{"id":"https://openalex.org/W4287448581","doi":"https://doi.org/10.1016/j.sjbs.2022.103396","title":"The anti-inflammatory properties of the methanolic extract of Cucumis melo Linn. against prostate enlargement in Wistar rats","display_name":"The anti-inflammatory properties of the methanolic extract of Cucumis melo Linn. against prostate enlargement in Wistar rats","publication_year":2022,"publication_date":"2022-07-25","ids":{"openalex":"https://openalex.org/W4287448581","doi":"https://doi.org/10.1016/j.sjbs.2022.103396","pmid":"https://pubmed.ncbi.nlm.nih.gov/35942162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9356295"},"language":"en","primary_location":{"id":"doi:10.1016/j.sjbs.2022.103396","doi":"https://doi.org/10.1016/j.sjbs.2022.103396","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sjbs.2022.103396","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319562X22003126/pdf","source":{"id":"https://openalex.org/S32679471","display_name":"Saudi Journal of Biological Sciences","issn_l":"1319-562X","issn":["1319-562X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1319562X22003126/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R.S. Rajasree","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.S. Rajasree","raw_affiliation_strings":["College of Pharmaceutical Sciences, Government Thirumala Devaswom Medical College, Alappuzha 688005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Government Thirumala Devaswom Medical College, Alappuzha 688005, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063978070","display_name":"Sibi P. Ittiyavirah","orcid":"https://orcid.org/0000-0001-7017-1452","observed_orcids":["https://orcid.org/0000-0001-7017-1452"]},"institutions":[{"id":"https://openalex.org/I4405258901","display_name":"Centre for Professional and Advanced Studies","ror":"https://ror.org/01cpasf18","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405258901"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sibi P. Ittiyavirah","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Centre for Professional and Advanced Sciences Cheruvandoor, Kottayam 686631, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Centre for Professional and Advanced Sciences Cheruvandoor, Kottayam 686631, India","institution_ids":["https://openalex.org/I4405258901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107944114","display_name":"Punnoth Poonkuzhi Naseef","orcid":"https://orcid.org/0000-0001-9692-6323","observed_orcids":["https://orcid.org/0000-0001-9692-6323"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Punnoth Poonkuzhi Naseef","raw_affiliation_strings":["Department of Pharmaceutics, Moulana College of Pharmacy, Perinthalmanna 679321, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Moulana College of Pharmacy, Perinthalmanna 679321, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066989709","display_name":"Mohamed Saheer Kuruniyan","orcid":"https://orcid.org/0000-0003-3341-0914","observed_orcids":["https://orcid.org/0000-0003-3341-0914"]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohamed Saheer Kuruniyan","raw_affiliation_strings":["Department of Dental Technology, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Technology, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052399997","display_name":"Muhammed Elayadeth\u2010Meethal","orcid":"https://orcid.org/0000-0003-0044-0762","observed_orcids":["https://orcid.org/0000-0003-0044-0762"]},"institutions":[{"id":"https://openalex.org/I335685885","display_name":"Kerala Veterinary and Animal Sciences University","ror":"https://ror.org/00rf3br26","country_code":"IN","type":"education","lineage":["https://openalex.org/I335685885"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Muhammed Elayadeth-Meethal","raw_affiliation_strings":["Department of Animal Breeding and Genetics, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad 675621, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Breeding and Genetics, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad 675621, India","institution_ids":["https://openalex.org/I335685885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067050742","display_name":"S Sankar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180771373","display_name":"Government Medical College","ror":"https://ror.org/05w6g2m14","country_code":"IN","type":"education","lineage":["https://openalex.org/I180771373"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S Sankar","raw_affiliation_strings":["Department of Pathology, Govt Medical College, Kottayam 686008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Govt Medical College, Kottayam 686008, India","institution_ids":["https://openalex.org/I180771373"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5107944114"],"corresponding_institution_ids":[],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":{"value":1350,"currency":"USD","value_usd":1350},"fwci":1.1774,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75457318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"9","first_page":"103396","last_page":"103396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.5687999725341797,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.5687999725341797,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.36250001192092896,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melon","display_name":"Cucumis melo","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.699999988079071},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.906000018119812},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.4869999885559082},{"id":"https://openalex.org/keywords/prostate-enlargement","display_name":"prostate enlargement","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2778369795","wikidata":"https://www.wikidata.org/wiki/Q148758","display_name":"Cucumis","level":2,"score":0.815489649772644},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7337065935134888},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.6791350841522217},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.6047960519790649},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6046727299690247},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.5887623429298401},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5153748393058777},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5027632713317871},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48880359530448914},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45037686824798584},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.41554051637649536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39579927921295166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34567561745643616},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2210618555545807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20676293969154358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13721752166748047},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.11968418955802917},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.sjbs.2022.103396","doi":"https://doi.org/10.1016/j.sjbs.2022.103396","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sjbs.2022.103396","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319562X22003126/pdf","source":{"id":"https://openalex.org/S32679471","display_name":"Saudi Journal of Biological Sciences","issn_l":"1319-562X","issn":["1319-562X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9356295","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9356295","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi J Biol Sci","raw_type":"Text"},{"id":"pmid:35942162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35942162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi journal of biological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1797dcca32f040a9aaef3556913961f8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1797dcca32f040a9aaef3556913961f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Saudi Journal of Biological Sciences, Vol 29, Iss 9, Pp 103396- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.sjbs.2022.103396","doi":"https://doi.org/10.1016/j.sjbs.2022.103396","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sjbs.2022.103396","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1319562X22003126/pdf","source":{"id":"https://openalex.org/S32679471","display_name":"Saudi Journal of Biological Sciences","issn_l":"1319-562X","issn":["1319-562X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Saudi Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1683656469","display_name":null,"funder_award_id":"RGP 2/218/43","funder_id":"https://openalex.org/F4320324433","funder_display_name":"King Khalid University"}],"funders":[{"id":"https://openalex.org/F4320322804","display_name":"Deanship of Scientific Research, King Faisal University","ror":"https://ror.org/00dn43547"},{"id":"https://openalex.org/F4320324433","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4287448581.pdf","grobid_xml":"https://content.openalex.org/works/W4287448581.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1569409938","https://openalex.org/W1970652854","https://openalex.org/W1981819970","https://openalex.org/W2065078105","https://openalex.org/W2113683216","https://openalex.org/W2609561116","https://openalex.org/W2742716416","https://openalex.org/W2746345908","https://openalex.org/W2754624641","https://openalex.org/W2766005576","https://openalex.org/W2792209051","https://openalex.org/W2795673785","https://openalex.org/W2797718322","https://openalex.org/W2799972478","https://openalex.org/W2802577659","https://openalex.org/W2804532125","https://openalex.org/W2808755202","https://openalex.org/W2810537390","https://openalex.org/W2885738092","https://openalex.org/W2894732797","https://openalex.org/W2914496214","https://openalex.org/W2919158319","https://openalex.org/W2938707679","https://openalex.org/W2938741348","https://openalex.org/W2938956554","https://openalex.org/W2942593099","https://openalex.org/W2942651424","https://openalex.org/W2951512731","https://openalex.org/W2964940371","https://openalex.org/W2967361352","https://openalex.org/W2974363873","https://openalex.org/W2993908729","https://openalex.org/W2996803333","https://openalex.org/W2998735788","https://openalex.org/W2999693090","https://openalex.org/W3006510877","https://openalex.org/W3010953141","https://openalex.org/W3012432607","https://openalex.org/W3013429924","https://openalex.org/W3023478961","https://openalex.org/W3039977092","https://openalex.org/W3082805365","https://openalex.org/W3096705036","https://openalex.org/W3102953020","https://openalex.org/W3110203744","https://openalex.org/W3113033233","https://openalex.org/W3132148284","https://openalex.org/W3135705588","https://openalex.org/W3138483653","https://openalex.org/W3149158096","https://openalex.org/W3156024823","https://openalex.org/W3160653615","https://openalex.org/W3177505682","https://openalex.org/W3185644254","https://openalex.org/W3194125366","https://openalex.org/W3194530884","https://openalex.org/W3196124457","https://openalex.org/W3197906260","https://openalex.org/W4250401124"],"related_works":["https://openalex.org/W2003283333","https://openalex.org/W3094575642","https://openalex.org/W2786747223","https://openalex.org/W2914246474","https://openalex.org/W1997298137","https://openalex.org/W3043581521","https://openalex.org/W4246565134","https://openalex.org/W2916534448","https://openalex.org/W7222948758","https://openalex.org/W2471914649"],"abstract_inverted_index":{"In":[0],"different":[1],"parts":[2],"of":[3,23,27,70,141],"the":[4,21,60,68,109,113,137,157],"world,":[5],"Cucumis":[6],"melo":[7,29,151],"Linn.":[8,30],"(C":[9],"melo)":[10],"is":[11],"used":[12],"for":[13,129],"its":[14,45,96],"medicinal":[15],"properties.":[16],"The":[17,74],"present":[18],"study":[19],"examined":[20],"effects":[22],"a":[24,63,105],"methanolic":[25],"extract":[26,61],"C":[28,150],"(F1":[31],"hybrid,":[32],"MECM)":[33],"on":[34,108],"benign":[35,81],"prostatic":[36,82],"hyperplasia":[37,83],"in":[38,48,91,112],"adult":[39],"male":[40],"Wistar":[41],"rats":[42],"and":[43,123,139,143],"evaluated":[44],"anti-inflammatory":[46,97],"activity":[47],"vivo.":[49],"MECM":[50,75,85,103,134],"treatment":[51],"reduced":[52],"prostate":[53],"weight":[54],"mildly.":[55],"Histopathological":[56],"studies":[57],"showed":[58,77],"that":[59,102,133],"produced":[62],"strong":[64],"protective":[65],"effect":[66,107],"against":[67,88],"development":[69],"BPH":[71],"by":[72],"testosterone.":[73],"also":[76],"protection":[78],"from":[79],"testosterone-induced":[80],"(BPH).":[84],"was":[86,100],"tested":[87],"carrageenan-induced":[89],"inflammation":[90],"rats'":[92],"paws":[93],"to":[94,155],"determine":[95],"activity.":[98],"It":[99],"shown":[101],"had":[104],"pronounced":[106],"inflammatory":[110],"response":[111],"late":[114],"phase,":[115],"i.e.,":[116],"one":[117],"hour":[118],"after":[119],"carrageenan":[120],"injection.":[121],"Prostaglandins":[122],"nitric":[124,144],"oxide":[125],"are":[126],"primarily":[127],"responsible":[128],"this":[130],"phase":[131],"indicating":[132],"can":[135],"modify":[136],"production":[138],"release":[140],"prostaglandin":[142],"oxide.":[145],"A":[146],"novel":[147],"formulation":[148],"containing":[149],"may":[152],"be":[153],"able":[154],"treat":[156],"conditions":[158],"mentioned":[159],"above.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-07-25T00:00:00"}