{"id":"https://openalex.org/W4286786433","doi":"https://doi.org/10.1002/ejoc.202200302","title":"Exploring Glycan Binding Specificity of Odorranalectin by Alanine Scanning Library","display_name":"Exploring Glycan Binding Specificity of Odorranalectin by Alanine Scanning Library","publication_year":2022,"publication_date":"2022-04-23","ids":{"openalex":"https://openalex.org/W4286786433","doi":"https://doi.org/10.1002/ejoc.202200302","pmid":"https://pubmed.ncbi.nlm.nih.gov/36120398","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9479679"},"language":"en","primary_location":{"id":"doi:10.1002/ejoc.202200302","doi":"https://doi.org/10.1002/ejoc.202200302","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ejoc.202200302","pdf_url":null,"source":{"id":"https://openalex.org/S21317199","display_name":"European Journal of Organic Chemistry","issn_l":"1099-0690","issn":["1099-0690","1434-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9479679","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062000893","display_name":"YashoNandini Singh","orcid":"https://orcid.org/0000-0002-1186-3376","observed_orcids":["https://orcid.org/0000-0002-1186-3376"]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YashoNandini Singh","raw_affiliation_strings":["Department of Chemistry and Biochemistry Florida Atlantic University  777 Glades Road Boca Raton Florida 33431 United States"],"raw_orcid":"https://orcid.org/0000-0002-1186-3376","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Florida Atlantic University  777 Glades Road Boca Raton Florida 33431 United States","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080724693","display_name":"Predrag \u010cudi\u0107","orcid":"https://orcid.org/0000-0002-5633-4275","observed_orcids":["https://orcid.org/0000-0002-5633-4275"]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Predrag Cudic","raw_affiliation_strings":["Department of Chemistry and Biochemistry Florida Atlantic University  777 Glades Road Boca Raton Florida 33431 United States"],"raw_orcid":"https://orcid.org/0000-0002-5633-4275","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Florida Atlantic University  777 Glades Road Boca Raton Florida 33431 United States","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060460570","display_name":"Mare \u010cudi\u0107","orcid":"https://orcid.org/0000-0002-7657-0400","observed_orcids":["https://orcid.org/0000-0002-7657-0400"]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mar\u00e9 Cudic","raw_affiliation_strings":["Department of Chemistry and Biochemistry Florida Atlantic University  777 Glades Road Boca Raton Florida 33431 United States"],"raw_orcid":"https://orcid.org/0000-0002-7657-0400","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry Florida Atlantic University  777 Glades Road Boca Raton Florida 33431 United States","institution_ids":["https://openalex.org/I63772739"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060460570","https://openalex.org/A5080724693"],"corresponding_institution_ids":["https://openalex.org/I63772739"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.2448,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40927164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2022","issue":"28","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.11869999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycan-binding-specificity","display_name":"glycan binding specificity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alanine-scanning","display_name":"alanine scanning","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fucose","display_name":"fucose","score":0.574999988079071},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":0.8370000123977661},{"id":"https://openalex.org/keywords/n-acetylgalactosamine","display_name":"N-acetylgalactosamine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/muc1-glycopeptide","display_name":"MUC1 glycopeptide","score":0.8330000042915344},{"id":"https://openalex.org/keywords/asialofetuin","display_name":"asialofetuin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fucoidan","display_name":"fucoidan","score":1.0},{"id":"https://openalex.org/keywords/binding-thermodynamics","display_name":"binding thermodynamics","score":0.875},{"id":"https://openalex.org/keywords/enthalpy-entropy-compensation","display_name":"enthalpy-entropy compensation","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8727620840072632},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.8704007863998413},{"id":"https://openalex.org/C2775909754","wikidata":"https://www.wikidata.org/wiki/Q1144687","display_name":"Fucoidan","level":3,"score":0.8223955035209656},{"id":"https://openalex.org/C2776841590","wikidata":"https://www.wikidata.org/wiki/Q66589589","display_name":"Fucose","level":3,"score":0.7205864191055298},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5334739089012146},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.5306239128112793},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5182645320892334},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.478360116481781},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.475471168756485},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.46782582998275757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46469470858573914},{"id":"https://openalex.org/C137610392","wikidata":"https://www.wikidata.org/wiki/Q2425020","display_name":"Glycopeptide","level":3,"score":0.45349442958831787},{"id":"https://openalex.org/C118859902","wikidata":"https://www.wikidata.org/wiki/Q133516","display_name":"Monosaccharide","level":2,"score":0.4344369173049927},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.2546781897544861},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.18319883942604065},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.14343580603599548},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/ejoc.202200302","doi":"https://doi.org/10.1002/ejoc.202200302","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ejoc.202200302","pdf_url":null,"source":{"id":"https://openalex.org/S21317199","display_name":"European Journal of Organic Chemistry","issn_l":"1099-0690","issn":["1099-0690","1434-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:36120398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36120398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of organic chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9479679","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9479679","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"European J Org Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9479679","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9479679","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"European J Org Chem","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8486554097","display_name":"Mechanistic insight into tumor-associated MUC1 glycopeptides binding to macrophage galactose-type lectin","funder_award_id":"R15CA242351","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W655735221","https://openalex.org/W1182461782","https://openalex.org/W1553087448","https://openalex.org/W1588979652","https://openalex.org/W1858566324","https://openalex.org/W1972770938","https://openalex.org/W1977560287","https://openalex.org/W1982413610","https://openalex.org/W1989270637","https://openalex.org/W2006716460","https://openalex.org/W2015189157","https://openalex.org/W2023268526","https://openalex.org/W2028734972","https://openalex.org/W2042143311","https://openalex.org/W2053481226","https://openalex.org/W2061193299","https://openalex.org/W2064847396","https://openalex.org/W2070570051","https://openalex.org/W2076595001","https://openalex.org/W2085106089","https://openalex.org/W2096914244","https://openalex.org/W2104194763","https://openalex.org/W2104467744","https://openalex.org/W2106982904","https://openalex.org/W2134294354","https://openalex.org/W2152991664","https://openalex.org/W2171521392","https://openalex.org/W2302861320","https://openalex.org/W2311800161","https://openalex.org/W2403741171","https://openalex.org/W2414750039","https://openalex.org/W2534505019","https://openalex.org/W2602337359","https://openalex.org/W2624283596","https://openalex.org/W2626933585","https://openalex.org/W2730217732","https://openalex.org/W2737256652","https://openalex.org/W2742564951","https://openalex.org/W2756296672","https://openalex.org/W2806299764","https://openalex.org/W2808618567","https://openalex.org/W2904251696","https://openalex.org/W2909638144","https://openalex.org/W2945126503","https://openalex.org/W2947334208","https://openalex.org/W2953209124","https://openalex.org/W2994365321","https://openalex.org/W2999821073","https://openalex.org/W3011461706","https://openalex.org/W3012713210","https://openalex.org/W3018175226","https://openalex.org/W3036448657","https://openalex.org/W3044523204","https://openalex.org/W3045811532","https://openalex.org/W3096958328","https://openalex.org/W3128188841","https://openalex.org/W3133926737"],"related_works":["https://openalex.org/W7212394047","https://openalex.org/W2069373873","https://openalex.org/W2005366795","https://openalex.org/W1933716345","https://openalex.org/W2156443620","https://openalex.org/W1530269986","https://openalex.org/W2061067607","https://openalex.org/W2056996668","https://openalex.org/W1534872489","https://openalex.org/W214472817"],"abstract_inverted_index":{"Abstract":[0],"Fluorescently":[1],"labelled":[2],"alanine":[3,91],"scan":[4],"analogues":[5,92],"of":[6,50,78,86,88,125],"odorranalectin":[7],"(OL),":[8],"a":[9],"cyclic":[10],"peptide":[11],"that":[12,31,70],"exhibits":[13,129],"lectin":[14,26],"like":[15],"properties,":[16],"were":[17,39,104],"screened":[18],"for":[19,41,80,106,116],"binding":[20,42,58,79,87,102],"BSA\u2010conjugated":[21],"monosaccharides":[22],"using":[23],"an":[24,73,132,141],"enzyme\u2010linked":[25],"assay":[27],"(ELLA).":[28],"Results":[29],"revealed":[30],"Lys5,":[32],"Phe7,":[33],"Tyr9,":[34],"Gly12,":[35],"Leu14,":[36],"and":[37,45,53,111,114],"Thr17":[38],"crucial":[40],"BSA\u2010L\u2010fucose,":[43],"BSA\u2010D\u2010galactose":[44],"BSA\u2010N\u2010acetyl\u2010D\u2010galactosamine.":[46,83],"Notably,":[47],"Ala":[48],"substitution":[49],"Ser3,":[51],"Pro4,":[52],"Val13":[54],"resulted":[55],"in":[56,76],"higher":[57],"affinities":[59,103],"compared":[60,135],"to":[61,100,131,136],"the":[62,89,107,117,137,147],"native":[63],"OL.":[64],"The":[65,84,122],"obtained":[66],"data":[67],"also":[68],"indicated":[69],"Arg8":[71],"plays":[72],"important":[74],"role":[75],"differentiation":[77],"BSA\u2010L\u2010fucose/D\u2010galactose":[81],"from":[82],"thermodynamics":[85],"selected":[90],"was":[93],"evaluated":[94],"by":[95],"isothermal":[96],"titration":[97],"calorimetry.":[98],"Low":[99],"moderate":[101],"determined":[105],"tetravalent":[108],"MUC1":[109],"glycopeptide":[110],"asialofetuin,":[112],"respectively,":[113],"high":[115],"fucose":[118],"rich":[119],"polysaccharide,":[120],"fucoidan.":[121],"thermodynamic":[123],"profile":[124],"interactions":[126],"with":[127,146],"asialofetuin":[128],"shift":[130],"entropy\u2010driven":[133],"mechanism":[134],"fucoidan,":[138],"which":[139],"displayed":[140],"enthalpy\u2010entropy":[142],"compensation,":[143],"typically":[144],"associated":[145],"carbohydrate\u2010lectin":[148],"recognition":[149],"process.":[150]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-07-24T00:00:00"}
