{"id":"https://openalex.org/W4286884809","doi":"https://doi.org/10.23869/bphjbr.28.1.20227","title":"Inhibitory activity of endophytic fungi against alpha-amylase isolated from raru (Cotylelobium melanoxylon)","display_name":"Inhibitory activity of endophytic fungi against alpha-amylase isolated from raru (Cotylelobium melanoxylon)","publication_year":2022,"publication_date":"2022-07-23","ids":{"openalex":"https://openalex.org/W4286884809","doi":"https://doi.org/10.23869/bphjbr.28.1.20227"},"language":"en","primary_location":{"id":"doi:10.23869/bphjbr.28.1.20227","doi":"https://doi.org/10.23869/bphjbr.28.1.20227","is_oa":true,"landing_page_url":"https://doi.org/10.23869/bphjbr.28.1.20227","pdf_url":"https://www.berkalahayati.org/index.php/jurnal/article/download/657/519","source":{"id":"https://openalex.org/S2737671603","display_name":"Berkala Penelitian Hayati","issn_l":"0852-6834","issn":["0852-6834","2337-389X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315019","host_organization_name":"Indonesian Biological Society","host_organization_lineage":["https://openalex.org/P4310315019"],"host_organization_lineage_names":["Indonesian Biological Society"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Berkala Penelitian Hayati","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4286884809"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.berkalahayati.org/index.php/jurnal/article/download/657/519","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091452135","display_name":"Pebrianiafrahul I Siregar","orcid":"https://orcid.org/0000-0002-5145-0074","observed_orcids":["https://orcid.org/0000-0002-5145-0074"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Pebrianiafrahul I Siregar","raw_affiliation_strings":["Master Program, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Diponegoro, Semarang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-5145-0074","affiliations":[{"raw_affiliation_string":"Master Program, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Diponegoro, Semarang, Indonesia","institution_ids":["https://openalex.org/I11855966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051009150","display_name":"Sri Pujiyanto","orcid":"https://orcid.org/0000-0002-2664-8660","observed_orcids":["https://orcid.org/0000-0002-2664-8660"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sri Pujiyanto","raw_affiliation_strings":["Department of Biology, Faculty of Mathematics and Natural Sciences, University of Diponegoro, Semarang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Mathematics and Natural Sciences, University of Diponegoro, Semarang, Indonesia","institution_ids":["https://openalex.org/I11855966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029195057","display_name":"Arina Tri Lunggani","orcid":"https://orcid.org/0000-0003-0204-8721","observed_orcids":["https://orcid.org/0000-0003-0204-8721"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Arina Tri Lunggani","raw_affiliation_strings":["Department of Biology, Faculty of Mathematics and Natural Sciences, University of Diponegoro, Semarang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-0204-8721","affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Mathematics and Natural Sciences, University of Diponegoro, Semarang, Indonesia","institution_ids":["https://openalex.org/I11855966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I11855966"],"apc_list":{"value":1625000,"currency":"IDR","value_usd":106},"apc_paid":{"value":1625000,"currency":"IDR","value_usd":106},"fwci":0.4948,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.58514667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"1","first_page":"44","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.1859000027179718,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.03970000147819519,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endophytic-fungi","display_name":"endophytic fungi","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cotylelobium-melanoxylon","display_name":"Cotylelobium melanoxylon","score":0.9789999723434448},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8450000286102295},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.6949999928474426},{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.6039999723434448},{"id":"https://openalex.org/keywords/1-3-benzenedicarboxylic-acid","display_name":"1,3-benzenedicarboxylic acid","score":0.8600000143051147},{"id":"https://openalex.org/keywords/isophthalic-acid","display_name":"isophthalic acid","score":0.7160000205039978},{"id":"https://openalex.org/keywords/starch-digestion","display_name":"starch hydrolysis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/plant-fungus-interactions","display_name":"plant-fungal interactions","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C173959671","wikidata":"https://www.wikidata.org/wiki/Q106951023","display_name":"Alpha-amylase","level":4,"score":0.7598617076873779},{"id":"https://openalex.org/C89638049","wikidata":"https://www.wikidata.org/wiki/Q7201546","display_name":"Plant use of endophytic fungi in defense","level":2,"score":0.6925374269485474},{"id":"https://openalex.org/C2777832050","wikidata":"https://www.wikidata.org/wiki/Q2839456","display_name":"Alpha-glucosidase","level":3,"score":0.6299020051956177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6069853901863098},{"id":"https://openalex.org/C170835558","wikidata":"https://www.wikidata.org/wiki/Q17153","display_name":"Amylase","level":3,"score":0.5337263941764832},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.48224931955337524},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4536324441432953},{"id":"https://openalex.org/C133446333","wikidata":"https://www.wikidata.org/wiki/Q38681","display_name":"Bark (sound)","level":2,"score":0.4517306089401245},{"id":"https://openalex.org/C118859902","wikidata":"https://www.wikidata.org/wiki/Q133516","display_name":"Monosaccharide","level":2,"score":0.42239224910736084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38571399450302124},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3605424761772156},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3458576798439026},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.33668774366378784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2003539502620697},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.1673920452594757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11686891317367554},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23869/bphjbr.28.1.20227","doi":"https://doi.org/10.23869/bphjbr.28.1.20227","is_oa":true,"landing_page_url":"https://doi.org/10.23869/bphjbr.28.1.20227","pdf_url":"https://www.berkalahayati.org/index.php/jurnal/article/download/657/519","source":{"id":"https://openalex.org/S2737671603","display_name":"Berkala Penelitian Hayati","issn_l":"0852-6834","issn":["0852-6834","2337-389X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315019","host_organization_name":"Indonesian Biological Society","host_organization_lineage":["https://openalex.org/P4310315019"],"host_organization_lineage_names":["Indonesian Biological Society"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Berkala Penelitian Hayati","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.23869/bphjbr.28.1.20227","doi":"https://doi.org/10.23869/bphjbr.28.1.20227","is_oa":true,"landing_page_url":"https://doi.org/10.23869/bphjbr.28.1.20227","pdf_url":"https://www.berkalahayati.org/index.php/jurnal/article/download/657/519","source":{"id":"https://openalex.org/S2737671603","display_name":"Berkala Penelitian Hayati","issn_l":"0852-6834","issn":["0852-6834","2337-389X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315019","host_organization_name":"Indonesian Biological Society","host_organization_lineage":["https://openalex.org/P4310315019"],"host_organization_lineage_names":["Indonesian Biological Society"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Berkala Penelitian Hayati","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286884809.pdf","grobid_xml":"https://content.openalex.org/works/W4286884809.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1503998292","https://openalex.org/W2002216694","https://openalex.org/W2054841530","https://openalex.org/W2086695404","https://openalex.org/W2130291518","https://openalex.org/W2229288464","https://openalex.org/W2341122032","https://openalex.org/W2409398523","https://openalex.org/W2530140933","https://openalex.org/W2766733934","https://openalex.org/W2781259227","https://openalex.org/W2785209506","https://openalex.org/W2791393203","https://openalex.org/W2801555785","https://openalex.org/W2891692615","https://openalex.org/W2942287302","https://openalex.org/W3110983435","https://openalex.org/W3153988679","https://openalex.org/W3161447021","https://openalex.org/W3194938240","https://openalex.org/W4254706845","https://openalex.org/W7165488365"],"related_works":["https://openalex.org/W6967536949","https://openalex.org/W2606829106","https://openalex.org/W7053293085","https://openalex.org/W2119680186","https://openalex.org/W4409001430","https://openalex.org/W1982149144","https://openalex.org/W2942287302","https://openalex.org/W7215759396","https://openalex.org/W2385910343","https://openalex.org/W7216126328"],"abstract_inverted_index":{"Diabetes":[0],"mellitus":[1],"is":[2],"a":[3,132,137,164,201],"metabolic":[4],"disorder":[5],"characterized":[6],"by":[7,35,69,190],"elevated":[8],"blood":[9,46],"glucose":[10,47],"levels.":[11,48],"Alpha-amylase":[12,124],"inhibitors":[13],"are":[14],"chemicals":[15],"that":[16],"prevent":[17],"amylase":[18],"from":[19,60,103],"degrading":[20],"carbohydrates":[21],"into":[22],"monosaccharides.":[23],"For":[24],"instance,":[25],"the":[26,36,61,93,98,114,118,142,151],"Raru":[27,62,104],"plant":[28,63],"(Cotylelobium":[29],"melanoxylon),":[30],"which":[31],"was":[32,42,54,84,90,125,146,158,188],"widely":[33],"used":[34,43,91],"local":[37],"people,":[38],"particularly":[39],"in":[40],"Sumatra,":[41],"to":[44,55,207],"lower":[45],"The":[49,80],"goal":[50],"of":[51,82,97,134,140,144,154,166,204],"this":[52],"study":[53],"isolate":[56,115],"an":[57],"endophytic":[58,99,191],"fungus":[59,100],"and":[64,75,88,110],"test":[65],"its":[66],"alpha-amylase":[67,76,83,120,145,155,194],"activity":[68,81],"optimizing":[70],"treatment":[71],"time,":[72],"substrate":[73,138],"concentration,":[74],"inhibitor":[77],"compound":[78,157,177],"extraction.":[79],"measured":[85],"using":[86],"spectrophotometry,":[87],"starch":[89],"as":[92],"substrate.":[94],"Four":[95],"isolates":[96],"were":[101],"isolated":[102],"bark,":[105],"including":[106],"TR1,":[107],"TR2,":[108],"TR3,":[109],"TR4.":[111],"Of":[112],"these,":[113],"TR3":[116],"had":[117],"highest":[119,152],"activity,":[121],"reaching":[122],"88.71%.":[123],"optimally":[126],"inhibited":[127],"for":[128],"7":[129],"days":[130],"with":[131,163],"percentage":[133,165],"90.13%.":[135],"At":[136],"concentration":[139],"2%,":[141],"inhibition":[143],"observed":[147,159],"at":[148,160],"96.34%.":[149],"While":[150],"extraction":[153],"inhibitory":[156,195],"0.13":[161],"ppm":[162],"74.71%":[167],"inhibition.":[168],"Based":[169],"on":[170],"GC-MS":[171],"(gas":[172],"chromatography":[173],"mass":[174],"spectrometry)":[175],"analysis,":[176],"24,":[178],"identified":[179],"as1,3-benzenedicarboxylic":[180],"acid,":[181],"bis":[182],"(2-ethylhexyl)":[183],"ester,":[184],"isophthalic":[185],"acid":[186],"group,":[187],"produced":[189],"fungi,":[192],"exerting":[193],"activity.":[196],"This":[197],"research":[198],"would":[199],"provide":[200],"new":[202],"source":[203],"chemical":[205],"agents":[206],"combat":[208],"diabetes.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2022-07-25T00:00:00"}