{"id":"https://openalex.org/W4286863523","doi":null,"title":"NA, K-ATPASE AND CL-ATPASE REGULATION BY DOPAMINE.","display_name":"NA, K-ATPASE AND CL-ATPASE REGULATION BY DOPAMINE.","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4286863523","pmid":"https://pubmed.ncbi.nlm.nih.gov/34897063"},"language":"en","primary_location":{"id":"pmid:34897063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34897063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georgian medical news","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009499490","display_name":"Gvantsa Chkadua","orcid":"https://orcid.org/0000-0001-6492-8818","observed_orcids":["https://orcid.org/0000-0001-6492-8818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Chkadua","raw_affiliation_strings":["Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074500035","display_name":"Leila Tsakadze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Tsakadze","raw_affiliation_strings":["Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087774461","display_name":"Lia Shioshvili","orcid":"https://orcid.org/0000-0003-1043-119X","observed_orcids":["https://orcid.org/0000-0003-1043-119X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Shioshvili","raw_affiliation_strings":["Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073539652","display_name":"Eka Nozadze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Nozadze","raw_affiliation_strings":["Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"320","first_page":"153","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/chloride-transport","display_name":"chloride transport","score":0.5929999947547913},{"id":"https://openalex.org/keywords/sodium-transport","display_name":"sodium transport","score":0.6539999842643738},{"id":"https://openalex.org/keywords/electrogenic-ion-transport","display_name":"electrogenic transport","score":0.503000020980835},{"id":"https://openalex.org/keywords/synaptic-membranes","display_name":"synaptic membranes","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6963909864425659},{"id":"https://openalex.org/C144082473","wikidata":"https://www.wikidata.org/wiki/Q213185","display_name":"Stoichiometry","level":2,"score":0.6698949933052063},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.6392716765403748},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.6029835939407349},{"id":"https://openalex.org/C132946820","wikidata":"https://www.wikidata.org/wiki/Q2509459","display_name":"Differential centrifugation","level":2,"score":0.47422099113464355},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4484517574310303},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40564462542533875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2236635684967041},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.12289547920227051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11614048480987549},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06630364060401917}],"mesh":[{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:34897063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34897063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georgian medical news","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2466246373","https://openalex.org/W2398879585","https://openalex.org/W3172635453","https://openalex.org/W147831979","https://openalex.org/W2052064597","https://openalex.org/W2046340372","https://openalex.org/W110414825","https://openalex.org/W2233173449","https://openalex.org/W2416383277","https://openalex.org/W2329208653"],"abstract_inverted_index":{"The":[0,23,76,129,152],"influence":[1],"of":[2,16,34,44,47,63,73,78,99,107,119,125,131,136,138,146,154],"dopamine":[3],"(DA)":[4],"on":[5,133],"the":[6,12,17,32,42,56,71,79,84,97,105,108,113,117,134,143,165],"Cl-ATPase":[7],"and":[8,37,123,163],"Na,":[9,35,91,139],"K-ATPase":[10,92,140],"in":[11,142],"synaptic":[13],"membrane":[14],"fraction":[15,24],"rat":[18],"brain":[19],"has":[20,52],"been":[21,53],"investigated.":[22],"was":[25,102],"obtained":[26],"by":[27],"differential":[28],"centrifugation.":[29],"To":[30],"analyze":[31],"function":[33],"K-ATPase,":[36],"Cl-ATPase,":[38],"we":[39],"have":[40],"applied":[41],"method":[43,58],"kinetic":[45,61],"analysis":[46],"multi-sited":[48,64],"enzyme":[49,65],"systems,":[50],"which":[51],"described":[54],"as":[55],"only":[57],"used":[59],"for":[60,83,112,149],"investigation":[62],"systems.":[66],"Dopamine":[67],"does":[68],"not":[69],"alter":[70],"stoichiometry":[72,118,157],"Cl-":[74,80],"transport.":[75],"number":[77,106,145],"sites":[81,110],"intended":[82,111],"essential":[85,114,147],"activator":[86],"(n)":[87],"remains":[88],"1.":[89],"During":[90],"activation":[93],"with":[94,96],"K+,":[95],"application":[98],"DA,":[100],"it":[101],"found":[103],"that":[104],"K+":[109,120],"activators":[115,148],"(i.e.":[116],"transport)":[121],"changes,":[122],"instead":[124],"two":[126],"becomes":[127],"one.":[128],"impact":[130],"DA":[132],"mechanism":[135],"Na+-activation":[137],"results":[141],"unchanged":[144],"Na+":[150],"(n=3).":[151],"ratio":[153],"Na:":[155],"K":[156],"changes":[158],"from":[159],"3:2":[160],"to":[161],"3:1":[162],"so":[164],"electrogenicity":[166],"coefficient":[167],"is":[168],"changed.":[169]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-25T00:00:00"}