{"id":"https://openalex.org/W4287076463","doi":"https://doi.org/10.5281/zenodo.5533943","title":"Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH","display_name":"Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH","publication_year":2021,"publication_date":"2021-07-15","ids":{"openalex":"https://openalex.org/W4287076463","doi":"https://doi.org/10.5281/zenodo.5533943"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.5533943","doi":"https://doi.org/10.5281/zenodo.5533943","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.5533943","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.5533943","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088398791","display_name":"Jorge Sim\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jorge Sim\u00f3n1,2, Naroa Goikoetxea-Usandizaga1, Marina Serrano-Maci\u00e11, David Fern\u00e1ndezRamos1,2,3, Diego S\u00e1enz De Urturi4, Jessica J. Gruskos5, Pablo Fern\u00e1ndez-Tussy1, Sof\u00eda  Lachiondo-Ortega1, Irene Gonz\u00e1lez-Recio1, Rub\u00e9n Rodr\u00edguez-Agudo1, Virginia Guti\u00e9rrezde-Juan1, Bego\u00f1a Rodr\u00edguez-Iruretagoyena1, Marta Varela-Rey1,2, Paula GimenezMascarell1, Mar\u00eda Mercado-Gomez1, Beatriz G\u00f3mez-Santos4, Carmen FernandezRodriguez1, Fernando Lopitz-Otsoa1,3, Maider Bizkarguenaga1,3, Sibylle Dames6, Ute  Schaeper6,","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088398791"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30888298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cnnm4","display_name":"CNNM4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/magnesium-homeostasis","display_name":"magnesium homeostasis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/microsomal-triglyceride-transfer-protein","display_name":"microsomal triglyceride transfer protein","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hepatic-lipid-accumulation","display_name":"hepatic lipid accumulation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9240000247955322},{"id":"https://openalex.org/keywords/vldl-secretion","display_name":"VLDL secretion","score":0.9290000200271606},{"id":"https://openalex.org/keywords/choline-deficient-high-fat-diet","display_name":"choline-deficient high-fat diet","score":0.7429999709129333},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C13028836","wikidata":"https://www.wikidata.org/wiki/Q21122998","display_name":"Microsomal triglyceride transfer protein","level":5,"score":0.6376065611839294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5679951310157776},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5120230317115784},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.49676114320755005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4490618109703064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32733267545700073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21813511848449707},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.12320977449417114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08539241552352905},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.5533943","doi":"https://doi.org/10.5281/zenodo.5533943","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.5533943","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.5533944","doi":"https://doi.org/10.5281/zenodo.5533944","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.5533944","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.5533943","doi":"https://doi.org/10.5281/zenodo.5533943","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.5533943","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1299766726","display_name":null,"funder_award_id":"RTC2019-007125","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2012452524","display_name":"Mch20: Detecci\u00f3n de da\u00f1o hep\u00e1tico a trav\u00e9s de la orina","funder_award_id":"DTS20/00138","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2118554301","display_name":null,"funder_award_id":"RTI2018-095134-B-100","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G2290633730","display_name":null,"funder_award_id":"RTC2019-007125-1","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2342579165","display_name":null,"funder_award_id":"SAF-2017-87301-R","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G2661025663","display_name":null,"funder_award_id":"BIO311","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G2749025989","display_name":null,"funder_award_id":"SEV-2016-0644","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G304302788","display_name":null,"funder_award_id":"SEV-2016-0644","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G3342290286","display_name":null,"funder_award_id":"RTC2019-007125-1","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G3527378470","display_name":null,"funder_award_id":"SEV-2016-0644","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G3569586882","display_name":null,"funder_award_id":"PAI BIO311","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G404992930","display_name":null,"funder_award_id":"BFU2016-77408-R","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4063455850","display_name":null,"funder_award_id":"IT971-16","funder_id":"https://openalex.org/F4320321705","funder_display_name":"Eusko Jaurlaritza"},{"id":"https://openalex.org/G4491386922","display_name":null,"funder_award_id":"BFU2015\u201070067REDC","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G4535546208","display_name":null,"funder_award_id":"BFU2015-70067-REDC","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4552910358","display_name":null,"funder_award_id":"RTC2019-007125-1","funder_id":"https://openalex.org/F4320321705","funder_display_name":"Eusko Jaurlaritza"},{"id":"https://openalex.org/G4914997810","display_name":null,"funder_award_id":"DTS20/00138","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G526084217","display_name":null,"funder_award_id":"RTI2018","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G546540753","display_name":"FIGHT-CNNM2: Mejora del diagn\u00f3stico y elucidaci\u00f3n de los mecanismos patol\u00f3gicos de la Hipomagnesemia rara en pacientes con mutaciones en CNNM2","funder_award_id":"AC19/00073","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5489899341","display_name":null,"funder_award_id":"DTS20/00138","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G5917330134","display_name":null,"funder_award_id":"BES-2017-080435","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6732200646","display_name":null,"funder_award_id":"SAF2017-87301-R","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G6938944540","display_name":null,"funder_award_id":"BFU2015-70067-REDC","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G7098144862","display_name":null,"funder_award_id":"DTS20/00138","funder_id":"https://openalex.org/F4320321705","funder_display_name":"Eusko Jaurlaritza"},{"id":"https://openalex.org/G7505807458","display_name":null,"funder_award_id":"RTI2018-096759","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8181105605","display_name":null,"funder_award_id":"RTI2018","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8374099137","display_name":null,"funder_award_id":"BFU2016-77408-R","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8653600395","display_name":null,"funder_award_id":"RTC2019-007125-1","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G945666960","display_name":null,"funder_award_id":"RTI2018-096759-A-100","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"}],"funders":[{"id":"https://openalex.org/F4320312058","display_name":"\u201cla Caixa\u201d Foundation","ror":"https://ror.org/03zhx9h04"},{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320321705","display_name":"Eusko Jaurlaritza","ror":"https://ror.org/00pz2fp31"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320323113","display_name":"Banco Bilbao Vizcaya Argentaria","ror":"https://ror.org/0537dnd74"},{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"},{"id":"https://openalex.org/F4320331548","display_name":"Silence Therapeutics","ror":"https://ror.org/03p3e4237"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335859","display_name":"Berrikuntza + Ikerketa + Osasuna Eusko Fundazioa","ror":"https://ror.org/054hj6489"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405108769","https://openalex.org/W4283804798","https://openalex.org/W3024344246","https://openalex.org/W2168570093","https://openalex.org/W2765446062","https://openalex.org/W1989636334","https://openalex.org/W2071838997","https://openalex.org/W4365998150","https://openalex.org/W2965000838","https://openalex.org/W4283204635"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"&":[2],"Aims:":[3],"Perturbations":[4],"of":[5,26,38,43,166,193,210,218,231],"intracellular":[6],"magnesium":[7,211],"(Mg2+)":[8],"homeostasis":[9],"have":[10],"implications":[11],"for":[12,179,190],"cell":[13,29],"physiology.":[14],"The":[15,215],"cyclin":[16],"M":[17],"family,":[18],"CNNM,":[19],"perform":[20],"key":[21],"functions":[22],"in":[23,40,57,85,87,96,101,121,133,141,172,202],"the":[24,36,41,122,134,164,191,208,213,229],"transport":[25],"Mg2+":[27,49,119,145,181],"across":[28],"membranes.":[30],"Herein,":[31],"we":[32],"aimed":[33],"to":[34,82,107],"elucidate":[35],"role":[37],"CNNM4":[39,53,115,139,169,184],"development":[42],"non-alcoholic":[44,203],"steatohepatitis":[45,204],"(NASH).":[46],"Methods:":[47],"Serum":[48],"levels":[50,120],"and":[51,66,72,100,117,131,151,176,206,227],"hepatic":[52,114,127,159],"expression":[54],"were":[55,62,80],"characterised":[56],"clinical":[58],"samples.":[59],"Primary":[60],"hepatocytes":[61,142],"cultured":[63],"under":[64],"methionine":[65,71],"choline":[67],"deprivation.":[68],"A":[69],"0.1%":[70],"choline-deficient":[73,77],"diet,":[74],"or":[75,105],"a":[76,186],"high-fat":[78],"diet":[79],"used":[81],"induce":[83],"NASH":[84,112,136,175,221],"our":[86],"vivo":[88,102],"rodent":[89,135],"models.":[90,137],"Cnnm4":[91,124,219],"was":[92],"silenced":[93],"using":[94],"siRNA,":[95],"vitro":[97],"with":[98,103,111,174],"DharmaFECT":[99],"Invivofectamine\u00ae":[104],"conjugated":[106],"N-acetylgalactosamine.":[108],"Results:":[109],"Patients":[110],"showed":[113],"overexpression":[116],"dysregulated":[118,180],"serum.":[123],"silencing":[125,217],"ameliorated":[126],"lipid":[128,160],"accumulation,":[129,146],"inflammation":[130],"fibrosis":[132],"Mechanistically,":[138],"knockdown":[140],"induced":[143],"cellular":[144],"reduced":[147],"endoplasmic":[148,224],"reticulum":[149,225],"stress,":[150],"increased":[152],"microsomal":[153,232],"triglyceride":[154,233],"transfer":[155,234],"activity,":[156],"which":[157],"promoted":[158],"clearance":[161],"by":[162,222],"increasing":[163],"secretion":[165],"VLDLs.":[167],"Conclusions:":[168],"is":[170,177,185,200],"overexpressed":[171,201],"patients":[173],"responsible":[178],"transport.":[182],"Hepatic":[183],"promising":[187],"therapeutic":[188],"target":[189],"treatment":[192],"NASH.":[194],"Lay":[195],"summary:":[196],"Cyclin":[197],"M4":[198],"(CNNM4)":[199],"(NASH)":[205],"promotes":[207],"export":[209],"from":[212],"liver.":[214],"liver-specific":[216],"ameliorates":[220],"reducing":[223],"stress":[226],"promoting":[228],"activity":[230],"protein.":[235]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2022-07-25T00:00:00"}