{"id":"https://openalex.org/W4286851603","doi":"https://doi.org/10.3791/2153-v","title":"Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice","display_name":"Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice","publication_year":2010,"publication_date":"2010-10-03","ids":{"openalex":"https://openalex.org/W4286851603","doi":"https://doi.org/10.3791/2153-v"},"language":"en","primary_location":{"id":"doi:10.3791/2153-v","doi":"https://doi.org/10.3791/2153-v","is_oa":false,"landing_page_url":"https://doi.org/10.3791/2153-v","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073054729","display_name":"Xi Huang","orcid":"https://orcid.org/0000-0002-7177-7525","observed_orcids":["https://orcid.org/0000-0002-7177-7525"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi Huang","raw_affiliation_strings":["Department of Cell and Developmental Biology, Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112853175","display_name":"Anuraag Sarangi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuraag Sarangi","raw_affiliation_strings":["Department of Neurology, Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029010074","display_name":"Tatiana Ketova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana Ketova","raw_affiliation_strings":["Department of Cell and Developmental Biology, Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030199250","display_name":"Ying Litingtung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Litingtung","raw_affiliation_strings":["Department of Cell and Developmental Biology, Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080699715","display_name":"Michael K. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael K. Cooper","raw_affiliation_strings":["Department of Neurology, Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108556196","display_name":"Chin C. Chiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin Chiang","raw_affiliation_strings":["Department of Cell and Developmental Biology, Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44899864,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":"44","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-cell-of-origin","display_name":"tumor cell of origin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cerebellar-granule-neuron-precursors","display_name":"cerebellar granule neuron precursors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.7990000247955322},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.9878675937652588},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5433505177497864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46896377205848694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4260491728782654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4193270206451416}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3791/2153-v","doi":"https://doi.org/10.3791/2153-v","is_oa":false,"landing_page_url":"https://doi.org/10.3791/2153-v","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125668457","https://openalex.org/W2284553164","https://openalex.org/W4388589469","https://openalex.org/W2027344173","https://openalex.org/W2028417396","https://openalex.org/W2406585712","https://openalex.org/W2082268355","https://openalex.org/W3145068934","https://openalex.org/W4386538882","https://openalex.org/W4392984966"],"abstract_inverted_index":{"Medulloblastoma":[0],"is":[1,52,87,93],"the":[2,8,26,31,48,69,135,144],"most":[3],"common":[4],"pediatric":[5],"tumor":[6,97,118,127,157],"of":[7,14,35,57,64,74,115,125,134,138,151],"nervous":[9],"system.":[10],"A":[11],"large":[12,45],"body":[13],"animal":[15],"studies":[16],"has":[17],"focused":[18],"on":[19,100],"cerebellar":[20],"granule":[21],"neuron":[22],"precursors":[23],"(CGNPs)":[24],"as":[25],"cell-of-origin":[27,98],"for":[28,147,166],"medulloblastoma1-4.":[29],"However,":[30],"diverse":[32],"clinical":[33],"presentations":[34],"medulloblastoma":[36,51,75,96,152],"subtypes":[37],"in":[38,54,129],"human":[39,58],"patients":[40,59],"(nodular,":[41],"desmoplastic,":[42],"classical":[43],"and":[44,47,71,79,159],"cell/anaplastic),":[46],"fact":[49],"that":[50,68],"found":[53],"a":[55],"subset":[56],"with":[60],"no":[61],"ectopic":[62],"expression":[63],"CGNP":[65],"marker5,":[66],"suggest":[67],"cellular":[70,136],"molecular":[72],"origins":[73],"are":[76],"more":[77],"complex":[78],"far":[80],"from":[81,155,169],"being":[82],"completely":[83],"deciphered.":[84],"Therefore,":[85],"it":[86],"essential":[88],"to":[89],"determine":[90],"whether":[91],"there":[92],"an":[94],"alternative":[95],"based":[99],"which":[101],"cell-type":[102],"specific":[103],"therapeutic":[104],"modality":[105],"can":[106,162],"be":[107,164],"developed.":[108],"To":[109],"this":[110,160],"end,":[111],"intracranial":[112,148],"orthotopic":[113,149],"allografting":[114,150],"genetically":[116],"marked":[117],"cell":[119,171],"types":[120],"followed":[121],"by":[122],"subsequent":[123],"analyses":[124],"secondary":[126],"development":[128],"recipients":[130],"will":[131],"allow":[132],"determination":[133],"origin":[137],"tumor-initiating":[139],"cells.":[140],"Here":[141],"we":[142],"describe":[143],"experimental":[145],"protocol":[146],"cells":[153,168],"derived":[154],"primary":[156],"tissue,":[158],"procedure":[161],"also":[163],"used":[165],"transplanting":[167],"established":[170],"lines.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2022-07-25T00:00:00"}