],"myocardial":[255],"patients,":[259],"this":[260],"suggests":[261],"identifying":[263],"higher":[266],"risk":[267],"earlier":[272],"inter\u00acvention":[273],"be":[275],"beneficial.":[276]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-25T00:00:00"}