{"id":"https://openalex.org/W4286742015","doi":"https://doi.org/10.1038/s41598-022-16849-1","title":"Saliva as alternative to naso-oropharyngeal swab for SARS-CoV-2 detection by RT-qPCR: a multicenter cross-sectional diagnostic validation study","display_name":"Saliva as alternative to naso-oropharyngeal swab for SARS-CoV-2 detection by RT-qPCR: a multicenter cross-sectional diagnostic validation study","publication_year":2022,"publication_date":"2022-07-23","ids":{"openalex":"https://openalex.org/W4286742015","doi":"https://doi.org/10.1038/s41598-022-16849-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/35871257","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9308781"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-16849-1","doi":"https://doi.org/10.1038/s41598-022-16849-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-16849-1","pdf_url":"https://www.nature.com/articles/s41598-022-16849-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-16849-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108779718","display_name":"Michael L. Tee","orcid":"https://orcid.org/0000-0003-0113-8290","observed_orcids":["https://orcid.org/0000-0003-0113-8290"]},"institutions":[{"id":"https://openalex.org/I2802181614","display_name":"Philippine General Hospital","ror":"https://ror.org/00a56am39","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I103911934","https://openalex.org/I2802181614"]},{"id":"https://openalex.org/I4405279074","display_name":"Medical Center Manila","ror":"https://ror.org/00zeg0323","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I4405279074"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":true,"raw_author_name":"Michael L. Tee","raw_affiliation_strings":["College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines. mltee@up.edu.ph","Medical Center Manila, Manila, National Capital Region, Philippines. mltee@up.edu.ph","College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines. mltee@up.edu.ph","institution_ids":["https://openalex.org/I2802181614","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Medical Center Manila, Manila, National Capital Region, Philippines. mltee@up.edu.ph","institution_ids":["https://openalex.org/I4405279074"]},{"raw_affiliation_string":"College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines","institution_ids":["https://openalex.org/I2802181614","https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064550724","display_name":"Aedrian A. Abrilla","orcid":"https://orcid.org/0000-0003-1938-3403","observed_orcids":["https://orcid.org/0000-0003-1938-3403"]},"institutions":[{"id":"https://openalex.org/I2802181614","display_name":"Philippine General Hospital","ror":"https://ror.org/00a56am39","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I103911934","https://openalex.org/I2802181614"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Aedrian A. Abrilla","raw_affiliation_strings":["College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines","institution_ids":["https://openalex.org/I2802181614","https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005823465","display_name":"Cherica Tee","orcid":"https://orcid.org/0000-0002-0766-0189","observed_orcids":["https://orcid.org/0000-0002-0766-0189"]},"institutions":[{"id":"https://openalex.org/I2802181614","display_name":"Philippine General Hospital","ror":"https://ror.org/00a56am39","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I103911934","https://openalex.org/I2802181614"]},{"id":"https://openalex.org/I4405279074","display_name":"Medical Center Manila","ror":"https://ror.org/00zeg0323","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I4405279074"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Cherica A. Tee","raw_affiliation_strings":["College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines","Medical Center Manila, Manila, National Capital Region, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines","institution_ids":["https://openalex.org/I2802181614","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Medical Center Manila, Manila, National Capital Region, Philippines","institution_ids":["https://openalex.org/I4405279074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061494396","display_name":"Leslie Michelle M. Dalmacio","orcid":"https://orcid.org/0000-0002-6475-232X","observed_orcids":["https://orcid.org/0000-0002-6475-232X"]},"institutions":[{"id":"https://openalex.org/I2802181614","display_name":"Philippine General Hospital","ror":"https://ror.org/00a56am39","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I103911934","https://openalex.org/I2802181614"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Leslie Michelle M. Dalmacio","raw_affiliation_strings":["College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine and Philippine General Hospital, University of the Philippines Manila, Pedro Gil Street, Ermita, 1000, Manila, National Capital Region, Philippines","institution_ids":["https://openalex.org/I2802181614","https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070712510","display_name":"Vivencio Jose P. Villaflor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vivencio Jose P. Villaflor","raw_affiliation_strings":["Dagupan Doctors Villaflor Memorial Hospital, Dagupan City, Pangasinan, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dagupan Doctors Villaflor Memorial Hospital, Dagupan City, Pangasinan, Philippines","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014212290","display_name":"Al-Zamzam A. Abubakar","orcid":"https://orcid.org/0009-0006-2639-007X","observed_orcids":["https://orcid.org/0009-0006-2639-007X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Al-Zamzam A. Abubakar","raw_affiliation_strings":["Ciudad Medical Zamboanga, Zamboanga City, Zamboanga del Sur, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciudad Medical Zamboanga, Zamboanga City, Zamboanga del Sur, Philippines","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012545427","display_name":"Pedrito Y. Tagayuna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedrito Y. Tagayuna","raw_affiliation_strings":["Fe Del Mundo Medical Center, Quezon City, National Capital Region, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fe Del Mundo Medical Center, Quezon City, National Capital Region, Philippines","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068141976","display_name":"Sheldon Steven C. Aquino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheldon Steven C. Aquino","raw_affiliation_strings":["Dagupan Doctors Villaflor Memorial Hospital, Dagupan City, Pangasinan, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dagupan Doctors Villaflor Memorial Hospital, Dagupan City, Pangasinan, Philippines","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044105012","display_name":"Vicente Aaron L. Bernardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vicente Aaron L. Bernardo","raw_affiliation_strings":["Dagupan Doctors Villaflor Memorial Hospital, Dagupan City, Pangasinan, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dagupan Doctors Villaflor Memorial Hospital, Dagupan City, Pangasinan, Philippines","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108744198","display_name":"Ronald R. Matias","orcid":"https://orcid.org/0000-0001-5257-803X","observed_orcids":["https://orcid.org/0000-0001-5257-803X"]},"institutions":[{"id":"https://openalex.org/I4210116402","display_name":"St. Luke's Medical Center","ror":"https://ror.org/02h4kdd20","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I4210116402"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Ronald R. Matias","raw_affiliation_strings":["St. Luke's Medical Center, National Capital Region, Quezon City, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Luke's Medical Center, National Capital Region, Quezon City, Philippines","institution_ids":["https://openalex.org/I4210116402"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108779718"],"corresponding_institution_ids":["https://openalex.org/I2802181614","https://openalex.org/I4405279074","https://openalex.org/I5791819"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":1.2159,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79790182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"12612","last_page":"12612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8320000171661377},{"id":"https://openalex.org/keywords/saliva-analysis","display_name":"saliva testing","score":0.8870000243186951},{"id":"https://openalex.org/keywords/rt-qpcr","display_name":"RT-qPCR","score":0.8500000238418579},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/rna-extraction","display_name":"RNA extraction","score":0.6200000047683716},{"id":"https://openalex.org/keywords/composite-reference-standard","display_name":"composite reference standard","score":0.8209999799728394},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.7498173117637634},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.7148106098175049},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.6761853098869324},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6351968050003052},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5895331501960754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5447668433189392},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.5385206341743469},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49073922634124756},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17988130450248718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1626960039138794},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.15507173538208008},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07267937064170837},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.071963369846344},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000086742","descriptor_name":"COVID-19 Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009305","descriptor_name":"Nasopharynx","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019411","descriptor_name":"Clinical Laboratory Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-022-16849-1","doi":"https://doi.org/10.1038/s41598-022-16849-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-16849-1","pdf_url":"https://www.nature.com/articles/s41598-022-16849-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1350489/v1","doi":"https://doi.org/10.21203/rs.3.rs-1350489/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1350489/v1","pdf_url":"https://www.researchsquare.com/article/rs-1350489/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9308781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9308781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:35871257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35871257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dbed8a1ef0194fc2a563c45a60daffd8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dbed8a1ef0194fc2a563c45a60daffd8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-16849-1","doi":"https://doi.org/10.1038/s41598-022-16849-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-16849-1","pdf_url":"https://www.nature.com/articles/s41598-022-16849-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324410","display_name":"University of the Philippines","ror":"https://ror.org/02hqkr514"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4286742015.pdf","grobid_xml":"https://content.openalex.org/works/W4286742015.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W2022961959","https://openalex.org/W2135181248","https://openalex.org/W2164777277","https://openalex.org/W3010719113","https://openalex.org/W3013613225","https://openalex.org/W3015058054","https://openalex.org/W3016053819","https://openalex.org/W3016764858","https://openalex.org/W3021274772","https://openalex.org/W3023118558","https://openalex.org/W3036122602","https://openalex.org/W3098622916","https://openalex.org/W3101614547","https://openalex.org/W3111603235","https://openalex.org/W3113716702","https://openalex.org/W3119343341","https://openalex.org/W3120226689","https://openalex.org/W3134589351","https://openalex.org/W3137107306","https://openalex.org/W3190544638","https://openalex.org/W4200373972","https://openalex.org/W4220671203","https://openalex.org/W4280582452","https://openalex.org/W4295202959","https://openalex.org/W4381953038","https://openalex.org/W7073803467"],"related_works":["https://openalex.org/W7080151752","https://openalex.org/W4282049764","https://openalex.org/W4389089073","https://openalex.org/W3120611829","https://openalex.org/W3188017990","https://openalex.org/W4410360173","https://openalex.org/W3081517366","https://openalex.org/W7017931140","https://openalex.org/W4293204614","https://openalex.org/W3157224068"],"abstract_inverted_index":{"Saliva":[0],"has":[1],"been":[2],"demonstrated":[3,150],"as":[4,53,70],"feasible":[5],"alternative":[6],"to":[7,57,101,142,146,169],"naso-oropharyngeal":[8],"swab":[9],"(NOS)":[10],"for":[11,43,123,138],"SARS-CoV-2":[12,71,84],"detection":[13,72],"through":[14],"reverse":[15],"transcription":[16],"quantitative/real-time":[17],"polymerase":[18],"chain":[19],"reaction":[20],"(RT-qPCR).":[21],"This":[22],"study":[23],"compared":[24,141],"the":[25],"diagnostic":[26,153],"agreement":[27],"of":[28,111],"conventional":[29,160,170],"NOS,":[30],"saliva":[31,37,94,163],"with":[32],"RNA":[33,39],"extraction":[34,40],"(SE)":[35],"and":[36,65,91,106,118,126,133,161],"without":[38],"(SalivaDirect)":[41],"processing":[42],"RT-qPCR":[44,125,140,164,172],"in":[45,73,87,173],"identifying":[46],"SARS-CoV-2.":[47,175],"All":[48],"techniques":[49],"were":[50,68,99],"also":[51],"compared,":[52],"separate":[54],"index":[55],"tests,":[56],"a":[58,103],"composite":[59],"reference":[60],"standard":[61],"(CRS)":[62],"where":[63],"positive":[64],"negative":[66],"results":[67],"defined":[69],"either":[74],"one":[75],"or":[76],"no":[77],"sample,":[78],"respectively.":[79],"Of":[80],"517":[81],"paired":[82],"samples,":[83],"was":[85],"detected":[86],"150":[88],"(29.01%)":[89],"NOS":[90,143,171],"151":[92],"(29.21%)":[93],"specimens.":[95],"The":[96],"saliva-based":[97],"tests":[98],"noted":[100],"have":[102],"sensitivity,":[104],"specificity":[105],"accuracy":[107],"(95%":[108],"confidence":[109],"interval)":[110],"92.67%":[112],"(87.26%,":[113],"96.28%),":[114],"97.55%":[115],"(95.40%,":[116],"98.87%)":[117],"96.13%":[119],"(94.09%,":[120],"97.62%),":[121],"respectively,":[122,137],"SE":[124],"91.33%":[127],"(85.64%,":[128],"95.30%),":[129],"98.91%":[130],"(97.23%,":[131],"99.70%)":[132],"96.71%":[134],"(94.79%,":[135],"98.07%),":[136],"SalivaDirect":[139],"RT-qPCR.":[144],"Compared":[145],"CRS,":[147],"all":[148],"platforms":[149],"statistically":[151],"similar":[152],"performance.":[154],"These":[155],"findings":[156],"suggest":[157],"that":[158],"both":[159],"streamlined":[162],"are":[165],"at":[166],"least":[167],"non-inferior":[168],"detecting":[174]},"counts_by_year":[{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-23T00:00:00"}