{"id":"https://openalex.org/W4287218261","doi":"https://doi.org/10.1038/s41375-022-01653-7","title":"Immune senescence in multiple myeloma\u2014a role for mitochondrial dysfunction?","display_name":"Immune senescence in multiple myeloma\u2014a role for mitochondrial dysfunction?","publication_year":2022,"publication_date":"2022-07-25","ids":{"openalex":"https://openalex.org/W4287218261","doi":"https://doi.org/10.1038/s41375-022-01653-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/35879358"},"language":"en","primary_location":{"id":"doi:10.1038/s41375-022-01653-7","doi":"https://doi.org/10.1038/s41375-022-01653-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41375-022-01653-7","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002489850","display_name":"Frances Seymour","orcid":"https://orcid.org/0000-0002-0887-7195","observed_orcids":["https://orcid.org/0000-0002-0887-7195"]},"institutions":[{"id":"https://openalex.org/I2799390153","display_name":"Leeds Teaching Hospitals NHS Trust","ror":"https://ror.org/00v4dac24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Frances Seymour","raw_affiliation_strings":["Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK. frances.seymour1@nhs.net","Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK"],"raw_orcid":"https://orcid.org/0000-0002-0887-7195","affiliations":[{"raw_affiliation_string":"Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK. frances.seymour1@nhs.net","institution_ids":["https://openalex.org/I2799390153"]},{"raw_affiliation_string":"Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK","institution_ids":["https://openalex.org/I2799390153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091517453","display_name":"Jonathan Carmichael","orcid":"https://orcid.org/0000-0001-5946-0384","observed_orcids":["https://orcid.org/0000-0001-5946-0384"]},"institutions":[{"id":"https://openalex.org/I2799390153","display_name":"Leeds Teaching Hospitals NHS Trust","ror":"https://ror.org/00v4dac24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I4210109306","display_name":"NIHR Leeds In Vitro Diagnostics Co-operative","ror":"https://ror.org/01ykn4490","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109306"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Carmichael","raw_affiliation_strings":["Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK","NIHR (Leeds) Medtech & In vitro Diagnostic Cooperative, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK","institution_ids":["https://openalex.org/I2799390153"]},{"raw_affiliation_string":"NIHR (Leeds) Medtech & In vitro Diagnostic Cooperative, Leeds, UK","institution_ids":["https://openalex.org/I4210109306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081066697","display_name":"Claire Taylor","orcid":"https://orcid.org/0000-0002-8998-5971","observed_orcids":["https://orcid.org/0000-0002-8998-5971"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Taylor","raw_affiliation_strings":["Experimental Haematology, Leeds Institute of Medical Research, University of Leeds UK, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Haematology, Leeds Institute of Medical Research, University of Leeds UK, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001499861","display_name":"Christopher Parrish","orcid":"https://orcid.org/0000-0001-9627-736X","observed_orcids":["https://orcid.org/0000-0001-9627-736X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2799390153","display_name":"Leeds Teaching Hospitals NHS Trust","ror":"https://ror.org/00v4dac24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Parrish","raw_affiliation_strings":["Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trial Research, University of Leeds UK, Leeds, UK","Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trial Research, University of Leeds UK, Leeds, UK","institution_ids":["https://openalex.org/I130828816","https://openalex.org/I4210135017"]},{"raw_affiliation_string":"Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK","institution_ids":["https://openalex.org/I2799390153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038580329","display_name":"Gordon Cook","orcid":"https://orcid.org/0000-0003-1717-0412","observed_orcids":["https://orcid.org/0000-0003-1717-0412"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2799390153","display_name":"Leeds Teaching Hospitals NHS Trust","ror":"https://ror.org/00v4dac24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I4210109306","display_name":"NIHR Leeds In Vitro Diagnostics Co-operative","ror":"https://ror.org/01ykn4490","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109306"]},{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gordon Cook","raw_affiliation_strings":["Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trial Research, University of Leeds UK, Leeds, UK","Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK","NIHR (Leeds) Medtech & In vitro Diagnostic Cooperative, Leeds, UK"],"raw_orcid":"https://orcid.org/0000-0003-1717-0412","affiliations":[{"raw_affiliation_string":"Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trial Research, University of Leeds UK, Leeds, UK","institution_ids":["https://openalex.org/I130828816","https://openalex.org/I4210135017"]},{"raw_affiliation_string":"Department of Haematology, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK","institution_ids":["https://openalex.org/I2799390153"]},{"raw_affiliation_string":"NIHR (Leeds) Medtech & In vitro Diagnostic Cooperative, Leeds, UK","institution_ids":["https://openalex.org/I4210109306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002489850"],"corresponding_institution_ids":["https://openalex.org/I2799390153"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.276,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.26007039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"36","issue":"10","first_page":"2368","last_page":"2373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9390000104904175},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.9649999737739563},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.6349999904632568},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.7919999957084656},{"id":"https://openalex.org/keywords/age-related-immune-dysfunction","display_name":"age-related immune dysfunction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-immune-interactions","display_name":"tumor-immune interactions","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.9298949837684631},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7619647979736328},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6460701823234558},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.635185956954956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5483024716377258},{"id":"https://openalex.org/C2910239545","wikidata":"https://www.wikidata.org/wiki/Q3843811","display_name":"Immune Dysfunction","level":3,"score":0.5207069516181946},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5102567672729492},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4551643133163452},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4471127688884735},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4257259964942932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2930361032485962},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15659284591674805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11259254813194275},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068884","descriptor_name":"Immunosenescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41375-022-01653-7","doi":"https://doi.org/10.1038/s41375-022-01653-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41375-022-01653-7","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmid:35879358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35879358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5809852914","display_name":"TRAnsFORM: Trial Assessments of Fitness and Outcomes Research in Myeloma","funder_award_id":"MR/W030128/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W184351544","https://openalex.org/W239602587","https://openalex.org/W1499820592","https://openalex.org/W1504110711","https://openalex.org/W1509411808","https://openalex.org/W1554322881","https://openalex.org/W1671380251","https://openalex.org/W1934195140","https://openalex.org/W1966311535","https://openalex.org/W1981629491","https://openalex.org/W1984850507","https://openalex.org/W1987631879","https://openalex.org/W1993026821","https://openalex.org/W1995120586","https://openalex.org/W2004075497","https://openalex.org/W2005936795","https://openalex.org/W2022070851","https://openalex.org/W2023003954","https://openalex.org/W2028815852","https://openalex.org/W2036574174","https://openalex.org/W2042697692","https://openalex.org/W2054878929","https://openalex.org/W2056320810","https://openalex.org/W2064096469","https://openalex.org/W2068493773","https://openalex.org/W2071079513","https://openalex.org/W2077116159","https://openalex.org/W2080665774","https://openalex.org/W2085522503","https://openalex.org/W2096059629","https://openalex.org/W2100140007","https://openalex.org/W2115364134","https://openalex.org/W2115428888","https://openalex.org/W2124966133","https://openalex.org/W2131263031","https://openalex.org/W2137310532","https://openalex.org/W2137890831","https://openalex.org/W2150391321","https://openalex.org/W2152590673","https://openalex.org/W2164059021","https://openalex.org/W2168231169","https://openalex.org/W2195147549","https://openalex.org/W2202756526","https://openalex.org/W2339229309","https://openalex.org/W2430137930","https://openalex.org/W2462347288","https://openalex.org/W2464116806","https://openalex.org/W2468925656","https://openalex.org/W2508541983","https://openalex.org/W2595342131","https://openalex.org/W2608624623","https://openalex.org/W2620825787","https://openalex.org/W2628145035","https://openalex.org/W2747103992","https://openalex.org/W2761356900","https://openalex.org/W2797192791","https://openalex.org/W2802436949","https://openalex.org/W2884081989","https://openalex.org/W2885738092","https://openalex.org/W2887324910","https://openalex.org/W2887653129","https://openalex.org/W2888440213","https://openalex.org/W2894660457","https://openalex.org/W2913166559","https://openalex.org/W2921707030","https://openalex.org/W2947548264","https://openalex.org/W2954254686","https://openalex.org/W2960339132","https://openalex.org/W2973705566","https://openalex.org/W2979948334","https://openalex.org/W2990398036","https://openalex.org/W2994384023","https://openalex.org/W3002944111","https://openalex.org/W3020653233","https://openalex.org/W3027187303","https://openalex.org/W3036660876","https://openalex.org/W3049244854","https://openalex.org/W3081277729","https://openalex.org/W3084140434","https://openalex.org/W3099114602","https://openalex.org/W3127197263","https://openalex.org/W3139367533","https://openalex.org/W3185322026","https://openalex.org/W7073646102","https://openalex.org/W7074255685"],"related_works":["https://openalex.org/W3214859407","https://openalex.org/W4417006172","https://openalex.org/W3093080524","https://openalex.org/W7221636227","https://openalex.org/W4312984269","https://openalex.org/W6980470582","https://openalex.org/W4376631082","https://openalex.org/W3184376520","https://openalex.org/W4312100064","https://openalex.org/W2339229309"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-25T00:00:00"}
