{"id":"https://openalex.org/W4287218669","doi":"https://doi.org/10.3389/fgene.2022.929293","title":"Identification of novel biomarkers in septic cardiomyopathy via integrated bioinformatics analysis and experimental validation","display_name":"Identification of novel biomarkers in septic cardiomyopathy via integrated bioinformatics analysis and experimental validation","publication_year":2022,"publication_date":"2022-07-25","ids":{"openalex":"https://openalex.org/W4287218669","doi":"https://doi.org/10.3389/fgene.2022.929293","pmid":"https://pubmed.ncbi.nlm.nih.gov/35957694","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9358039"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2022.929293","doi":"https://doi.org/10.3389/fgene.2022.929293","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.929293","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fgene.2022.929293","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002680408","display_name":"Feng L\u00fc","orcid":"https://orcid.org/0000-0002-5695-6015","observed_orcids":["https://orcid.org/0000-0002-5695-6015"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Lu","raw_affiliation_strings":["Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030820574","display_name":"Feng Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Hu","raw_affiliation_strings":["Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076756515","display_name":"Bai\u2010Quan Qiu","orcid":"https://orcid.org/0000-0001-8471-004X","observed_orcids":["https://orcid.org/0000-0001-8471-004X"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baiquan Qiu","raw_affiliation_strings":["Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009298100","display_name":"Hong-Peng Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongpeng Zou","raw_affiliation_strings":["Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011100608","display_name":"Jianjun Xu","orcid":"https://orcid.org/0000-0002-4668-8395","observed_orcids":["https://orcid.org/0000-0002-4668-8395"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianjun Xu","raw_affiliation_strings":["Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210108480"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011100608"],"corresponding_institution_ids":["https://openalex.org/I4210108480"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.6854,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.89361702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"929293","last_page":"929293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septic-cardiomyopathy","display_name":"septic cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9599999785423279},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.9779999852180481},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8550000190734863},{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il1r2","display_name":"IL1R2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/junb","display_name":"JunB","score":0.9990000128746033},{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":1.0},{"id":"https://openalex.org/keywords/osmr","display_name":"OSMR","score":0.9990000128746033},{"id":"https://openalex.org/keywords/zfp36","display_name":"ZFP36","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepcidin","display_name":"hepcidin","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hl-1-cells","display_name":"HL-1 cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ac16-cells","display_name":"AC16 cells","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6005427837371826},{"id":"https://openalex.org/C2781085546","wikidata":"https://www.wikidata.org/wiki/Q18028096","display_name":"JUNB","level":4,"score":0.5697816014289856},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.5091678500175476},{"id":"https://openalex.org/C2777453290","wikidata":"https://www.wikidata.org/wiki/Q18031090","display_name":"RELB","level":5,"score":0.43007487058639526},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.42510685324668884},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4102494716644287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40674322843551636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39584600925445557},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3715449571609497},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.21504390239715576},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20583492517471313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1597607135772705},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.14266818761825562},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.0709165632724762},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fgene.2022.929293","doi":"https://doi.org/10.3389/fgene.2022.929293","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.929293","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9358039","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9358039/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9358039/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmid:35957694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35957694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:146b2907855447d68b67f7ec4977ed0e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/146b2907855447d68b67f7ec4977ed0e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2022.929293","doi":"https://doi.org/10.3389/fgene.2022.929293","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2022.929293","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4287218669.pdf","grobid_xml":"https://content.openalex.org/works/W4287218669.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1574290496","https://openalex.org/W1946039161","https://openalex.org/W1989940911","https://openalex.org/W2006919847","https://openalex.org/W2020541351","https://openalex.org/W2031721046","https://openalex.org/W2046951291","https://openalex.org/W2077121523","https://openalex.org/W2097795961","https://openalex.org/W2098775968","https://openalex.org/W2101173010","https://openalex.org/W2103491454","https://openalex.org/W2105924489","https://openalex.org/W2125242137","https://openalex.org/W2136746865","https://openalex.org/W2144589352","https://openalex.org/W2146512944","https://openalex.org/W2155142785","https://openalex.org/W2158038801","https://openalex.org/W2170874249","https://openalex.org/W2173669545","https://openalex.org/W2211845703","https://openalex.org/W2280404143","https://openalex.org/W2329970281","https://openalex.org/W2345774905","https://openalex.org/W2402755236","https://openalex.org/W2407236477","https://openalex.org/W2508709866","https://openalex.org/W2524789477","https://openalex.org/W2621241757","https://openalex.org/W2790014871","https://openalex.org/W2811159409","https://openalex.org/W2896097028","https://openalex.org/W2896180430","https://openalex.org/W2912555011","https://openalex.org/W2943532720","https://openalex.org/W2944391397","https://openalex.org/W2948029220","https://openalex.org/W2965099074","https://openalex.org/W2969941637","https://openalex.org/W2982583040","https://openalex.org/W2985156440","https://openalex.org/W3010382128","https://openalex.org/W3013966184","https://openalex.org/W3022062050","https://openalex.org/W3026964594","https://openalex.org/W3027743527","https://openalex.org/W3029550272","https://openalex.org/W3040531409","https://openalex.org/W3048647839","https://openalex.org/W3084742155","https://openalex.org/W3117313514","https://openalex.org/W3182079064","https://openalex.org/W3215369806","https://openalex.org/W4210762050","https://openalex.org/W4211227031"],"related_works":["https://openalex.org/W2969941637","https://openalex.org/W7071925516","https://openalex.org/W4313571308","https://openalex.org/W7140564752","https://openalex.org/W4388946582","https://openalex.org/W4404412103","https://openalex.org/W7125009462","https://openalex.org/W4297906087","https://openalex.org/W4402638980","https://openalex.org/W4391350382"],"abstract_inverted_index":{"Purpose:Septic":[0],"cardiomyopathy":[1],"(SCM)":[2],"is":[3,16],"an":[4,60],"important":[5,153],"world":[6],"public":[7],"health":[8],"problem":[9],"with":[10,100],"high":[11],"morbidity":[12],"and":[13,31,46,67,75,86,97,102,120,134,149],"mortality.":[14],"It":[15],"necessary":[17],"to":[18,26,58],"identify":[19,27],"SCM":[20,35,89,128],"biomarkers":[21],"at":[22],"the":[23,50,88,126],"genetic":[24],"level":[25],"new":[28],"therapeutic":[29],"targets":[30],"strategies.":[32],"Method:DEGs":[33],"in":[34,125,155],"were":[36,84,108,122],"identified":[37],"by":[38,93],"comprehensive":[39],"bioinformatics":[40,54,132],"analysis":[41,55,133],"of":[42,63],"microarray":[43],"datasets":[44],"(GSE53007":[45],"GSE79962)":[47],"downloaded":[48],"from":[49],"GEO":[51],"database.":[52],"Subsequently,":[53],"was":[56,91,138],"used":[57],"conduct":[59],"in-depth":[61],"exploration":[62],"DEGs,":[64],"including":[65],"GO":[66],"KEGG":[68],"pathway":[69],"enrichment":[70],"analysis,":[71],"PPI":[72],"network":[73],"construction,":[74],"key":[76],"gene":[77],"identification.":[78],"The":[79],"top":[80,104],"ten":[81,105],"Hub":[82,106],"genes":[83,107],"identified,":[85],"then":[87],"model":[90],"constructed":[92],"treating":[94],"HL-1":[95],"cells":[96,99,129],"AC16":[98],"LPS,":[101],"these":[103],"examined":[109],"using":[110],"qPCR.":[111],"Result:STAT3,":[112],"SOCS3,":[113,142],"CCL2,":[114,143],"IL1R2,":[115,144],"JUNB,":[116,145],"S100A9,":[117,146],"OSMR,":[118,147],"ZFP36,":[119,148],"HAMP":[121,150],"significantly":[123],"elevated":[124],"established":[127],"model.":[130],"Conclusion:After":[131],"experimental":[135],"verification,":[136],"it":[137],"demonstrated":[139],"that":[140],"STAT3,":[141],"might":[151],"play":[152],"roles":[154],"SCM.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-07-25T00:00:00"}
