{"id":"https://openalex.org/W4286841978","doi":"https://doi.org/10.7302/4683","title":"Investigating Protein-Membrane Interactions Mediated by Factor X That Regulate the Blood Clotting Cascade","display_name":"Investigating Protein-Membrane Interactions Mediated by Factor X That Regulate the Blood Clotting Cascade","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4286841978","doi":"https://doi.org/10.7302/4683"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/172654","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/172654","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/f6ea7678-3b72-4e34-b7c4-affb1cb601e7/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://deepblue.lib.umich.edu/bitstreams/f6ea7678-3b72-4e34-b7c4-affb1cb601e7/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075734010","display_name":"Divyani Paul","orcid":"https://orcid.org/0000-0002-4544-1825","observed_orcids":["https://orcid.org/0000-0002-4544-1825"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul, Divyani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075734010"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-x","display_name":"factor X","score":0.9010000228881836},{"id":"https://openalex.org/keywords/factor-xa","display_name":"factor Xa","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gla-domain","display_name":"Gla domain","score":0.781000018119812},{"id":"https://openalex.org/keywords/protein-membrane-interactions","display_name":"protein-membrane interactions","score":0.9509999752044678},{"id":"https://openalex.org/keywords/phosphatidylserine-binding","display_name":"phosphatidylserine binding","score":0.953000009059906},{"id":"https://openalex.org/keywords/coagulation-cascade","display_name":"coagulation cascade","score":0.7720000147819519},{"id":"https://openalex.org/keywords/extrinsic-coagulation-pathway","display_name":"extrinsic coagulation pathway","score":0.8479999899864197},{"id":"https://openalex.org/keywords/russell-s-viper-venom","display_name":"Russell's viper venom","score":0.7710000276565552},{"id":"https://openalex.org/keywords/snake-venom","display_name":"snake venom","score":0.4519999921321869},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.4950000047683716},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/lipid-membrane-binding","display_name":"lipid membrane binding","score":0.4000000059604645},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.718999981880188},{"id":"https://openalex.org/keywords/calcium-dependent-binding","display_name":"calcium-dependent binding","score":0.6359999775886536},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2992598832","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Blood clotting","level":2,"score":0.7987446188926697},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.6858619451522827},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.5514411330223083},{"id":"https://openalex.org/C3019190606","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation cascade","level":4,"score":0.49404600262641907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45893144607543945},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40449023246765137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2813435196876526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.234136700630188},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21633392572402954},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18174859881401062},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.17914822697639465},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.15701764822006226},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.07807120680809021}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/172654","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/172654","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/f6ea7678-3b72-4e34-b7c4-affb1cb601e7/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"doi:10.7302/4683","doi":"https://doi.org/10.7302/4683","is_oa":true,"landing_page_url":"https://doi.org/10.7302/4683","pdf_url":null,"source":{"id":"https://openalex.org/S7407053136","display_name":"University of Michigan Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/172654","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/172654","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/f6ea7678-3b72-4e34-b7c4-affb1cb601e7/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286841978.pdf","grobid_xml":"https://content.openalex.org/works/W4286841978.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2742581838","https://openalex.org/W2471572827","https://openalex.org/W7098373905","https://openalex.org/W4200290089","https://openalex.org/W2014963007","https://openalex.org/W958189304","https://openalex.org/W2049234188","https://openalex.org/W1992156297","https://openalex.org/W2611081569","https://openalex.org/W1999883318"],"abstract_inverted_index":{"Vascular":[0],"trauma":[1],"triggers":[2],"the":[3,28,37,51,57,68,75,84,91,117,120,126,134,153,167,177,180,199,215,220,229,246,252,256,267,273,285,318,346,359,390,405,408,412,418,427,438,444,455,471,497],"blood":[4,61,154],"clotting":[5,38,69,92,155,184,257,460],"cascade":[6,39],"to":[7,15,33,56,102,197,205,241,317,328,357,373,385,403,443],"maintain":[8],"hemostasis":[9],"by":[10,27,79,125,251,377,395,399],"sequentially":[11],"converting":[12],"several":[13,459],"zymogens":[14],"active":[16],"enzymes":[17],"via":[18],"limited":[19],"proteolysis.":[20],"Coagulation":[21],"factor":[22],"X":[23],"(FX)":[24],"is":[25],"activated":[26,42,398],"extrinsic":[29,286,445],"and":[30,35,183,332,367,432,508],"intrinsic":[31],"pathway":[32,53],"initiate":[34],"propagate":[36],"respectively.":[40],"Further,":[41],"FX":[43,65,78,101,123,146,161,190,206,230,238,249,274,293,365,369,393,397,422,431,439,475,512],"(FXa)":[44],"also":[45,325],"participates":[46],"in":[47,50,67,90,107,130,138,152,208,228,272,278,284,305,310,337,343,378,421,454,487,496,511],"downstream":[48],"reactions":[49,461],"common":[52,456],"that":[54,115,145,186,276,342,437,479],"leads":[55],"formation":[58],"of":[59,77,81,87,122,136,160,179,201,237,248,255,292,321,345,392,407,474,499],"a":[60,108,149,223,334,448,488],"clot,":[62],"thereby,":[63],"positioning":[64],"centrally":[66],"cascade.":[70,93,156,258],"Anionic":[71],"membrane":[72,181,202,211,262,464,485],"surfaces":[73],"accelerate":[74],"activation":[76,124,250,394],"thousands":[80],"times,":[82],"underscoring":[83],"regulatory":[85],"function":[86],"protein-membrane":[88],"interactions":[89,140,159,175,283,363,429,473],"The":[94],"N-terminal,":[95],"\u03b3-carboxyglutamate":[96],"rich":[97],"domain":[98],"(Gla-domain)":[99],"enables":[100],"reversibly":[103],"bind":[104],"phosphatidylserine":[105],"(PS),":[106],"calcium":[109,489],"dependent":[110],"manner.":[111,491],"Previous":[112],"studies":[113,194,236,264,340,382],"showed":[114,341],"removing":[116],"Gla-domain":[118,137,147,162,207,239,275,366,370,423,440],"diminished":[119],"rates":[121,247,391],"initiation":[127,253],"complex":[128,254],"even":[129],"solution,":[131],"which":[132],"indicates":[133],"participation":[135],"protein-protein":[139,280],"as":[141,300,333,506],"well.":[142],"This":[143],"demonstrates":[144],"plays":[148],"crucial":[150,442],"role":[151],"However,":[157,315],"these":[158,174],"are":[163],"poorly":[164,349],"characterized":[165],"at":[166],"molecular":[168,362,428,472],"level.":[169],"Therefore,":[170,352],"here":[171],"we":[172,218,233,265,353,416,435,466],"investigated":[173],"from":[176,294],"perspectives":[178],"phospholipids":[182],"proteins":[185],"directly":[187],"interact":[188,374],"with":[189,260,375],"Gla-domain.":[191,231,476],"Quantitative":[192],"binding":[193,204,226,263,486],"were":[195,383],"utilized":[196,402],"identify":[198,242,358],"stoichiometry":[200],"lipids":[203],"physiologically":[209],"comparable":[210],"surfaces.":[212],"Here":[213],"for":[214,222,425],"first":[216],"time,":[217],"present":[219],"evidence":[221],"unique":[224],"PS":[225],"site":[227],"Next,":[232],"employed":[234],"mutagenesis":[235],"residues":[240,271,360,371,410,420,441],"their":[243,311,387],"impact":[244,450],"on":[245,389,411,451,463],"Along":[259],"additional":[261],"identified":[266,417],"critical":[268],"amino":[269],"acid":[270],"participate":[277],"either":[279],"or":[281,313],"membrane-protein":[282],"pathway.":[287,457],"A":[288],"potent":[289],"external":[290],"activator":[291],"Russell\u2019s":[295],"Viper":[296],"Venom":[297],"(also":[298],"known":[299],"RVV-X)":[301],"causes":[302],"thrombotic":[303],"complications":[304],"snake-bite":[306],"victims,":[307],"ultimately":[308],"resulting":[309],"death":[312],"disability.":[314],"due":[316],"high":[319],"potency":[320],"RVV-X":[322,348,376,400],"it":[323],"has":[324],"been":[326],"used":[327],"treat":[329],"minor":[330],"injuries":[331],"diagnostic":[335],"tool":[336],"research.":[338],"Biochemical":[339],"absence":[344],"Gla-domain,":[347],"activates":[350],"FX.":[351],"extended":[354],"our":[355,468],"study":[356,469],"mediating":[361,426],"between":[364,430],"RVV-X.":[368,396,433],"predicted":[372],"silico":[379],"structural":[380],"alignment":[381],"mutated":[384,409],"test":[386],"influence":[388],"was":[401],"investigate":[404],"effects":[406],"thrombin":[413,452],"generation.":[414],"Thus,":[415],"key":[419],"essential":[424],"Surprisingly,":[434],"observed":[436],"pathway,":[446],"had":[447],"minimal":[449],"generation":[453],"Since":[458],"occur":[462],"surfaces,":[465],"diversified":[467],"beyond":[470],"We":[477],"found":[478],"an":[480],"anticoagulant":[481],"protein,":[482],"lactadherin,":[483],"exhibited":[484],"independent":[490],"These":[492],"findings":[493],"will":[494],"aid":[495],"development":[498],"therapeutic":[500],"efforts":[501],"against":[502],"pathological":[503],"conditions":[504],"such":[505],"thrombosis":[507],"bleeding":[509],"disorders":[510],"deficient":[513],"patients.":[514]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-07-24T00:00:00"}
