{"id":"https://openalex.org/W4287009074","doi":"https://doi.org/10.1007/s00125-022-05756-9","title":"Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice","display_name":"Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice","publication_year":2022,"publication_date":"2022-07-25","ids":{"openalex":"https://openalex.org/W4287009074","doi":"https://doi.org/10.1007/s00125-022-05756-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/35871651","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10208275"},"language":"en","primary_location":{"id":"doi:10.1007/s00125-022-05756-9","doi":"https://doi.org/10.1007/s00125-022-05756-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-022-05756-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-022-05756-9.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s00125-022-05756-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015490534","display_name":"Joseph Castillo","orcid":"https://orcid.org/0000-0003-4080-2545","observed_orcids":["https://orcid.org/0000-0003-4080-2545"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph J. Castillo","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4080-2545","affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044343242","display_name":"Alfred C. Aplin","orcid":"https://orcid.org/0000-0002-3346-9484","observed_orcids":["https://orcid.org/0000-0002-3346-9484"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred C. Aplin","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3346-9484","affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114026012","display_name":"Daryl J. Hackney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daryl J. Hackney","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030928703","display_name":"Meghan F. Hogan","orcid":"https://orcid.org/0000-0002-5767-1599","observed_orcids":["https://orcid.org/0000-0002-5767-1599"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan F. Hogan","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5767-1599","affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066048936","display_name":"Nathalie Esser","orcid":"https://orcid.org/0000-0003-1823-3817","observed_orcids":["https://orcid.org/0000-0003-1823-3817"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathalie Esser","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017289336","display_name":"Andrew T. Templin","orcid":"https://orcid.org/0000-0002-6241-9304","observed_orcids":["https://orcid.org/0000-0002-6241-9304"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew T. Templin","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6241-9304","affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007135505","display_name":"Rehana Akter","orcid":"https://orcid.org/0000-0001-6922-350X","observed_orcids":["https://orcid.org/0000-0001-6922-350X","https://orcid.org/0000-0002-4475-3093"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rehana Akter","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4475-3093","affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066700951","display_name":"Steven E. Kahn","orcid":"https://orcid.org/0000-0001-7307-9002","observed_orcids":["https://orcid.org/0000-0001-7307-9002"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Kahn","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7307-9002","affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049680513","display_name":"Daniel P. Raleigh","orcid":"https://orcid.org/0000-0003-3248-7493","observed_orcids":["https://orcid.org/0000-0003-3248-7493"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Daniel P. Raleigh","raw_affiliation_strings":["Department of Chemistry, Stony Brook University, Stony Brook, NY, USA","Research Department of Structural and Molecular Biology, University College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-3248-7493","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Research Department of Structural and Molecular Biology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044641878","display_name":"Sakeneh Zraika","orcid":"https://orcid.org/0000-0003-4831-7034","observed_orcids":["https://orcid.org/0000-0003-4831-7034"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sakeneh Zraika","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4831-7034","affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020262381","display_name":"Rebecca L. Hull","orcid":"https://orcid.org/0000-0001-9690-4087","observed_orcids":["https://orcid.org/0000-0001-9690-4087"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca L. Hull","raw_affiliation_strings":["Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. rhull@uw.edu","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. rhull@uw.edu","Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9690-4087","affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. rhull@uw.edu","institution_ids":["https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA. rhull@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020262381"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210094549"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":3.7865,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.94503747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"65","issue":"10","first_page":"1687","last_page":"1700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amylin","display_name":"amylin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/iapp-aggregation","display_name":"IAPP aggregation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/islet-endothelial-cells","display_name":"islet endothelial cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/endothelial-cell-cytotoxicity","display_name":"endothelial cell cytotoxicity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/proinflammatory-response","display_name":"pro-inflammatory response","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tlr2-4","display_name":"TLR2/4","score":0.7699999809265137},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.6169999837875366},{"id":"https://openalex.org/keywords/congo-red","display_name":"Congo red","score":0.871999979019165},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/pericytes","display_name":"pericytes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/capillary-density","display_name":"capillary density","score":0.7099999785423279},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6899999976158142},{"id":"https://openalex.org/keywords/islet-vasculature","display_name":"islet vasculature","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8720455765724182},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6338979601860046},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5539587140083313},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5496554970741272},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5347508192062378},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4869436025619507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46373099088668823},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.46257784962654114},{"id":"https://openalex.org/C2780705028","wikidata":"https://www.wikidata.org/wiki/Q424643","display_name":"Amylin","level":4,"score":0.4562557339668274},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.4478616416454315},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.43347835540771484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39180880784988403},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.33732038736343384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32781121134757996},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3222593367099762},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3217417597770691},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.17912787199020386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12541267275810242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12009385228157043},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003224","descriptor_name":"Congo Red","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003224","descriptor_name":"Congo Red","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00125-022-05756-9","doi":"https://doi.org/10.1007/s00125-022-05756-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-022-05756-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-022-05756-9.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},{"id":"pmid:35871651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35871651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10208275","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10208275","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10208275/pdf/nihms-1895138.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Diabetologia","raw_type":"Text"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/297110","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/297110","pdf_url":"https://orbi.uliege.be/bitstream/2268/297110/1/Castillo%20et%20al%20Islet%20amyloid%20endo%20Diabetologia%202022.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetologia, 65 (10), 1687 - 1700 (2022-10)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/44130","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/44130","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1007/s00125-022-05756-9","doi":"https://doi.org/10.1007/s00125-022-05756-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00125-022-05756-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00125-022-05756-9.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1239861031","display_name":"The Role of Laminin Alpha 4 in Beta-cell Function and Survival","funder_award_id":"F32DK109584","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1561476614","display_name":null,"funder_award_id":"I01BX001060","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2591708002","display_name":null,"funder_award_id":"P30 DK017047","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2972671007","display_name":null,"funder_award_id":"CDA-2 IK2 BX004659","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3731066545","display_name":"Biophysical Studies of Amyloid Formation by Polypeptide Hormones","funder_award_id":"R01GM078114","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3736763701","display_name":null,"funder_award_id":"P30DK017047","funder_id":"https://openalex.org/F4320310094","funder_display_name":"University of Washington"},{"id":"https://openalex.org/G4255429764","display_name":"Islet Endothelial Dysfunction in Diabetes","funder_award_id":"R01DK088082","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4310634654","display_name":null,"funder_award_id":"P30 DK017047","funder_id":"https://openalex.org/F4320332672","funder_display_name":"Diabetes Research Center, University of Washington"},{"id":"https://openalex.org/G4535293045","display_name":null,"funder_award_id":"VA CDA-2","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5029621140","display_name":null,"funder_award_id":"BX001060","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5943856967","display_name":null,"funder_award_id":"IK2BX004659","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G7640278689","display_name":null,"funder_award_id":"I01 BX004063","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G806246556","display_name":null,"funder_award_id":"CDA\u20102","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000208812","display_name":null,"funder_award_id":"DK-017047","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000866694","display_name":"Nutrition, Obesity and Atherosclerosis Training Program","funder_award_id":"T32HL007028","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000881174","display_name":"Diabetes Research Center","funder_award_id":"P30DK017047","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000910917","display_name":"Vision Research Core","funder_award_id":"P30EY001730","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000920257","display_name":"Diabetes, Obesity and Metabolism Training Program","funder_award_id":"T32DK007247","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332672","display_name":"Diabetes Research Center, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4287009074.pdf","grobid_xml":"https://content.openalex.org/works/W4287009074.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W56426715","https://openalex.org/W1500760933","https://openalex.org/W1511286995","https://openalex.org/W1937219527","https://openalex.org/W1964172387","https://openalex.org/W1965562132","https://openalex.org/W1965649701","https://openalex.org/W1967632213","https://openalex.org/W1973191606","https://openalex.org/W1981114929","https://openalex.org/W2001686756","https://openalex.org/W2023195670","https://openalex.org/W2024231537","https://openalex.org/W2029526781","https://openalex.org/W2034946303","https://openalex.org/W2037611980","https://openalex.org/W2056784230","https://openalex.org/W2056947872","https://openalex.org/W2061111679","https://openalex.org/W2067820229","https://openalex.org/W2068834560","https://openalex.org/W2070114315","https://openalex.org/W2082038580","https://openalex.org/W2087932423","https://openalex.org/W2096532617","https://openalex.org/W2096691913","https://openalex.org/W2117637410","https://openalex.org/W2126264030","https://openalex.org/W2127372775","https://openalex.org/W2135560234","https://openalex.org/W2140993611","https://openalex.org/W2145124130","https://openalex.org/W2150461406","https://openalex.org/W2158141897","https://openalex.org/W2169273342","https://openalex.org/W2281650010","https://openalex.org/W2309593741","https://openalex.org/W2407144023","https://openalex.org/W2463773054","https://openalex.org/W2520532873","https://openalex.org/W2551389730","https://openalex.org/W2606611764","https://openalex.org/W2790518348","https://openalex.org/W2991533913","https://openalex.org/W3026376247","https://openalex.org/W3091748553","https://openalex.org/W3096866785","https://openalex.org/W3098150858","https://openalex.org/W3112410415","https://openalex.org/W3164215938","https://openalex.org/W3201026687","https://openalex.org/W4256148575"],"related_works":["https://openalex.org/W2948570536","https://openalex.org/W2337169201","https://openalex.org/W3176382120","https://openalex.org/W3034747345","https://openalex.org/W7130936845","https://openalex.org/W2080139632","https://openalex.org/W2981606744","https://openalex.org/W2527381184","https://openalex.org/W2115338157","https://openalex.org/W2209022283"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-07-25T00:00:00"}
